EKS-GAG-00225
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00225
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/DYRK454.52.2E-136190518329
StatusUnreviewed
Ensembl ProteinENSGALP00000002998
UniProt AccessionE1BW82;
Protein Name
Protein Synonyms/Alias
Gene NameHIPK1
Gene Synonyms/Alias HIPK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000001939ENSGALP00000002998ENSGALT00000003002
OrganismGallus gallus
Functional Description
Protein Length1214
Protein Sequence
(FASTA)
MASQLQVFSP PSVSSSAFCS AKKLKVEPSV WDVSGQSSSD KYYTHSKNLP AAQGQASSSH 60
QVANFSVPAY DQNLLLPAPS VEHIVVTAAD STGSSATASF QNSQTLTHRT NLSLLEPYQK 120
CGLKRKSEEV DSNGSVQIIE EHPPLMLQNR PAVGAAATTT TVTTKSSNSS GEGDYQLVQH 180
EILCSMTNSY EVLEFLGRGT FGQVAKCWKR STKEIVAIKI LKNHPSYARQ GQIEVSILSR 240
LSSENADEYN FVRSYECFQH KNHTCLVFEM LEQNLYDFLK QNKFSPLPLK YIRPILQQVA 300
TALMKLKSLG LIHADLKPEN IMLVDPARQP YRVKVIDFGS ASHVSKAVCS TYLQSRYYRA 360
PEIILGLPFC EAIDMWSLGC VIAELFLGWP LYPGASEYDQ IRYISQTQGL PAEYLLSAGT 420
KTSRFFNRDP NLGYPLWRLK TPEEHELETG IKSKEARKYI FNCLDDMAQV NMSTDLEGTD 480
MLAEKADRRE YIDLLKKMLT IDADKRITPL KTLNHPFVTM THLLDFPHSN HVKSCFQNME 540
ICKRRVNMYD TVNQIKSPFT THVAPNTSTN LTMSFNNQLN TVHNQASVLA SNSTAAATLS 600
LANSDVSLLN YQSALYPSSA APVAGVAQQS VSLQPGTTQI CTQTDPFQQT FIVCPPAFQT 660
GLQATTKHSG FPVRMENAVP IVPQAPAAQP LQIQSGVLTQ GSCTPLMVAT LHPQVATITP 720
QYAVPFTLNC AAGRPALVEQ TAAVLQAWPG GTQQILLPST WQQLPGVALH NSVQPAAVIP 780
ETIGSSQQLA DWSPRNAHSH GNQYSTLMQQ PSLLTNHVTL ATAQPLNVGV AHVVRQQQSS 840
NVPAKKNKQP APSTAKSSST LETVPTQVYS LIGSSPLRST SSSSNVLVPV QEQHQPIVIP 900
DTPSPPVSVI TIRSDTDEEE DSKYKPASLG MKQRSNVISY VTVNDSPDSD SSLNSPYATD 960
PLSSLRSTGG ALELPSRGAA DSSNSRTIIV PPLKTQLNDC IVATQASGIL SNTSKTKPVA 1020
SVSGQSSGCC ITPTGYRPHR VVANGVQPLN LSQNQQTTVL ASQERSGNAV PRRQQAYVAP 1080
LTSTISQAPY TFQHSSPVHP HLAAATANAH LSSQPHMYTY APTTAATLGS TTSIAHLFSP 1140
QGSSRHTQYA AHPSTLVHQV PVSVGPSLLT SANVPPAQYQ HQFAPQSYIG ASRGSAIYTG 1200
YPLSPTKINQ YSYL 1214
Nucleotide Sequence
(FASTA)
ATGGCCTCAC AGCTGCAGGT GTTTTCCCCT CCGTCAGTAT CCTCGAGTGC CTTCTGCAGT 60
GCCAAGAAAC TGAAAGTGGA GCCATCTGTC TGGGATGTTT CAGGACAGAG CAGTAGTGAC 120
AAGTATTATA CCCACAGCAA AAACCTCCCA GCAGCTCAAG GGCAAGCAAG CTCTTCTCAT 180
CAGGTAGCCA ACTTCAGTGT CCCTGCGTAC GACCAGAACC TCCTTCTCCC CGCTCCTTCG 240
GTTGAGCACA TTGTGGTTAC AGCAGCTGAC AGCACGGGCA GCAGTGCAAC AGCATCCTTC 300
