EKS-GAG-00215
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00215
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/CAMKL255.26.3E-7651311261
StatusUnreviewed
Ensembl ProteinENSGALP00000004239
UniProt AccessionF1NG57;
Protein Name
Protein Synonyms/Alias Serine/threonine-protein kinase STK11;
Gene NameSTK11
Gene Synonyms/Alias STK11;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000002694ENSGALP00000004239ENSGALT00000004248
OrganismGallus gallus
Functional Description
Protein Length441
Protein Sequence
(FASTA)
SRMDMQESQQ LGMFGESELM SVGMDTFIHR IDSTEVIYQP RRKRAKLIGK YLMGDLLGEG 60
SYGKVKEMLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK NVIQLVDVLY 120
NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVFQAHGYFC QLIDGLEYLH SQGIVHKDIK 180
PGNLLLTTNG TLKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL DTFSGFKVDI 240
WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDFTIPEDC GPPLSDLLRG MLEYDPAKRF 300
SIQQIRQHNW FRKKHAQAET LVPIPPSPET KDKWRSMTAV PYLEDLHGYN EDEDDDLYDI 360
EDDIIYTQDF TVPGQVPEEE AGQNGQSRGR GLPKAICMNG TEPGQLSTKS KAERRASASS 420
NPSRKGSASS KIRKLSTCKQ Q 441
Nucleotide Sequence
(FASTA)
TCCAGGATGG ATATGCAGGA GTCTCAGCAG CTGGGTATGT TTGGAGAGAG CGAGCTGATG 60
TCTGTGGGGA TGGACACTTT TATCCATCGC ATCGACTCTA CTGAAGTCAT CTACCAGCCA 120
CGGCGGAAAA GGGCCAAGCT CATTGGCAAG TACTTGATGG GAGACTTGCT TGGAGAAGGA 180
TCTTATGGCA AAGTCAAGGA GATGCTGGAC TCTGAAACCC TCTGTAGGAG AGCTGTGAAG 240
ATTCTGAAGA AGAAGAAGCT ACGCAGAATT CCCAACGGGG AGGCAAATGT GAAAAAGGAA 300
ATTCAGCTCC TGCGACGACT GCGGCACAAA AATGTTATCC AGTTGGTAGA TGTGTTATAC 360
AATGAAGAGA AGCAGAAAAT GTATATGGTG ATGGAGTACT GTGTGTGTGG GATGCAGGAG 420
ATGCTGGACA GTGTCCCAGA AAAGAGGTTT CCAGTTTTTC AGGCTCATGG GTACTTCTGT 480
CAGCTTATAG ATGGCTTAGA ATACTTGCAC AGCCAAGGGA TTGTCCACAA GGATATAAAA 540
CCTGGGAACC TCCTGCTGAC CACCAATGGG ACGCTGAAAA TATCTGATTT AGGGGTAGCA 600
GAGGCATTGC ATCCATTTGC AGAGGATGAC ACGTGCCGAA CGAGCCAAGG GTCGCCAGCA 660
TTCCAGCCAC CAGAAATTGC CAATGGCCTT GATACCTTTT CAGGCTTTAA AGTAGACATC 720
TGGTCCGCAG GGGTCACACT ATACAACATT ACAACGGGTC TATACCCCTT TGAAGGGGAT 780
AATATATATA AGTTATTTGA AAACATCGGG AAAGGTGACT TCACAATTCC AGAGGATTGT 840
GGTCCTCCAC TCTCAGACCT ATTGAGAGGG ATGCTTGAAT ACGACCCAGC CAAGAGATTT 900
TCAATACAGC AGATAAGGCA GCACAATTGG TTTCGTAAGA AACATGCTCA GGCAGAGACT 960
CTGGTGCCCA TACCTCCTAG CCCAGAAACA AAGGACAAGT GGAGAAGTAT GACGGCGGTG 1020
CCTTATCTGG AAGATCTGCA TGGCTACAAT GAGGACGAAG ATGATGACTT GTATGACATT 1080
GAAGATGATA TCATCTACAC TCAGGACTTC ACAGTACCAG GACAGGTGCC TGAGGAGGAG 1140
GCAGGGCAGA ACGGGCAGAG CCGTGGCCGG GGGCTGCCCA AGGCCATCTG CATGAACGGG 1200
ACGGAGCCGG GACAGCTGAG CACCAAATCC AAGGCGGAGC GCCGGGCCAG CGCCTCCTCC 1260
AACCCCTCGC GCAAGGGCTC GGCCAGCAGC AAGATCCGCA AGCTCTCCAC CTGCAAGCAG 1320
CAGTGA 1326
Domain Profile
S: 1     ykllktlGegsfgkVklakhketkekvavKiikkkkl..seeslekikrEieilkklkhp  58
         y +++ lGegs+gkVk++ ++et  + avKi+kkkkl    +   ++k+Ei++l++l+h+
Q: 51    YLMGDLLGEGSYGKVKEMLDSETLCRRAVKILKKKKLrrIPNGEANVKKEIQLLRRLRHK  110
         778999******************************965334567***************
