EKS-GAG-00181
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00181
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/NKF2423.94.5E-12771428358
StatusUnreviewed
Ensembl ProteinENSGALP00000004900
UniProt AccessionF1NAN0;
Protein Name
Protein Synonyms/Alias
Gene NamePINK1
Gene Synonyms/Alias PINK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003109ENSGALP00000004900ENSGALT00000004909
OrganismGallus gallus
Functional Description
Protein Length498
Protein Sequence
(FASTA)
AGLAAMAVRR ARAGPCMALA LGLALLEPPL EEQRRARAVC GRIQTVFVGK NKAQKDPLSS 60
LRWQGFKLED YLIGQPLGKG CSAAVYEAAI PSSPHHQGST ESSALPVSEE EPADKCQQQA 120
QESVLSLDLH FSIRLLQSVS VICPLSDARN KTCMYVDPCK KVYLETLTVL VTQKREHVLG 180
RKRLRPHPNI IQVIRAFTSS VPLLPGALTD YPDVLPVSLN PRGIGRSHTL FLVMKNYPCT 240
LCQYLRDNSP DSRLSTMMIL QLLEGVDHLV RHRIAHRDLK SDNILVEFDS AGCPRLVITD 300
FGCCLADDSI GLRLPFTSID MDRGGNSSLM PPEVTTASAG PGMVIDYSKA DAWAVGAIAY 360
EILGLPNPFY SCGDSFLESR SYREEELPSL PNGVPCEVKQ VIRMLLQRDP NKRLSARVAA 420
NVLHLSLWGE SILASEALKP DQMTAWLLCQ SAATLLMDGL VDKSRVETKM KMCFLANLDF 480
EDLWTAVFLL LAWRNQSG 498
Nucleotide Sequence
(FASTA)
GCCGGGCTGG CGGCCATGGC GGTGCGGCGG GCCCGGGCCG GGCCGTGCAT GGCGCTGGCG 60
CTGGGGTTGG CGCTGCTGGA GCCGCCGCTG GAGGAGCAGC GCCGGGCGAG GGCCGTGTGC 120
GGCCGCATCC AGACAGTATT TGTTGGGAAG AACAAGGCGC AGAAGGATCC GCTGAGCTCT 180
TTGCGCTGGC AGGGCTTCAA GCTGGAGGAC TATCTCATCG GGCAGCCCCT TGGCAAGGGC 240
TGCAGTGCAG CCGTCTATGA AGCAGCGATT CCTTCATCTC CCCATCACCA GGGGAGCACG 300
GAGAGCTCAG CTCTGCCTGT GTCTGAAGAG GAGCCGGCAG ACAAATGCCA GCAGCAAGCT 360
CAAGAAAGTG TTCTTTCTCT CGATTTGCAC TTCTCTATTA GGCTCCTACA GTCTGTGTCA 420
GTGATCTGTC CCCTCTCTGA TGCAAGGAAT AAAACCTGTA TGTATGTAGA TCCCTGTAAG 480
AAGGTGTACC TGGAGACCCT CACTGTGCTA GTTACTCAAA AAAGAGAGCA TGTCCTTGGG 540
AGGAAGAGGT TGCGACCTCA TCCAAATATA ATCCAGGTGA TCCGAGCTTT CACATCATCT 600
GTCCCGTTGC TGCCTGGAGC CCTCACAGAC TATCCTGATG TTCTTCCAGT GAGCCTGAAT 660
CCCAGAGGGA TCGGTCGCAG CCACACGCTC TTCTTAGTGA TGAAAAACTA TCCGTGCACC 720
CTGTGCCAGT ATTTGAGGGA CAACAGCCCG GATAGCCGCC TCTCCACCAT GATGATTTTG 780
CAGTTGTTGG AAGGTGTGGA CCATCTCGTT CGACACAGGA TAGCACACAG AGACCTGAAG 840
TCTGACAACA TCTTGGTTGA GTTCGATTCT GCTGGCTGCC CCCGGCTGGT GATCACAGAC 900
TTCGGTTGCT GTTTGGCAGA TGACAGCATT GGCCTGAGGC TGCCCTTCAC CAGCATTGAC 960
ATGGATCGTG GTGGCAATAG CTCTCTTATG CCACCTGAGG TGACCACAGC GTCAGCAGGT 1020
CCAGGCATGG TGATTGACTA CAGCAAAGCT GATGCCTGGG CTGTTGGAGC GATTGCCTAT 1080
GAAATCCTGG GCCTGCCCAA TCCTTTCTAC AGCTGTGGGG ACTCGTTCCT GGAAAGCAGA 1140
AGTTACCGTG AGGAGGAGCT GCCAAGCCTG CCTAATGGTG TGCCCTGTGA GGTGAAGCAA 1200
GTGATAAGGA TGCTGCTTCA GAGGGATCCC AACAAGAGAT TATCTGCTAG AGTTGCTGCT 1260
AACGTGCTCC ACTTGAGCCT CTGGGGTGAA AGCATTCTGG CATCCGAGGC CCTGAAGCCC 1320
GACCAGATGA CTGCCTGGCT TCTCTGCCAG TCTGCAGCCA CTTTGCTCAT GGATGGACTG 1380
GTGGACAAAA GCAGGGTAGA AACCAAAATG AAGATGTGCT TTTTGGCCAA CCTCGACTTC 1440
GAAGACCTCT GGACAGCAGT TTTCTTGTTG CTGGCCTGGA GAAACCAGTC TGGGTGA 1497
Domain Profile
S: 1     yligealgkgcnaavyeatlatldqelekakhlgllgkevtvvlaeid.qesavaakkfp  59
         ylig+ lgkgc+aavyea +++++++  ++++  l   e +   + ++  +++v +  + 
Q: 71    YLIGQPLGKGCSAAVYEAAIPSSPHHQGSTESSALPVSEEEPADKCQQqAQESVLSLDLH  130
         99************************9999988887555544444333034456677899
S: 60    laiklmfnieadssseallksmsqelvpasrvaldgeygav.........pkllakhPni  110
         ++i+l+  ++         ++    + p  +v l+     v         +k+l +hPni