CAGAACAGCC AAACCCTAAC GCATAGGACC AACCTTTCTT TACTGGAACC ATACCAAAAA 360
TGTGGATTAA AAAGGAAAAG TGAAGAGGTA GACAGCAACG GTAGTGTGCA GATAATTGAG 420
GAACATCCAC CTCTCATGCT GCAAAACAGA CCTGCGGTGG GTGCTGCGGC CACGACCACC 480
ACGGTAACCA CAAAGAGCAG CAATTCCAGC GGAGAAGGAG ATTATCAGCT GGTCCAGCAT 540
GAGATCCTGT GCTCTATGAC TAACAGCTAT GAGGTCTTGG AATTCCTGGG CCGTGGGACG 600
TTTGGGCAGG TGGCGAAGTG CTGGAAGCGT AGCACGAAGG AGATTGTAGC CATCAAAATC 660
CTGAAGAACC ATCCTTCCTA TGCCAGGCAG GGCCAGATAG AGGTGAGCAT CCTCTCTCGC 720
CTGAGCAGTG AGAATGCAGA CGAATATAAC TTTGTTCGCT CCTATGAATG CTTTCAACAC 780
AAGAATCATA CATGCCTTGT ATTTGAGATG CTGGAACAGA ACTTATATGA TTTCTTAAAA 840
CAAAACAAGT TCAGCCCGTT GCCCCTGAAA TACATCCGGC CAATTCTGCA GCAAGTGGCT 900
ACTGCCTTGA TGAAGTTAAA GAGCTTGGGT CTGATACATG CCGATTTGAA GCCAGAAAAC 960
ATTATGTTGG TGGATCCTGC ACGCCAGCCC TACAGAGTGA AGGTGATAGA CTTTGGTTCA 1020
GCCAGCCACG TATCCAAAGC CGTGTGCTCC ACTTACCTGC AGTCGCGCTA TTATAGGGCT 1080
CCTGAGATCA TCCTGGGTTT ACCGTTCTGT GAAGCTATTG ACATGTGGTC GCTGGGCTGT 1140
GTGATAGCTG AGCTGTTTCT GGGCTGGCCT CTGTATCCAG GAGCCTCTGA GTATGATCAG 1200
ATTCGTTATA TTTCACAAAC TCAAGGCCTT CCAGCGGAGT ATCTTCTCAG TGCAGGAACG 1260
AAAACAAGCA GGTTTTTTAA CAGAGATCCA AATTTGGGAT ACCCACTGTG GAGGCTAAAG 1320
ACCCCAGAAG AGCATGAGTT GGAGACAGGG ATAAAATCAA AAGAAGCAAG GAAATATATA 1380
TTCAACTGTT TGGATGATAT GGCGCAGGTG AATATGTCTA CAGACTTAGA AGGGACCGAC 1440
ATGTTGGCAG AGAAGGCTGA CCGAAGGGAG TATATTGATT TGTTGAAGAA AATGTTGACT 1500
ATTGATGCAG ATAAGAGAAT TACTCCGCTG AAGACTTTGA ACCATCCGTT TGTTACAATG 1560
ACCCATCTGC TGGATTTCCC ACACAGTAAT CACGTGAAAT CCTGCTTTCA GAATATGGAG 1620
ATCTGCAAGC GAAGAGTTAA TATGTATGAT ACAGTGAATC AGATTAAGAG CCCATTCACA 1680
ACTCACGTTG CTCCTAATAC AAGCACAAAT CTGACAATGA GCTTTAACAA CCAGCTCAAT 1740
ACAGTACACA ACCAGGCCAG TGTGTTGGCT TCCAATTCTA CTGCTGCTGC TACTCTTTCC 1800
CTGGCAAACT CGGATGTCTC CTTGCTAAAC TACCAGTCTG CTCTCTATCC GTCGTCTGCA 1860
GCACCTGTTG CAGGTGTGGC ACAACAGAGT GTCTCCTTGC AACCTGGAAC CACCCAGATC 1920
TGCACGCAGA CTGACCCGTT CCAGCAGACA TTCATTGTTT GTCCCCCTGC TTTCCAAACT 1980
GGACTTCAGG CAACTACAAA GCATTCCGGG TTCCCAGTAA GGATGGAGAA TGCTGTCCCA 2040
ATTGTACCAC AAGCACCTGC AGCACAGCCA CTGCAGATCC AATCTGGAGT TCTCACACAG 2100
GGAAGCTGTA CACCACTAAT GGTAGCAACT CTTCATCCTC AAGTAGCCAC CATCACGCCG 2160
CAGTATGCGG TCCCCTTTAC TCTGAACTGC GCAGCCGGCC GGCCAGCGCT AGTAGAACAG 2220
ACGGCTGCAG TACTGCAGGC CTGGCCTGGG GGAACCCAGC AGATACTGCT TCCTTCCACC 2280
