EKS-GAG-00051
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00051
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/CDK372.91.0E-1117281021294
StatusUnreviewed
Ensembl ProteinENSGALP00000002654
UniProt AccessionE1BUG0;
Protein Name
Protein Synonyms/Alias
Gene NameCDK12
Gene Synonyms/Alias CDK12;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000001731ENSGALP00000002654ENSGALT00000002657
OrganismGallus gallus
Functional Description
Protein Length1043
Protein Sequence
(FASTA)
MPNPERHGGK KDGGGGGSSQ HAPGSSNSKE RHRVASRHKR HKSRHSKESP LAAQETAAPL 60
GAVIKPLVEY DDISSDSDTF SDDVALKLDR RENEERKADR SERTQKHRHH QHKRIRELMK 120
SKQAEKERKL EKSLEASSRS GSTKDRVSGS SKRLLESEEH PKALSSKSSN KESRSAKAHK 180
EKSRKDRELK SSHKERSKSH RKRDAPKSYK TIDSPKRKSR SPHRKWLDSP KLDDSPSGAS 240
YVQEYDLSPP RSHTSSNYDP YRKSPGGSSR RQSISPPYKE PVAYQSNTRS PSPYSRRQRS 300
ISPYNRRRSS SYERGSGSYS GRSPSPYGRR RSSSPFAAKR SMSRSPIASR KSVKSRSRSP 360
GYSRHSSSHS KKQRSGSRSR HSSISPTRLP LNSSLGAELS RKKKERAAAA AAAAKVDGKE 420
VKGSPVFLSK KENSLAELKE SGTESKKVIK TVRSEKSSSD TELVNLLCSN AETKAPAETT 480
KTKAEENSER KHPVPVRDSK QLGTKDLKPV AVTEDLRSPK ETDAAEKEIP PPLPSIKSPP 540
PPLPTTTPPP PTPPLPPLPP SPAVPPLPPS QQTPIQVPPS VPTSLSSSSH PRTSTLSSQV 600
NSQSSVQVAT KTQASVTAAI PHLKTSTLPP LPLPPILVGE DDLDSPKEIL PPKPVKKDRE 660
QRPRHLLTDL PLPPELPGGD PSPPDSPEPK AATPPQQPFK KRPKICCPRY GERRQTESDW 720
GKRCVDKFDI IGIIGEGTYG QVYKAKDKDT GELVALKKVR LDNEKEGFPI TAIREIKILR 780
QLIHRSVVNM KEIVTDKQDA LDFKKDKGAF YLVFEYMDHD LMGLLESGLV HFSEDHIKSF 840
MKQLMEGLDY CHKKNFLHRD IKCSNILLNN SGQIKLADFG LARLYSSEES RPYTNKVITL 900
WYRPPELLLG EERYTPAIDV WSCGCILGEL FTKKPIFQAN LELAQLELIS RLCGSPCPAV 960
WPDVIKLPYF NTMKPKKQYR RRLREEFSFI PSSALDLLDH MLTLDPGKRC TAEQALQSDF 1020
LKDVDLSKMA PPEPPHSQSC NEI 1043
Nucleotide Sequence
(FASTA)
ATGCCAAACC CGGAGAGACA TGGGGGCAAG AAGGATGGGG GCGGCGGGGG GTCCTCGCAG 60
CACGCGCCCG GCAGCTCCAA CAGCAAGGAG AGGCACCGGG TGGCTTCCAG GCACAAGAGG 120
CACAAATCCC GGCACTCCAA GGAGTCACCG CTGGCGGCCC AGGAGACGGC GGCACCTCTG 180
GGAGCTGTGA TCAAACCGCT GGTGGAGTAC GATGACATCA GTTCGGATTC GGACACCTTC 240
TCGGATGATG TGGCCCTCAA GTTGGACAGG AGGGAGAACG AGGAGAGGAA AGCGGATAGG 300
AGCGAAAGGA CACAGAAGCA CCGGCACCAC CAGCACAAAC GCATCCGTGA GCTGATGAAG 360
AGCAAACAGG CAGAGAAAGA GAGGAAGTTG GAAAAGAGCC TGGAGGCCTC CAGCAGGTCC 420
GGGTCTACCA AGGACAGGGT ATCGGGGTCC TCCAAGAGAC TGCTTGAAAG CGAGGAGCAC 480
CCGAAGGCGC TGTCCTCAAA GAGTAGCAAC AAGGAGTCCC GCTCAGCCAA AGCGCACAAA 540
GAGAAGTCCA GGAAGGATCG GGAGCTCAAG TCCAGCCACA AAGAGCGCAG TAAAAGCCAT 600
CGGAAAAGGG ATGCTCCCAA AAGTTATAAA ACCATTGACA GCCCGAAACG GAAATCCAGA 660
AGTCCCCACA GAAAATGGTT GGACAGCCCG AAATTGGACG ACAGCCCTTC TGGAGCCTCC 720
TATGTCCAGG AGTATGACCT CAGCCCGCCC CGCTCGCATA CGTCCAGTAA CTACGATCCC 780
TACAGGAAGA GCCCCGGCGG TTCGTCGCGC CGGCAGTCCA TCAGCCCACC CTACAAGGAA 840