Q: 131   FSIRLLQSVSVICPLSDARNKTCMYVDPCKKVYLETLTVLVtqkrehvlgRKRLRPHPNI  190
         9********998776556777788899999999998777668999999**999*******
S: 111   vrvlrafidsvkllPdalldyPdalparlypeglgegktlylvmkrydqtlreylesqdr  170
         ++v+raf++sv+llP+al+dyPd+lp  l+p+g+g+++tl+lvmk+y++tl +yl  +++
Q: 191   IQVIRAFTSSVPLLPGALTDYPDVLPVSLNPRGIGRSHTLFLVMKNYPCTLCQYLRDNSP  250
         ************************************************************
S: 171   strlaalllaqlleavdhlvkhgvahrdlksdnilveldddeiPvlviadfGCcladkvd  230
         ++rl++++++qlle+vdhlv+h++ahrdlksdnilve+d+ ++P lvi+dfGCclad+++
Q: 251   DSRLSTMMILQLLEGVDHLVRHRIAHRDLKSDNILVEFDSAGCPRLVITDFGCCLADDSI  310
         ************************************************************
S: 231   glrlpyessevdkGGnaalmaPeistavpGpsavinyekadtWavGalayeifglsnPfy  290
         glrlp++s ++d+GGn++lm Pe++ta +Gp  vi+y+kad+WavGa+ayei+gl nPfy
Q: 311   GLRLPFTSIDMDRGGNSSLMPPEVTTASAGPGMVIDYSKADAWAVGAIAYEILGLPNPFY  370
         ************************************************************
S: 291   gegkaslesasyqeaqlPalpesvppelrqlvydllkreaskrvsadiaanvlqlslf  348
           g   les+sy+e++lP+lp+ vp e++q+++ ll+r+++kr sa++aanvl+lsl+
Q: 371   SCGDSFLESRSYREEELPSLPNGVPCEVKQVIRMLLQRDPNKRLSARVAANVLHLSLW  428
         *********************************************************9
Domain Sequence
(FASTA)
YLIGQPLGKG CSAAVYEAAI PSSPHHQGST ESSALPVSEE EPADKCQQQA QESVLSLDLH 60
FSIRLLQSVS VICPLSDARN KTCMYVDPCK KVYLETLTVL VTQKREHVLG RKRLRPHPNI 120
IQVIRAFTSS VPLLPGALTD YPDVLPVSLN PRGIGRSHTL FLVMKNYPCT LCQYLRDNSP 180
DSRLSTMMIL QLLEGVDHLV RHRIAHRDLK SDNILVEFDS AGCPRLVITD FGCCLADDSI 240
GLRLPFTSID MDRGGNSSLM PPEVTTASAG PGMVIDYSKA DAWAVGAIAY EILGLPNPFY 300
SCGDSFLESR SYREEELPSL PNGVPCEVKQ VIRMLLQRDP NKRLSARVAA NVLHLSLW 358
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00200
EKS-BOT-00215
EKS-CAE-00184
EKS-CAJ-00221
EKS-CAF-00221
EKS-CAP-00240
EKS-CHH-00045
EKS-CIS-00247
EKS-DAR-00520
EKS-DIO-00111
EKS-DRM-00108
EKS-ECT-00082
EKS-EQC-00209
EKS-FEC-00202
EKS-GAM-00122
EKS-GAA-00264
EKS-GOG-00211
EKS-HOS-00221
EKS-ICT-00205
EKS-LAC-00227
EKS-LOA-00212
EKS-MAM-00217
EKS-MOD-00214
EKS-MUM-00218
EKS-MUP-00216
EKS-MYL-00218
EKS-NOL-00201
EKS-OCP-00140
EKS-ORN-00275
EKS-ORA-00189
EKS-ORC-00196
EKS-ORL-00255
EKS-OTG-00221
EKS-PAT-00204
EKS-PES-00192
EKS-POA-00209
EKS-RAN-00210
EKS-SAH-00204
EKS-SOA-00066
EKS-SUS-00188
EKS-TAG-00234
EKS-TAR-00275
EKS-TEN-00271
EKS-TUB-00057
EKS-XIM-00267
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0010857; F:calcium-dependent protein kinase activity
GO:0000287; F:magnesium ion binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007243; P:intracellular protein kinase cascade
GO:0000422; P:mitochondrion degradation
GO:0018105; P:peptidyl-serine phosphorylation
GO:0033603; P:positive regulation of dopamine secretion
GO:0043123; P:positive regulation of I-kappaB kinase/NF-kappaB cascade
GO:0090200; P:positive regulation of release of cytochrome c from mitochondria
GO:0032226; P:positive regulation of synaptic transmission, dopaminergic
GO:0043254; P:regulation of protein complex assembly
GO:0031396; P:regulation of protein ubiquitination
GO:0006950; P:response to stress
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
Prosites
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013