TGGCAGCAGC TCCCAGGGGT TGCCTTGCAC AATTCTGTTC AGCCAGCAGC TGTGATTCCA 2340
GAGACGATCG GCAGCAGCCA GCAATTAGCT GACTGGAGCC CCAGGAATGC ACATTCCCAT 2400
GGAAATCAGT ACAGCACCCT CATGCAACAG CCATCGTTAC TGACCAACCA TGTGACGTTA 2460
GCTACAGCGC AGCCTCTGAA TGTTGGAGTT GCTCATGTTG TTAGGCAGCA GCAAAGCAGC 2520
AATGTTCCAG CAAAGAAGAA CAAGCAGCCA GCACCAAGCA CAGCCAAGTC CAGCTCCACT 2580
CTAGAAACTG TGCCCACTCA AGTTTACTCT CTCATTGGGA GCAGTCCTCT GCGCTCCACA 2640
TCCTCCTCCT CCAACGTGCT CGTCCCAGTG CAGGAGCAGC ACCAGCCCAT TGTGATCCCA 2700
GACACTCCAA GCCCTCCCGT CAGCGTCATC ACCATTCGCA GTGACACTGA TGAGGAAGAG 2760
GACAGCAAAT ATAAACCTGC CAGTTTGGGT ATGAAGCAGA GATCCAATGT CATCAGCTAC 2820
GTTACTGTTA ATGACTCCCC TGATTCCGAC TCCTCCCTGA ACAGCCCCTA TGCCACAGAC 2880
CCACTTTCTT CTCTCAGGAG TACAGGTGGT GCCCTGGAGC TGCCAAGCAG AGGAGCAGCT 2940
GACAGCTCCA ACTCTCGGAC TATCATTGTG CCACCATTGA AAACACAGCT CAATGACTGC 3000
ATTGTAGCTA CCCAAGCTTC AGGCATCCTG AGCAACACCA GTAAGACCAA GCCCGTGGCC 3060
TCTGTGAGTG GGCAGTCATC AGGATGCTGT ATAACACCAA CTGGGTACCG ACCACACCGC 3120
GTGGTAGCAA ACGGTGTGCA GCCTCTCAAT CTCAGCCAGA ACCAGCAAAC TACAGTGCTG 3180
GCCTCACAGG AGAGAAGTGG AAATGCAGTC CCACGTAGGC AGCAAGCTTA TGTGGCACCC 3240
CTCACATCAA CTATTTCTCA GGCTCCCTAC ACGTTTCAAC ACAGCAGCCC AGTGCATCCC 3300
CACCTGGCAG CAGCGACTGC GAATGCACAC CTGTCCAGCC AGCCACATAT GTACACTTAT 3360
GCTCCAACTA CTGCTGCAAC GTTGGGCTCC ACCACCTCCA TCGCCCATCT CTTCTCCCCT 3420
CAGGGCTCCT CACGGCACAC CCAGTACGCT GCCCACCCCA GCACACTTGT CCACCAGGTC 3480
CCTGTGAGTG TTGGTCCGAG TCTGCTGACT TCTGCAAATG TTCCACCTGC CCAGTACCAA 3540
CACCAGTTTG CTCCCCAGTC CTATATTGGT GCTTCCAGAG GATCTGCTAT TTACACTGGA 3600
TATCCGCTGA GCCCTACAAA GATCAACCAG TACTCATACT TATAG 3645
Domain Profile
S: 1     yevlevigkGsfgqVvkaldkktkeivaikiiknkkrfarqaqeEveiLeklnkkdkeek  60
         yevle++g+G+fgqV+k+++++tkeivaiki+kn++++arq+q+Ev+iL++l++ +++++
Q: 190   YEVLEFLGRGTFGQVAKCWKRSTKEIVAIKILKNHPSYARQGQIEVSILSRLSS-ENADE  248
         9****************************************************9.999**
S: 61    ynvvrllelfvfrnhlclvfellsqnLyellkknkfsglslklvrklaqqilkaLklLke  120
         yn+vr +e+f+++nh+clvfe+l+qnLy++lk+nkfs+l+lk++r+++qq+++aL++Lk+
Q: 249   YNFVRSYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPILQQVATALMKLKS  308
         ************************************************************
S: 121   lkiiHaDlKPeNillvekkrse..vkviDFGsssavsqkeiytyiqsrfYraPEiilglk  178
