EPS-GAG-00031

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAG-00031

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	183.1	8.8E-54	154	409	256

Status

Unreviewed

Ensembl Protein

ENSGALP00000002266

UniProt Accession

F1NRQ1;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1F

Gene Synonyms/Alias

PPM1F;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000001493	ENSGALP00000002266	ENSGALT00000002268

Organism

Gallus gallus

Functional Description

Protein Length

450

Protein Sequence
(FASTA)

PPPRAPTAVS ALMALEAEAA GSPLGSFLRD FPSALGPGEP LPWSSAGSGA VSEVEAPGAL 60

AELARNLLGG SRGVSPLLAA SLIHAAVDEV LRTDLTEFKK ESVERQGEGD EERLTLLDGE 120

LLQRCFFNKL RDVCFEWQKQ LPPLRSLKRF LLVSIHAIRN TRRKMEDRHV ILTEFNQLFG 180

LAQKDDIDRA YFAIFDGHGG VDAANYSATH LHVNVGLHEE IVKNPAEALK CSFRKTDEMF 240

LLKAKRERLR SGTTGVSALI VGNKLHIAWL GDSQVMLVQQ GNAVTLMEPH KPEREDERAR 300

IEALGGCVTY MDCWRVNGTL AVSRAIGDVC QKPYISGDAD GDTFDLTGSE DYLLLACDGF 360

FDAVKPYEVV DLVLDHLMQT KGVGLKAAER LVAAAKENGS NDNITVLVVF LRDPQDILAD 420

CLRDTKSLEA GDDARSSPFN FLSCEAAATQ 450

Nucleotide Sequence
(FASTA)

