EKS-GAG-00250
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00250
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/EGFR502.81.9E-151566823258
StatusUnreviewed
Ensembl ProteinENSGALP00000004934
UniProt AccessionF1P258;
Protein Name
Protein Synonyms/Alias
Gene NameERBB4
Gene Synonyms/Alias ERBB4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003126ENSGALP00000039163ENSGALT00000039956
ENSGALG00000003126ENSGALP00000039167ENSGALT00000039960
ENSGALG00000003126ENSGALP00000039169ENSGALT00000039962
ENSGALG00000003126ENSGALP00000004934ENSGALT00000004943
OrganismGallus gallus
Functional Description
Protein Length1137
Protein Sequence
(FASTA)
KFLCFADTIH WQDIVRNPWA SNFTLVPTNG SSGCGRCHKS CTGRCWGPTE NHCQTLTKTV 60
CAEQCDGRCY GPYVSDCCHR ECAGGCSGPK DTDCFACMNF NDSGACVTQC PQTFVYNPTT 120
FQLEHNHNAK YTYGAFCVKK CPHNFVVDSS SCVRACPSSK MEVEENGIKM CKPCTDICPK 180
ACDGIGTGSL VSAQTVDSSN IDKFINCTKI NGNLIFLVTG IHGDPYHTIA AINPEKLNIF 240
QTVREITGYL NIQSWPENMT DFRVFSNLVT IGGRALYSGL SLLILKQQGI TSLQFQSLKQ 300
ISAGNIYITD NSNLCYYHTV NWTSLFSTPS QKTVIHRNKK AENCTADGMV CNELCSSDGC 360
WGPGPDQCLS CKRFIRGRTC IESCNLYDGE FREFANGSVC MECDPQCEKM EDNMITCYGP 420
GPDHCTKCFH FKDGPNCVEK CPDGLQGANS FIFKYADEDR ECHPCHPNCT QGCRGPASHD 480
CIYYPWTRQS TLPQHARTPL IAAGVIGGLF IIVIMGLTFA VYVRRKSIKK KRALRRFLET 540
ELVEPLTPSG TAPNQAQLRI LKETELKRVK VLGSGAFGTV YKGIWVPEGE TVKIPVAIKI 600
LNETTGPKAN VEFMDEALIM ASMDHPHLVR LLGVCLSPTI QLVTQLMPHG CLLDYVHEHK 660
DNIGSQLLLN WCVQIAKGMM YLEERRLVHR DLAARNVLVK SPNHVKITDF GLARLLEGDE 720
KEYNADGGKM PIKWMALECI HYRKFTHQSD VWSYGVTIWE LMTFGGKPYD GIPTREIPDL 780
LEKGERLPQP PICTIDVYMV MVKCWMIDAD SRPKFKELAA EFSRMARDPQ RYLVIQGDDR 840
MKLPSPNDSK FFQNLLDEED LEDMMDAEEY LVPQAFNIPP PIYTSRTRID SNRNQFVYRD 900
GGYAAEQGVP MPYRAPGCII PEAPVAQGAT AEIFEDTCCN GTLRKQVATL AKEDSSTQRY 960
SADPTVFIPE RVIRGELDED GYMTPMRDKP KTDYLNPVEE NPFVSRRKNG DLQAVDNPEY 1020
HNAPNGQPKA EDEYVNEPLY LNTFANTLEN AEYLKNNLPE KAKKAFDNPD YWNHSLPPRS 1080
TLQHPDYLQE YSTKYFYKQN GRIRPIVAEN PEYLSEFSLK PGTVLPPPPY RHRNTVV 1137
Nucleotide Sequence
(FASTA)
AAATTTCTTT GCTTCGCAGA CACCATTCAT TGGCAGGATA TCGTGCGTAA CCCCTGGGCC 60
TCCAACTTCA CTTTGGTTCC AACGAATGGC AGCTCGGGAT GTGGTCGATG CCACAAGTCC 120
TGCACGGGCC GATGCTGGGG ACCCACAGAG AATCACTGCC AGACCTTAAC AAAGACAGTG 180
TGTGCAGAGC AGTGTGATGG ACGGTGCTAC GGGCCCTACG TCAGCGACTG CTGCCACCGG 240
GAGTGCGCTG GAGGCTGTTC TGGACCCAAA GACACTGATT GCTTTGCCTG CATGAATTTC 300
