EKS-GAG-00242
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00242
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/DDR484.31.3E-145565855291
StatusUnreviewed
Ensembl ProteinENSGALP00000004224
UniProt AccessionF1NG66;
Protein Name
Protein Synonyms/Alias
Gene NameDDR2
Gene Synonyms/Alias DDR2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000002687ENSGALP00000004224ENSGALT00000004233
ENSGALG00000002687ENSGALP00000039297ENSGALT00000040088
OrganismGallus gallus
Functional Description
Protein Length862
Protein Sequence
(FASTA)
MPALPRAALL LLLLLLLCIL LAARAQVNPA VCRYPLGMSG GHIPDEDISA SSQWSESTAA 60
KYGRLDSEEG DGAWCPEIPV EPDDLKEFLQ IDLRALHFIT LVGTQGRHAG GHGNEFAPMY 120
KINYSRDGTR WISWRNRHGK QVLDGNSNPY DIVLKDLEPP LIARFVRFIP VTDHSMNVCL 180
RVELYGCAWL DGLVSYSAPA GQQLVLPSGT VIYLNDSVYD GAFGYSMTEG LGQLTDGVSG 240
LDDFTQTHEY HVWPGYDYVG WRNESTAGGY VEITFEFDRI RNFTTMKVHC NNMFAKGVKI 300
FKEVQCYFRS DANEWEPNAI SSVLVLDDVN PSARFVTVPL LHRMASAIKC QYYFADTWMM 360
FSEITFQSDA AMYNNSAVPP EMPMAPTTYD PTLKMDDSNT RILIGCLVAI IFILVAIIVI 420
ILWRQFWQKM LEKASRRMLD DEMTVSLSLP SESSMFNHNR SSSSSEHESN STYDRIFPLG 480
PDYQEPSRLI RKLPEFTAGE EDTGCSGLVK PSPASGPEGV PHYAEAEIVN LQGVTGGNTY 540
SVPALTMDLL SGKDVAVEEF PRKLLTFKEK LGEGQFGEVH LCEVEGMEKF ADKEFTLEGL 600
DASPNCPVLV AVKMLRADAN KNARNDFLKE IKIMSRLKDP NIIRLLAVCI TDDPLCMITE 660
YMMENGDLNQ FLSRHEAQSP PDASVPTISY SDLRFMATQI ASGMKYLSSL NFVHRDLATR 720
NCLVGKRYTI KIADFGMSRN LYSGDYYRIQ GRAVLPIRWM SWESILLGKF TTASDVWAFG 780
VTLWETFTLC REQPYSQLSD EQVIENTGEF FRDQGRQTYL PKPALCPDSV YKLMLSCWRR 840
DTKDRPSFQD LHRQLQEAAT EE 862
Nucleotide Sequence
(FASTA)
ATGCCGGCCC TGCCCAGAGC TGCCCTGCTA CTGCTGCTGC TGCTGCTGCT GTGCATCCTC 60
CTGGCAGCCA GAGCCCAGGT CAACCCCGCT GTGTGCCGGT ACCCCCTGGG AATGTCGGGT 120
GGGCACATCC CTGATGAGGA CATCTCAGCC TCCAGCCAGT GGTCCGAGTC CACGGCCGCC 180
AAGTACGGAC GGCTGGACTC GGAGGAGGGC GATGGTGCCT GGTGCCCCGA GATCCCAGTA 240
GAGCCTGACG ACCTGAAGGA GTTCCTGCAG ATTGACCTGC GTGCCCTCCA CTTCATCACA 300
CTGGTGGGCA CCCAGGGCCG TCACGCCGGA GGGCATGGCA ATGAGTTTGC CCCCATGTAC 360
AAGATCAACT ACAGCCGGGA CGGCACCCGC TGGATCTCCT GGCGGAACCG GCACGGGAAG 420
CAGGTCCTGG ATGGAAACTC CAACCCCTAC GACATCGTCC TCAAGGACCT GGAGCCACCG 480
CTCATTGCGC GCTTCGTCCG CTTCATCCCC GTCACCGACC ACTCCATGAA CGTGTGCCTG 540
CGTGTGGAGC TGTACGGCTG CGCGTGGCTT GACGGGCTGG TGTCCTACAG TGCTCCGGCC 600
GGGCAGCAGC TCGTCCTACC CAGCGGCACC GTCATCTACC TGAACGACTC TGTGTATGAT 660
GGGGCCTTCG GGTACAGCAT GACAGAGGGC CTGGGCCAGC TGACAGATGG CGTGTCGGGG 720
CTGGATGACT TCACACAGAC CCACGAGTAC CACGTCTGGC CGGGCTATGA CTACGTGGGC 780
TGGCGCAATG AGAGCACAGC CGGCGGCTAC GTGGAGATCA CCTTCGAGTT TGACCGCATC 840
AGGAACTTCA CCACCATGAA GGTGCACTGC AACAACATGT TCGCCAAAGG GGTGAAGATC 900
TTCAAGGAGG TGCAATGCTA TTTCCGATCC GATGCCAACG AGTGGGAGCC CAACGCCATC 960
