EKS-GAG-00046

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00046

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	416.5	5.1E-125	4	287	284

Status

Unreviewed

Ensembl Protein

ENSGALP00000004867

UniProt Accession

F1NBD7;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC2

Gene Synonyms/Alias

CDC2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000003085	ENSGALP00000004867	ENSGALT00000004876

Organism

Gallus gallus

Functional Description

Protein Length

303

Protein Sequence
(FASTA)

MEDYTKIEKI GEGTYGVVYK GRHKTTGQVV AMKKIRLESE EEGVPSTAIR EISLLKELHH 60

PNIVCLQDVL MQDARLYLIF EFLSMDLKKY LDTIPSGQYL DRSRVKSYLY QILQGIVFCH 120

SRRVLHRDLK PQNLLIDDKG VIKLADFGLA RAFGIPVRVY THEVVTLWYR SPEVLLGSAR 180

YSTPVDIWSI GTIFAELATK KPLFHGDSEI DQLFRIFRAL GTPNNDVWPD VESLQDYKNT 240

FPKWKPGSLG THVQNLDEDG LDLLSKMLIY DPAKRISGKM ALNHPYFDDL DKSTLPANLI 300

KKF 303

Nucleotide Sequence
(FASTA)

ATGGAGGATT ACACGAAGAT AGAGAAGATT GGGGAAGGTA CCTATGGTGT TGTGTATAAA 60

GGGCGCCACA AAACCACAGG CCAAGTGGTT GCAATGAAGA AAATACGTCT AGAAAGTGAG 120

GAGGAAGGTG TTCCAAGTAC TGCTATCCGA GAAATTTCTT TGTTAAAAGA GCTGCATCAT 180

CCCAATATAG TCTGTCTTCA GGATGTTCTT ATGCAGGATG CAAGGCTGTA CCTCATTTTT 240

GAATTCCTTT CCATGGACCT CAAGAAATAC TTGGATACTA TTCCATCTGG CCAATATTTG 300

GATCGTTCGC GTGTTAAGAG TTACCTGTAT CAGATCTTGC AAGGTATCGT CTTCTGCCAT 360

TCAAGACGAG TTCTGCACAG AGACTTAAAA CCTCAGAATC TTCTAATAGA TGACAAAGGG 420

GTGATTAAAC TGGCAGATTT TGGATTGGCT CGAGCCTTTG GAATCCCAGT GCGGGTATAC 480

ACTCATGAAG TAGTGACACT GTGGTACAGG TCTCCAGAGG TACTGCTAGG ATCTGCTCGT 540

TATTCCACTC CTGTAGACAT ATGGAGCATA GGTACCATAT TTGCAGAGTT AGCAACTAAA 600

AAGCCACTTT TCCACGGGGA CTCAGAGATT GACCAGCTCT TCAGAATCTT CAGAGCTTTA 660

GGGACACCCA ACAATGATGT GTGGCCTGAT GTGGAATCCT TGCAAGACTA TAAAAACACT 720

TTCCCAAAAT GGAAACCTGG CAGCCTGGGA ACGCATGTCC AAAACTTAGA TGAGGATGGA 780

CTCGATCTGT TGTCTAAAAT GTTAATTTAT GATCCTGCAA AAAGAATTTC TGGCAAAATG 840

GCCTTGAACC ACCCATACTT CGATGACTTG GACAAATCTA CTCTTCCTGC TAATCTGATT 900

AAGAAATTCT AA 912

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         y+k+ekigeGtyg+vyk+++k+tg+vvA+Kkirle+e+egvp+ta+rEisllkel+h+ni

Q: 4     YTKIEKIGEGTYGVVYKGRHKTTGQVVAMKKIRLESEEEGVPSTAIREISLLKELHHPNI  63

         89**********************************************************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkk.klsleevkslllqlleglaylHsn  119

         v L++v++ ++++lyL+fefl++dLkk+l++ ++  +l++++vks+l+q+l+g+ ++Hs+

Q: 64    VCLQDVLM-QDARLYLIFEFLSMDLKKYLDTIPSGqYLDRSRVKSYLYQILQGIVFCHSR  122

         ********.99********************9876599**********************

S: 120   kilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYs  179

         ++lHRDlKpqNlLi+++g++klaDfGlaraf+ p++ yt+evvTlwYr+Pe+Llg+ +Ys

Q: 123   RVLHRDLKPQNLLIDDKGVIKLADFGLARAFGIPVRVYTHEVVTLWYRSPEVLLGSARYS  182

         ************************************************************

S: 180   tavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevsklpeykksfp  239

         t vDiWs+g i+ael+t+kplf+g+seidql+rif+ lgtp+++vwp+v++l++yk++fp

Q: 183   TPVDIWSIGTIFAELATKKPLFHGDSEIDQLFRIFRALGTPNNDVWPDVESLQDYKNTFP  242

         ************************************************************

S: 240   kkkkkklkekvkklkekaldllekllaldpkkRisakealqhkyf  284

         k+k+ +l ++v++l+e++ldll+k+l +dp+kRis k al+h+yf

Q: 243   KWKPGSLGTHVQNLDEDGLDLLSKMLIYDPAKRISGKMALNHPYF  287

         ********************************************9

Domain Sequence
(FASTA)

YTKIEKIGEG TYGVVYKGRH KTTGQVVAMK KIRLESEEEG VPSTAIREIS LLKELHHPNI 60

VCLQDVLMQD ARLYLIFEFL SMDLKKYLDT IPSGQYLDRS RVKSYLYQIL QGIVFCHSRR 120

VLHRDLKPQN LLIDDKGVIK LADFGLARAF GIPVRVYTHE VVTLWYRSPE VLLGSARYST 180

PVDIWSIGTI FAELATKKPL FHGDSEIDQL FRIFRALGTP NNDVWPDVES LQDYKNTFPK 240

WKPGSLGTHV QNLDEDGLDL LSKMLIYDPA KRISGKMALN HPYF 284

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dasypus novemcinctus"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0030496	; C:midbody
GO:0005634	; C:nucleus
GO:0005876	; C:spindle microtubule
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0008353	; F:RNA polymerase II carboxy-terminal domain kinase activity
GO:0007095	; P:mitotic cell cycle G2/M transition DNA damage checkpoint
GO:0034501	; P:protein localization to kinetochore

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013