S: 59    niikllevi..etkkklylvleyasgg..eLfdyieekgrlkekearklfkqlvsavkYl  114
         n+i+l++v+  e+k+k+y+v+ey+  g  e++d +  ++r++  +a+ +f ql+++++Yl
Q: 111   NVIQLVDVLynEEKQKMYMVMEYCVCGmqEMLDSV-PEKRFPVFQAHGYFCQLIDGLEYL  169
         ********9888999********998888*****6.8899********************
S: 115   hskgivHrDlKpeNllldkkenikiaDFGlan...lfkegklletfcGsppYaaPellkg  171
         hs+givH+D+Kp Nlll++++++ki+D+G+a+    f e+++++t++Gsp++++Pe+ +g
Q: 170   HSQGIVHKDIKPGNLLLTTNGTLKISDLGVAEalhPFAEDDTCRTSQGSPAFQPPEIANG  229
         *******************************966567788******************99
S: 172   .kkYegpkvDvWslGvvLyalvtgklPfdeenlkellekilkgkleipkklskelesLlr  230
          ++++g kvD+Ws+Gv+Ly++ tg +Pf+++n+ +l+e+i kg+++ip+ + + l++Llr
Q: 230   lDTFSGFKVDIWSAGVTLYNITTGLYPFEGDNIYKLFENIGKGDFTIPEDCGPPLSDLLR  289
         899*********************************************************
S: 231   klLvvdpekRatieeilkhewl  252
          +L+ dp+kR++i++i++h+w+
Q: 290   GMLEYDPAKRFSIQQIRQHNWF  311
         *********************7
Domain Sequence
(FASTA)
YLMGDLLGEG SYGKVKEMLD SETLCRRAVK ILKKKKLRRI PNGEANVKKE IQLLRRLRHK 60
NVIQLVDVLY NEEKQKMYMV MEYCVCGMQE MLDSVPEKRF PVFQAHGYFC QLIDGLEYLH 120
SQGIVHKDIK PGNLLLTTNG TLKISDLGVA EALHPFAEDD TCRTSQGSPA FQPPEIANGL 180
DTFSGFKVDI WSAGVTLYNI TTGLYPFEGD NIYKLFENIG KGDFTIPEDC GPPLSDLLRG 240
MLEYDPAKRF SIQQIRQHNW F 261
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00236
EKS-ANC-00248
EKS-BOT-00255
EKS-CAE-00230
EKS-CAF-00264
EKS-CAP-00292
EKS-CII-00153
EKS-CIS-00029
EKS-DAR-00584
EKS-DIO-00016
EKS-DRM-00132
EKS-EQC-00250
EKS-FEC-00240
EKS-GAM-00158
EKS-GAA-00316
EKS-GOG-00253
EKS-HOS-00265
EKS-ICT-00242
EKS-LAC-00269
EKS-LOA-00259
EKS-MAM-00257
EKS-MEG-00200
EKS-MOD-00254
EKS-MUM-00286
EKS-MUP-00254
EKS-MYL-00257
EKS-NOL-00237
EKS-ORN-00333
EKS-ORA-00224
EKS-OTG-00262
EKS-PAT-00243
EKS-PES-00226
EKS-PEM-00131
EKS-POA-00250
EKS-PTV-00024
EKS-RAN-00267
EKS-SAH-00242
EKS-SUS-00218
EKS-TAG-00272
EKS-TAR-00329
EKS-TEN-00324
EKS-XET-00334
EKS-XIM-00325
Gene Ontology
GO:0005829; C:cytosol
GO:0016020; C:membrane
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0030295; F:protein kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0043276; P:anoikis
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0007050; P:cell cycle arrest
GO:0030010; P:establishment of cell polarity
GO:0042593; P:glucose homeostasis
GO:0051645; P:Golgi localization
GO:0072332; P:intrinsic apoptotic signaling pathway by p53 class mediator
GO:0030308; P:negative regulation of cell growth
GO:0060770; P:negative regulation of epithelial cell proliferation involved in prostate gland development
GO:0030511; P:positive regulation of transforming growth factor beta receptor signaling pathway
GO:0046777; P:protein autophosphorylation
GO:0051896; P:regulation of protein kinase B signaling cascade
GO:0030111; P:regulation of Wnt receptor signaling pathway
GO:0010212; P:response to ionizing radiation
KEGG
InterPros
IPR020636; Ca/CaM-dep_Ca-dep_prot_Kinase.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013