         l++iHaDlKPeNi+lv++ r++  vkviDFGs+s+vs+++++ty+qsr+YraPEiilgl+
Q: 309   LGLIHADLKPENIMLVDPARQPyrVKVIDFGSASHVSKAVCSTYLQSRYYRAPEIILGLP  368
         *********************999************************************
S: 179   ydeaiDmWSlGcvlaElftGkpLfpGenevdqlalivevlglppekllekakkakkff..  236
         ++eaiDmWSlGcv+aElf+G+pL+pG++e+dq+++i++++glp+e+ll++++k+++ff  
Q: 369   FCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTSRFFnr  428
         **********************************************************66
S: 237   .tkkeapkyilktk.........ksdrkkklvlnvkkaakkrkaplskelgealkekedk  286
           + ++p ++lkt          ks++++k+++n+ +++++++++++ e +++l+ek+d+
Q: 429   dPNLGYPLWRLKTPeeheletgiKSKEARKYIFNCLDDMAQVNMSTDLEGTDMLAEKADR  488
         556778889998889********************************************9
S: 287   l.fkdllkrmleldpakRitpkealkhpfv  315
         + ++dllk+ml++d++kRitp ++l+hpfv
Q: 489   ReYIDLLKKMLTIDADKRITPLKTLNHPFV  518
         99***************************7
Domain Sequence
(FASTA)
YEVLEFLGRG TFGQVAKCWK RSTKEIVAIK ILKNHPSYAR QGQIEVSILS RLSSENADEY 60
NFVRSYECFQ HKNHTCLVFE MLEQNLYDFL KQNKFSPLPL KYIRPILQQV ATALMKLKSL 120
GLIHADLKPE NIMLVDPARQ PYRVKVIDFG SASHVSKAVC STYLQSRYYR APEIILGLPF 180
CEAIDMWSLG CVIAELFLGW PLYPGASEYD QIRYISQTQG LPAEYLLSAG TKTSRFFNRD 240
PNLGYPLWRL KTPEEHELET GIKSKEARKY IFNCLDDMAQ VNMSTDLEGT DMLAEKADRR 300
EYIDLLKKML TIDADKRITP LKTLNHPFV 329
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00250
EKS-ANC-00257
EKS-BOT-00268
EKS-CAE-00238
EKS-CAJ-00274
EKS-CAF-00275
EKS-CAP-00303
EKS-ECT-00028
EKS-EQC-00260
EKS-ERE-00020
EKS-FEC-00254
EKS-GAM-00167
EKS-GOG-00268
EKS-HOS-00274
EKS-LAC-00279
EKS-LOA-00278
EKS-MAM-00270
EKS-MAE-00017
EKS-MEG-00213
EKS-MOD-00265
EKS-MUP-00265
EKS-MYL-00270
EKS-NOL-00245
EKS-ORC-00253
EKS-OTG-00274
EKS-PAT-00253
EKS-PES-00238
EKS-POA-00259
EKS-PRC-00023
EKS-PTV-00035
EKS-RAN-00283
EKS-SAH-00252
EKS-SUS-00239
EKS-TAG-00284
EKS-TUT-00033
EKS-VIP-00011
EKS-XET-00343
EKS-XIM-00338
Gene Ontology
GO:0005737; C:cytoplasm
GO:0016607; C:nuclear speck
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0042771; P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
GO:0008284; P:positive regulation of cell proliferation
GO:0010803; P:regulation of tumor necrosis factor-mediated signaling pathway
GO:0007224; P:smoothened signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013