CCCGTGGCCT ACCAGTCCAA CACACGGTCT CCCAGTCCCT ACAGCCGGAG GCAGAGGTCC 900
ATAAGCCCCT ACAACAGGAG GCGCTCCTCG AGCTACGAGA GGGGGAGTGG ATCATACAGT 960
GGGCGCTCAC CGAGTCCCTA CGGCCGAAGG CGCTCCAGCA GCCCTTTTGC TGCCAAGCGC 1020
TCCATGAGCC GAAGCCCCAT AGCCAGCAGG AAGTCTGTGA AGTCCCGAAG CCGAAGCCCG 1080
GGCTATTCGA GGCACTCATC ATCTCACAGC AAAAAGCAGA GGTCTGGCTC ACGCAGTCGC 1140
CATTCCAGTA TATCACCCAC AAGGCTGCCC CTCAACTCCA GTCTGGGGGC AGAGCTCAGC 1200
AGGAAGAAAA AGGAACGAGC GGCGGCGGCG GCAGCGGCTG CGAAGGTGGA TGGGAAGGAG 1260
GTGAAGGGCT CCCCTGTTTT CCTGTCAAAA AAGGAGAACA GCTTAGCTGA ACTTAAGGAG 1320
TCTGGAACGG AATCTAAAAA GGTCATCAAA ACTGTTAGAT CTGAAAAATC ATCTTCGGAT 1380
ACAGAATTAG TTAATTTACT GTGTTCGAAT GCAGAGACTA AAGCACCTGC GGAGACAACA 1440
AAAACCAAGG CAGAGGAGAA CTCGGAAAGG AAACATCCTG TTCCAGTTAG AGATTCGAAA 1500
CAGCTGGGAA CAAAAGACTT GAAGCCTGTA GCAGTGACAG AGGACCTTCG ATCTCCAAAG 1560
GAGACAGACG CAGCAGAGAA GGAGATTCCA CCCCCGCTGC CCTCCATAAA ATCACCTCCT 1620
CCACCTCTGC CGACCACCAC ACCGCCGCCT CCGACTCCAC CACTGCCACC TCTGCCTCCA 1680
TCGCCTGCTG TTCCGCCTTT GCCTCCATCC CAACAGACTC CCATTCAGGT CCCTCCTTCA 1740
GTCCCAACGT CTTTGTCATC ATCTTCCCAC CCAAGGACGT CTACTTTATC CTCTCAGGTG 1800
AACTCCCAGT CCTCTGTCCA AGTCGCTACA AAAACCCAAG CGTCTGTGAC GGCTGCTATC 1860
CCACACCTGA AAACTTCAAC GTTGCCTCCG CTTCCGCTCC CCCCTATTTT AGTTGGGGAA 1920
GATGACTTGG ATAGTCCAAA AGAGATTCTT CCTCCAAAAC CTGTGAAGAA AGATAGAGAG 1980
CAGAGACCAC GACACTTACT CACGGACCTC CCGCTCCCTC CAGAGCTCCC TGGAGGGGAT 2040
CCATCTCCTC CTGACTCCCC GGAACCAAAG GCAGCCACAC CACCTCAGCA ACCCTTCAAA 2100
AAGAGACCAA AAATCTGTTG TCCTCGGTAT GGGGAAAGGA GACAGACAGA AAGCGACTGG 2160
GGGAAGCGCT GTGTGGACAA GTTTGATATC ATTGGGATTA TTGGAGAAGG GACGTATGGG 2220
CAGGTGTACA AAGCCAAGGA CAAGGACACA GGTGAATTGG TGGCTCTCAA GAAGGTGCGA 2280
CTGGACAATG AGAAGGAGGG CTTCCCCATC ACAGCCATCC GTGAGATCAA AATCCTCCGG 2340
CAGCTGATCC ACCGCAGTGT TGTGAACATG AAGGAAATCG TCACGGACAA ACAAGATGCA 2400
CTGGATTTCA AAAAGGACAA AGGTGCCTTT TACCTTGTAT TTGAGTACAT GGACCATGAC 2460
CTAATGGGGC TGCTAGAATC TGGCTTGGTA CATTTCTCAG AGGACCATAT CAAGTCTTTC 2520
ATGAAACAGT TAATGGAAGG TCTGGATTAC TGTCACAAAA AGAATTTCCT TCATCGGGAT 2580
ATTAAGTGCT CCAACATCTT ATTGAACAAC AGTGGGCAAA TCAAACTTGC AGATTTTGGA 2640
CTTGCCCGAC TCTACAGCTC GGAGGAGAGC CGTCCATACA CAAATAAAGT CATTACATTA 2700
TGGTATCGAC CTCCAGAATT GCTGCTAGGT GAGGAGCGTT ACACGCCAGC CATAGATGTG 2760
TGGAGCTGTG GCTGTATCCT CGGGGAACTG TTTACAAAGA AGCCTATTTT TCAAGCCAAT 2820
CTGGAACTGG CTCAGCTTGA ATTAATCAGC CGGCTCTGTG GGAGCCCCTG TCCAGCAGTG 2880
TGGCCCGATG TCATCAAGTT GCCCTACTTC AACACTATGA AACCGAAGAA GCAATACCGA 2940
AGGCGCCTGC GTGAGGAGTT CTCCTTCATT CCTTCATCTG CTCTCGACCT GCTGGACCAC 3000
ATGCTGACGC TGGACCCTGG CAAGCGCTGC ACAGCAGAGC AGGCCCTGCA GAGTGACTTC 3060