AATGATAGTG GAGCATGTGT CACACAGTGC CCCCAGACAT TTGTGTACAA TCCTACTACC 360
TTCCAACTGG AGCATAATCA CAATGCCAAG TACACGTACG GGGCTTTTTG CGTCAAGAAG 420
TGCCCACACA ACTTTGTGGT AGATTCCAGC TCTTGTGTCC GTGCATGTCC AAGCTCCAAG 480
ATGGAGGTTG AAGAAAATGG TATTAAGATG TGTAAGCCCT GCACTGACAT TTGTCCTAAA 540
GCATGCGATG GCATTGGAAC AGGGAGCTTA GTGTCAGCTC AGACGGTGGA TTCCAGCAAC 600
ATTGACAAGT TCATAAACTG TACTAAGATC AATGGCAACC TTATCTTCCT TGTTACTGGG 660
ATTCATGGGG ATCCATATCA CACAATCGCT GCAATTAATC CTGAGAAATT AAATATCTTC 720
CAAACAGTGA GAGAGATAAC AGGGTATTTG AACATACAGT CATGGCCTGA GAACATGACT 780
GACTTCAGGG TGTTTTCTAA CTTGGTTACT ATTGGTGGAA GAGCTCTGTA TAGTGGCCTT 840
TCCTTACTCA TCCTGAAGCA GCAAGGCATT ACCTCCTTAC AGTTCCAGTC CTTGAAGCAA 900
ATCAGTGCTG GTAACATCTA CATAACAGAC AACAGCAATT TATGCTACTA CCACACAGTC 960
AACTGGACCA GCCTTTTCAG CACACCCAGC CAAAAGACGG TGATTCATCG GAATAAAAAA 1020
GCAGAGAACT GCACTGCTGA TGGGATGGTG TGTAATGAGT TATGCTCAAG TGATGGCTGC 1080
TGGGGGCCAG GGCCAGACCA GTGTCTCTCC TGCAAGCGCT TCATCAGGGG GAGGACCTGC 1140
ATAGAATCTT GTAACCTGTA TGATGGGGAA TTTCGAGAGT TTGCAAATGG TTCTGTTTGC 1200
ATGGAGTGTG ATCCCCAGTG TGAGAAGATG GAAGACAACA TGATCACGTG CTATGGGCCG 1260
GGGCCTGACC ACTGCACGAA GTGCTTCCAT TTTAAGGATG GTCCGAACTG TGTGGAGAAA 1320
TGTCCTGATG GCTTACAGGG GGCAAACAGT TTCATTTTCA AATATGCCGA TGAGGATCGT 1380
GAGTGCCATC CGTGTCATCC AAATTGCACC CAAGGGTGTA GAGGTCCCGC TAGTCATGAC 1440
TGCATTTACT ATCCATGGAC ACGACAGTCC ACTTTACCAC AACATGCTAG AACCCCTTTG 1500
ATTGCTGCGG GAGTTATTGG TGGCCTCTTC ATCATCGTCA TCATGGGCCT GACGTTTGCT 1560
GTGTACGTTC GACGCAAGAG CATCAAAAAG AAGAGAGCGT TGCGGAGGTT CCTGGAGACT 1620
GAGCTTGTGG AACCCTTGAC TCCAAGTGGT ACGGCACCCA ACCAAGCTCA GCTTCGTATC 1680
CTGAAGGAAA CTGAGCTGAA ACGAGTGAAG GTTCTTGGCT CTGGAGCCTT TGGAACAGTA 1740
TACAAGGGTA TTTGGGTCCC CGAGGGAGAA ACTGTTAAGA TTCCTGTGGC CATTAAGATC 1800
CTTAATGAGA CCACTGGTCC CAAAGCCAAC GTGGAGTTTA TGGACGAAGC TCTCATCATG 1860
GCCAGCATGG ACCACCCACA CCTGGTGAGA CTCCTGGGCG TCTGCTTGAG CCCAACCATC 1920
CAGCTCGTCA CTCAGCTGAT GCCTCATGGC TGCCTGTTGG ATTATGTTCA TGAACATAAG 1980
GACAACATTG GCTCCCAGCT TCTGCTAAAC TGGTGTGTCC AAATAGCAAA GGGAATGATG 2040
TACCTGGAAG AGAGAAGGCT TGTGCACCGG GACCTGGCAG CCCGCAATGT CTTGGTAAAA 2100
TCACCAAACC ATGTGAAGAT CACTGACTTT GGCCTGGCCA GACTTCTGGA AGGGGATGAG 2160
AAGGAATATA ATGCTGATGG AGGGAAGATG CCAATTAAGT GGATGGCTCT GGAGTGTATA 2220
CACTACAGGA AATTTACCCA TCAGAGCGAT GTCTGGAGCT ATGGAGTCAC TATCTGGGAG 2280
CTTATGACCT TTGGTGGAAA GCCATATGAT GGGATCCCAA CTCGAGAGAT CCCAGACCTC 2340