TCCTCGGTGC TGGTGCTGGA CGACGTCAAC CCCAGCGCCC GCTTCGTCAC CGTGCCCCTG 1020
CTGCACCGCA TGGCCAGTGC CATCAAGTGC CAGTACTACT TTGCCGACAC CTGGATGATG 1080
TTCAGCGAGA TCACCTTCCA GTCGGATGCA GCCATGTACA ACAACTCAGC AGTTCCCCCG 1140
GAGATGCCCA TGGCCCCCAC CACATACGAC CCCACGCTCA AGATGGACGA TAGCAACACA 1200
CGCATCCTGA TCGGGTGCCT GGTGGCAATC ATCTTCATCC TGGTGGCCAT CATCGTCATC 1260
ATTCTGTGGC GGCAGTTCTG GCAGAAGATG CTGGAGAAGG CATCACGGAG GATGCTGGAT 1320
GACGAGATGA CCGTCAGCCT CTCCCTGCCC AGTGAATCCA GCATGTTCAA CCACAATCGC 1380
TCCTCCTCCT CCAGCGAGCA CGAGTCCAAT TCCACCTACG ACCGCATATT TCCCTTGGGT 1440
CCGGACTACC AGGAGCCCTC ACGCCTGATC CGCAAGCTGC CTGAGTTCAC GGCGGGTGAG 1500
GAGGACACGG GCTGCAGTGG CCTCGTGAAG CCATCCCCGG CCAGCGGCCC CGAGGGTGTC 1560
CCGCACTACG CCGAGGCTGA GATTGTGAAC CTGCAGGGCG TCACGGGTGG CAACACCTAC 1620
TCGGTGCCGG CCCTCACCAT GGACCTGCTG TCTGGCAAGG ACGTGGCTGT CGAGGAGTTC 1680
CCCAGGAAGC TGCTGACCTT CAAGGAGAAG CTAGGGGAGG GCCAGTTTGG GGAGGTTCAT 1740
CTCTGTGAGG TGGAGGGGAT GGAGAAGTTC GCGGACAAGG AGTTCACCCT GGAGGGCTTG 1800
GATGCCAGCC CCAACTGCCC CGTTCTAGTG GCTGTGAAGA TGCTGCGGGC CGATGCCAAC 1860
AAGAATGCCA GGAATGATTT CCTGAAGGAA ATCAAGATCA TGTCACGGCT CAAGGACCCC 1920
AACATCATCC GGCTGCTGGC GGTGTGCATC ACGGACGACC CGCTGTGCAT GATCACTGAG 1980
TACATGATGG AGAACGGCGA CCTCAACCAG TTCCTGTCCC GCCACGAGGC ACAGAGCCCA 2040
CCTGATGCCT CTGTGCCCAC CATCAGCTAC AGCGACCTGC GCTTCATGGC CACCCAGATC 2100
GCCTCCGGCA TGAAGTACCT GTCCTCCCTC AACTTCGTGC ACCGTGACCT GGCCACACGC 2160
AACTGCCTGG TGGGCAAGAG GTACACCATC AAGATCGCCG ACTTCGGCAT GAGCCGGAAC 2220
CTCTACAGCG GGGACTACTA CCGCATCCAG GGCCGTGCTG TGCTGCCCAT CCGCTGGATG 2280
TCCTGGGAGA GCATCCTGCT GGGCAAATTC ACCACGGCCA GCGATGTGTG GGCGTTTGGT 2340
GTGACACTGT GGGAGACCTT CACGCTGTGC CGGGAGCAGC CCTACTCACA GCTGTCTGAC 2400
GAGCAGGTCA TCGAGAACAC CGGGGAGTTC TTCCGGGACC AGGGCCGGCA GACGTACCTT 2460
CCCAAGCCTG CACTGTGCCC CGACTCTGTC TATAAGCTAA TGCTGAGCTG CTGGAGACGG 2520
GACACTAAAG ACCGTCCCTC CTTCCAGGAC CTGCACCGCC AGCTGCAGGA GGCGGCCACC 2580
GAGGAGTGA 2589
Domain Profile
S: 1     LlikeklGeGkfgevklCevegledlkekd........skgsallvavkslredanknar  52
         L++keklGeG+fgev+lCeveg+e++ +k+        s + ++lvavk+lr+danknar
Q: 565   LTFKEKLGEGQFGEVHLCEVEGMEKFADKEftlegldaSPNCPVLVAVKMLRADANKNAR  624
         789**************************999****999999******************
S: 53    kdflkeikilsrlkdPnivrllgvcvrdeplclileyv.enGdlnqflseheaedselak  111
         +dflkeiki+srlkdPni+rll+vc++d+plc+i+ey+ enGdlnqfls+hea++   a+
Q: 625   NDFLKEIKIMSRLKDPNIIRLLAVCITDDPLCMITEYMmENGDLNQFLSRHEAQSPPDAS  684
         *************************************6489*******************
S: 112   ektlsyellvsiatqiasglkyLeslnfvhrdlatrnclvgeeftvkiadfglsrslyag  171
          +t+sy+ l ++atqiasg+kyL+slnfvhrdlatrnclvg+ +t+kiadfg+sr+ly+g
Q: 685   VPTISYSDLRFMATQIASGMKYLSSLNFVHRDLATRNCLVGKRYTIKIADFGMSRNLYSG  744