CTTAAGGATG TTGACCTCAG CAAAATGGCA CCTCCAGAGC CACCACACTC TCAAAGTTGT 3120
AATGAAATC 3129
Domain Profile
S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60
         ++ +  igeGtyg+vykakdk+tge+vAlKk+rl++ekeg+pita+rEi++l++l h+ +
Q: 728   FDIIGIIGEGTYGQVYKAKDKDTGELVALKKVRLDNEKEGFPITAIREIKILRQLIHRSV  787
         667889******************************************************
S: 61    vkLlevva.........kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlle  111
         v+++e+v+         kdk  +yLvfe++++dL+ ll++    ++s++++ks+++ql+e
Q: 788   VNMKEIVTdkqdaldfkKDKGAFYLVFEYMDHDLMGLLESGLV-HFSEDHIKSFMKQLME  846
         ****************8899********************999.****************
S: 112   glaylHsnkilHRDlKpqNlLiskegklklaDfGlarafssplk.tytkevvTlwYraPe  170
         gl+y+H++++lHRD+K++N+L++++g++klaDfGlar +ss+++  yt++v+TlwYr+Pe
Q: 847   GLDYCHKKNFLHRDIKCSNILLNNSGQIKLADFGLARLYSSEESrPYTNKVITLWYRPPE  906
         ***************************************7665527**************
S: 171   lLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsk  230
         lLlg+++Y+ a+D+Ws+gcil el+t+kp+fq++ e  qle i++l+g+p  +vwp+v k
Q: 907   LLLGEERYTPAIDVWSCGCILGELFTKKPIFQANLELAQLELISRLCGSPCPAVWPDVIK  966
         ************************************************************
S: 231   lpeykksfpkkkkk.klkekvkklkekaldllekllaldpkkRisakealqhkyf  284
         lp +++  pkk+++ +l+e+++ + ++aldll+++l+ldp kR++a++alq++++
Q: 967   LPYFNTMKPKKQYRrRLREEFSFIPSSALDLLDHMLTLDPGKRCTAEQALQSDFL  1021
         *****7777777777******9999**************************9985
Domain Sequence
(FASTA)
FDIIGIIGEG TYGQVYKAKD KDTGELVALK KVRLDNEKEG FPITAIREIK ILRQLIHRSV 60
VNMKEIVTDK QDALDFKKDK GAFYLVFEYM DHDLMGLLES GLVHFSEDHI KSFMKQLMEG 120
LDYCHKKNFL HRDIKCSNIL LNNSGQIKLA DFGLARLYSS EESRPYTNKV ITLWYRPPEL 180
LLGEERYTPA IDVWSCGCIL GELFTKKPIF QANLELAQLE LISRLCGSPC PAVWPDVIKL 240
PYFNTMKPKK QYRRRLREEF SFIPSSALDL LDHMLTLDPG KRCTAEQALQ SDFL 294
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>
EKS-AIM-00061
EKS-BOT-00067
EKS-CAJ-00060
EKS-CAF-00064
EKS-CAP-00063
EKS-EQC-00064
EKS-FEC-00063
EKS-GOG-00064
EKS-HOS-00066
EKS-LOA-00063
EKS-MAM-00063
EKS-MOD-00061
EKS-MUM-00065
EKS-MUP-00067
EKS-MYL-00064
EKS-NOL-00058
EKS-ORA-00051
EKS-ORC-00061
EKS-OTG-00068
EKS-PES-00056
EKS-POA-00060
EKS-RAN-00061
EKS-SAH-00058
EKS-SUS-00057
EKS-TAG-00054
EKS-TUT-00059
EKS-VIP-00026
EKS-XET-00059
EKS-SAC-00066
Gene Ontology
GO:0016607; C:nuclear speck
GO:0005730; C:nucleolus
GO:0005524; F:ATP binding
GO:0008353; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0070816; P:phosphorylation of RNA polymerase II C-terminal domain
GO:0046777; P:protein autophosphorylation
GO:0043405; P:regulation of MAP kinase activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013