EKS-GAG-00150

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00150

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	429.3	6.1E-129	358	614	257

Status

Unreviewed

Ensembl Protein

ENSGALP00000035514

UniProt Accession

F1P3G1;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKCD

Gene Synonyms/Alias

PRKCD;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000002016	ENSGALP00000003132	ENSGALT00000003137
ENSGALG00000002016	ENSGALP00000035514	ENSGALT00000036292

Organism

Gallus gallus

Functional Description

Protein Length

687

Protein Sequence
(FASTA)

MAPFLRISFN SFELGPVQNQ GEQLQPFCAI KMKEALTTER GKTLIQRKPT MYPEWKSTFD 60

AHIYEGRVIQ IVLMKAAEEP LSEVTVGVSV LAERCKKGSG KAEFWLDLQP QGKVLMAVQY 120

FLEDADCRQS MREEEGTVTI NRRGAIKQAK IHYIKNHEFI ATFFGQPTFC SVCKDFVWGL 180

NKQGYKCRQC NAAIHKKCID KIIGRCTGTA ANSRDTMFQK ERFNIDMPHR FKVYNYMSPT 240

FCDHCGSLLW GLVRQGLKCE ECAMNVHHKC QKKVANLCGI NQKLLAEALT QVSQKSTRRS 300

DSGSVENVGI YQDFDKKPRG PGGDTGADNS QYDKLWEGST AKAAPRIASR RKFNIDSFVF 360

HKVLGKGSFG KVLLAELKGK NEFFAIKALK KDVVLIDDDV ECTMVEKRVL ALAWENPFLT 420

HLYCTFQTKD HLFFVMEFLN GGDLMFHIQD KGRFDLYRAT FYGAEILCGL QFLHSKGIIY 480

RDLKLDNVML DKEGHIKIAD FGMCKENVVG ENKASTFCGT PDYIAPENKI LQGLKYTFSV 540

DWWSFGVLLY EMLIGQSPFH GDDEDELFES IRVDTPHYPR WITKESKDLL EKLFERDPTR 600

RLGVTGNIRD HPFFKTINWT TLEKREIDPP FKPKVKSASD YNNFDREFLN EKPKLSYSDK 660

NLIDSMDQSA FAGFSFTNPK FEQILEK 687

Nucleotide Sequence
(FASTA)