         ************************************************************
S: 172   dyyrvqGravlPiRwmawesillgkfttasDvWafgvtlweiltlcreqPyeeltdeqvi  231
         dyyr+qGravlPiRwm+wesillgkfttasDvWafgvtlwe++tlcreqPy++l+deqvi
Q: 745   DYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTLCREQPYSQLSDEQVI  804
         ************************************************************
S: 232   enagelfrdqkrkvvlsrPavcpselyelllrCwrrdeseRPsfeelhkll  282
         en+ge+frdq+r+++l++Pa+cp+++y+l+l+Cwrrd+++RPsf++lh+ l
Q: 805   ENTGEFFRDQGRQTYLPKPALCPDSVYKLMLSCWRRDTKDRPSFQDLHRQL  855
         ************************************************976
Domain Sequence
(FASTA)
LTFKEKLGEG QFGEVHLCEV EGMEKFADKE FTLEGLDASP NCPVLVAVKM LRADANKNAR 60
NDFLKEIKIM SRLKDPNIIR LLAVCITDDP LCMITEYMME NGDLNQFLSR HEAQSPPDAS 120
VPTISYSDLR FMATQIASGM KYLSSLNFVH RDLATRNCLV GKRYTIKIAD FGMSRNLYSG 180
DYYRIQGRAV LPIRWMSWES ILLGKFTTAS DVWAFGVTLW ETFTLCREQP YSQLSDEQVI 240
ENTGEFFRDQ GRQTYLPKPA LCPDSVYKLM LSCWRRDTKD RPSFQDLHRQ L 291
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00271
EKS-ANC-00279
EKS-BOT-00289
EKS-CAJ-00295
EKS-CAF-00295
EKS-CAP-00324
EKS-DAR-00636
EKS-DRM-00147
EKS-ECT-00035
EKS-EQC-00280
EKS-FEC-00275
EKS-GAM-00184
EKS-GAA-00357
EKS-GOG-00288
EKS-HOS-00295
EKS-ICT-00274
EKS-LAC-00303
EKS-LOA-00299
EKS-MAM-00292
EKS-MEG-00231
EKS-MOD-00284
EKS-MUM-00320
EKS-MUP-00285
EKS-MYL-00292
EKS-NOL-00266
EKS-ORN-00376
EKS-ORC-00271
EKS-ORL-00347
EKS-OTG-00295
EKS-PAT-00274
EKS-PES-00257
EKS-POA-00282
EKS-RAN-00306
EKS-SAH-00271
EKS-SUS-00254
EKS-TAG-00304
EKS-TAR-00379
EKS-TEN-00374
EKS-TUB-00030
EKS-XET-00361
EKS-XIM-00368
Gene Ontology
GO:0016020; C:membrane
GO:0005524; F:ATP binding
GO:0038062; F:protein tyrosine kinase collagen receptor activity
GO:0007155; P:cell adhesion
GO:0035988; P:chondrocyte proliferation
GO:0030199; P:collagen fibril organization
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0090091; P:positive regulation of extracellular matrix disassembly
GO:0010763; P:positive regulation of fibroblast migration
GO:0048146; P:positive regulation of fibroblast proliferation
GO:0045669; P:positive regulation of osteoblast differentiation
GO:0045860; P:positive regulation of protein kinase activity
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0046777; P:protein autophosphorylation
GO:0030500; P:regulation of bone mineralization
KEGG
InterPros
IPR000421; Coagulation_fac_5/8-C_type_dom.
IPR008979; Galactose-bd-like.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00754; F5_F8_type_C; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00231; FA58C; 1.
SM00219; TyrKc; 1.
Prosites
PS01285; FA58C_1; 1.
PS01286; FA58C_2; 1.
PS50022; FA58C_3; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013