EKS-GAG-00381

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00381

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CK1/CK1	467.7	9.8E-141	24	286	263

Status

Reviewed

Ensembl Protein

ENSGALP00000039481

UniProt Accession

Q5ZJS0;

Protein Name

Casein kinase I isoform gamma-1

Protein Synonyms/Alias

CKI-gamma 1;

Gene Name

CSNK1G1

Gene Synonyms/Alias

CSNK1G1; RCJMB04_16d5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000002279	ENSGALP00000003568	ENSGALT00000003575
ENSGALG00000002279	ENSGALP00000039481	ENSGALT00000040282
ENSGALG00000002279	ENSGALP00000003571	ENSGALT00000003578

Organism

Gallus gallus

Functional Description

Casein kinases are operationally defined by theirpreferential utilization of acidic proteins such as caseins as substrates. It can phosphorylate a large number of proteins. Participates in Wnt signaling (By similarity).

Protein Length

394

Protein Sequence
(FASTA)

GRSGHGSRPS SSASSGVLMV GPNFRVGKKI GCGNFGELRL GKNLYTNEYV AIKLEPIKSR 60

APQLHLEYRF YKQLGSAEGL PQVYYFGPCG KYNAMVLELL GPSLEDLFDL CDRTFTLKTV 120

LMIAIQLISR MEYVHSKNLI YRDVKPENFL IGRQGNKKDH VIHIIDFGLA KEYIDPETKK 180

HIPYREHKSL TGTARYMSIN THLGKEQSRR DDLEALGHMF MYFLRGSLPW QGLKADTLKE 240

RYQKIGDTKR NTPVEVLCEN FPEEMATYLR YVRRLDFFER PDYDYLRTIF TELFEKKGYT 300

FDYAYDWVGR PIPTPVGSVH VDSGTSAITR DSHVHRDRPS QVVSSTNGEL NVDDPTGAHS 360

NAPITAQAEV EVVEEAKCCC FFKRKRKKTA QRHK 394

Nucleotide Sequence
(FASTA)