ATGGCCCCCT TCTTACGGAT ATCTTTCAAC TCATTTGAGC TGGGACCTGT GCAGAATCAA 60

GGGGAACAAC TACAGCCTTT CTGCGCTATC AAGATGAAGG AGGCACTGAC TACAGAGAGA 120

GGAAAAACTC TGATTCAGAG GAAACCCACC ATGTATCCAG AATGGAAGTC TACTTTTGAT 180

GCCCACATTT ATGAAGGACG CGTGATTCAG ATTGTTCTCA TGAAAGCAGC AGAAGAGCCA 240

TTATCTGAAG TGACTGTAGG TGTGTCTGTC CTGGCGGAGC GTTGCAAGAA GGGCAGTGGC 300

AAAGCAGAAT TCTGGCTTGA CCTACAGCCT CAGGGGAAGG TGCTGATGGC AGTGCAGTAT 360

TTTTTAGAAG ACGCAGATTG CAGACAGTCA ATGAGGGAAG AAGAGGGAAC AGTAACTATC 420

AACAGGAGAG GAGCTATCAA GCAAGCAAAA ATCCACTACA TCAAAAATCA TGAATTTATC 480

GCTACCTTCT TTGGACAGCC CACGTTTTGT TCTGTCTGCA AAGACTTCGT CTGGGGACTG 540

AACAAACAAG GATACAAATG TAGGCAGTGC AACGCTGCTA TTCATAAGAA ATGTATTGAT 600

AAAATCATTG GGAGATGTAC TGGTACTGCA GCCAACAGCA GAGACACAAT GTTTCAGAAG 660

GAACGTTTCA ACATCGACAT GCCTCACCGC TTCAAAGTTT ACAACTACAT GAGCCCTACC 720

TTCTGTGACC ACTGTGGCAG CCTGCTCTGG GGGCTGGTCA GGCAAGGACT CAAATGTGAA 780

GAATGTGCAA TGAATGTGCA TCATAAATGC CAAAAGAAGG TGGCCAACCT GTGTGGAATT 840

AACCAGAAGT TGCTAGCTGA AGCTTTAACT CAAGTCAGCC AGAAGTCTAC GCGAAGATCT 900

GATTCTGGAT CTGTAGAAAA TGTTGGCATT TACCAAGATT TTGATAAGAA ACCTCGAGGT 960

CCAGGAGGGG ATACAGGAGC AGATAACAGC CAGTATGATA AACTCTGGGA GGGAAGCACT 1020

GCCAAGGCAG CGCCACGAAT TGCAAGCAGG AGAAAATTCA ATATAGACAG CTTTGTCTTC 1080

CATAAAGTAC TGGGGAAAGG AAGTTTTGGA AAGGTACTGC TTGCTGAGCT AAAAGGAAAG 1140

AATGAGTTCT TTGCTATCAA AGCTCTGAAA AAAGACGTGG TGCTAATTGA TGATGATGTG 1200

GAATGTACCA TGGTGGAGAA GCGGGTCCTG GCACTTGCAT GGGAAAATCC ATTTCTCACA 1260

CACCTTTATT GCACGTTCCA GACAAAGGAT CACCTGTTTT TTGTTATGGA GTTCCTGAAT 1320

GGGGGAGACC TGATGTTTCA CATACAAGAC AAGGGGCGTT TTGATCTCTA CAGAGCAACG 1380

TTTTATGGAG CTGAAATTTT ATGTGGGCTA CAGTTTCTTC ACAGCAAAGG CATTATTTAT 1440

AGAGACCTAA AACTGGACAA TGTTATGCTC GATAAAGAAG GCCACATCAA AATAGCTGAT 1500

TTTGGAATGT GCAAAGAAAA TGTAGTTGGT GAGAACAAGG CAAGCACTTT CTGTGGGACC 1560

CCAGACTACA TTGCTCCAGA GAACAAGATT CTGCAAGGCT TGAAGTACAC ATTCTCTGTG 1620

GACTGGTGGT CATTTGGAGT CCTGCTATAC GAGATGCTCA TTGGACAGTC TCCTTTCCAT 1680

GGGGATGATG AAGATGAGTT GTTTGAGTCA ATCCGAGTGG ACACACCTCA CTACCCACGA 1740

TGGATTACCA AGGAATCAAA AGATTTATTA GAAAAGCTGT TTGAAAGAGA TCCAACAAGA 1800

AGACTTGGTG TCACTGGGAA TATCAGAGAT CATCCTTTCT TCAAAACCAT CAACTGGACG 1860

ACCCTAGAGA AGAGGGAGAT AGACCCTCCT TTCAAGCCAA AAGTGAAGTC AGCAAGTGAC 1920

TACAACAACT TCGACAGAGA ATTTCTGAAT GAGAAGCCAA AGCTTTCTTA CAGTGACAAA 1980

AACCTGATCG ACTCCATGGA CCAGTCTGCA TTCGCTGGCT TCTCGTTCAC CAACCCCAAA 2040

TTTGAGCAGA TCTTAGAAAA ATAG 2064

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f ++kvlGkGsfgkvllaelk+++e++aik lkkdvvl dddve+t+vekrvlala+++p

Q: 358   FVFHKVLGKGSFGKVLLAELKGKNEFFAIKALKKDVVLIDDDVECTMVEKRVLALAWENP  417

         889*********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl++l+++fqt+d+lffv+e++nGGdlmfhiq++++++  ra+fy aei+++l+flh+kg

Q: 418   FLTHLYCTFQTKDHLFFVMEFLNGGDLMFHIQDKGRFDLYRATFYGAEILCGLQFLHSKG  477

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPe..ilkeeeyg  178

         iiyrdlkldnv+ld+eGhik+adfG+cke+++ ++++stfcGtPdyiaPe  il++ +y+

Q: 478   IIYRDLKLDNVMLDKEGHIKIADFGMCKENVVGENKASTFCGTPDYIAPEnkILQGLKYT  537

         *************************************************9889*******

S: 179   ksvdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkd  238

         +svdww++Gvllyeml+gqsPf+g+dedelfesi+ ++++yP++++ke++++l++l+++d

Q: 538   FSVDWWSFGVLLYEMLIGQSPFHGDDEDELFESIRVDTPHYPRWITKESKDLLEKLFERD  597

         ************************************************************

S: 239   pekrlGvkeegeedikehaff  259

         p++rlGv  +g  +i++h+ff

Q: 598   PTRRLGV--TG--NIRDHPFF  614

         *******..56..89****98

Domain Sequence
(FASTA)

FVFHKVLGKG SFGKVLLAEL KGKNEFFAIK ALKKDVVLID DDVECTMVEK RVLALAWENP 60

FLTHLYCTFQ TKDHLFFVME FLNGGDLMFH IQDKGRFDLY RATFYGAEIL CGLQFLHSKG 120

IIYRDLKLDN VMLDKEGHIK IADFGMCKEN VVGENKASTF CGTPDYIAPE NKILQGLKYT 180

FSVDWWSFGV LLYEMLIGQS PFHGDDEDEL FESIRVDTPH YPRWITKESK DLLEKLFERD 240

PTRRLGVTGN IRDHPFF 257

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005911	; C:cell-cell junction
GO:0005829	; C:cytosol
GO:0005783	; C:endoplasmic reticulum
GO:0016363	; C:nuclear matrix
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0008047	; F:enzyme activator activity
GO:0046872	; F:metal ion binding
GO:0004697	; F:protein kinase C activity
GO:0006915	; P:apoptotic process
GO:0042100	; P:B cell proliferation
GO:0090398	; P:cellular senescence
GO:0016064	; P:immunoglobulin mediated immune response
GO:0035556	; P:intracellular signal transduction
GO:0030837	; P:negative regulation of actin filament polymerization
GO:0051490	; P:negative regulation of filopodium assembly
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0043407	; P:negative regulation of MAP kinase activity
GO:0050732	; P:negative regulation of peptidyl-tyrosine phosphorylation
GO:0090331	; P:negative regulation of platelet aggregation
GO:0042119	; P:neutrophil activation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:2000304	; P:positive regulation of ceramide biosynthetic process
GO:2000753	; P:positive regulation of glucosylceramide catabolic process
GO:1900163	; P:positive regulation of phospholipid scramblase activity
GO:0035307	; P:positive regulation of protein dephosphorylation
GO:2001022	; P:positive regulation of response to DNA damage stimulus
GO:2000755	; P:positive regulation of sphingomyelin catabolic process
GO:0032930	; P:positive regulation of superoxide anion generation
GO:0023021	; P:termination of signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR014376	; Prot_kin_PKC_delta.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00130	; C1_1; 2.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00008

; DAGPEDOMAIN.

Created Date

20-Feb-2013