CTGGAGAAGG GAGAGCGGTT GCCCCAGCCT CCAATCTGCA CTATTGATGT TTATATGGTG 2400
ATGGTGAAAT GCTGGATGAT CGATGCTGAC AGTCGGCCTA AATTCAAGGA GCTGGCTGCT 2460
GAATTTTCTA GAATGGCTCG AGACCCCCAG AGGTACCTGG TAATTCAGGG AGACGATCGT 2520
ATGAAGCTCC CCAGCCCAAA TGACAGCAAG TTCTTCCAAA ACCTTCTCGA TGAGGAAGAC 2580
CTGGAAGATA TGATGGATGC TGAAGAGTAT CTTGTTCCTC AAGCCTTCAA CATCCCTCCT 2640
CCCATCTACA CTTCCAGGAC AAGAATTGAT TCCAACAGGA ACCAGTTTGT GTACAGAGAT 2700
GGCGGCTATG CTGCGGAGCA GGGAGTGCCG ATGCCGTACA GAGCTCCTGG CTGCATCATC 2760
CCAGAAGCCC CAGTTGCTCA GGGGGCGACA GCAGAGATCT TTGAAGACAC CTGCTGCAAC 2820
GGCACGCTGC GGAAGCAGGT GGCCACGCTG GCAAAGGAGG ACAGCAGCAC CCAGAGGTAC 2880
AGCGCTGATC CCACAGTCTT CATACCGGAG CGGGTGATCC GGGGAGAGCT GGATGAGGAC 2940
GGCTACATGA CGCCGATGCG AGACAAACCC AAAACAGATT ACCTGAATCC AGTGGAAGAG 3000
AACCCATTTG TCTCCCGGCG AAAGAACGGA GATCTCCAAG CTGTGGACAA CCCAGAGTAT 3060
CACAACGCTC CGAATGGGCA GCCCAAAGCA GAGGATGAGT ACGTGAATGA GCCATTGTAC 3120
CTCAACACTT TTGCTAACAC CTTGGAAAAC GCCGAGTACC TGAAGAACAA TTTGCCAGAG 3180
AAAGCCAAGA AGGCCTTTGA CAACCCAGAC TACTGGAATC ACAGCCTGCC CCCACGAAGC 3240
ACTCTCCAGC ACCCGGACTA CCTGCAAGAG TACAGCACAA AATACTTTTA CAAACAGAAC 3300
GGACGGATCC GGCCCATTGT GGCAGAGAAT CCCGAATACC TCTCCGAGTT CTCCCTGAAG 3360
CCTGGCACTG TGCTGCCCCC GCCACCCTAC AGACACCGGA ACACAGTGGT GTAG 3414
Domain Profile
S: 1     lkklkvlGsGafGtvykGiwipegenvkipvaikvleektgkkankelldealvlasldh  60
         lk++kvlGsGafGtvykGiw+pege+vkipvaik+l+e+tg+kan e++deal++as+dh
Q: 566   LKRVKVLGSGAFGTVYKGIWVPEGETVKIPVAIKILNETTGPKANVEFMDEALIMASMDH  625
         699*********************************************************
S: 61    anlvrllglclsstlqlvtqllplGclldyvrehkdklGsqellnwcvqiakGmsyleek  120
         ++lvrllg+cls t+qlvtql+p+Gclldyv+ehkd++Gsq llnwcvqiakGm+ylee+
Q: 626   PHLVRLLGVCLSPTIQLVTQLMPHGCLLDYVHEHKDNIGSQLLLNWCVQIAKGMMYLEER  685
         ************************************************************
S: 121   rlvhrdlaarnvlvkspnhvkitdfGlaklleadekelkaeggkvpikwlalesilkrky  180
         rlvhrdlaarnvlvkspnhvkitdfGla+lle deke++a+ggk+pikw+ale+i++rk+
Q: 686   RLVHRDLAARNVLVKSPNHVKITDFGLARLLEGDEKEYNADGGKMPIKWMALECIHYRKF  745
         ************************************************************
S: 181   thqsdvwsyGvtvwelltfGakpydgipakeipdllekGerlaqppictidvymvlvkcw  240
         thqsdvwsyGvt+wel+tfG kpydgip++eipdllekGerl+qppictidvymv+vkcw
Q: 746   THQSDVWSYGVTIWELMTFGGKPYDGIPTREIPDLLEKGERLPQPPICTIDVYMVMVKCW  805
         ************************************************************