CCCCCCCCTC GGGCGCCCAC GGCAGTCAGC GCGCTGATGG CGCTGGAAGC GGAGGCGGCC 60

GGGTCTCCCC TCGGCTCCTT CCTCAGGGAC TTCCCGTCCG CGCTCGGCCC GGGGGAGCCA 120

CTGCCGTGGA GCTCGGCGGG GAGCGGCGCC GTGAGCGAGG TCGAGGCGCC GGGCGCACTG 180

GCCGAGTTGG CGAGGAACCT CCTGGGCGGC AGCAGAGGTG TTTCACCACT CCTTGCAGCA 240

TCGTTGATCC ACGCTGCAGT TGATGAAGTT CTCCGAACAG ACTTGACTGA ATTTAAGAAG 300

GAAAGTGTGG AAAGGCAGGG AGAAGGAGAT GAGGAAAGGC TCACCTTGCT GGATGGAGAG 360

TTGCTGCAGC GCTGCTTCTT TAACAAACTT CGGGATGTCT GCTTTGAATG GCAGAAGCAG 420

TTGCCACCAC TGAGATCACT GAAGCGTTTC CTGCTTGTTT CCATCCATGC CATCCGTAAC 480

ACTCGACGGA AAATGGAGGA CCGCCACGTT ATCCTCACGG AGTTCAATCA GCTGTTTGGC 540

TTAGCACAAA AGGATGACAT CGATCGTGCT TACTTTGCGA TATTTGACGG CCATGGTGGA 600

GTGGATGCTG CCAATTATTC AGCAACCCAT TTACATGTAA ATGTGGGGCT ACATGAAGAG 660

ATTGTTAAGA ATCCAGCTGA GGCCTTGAAA TGCTCTTTCC GGAAGACAGA TGAAATGTTT 720

CTTCTCAAAG CCAAAAGAGA GAGGCTGCGG AGTGGTACAA CAGGTGTATC TGCATTGATT 780

GTAGGGAACA AGCTACACAT AGCATGGCTA GGCGACTCGC AGGTAATGCT TGTGCAGCAA 840

GGAAATGCTG TCACATTAAT GGAGCCTCAC AAACCAGAGA GAGAAGATGA GAGAGCGCGT 900

ATTGAGGCTC TGGGTGGATG TGTAACCTAC ATGGACTGCT GGCGGGTTAA TGGCACTTTG 960

GCTGTTTCCA GAGCAATTGG TGATGTGTGT CAAAAGCCTT ACATCTCTGG TGATGCAGAT 1020

GGAGATACAT TTGATCTGAC TGGTTCTGAA GATTACTTGC TCCTAGCCTG TGATGGATTC 1080

TTCGATGCTG TCAAGCCATA TGAGGTTGTA GACTTAGTCC TAGATCATTT AATGCAAACC 1140

AAAGGAGTGG GTCTCAAAGC AGCAGAAAGA CTGGTGGCTG CTGCGAAGGA AAATGGATCC 1200

AATGACAACA TTACTGTTTT AGTGGTGTTC TTGAGGGATC CACAGGACAT CTTGGCAGAC 1260

TGTCTCAGAG ACACTAAGAG CCTTGAGGCT GGGGATGATG CTCGGAGCTC ACCCTTTAAT 1320

TTCCTCAGCT GTGAGGCAGC AGCCACACAG TGA 1353

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr....laffgvyDGhggsevakfcseklhe  59

         ++ ++ + r++med++ + ++f +  +  ++     a+f+++DGhgg ++a++ +++lh

Q: 154   SIHAIRNTRRKMEDRHVILTEFNQLFGLAQKddidRAYFAIFDGHGGVDAANYSATHLHV  213

         5678999**************999887777777889***********************9

S: 60    ilaeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyv  119

          +    e      ++  +al+ +F +tde +  l +++ +  +sG+t v ali ++kl++

Q: 214   NVGLHEE----IVKNPAEALKCSFRKTDEMF--LLKAKRERLRSGTTGVSALIVGNKLHI  267

         9998855....999999**************..6666688888*****************

S: 120   anvGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdgaRvlGvLavsRalG  179

         a +GdS+++L ++g+av+l + Hkp+redE++Rie+ gg v++ d+ Rv+G LavsRa+G

Q: 268   AWLGDSQVMLVQQGNAVTLMEPHKPEREDERARIEALGGCVTYMDCWRVNGTLAVSRAIG  327

         *********************************************99*************

S: 180   dlylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqea  238

         d+  kpy++ + +   ++lt ++++l La+DG +d v++ e+v+lv d+l  +k    +a

Q: 328   DVCQKPYISGDADGDTFDLTGSEDYLLLACDGFFDAVKPYEVVDLVLDHLMqTKGVGLKA  387

         ***********************************************998846667889*

S: 239   akkLvklalargskdnvsaivv  260

         a++Lv+ a ++gs+dn++++vv

Q: 388   AERLVAAAKENGSNDNITVLVV  409

         *****************99987

Domain Sequence
(FASTA)

SIHAIRNTRR KMEDRHVILT EFNQLFGLAQ KDDIDRAYFA IFDGHGGVDA ANYSATHLHV 60

NVGLHEEIVK NPAEALKCSF RKTDEMFLLK AKRERLRSGT TGVSALIVGN KLHIAWLGDS 120

QVMLVQQGNA VTLMEPHKPE REDERARIEA LGGCVTYMDC WRVNGTLAVS RAIGDVCQKP 180

YISGDADGDT FDLTGSEDYL LLACDGFFDA VKPYEVVDLV LDHLMQTKGV GLKAAERLVA 240

AAKENGSNDN ITVLVV 256

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0043234	; C:protein complex
GO:0033192	; F:calmodulin-dependent protein phosphatase activity
GO:0046872	; F:metal ion binding
GO:0035690	; P:cellular response to drug
GO:0097193	; P:intrinsic apoptotic signaling pathway
GO:0033137	; P:negative regulation of peptidyl-serine phosphorylation
GO:0044387	; P:negative regulation of protein kinase activity by regulation of protein phosphorylation
GO:0045892	; P:negative regulation of transcription, DNA-dependent
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0050921	; P:positive regulation of chemotaxis
GO:0043280	; P:positive regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0051894	; P:positive regulation of focal adhesion assembly
GO:0010628	; P:positive regulation of gene expression
GO:0045927	; P:positive regulation of growth
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013