GGGAGGAGCG GTCACGGCTC TCGGCCGAGC TCGTCTGCAT CTTCTGGTGT TCTTATGGTG 60

GGACCCAACT TCAGAGTGGG CAAGAAGATT GGGTGTGGGA ACTTTGGCGA GCTCAGACTA 120

GGCAAAAATC TCTACACCAA TGAATACGTA GCAATCAAAC TGGAACCAAT AAAATCACGT 180

GCACCACAAC TCCATTTAGA ATACAGATTT TACAAACAGC TTGGAAGTGC GGAAGGGCTT 240

CCCCAGGTTT ATTACTTTGG ACCGTGCGGA AAGTACAACG CCATGGTGCT GGAGCTGCTT 300

GGTCCTAGCT TGGAAGACTT GTTCGACCTC TGCGACAGGA CGTTCACTCT GAAAACGGTA 360

TTAATGATAG CCATCCAGCT GATCTCTCGA ATGGAATACG TGCATTCGAA GAACCTCATC 420

TACCGAGATG TCAAGCCAGA AAACTTCCTT ATCGGCCGGC AAGGCAATAA GAAAGACCAC 480

GTCATTCACA TCATAGACTT TGGACTGGCG AAGGAGTACA TTGACCCAGA AACCAAAAAA 540

CACATACCTT ACAGGGAACA CAAGAGCTTA ACTGGAACGG CGAGATACAT GTCCATCAAC 600

ACGCATCTTG GCAAAGAGCA AAGTCGTCGA GATGACTTGG AAGCCCTTGG CCACATGTTT 660

ATGTATTTCC TCCGAGGCAG TCTGCCCTGG CAAGGACTGA AGGCTGACAC CTTAAAAGAG 720

AGGTATCAGA AGATCGGGGA CACGAAGAGA AACACTCCAG TTGAAGTTCT CTGTGAGAAC 780

TTTCCAGAGG AGATGGCCAC ATACCTCCGT TATGTTCGGC GGTTAGATTT CTTCGAGAGA 840

CCAGACTATG ACTACTTACG AACCATCTTC ACGGAGCTGT TTGAGAAGAA AGGCTACACC 900

TTTGACTACG CCTATGACTG GGTCGGCAGG CCAATCCCTA CTCCAGTGGG ATCTGTTCAC 960

GTAGATTCCG GGACGTCTGC AATAACAAGA GACAGCCACG TCCATCGGGA CCGACCATCA 1020

CAGGTGGTTA GCTCGACCAA CGGAGAGCTG AACGTGGACG ACCCGACGGG GGCACACTCC 1080

AACGCACCTA TCACAGCACA GGCAGAGGTG GAAGTGGTGG AGGAAGCTAA GTGCTGCTGC 1140

TTCTTTAAGA GGAAACGGAA GAAGACGGCT CAGCGTCACA AG 1182

Domain Profile

S: 1     yrvvkkiGsGsfGdiylgknlasgeevaikleskkskapqlklesrvykilqggvgiPev  60

         +rv+kkiG+G+fG+++lgknl+++e+vaikle++ks+apql+le+r+yk+l +++g+P+v

Q: 24    FRVGKKIGCGNFGELRLGKNLYTNEYVAIKLEPIKSRAPQLHLEYRFYKQLGSAEGLPQV  83

         89**********************************************************

S: 61    ryfgkekkynvlvldllGpsledlfdlcerkfslktvllladqlisrieyvhskeliyrd  120

         +yfg+++kyn++vl+llGpsledlfdlc+r+f+lktvl++a+qlisr+eyvhsk+liyrd

Q: 84    YYFGPCGKYNAMVLELLGPSLEDLFDLCDRTFTLKTVLMIAIQLISRMEYVHSKNLIYRD  143

         ************************************************************

S: 121   ikPdnfllgigrkgkk....vylidfGlakkyrdaktkkhipyreeksltGtaryasint  176

         +kP+nfl  igr+g+k    +++idfGlak+y+d++tkkhipyre+ksltGtary+sint

Q: 144   VKPENFL--IGRQGNKkdhvIHIIDFGLAKEYIDPETKKHIPYREHKSLTGTARYMSINT  201

         *******..77777777788****************************************

S: 177   hlgkeqsrrddleslgyvllyflrgslPWqglkaatkkqkyekisekklstsievlcegf  236

         hlgkeqsrrddle+lg++++yflrgslPWqglka+t k++y+ki+++k++t++evlce+f

Q: 202   HLGKEQSRRDDLEALGHMFMYFLRGSLPWQGLKADTLKERYQKIGDTKRNTPVEVLCENF  261

         ************************************************************

S: 237   PeefatylkyvrklkfeekPdyeyl  261

         Pee+atyl+yvr+l+f+e+Pdy+yl

Q: 262   PEEMATYLRYVRRLDFFERPDYDYL  286

         ***********************97

Domain Sequence
(FASTA)

FRVGKKIGCG NFGELRLGKN LYTNEYVAIK LEPIKSRAPQ LHLEYRFYKQ LGSAEGLPQV 60

YYFGPCGKYN AMVLELLGPS LEDLFDLCDR TFTLKTVLMI AIQLISRMEY VHSKNLIYRD 120

VKPENFLIGR QGNKKDHVIH IIDFGLAKEY IDPETKKHIP YREHKSLTGT ARYMSINTHL 180

GKEQSRRDDL EALGHMFMYF LRGSLPWQGL KADTLKERYQ KIGDTKRNTP VEVLCENFPE 240

EMATYLRYVR RLDFFERPDY DYL 263

Keyword

ATP-binding; Complete proteome; Cytoplasm; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase; Wnt signaling pathway.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0016055	; P:Wnt receptor signaling pathway

KEGG

gga:415328

;

InterPros

IPR022247	; Casein_kinase-1_gamma_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF12605	; CK1gamma_C; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013