S: 241   midaesrpkfkelaeefs  258
         mida+srpkfkela+efs
Q: 806   MIDADSRPKFKELAAEFS  823
         ****************96
Domain Sequence
(FASTA)
LKRVKVLGSG AFGTVYKGIW VPEGETVKIP VAIKILNETT GPKANVEFMD EALIMASMDH 60
PHLVRLLGVC LSPTIQLVTQ LMPHGCLLDY VHEHKDNIGS QLLLNWCVQI AKGMMYLEER 120
RLVHRDLAAR NVLVKSPNHV KITDFGLARL LEGDEKEYNA DGGKMPIKWM ALECIHYRKF 180
THQSDVWSYG VTIWELMTFG GKPYDGIPTR EIPDLLEKGE RLPQPPICTI DVYMVMVKCW 240
MIDADSRPKF KELAAEFS 258
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Phosphoprotein; Reference proteome; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00279
EKS-ANC-00288
EKS-BOT-00300
EKS-CAJ-00303
EKS-CAF-00303
EKS-CAP-00332
EKS-CII-00175
EKS-DAR-00650
EKS-EQC-00288
EKS-GAM-00190
EKS-GAA-00369
EKS-GOG-00294
EKS-HOS-00303
EKS-LAC-00313
EKS-LOA-00307
EKS-MAM-00300
EKS-MEG-00242
EKS-MOD-00291
EKS-MUM-00328
EKS-MUP-00294
EKS-MYL-00299
EKS-NOL-00273
EKS-OCP-00048
EKS-ORN-00387
EKS-ORA-00263
EKS-ORC-00279
EKS-ORL-00356
EKS-OTG-00306
EKS-PAT-00282
EKS-PES-00266
EKS-PEM-00164
EKS-POA-00290
EKS-PTV-00063
EKS-RAN-00313
EKS-SAH-00281
EKS-SUS-00266
EKS-TAG-00313
EKS-TAR-00389
EKS-TEN-00384
EKS-TUT-00065
EKS-VIP-00031
EKS-XET-00370
EKS-XIM-00381
Gene Ontology
GO:0016323; C:basolateral plasma membrane
GO:0016021; C:integral to membrane
GO:0005739; C:mitochondrion
GO:0005524; F:ATP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0044212; F:transcription regulatory region DNA binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0006915; P:apoptotic process
GO:0045165; P:cell fate commitment
GO:0016477; P:cell migration
GO:0043066; P:negative regulation of apoptotic process
GO:0008285; P:negative regulation of cell proliferation
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0043552; P:positive regulation of phosphatidylinositol 3-kinase activity
GO:2000366; P:positive regulation of STAT protein import into nucleus
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0042523; P:positive regulation of tyrosine phosphorylation of Stat5 protein
GO:0046777; P:protein autophosphorylation
GO:0030334; P:regulation of cell migration
GO:0023014; P:signal transduction by phosphorylation
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016245; Tyr_kinase_EGF/ERB/XmrK_rcpt.
Pfam
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00261; FU; 5.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013