EKS-GAG-00126
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00126
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/FGFR555.41.9E-167473749277
StatusUnreviewed
Ensembl ProteinENSGALP00000005237
UniProt AccessionF1NJ92;
Protein NameFibroblast growth factor receptor
Protein Synonyms/Alias
Gene NameFGFR1
Gene Synonyms/Alias FGFR1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003311ENSGALP00000005237ENSGALT00000005246
OrganismGallus gallus
Functional Description
Protein Length816
Protein Sequence
(FASTA)
RCLILWAVLV TATLSAARPA PTLPDQALPK ANIEVESHSA HPGDLLQLRC RLRDDVQSIN 60
WVRDGVQLPE NNRTRITGEE VEVRDAVPED SGLYACMTNS PSGSETTYFS VNVSDALPSA 120
EDDDDEDDSS SEEKEADNTK PNQAVAPYWT YPEKMEKKLH AVPAAKTVKF KCPSGGTPNP 180
TLRWLKNGKE FKPDHRIGGY KVRYATWSII MDSVVPSDKG NYTCIVENKY GSINHTYQLD 240
VVGEEPHQPC LLRSGLSWRS WNVTEAESGE YVCKVSNYIG EANQSAWLTV TRPLAKGGPL 300
PACSDGQTAG VNTTDKEMEV LHLRNVSFED AGEYTCLAGN SIGISHHSAW LTVLEATEQS 360
PAMMTSPLYL EIIIYCTGAF LISCMVVTVI IYKMKSTTKK TDFNSQLAVH KLAKSIPLRR 420
QVTVSADSSS SMNSGVMLVR PSRLSSSGTP MLAGVSEYEL PEDPRWELPR DRLILGKPLG 480
EGCFGQVVLA EAIGLDKDKP NRVTKVAVKM LKSDATEKDL SDLISEMEMM KMIGKHKNII 540
NLLGACTQDG PLYVIVEYAS KGNLREYLQA RRPPGMEYCY NPTRIPEEQL SFKDLVSCAY 600
QVARGMEYLA SKKCIHRDLA ARNVLVTEDN VMKIADFGLA RDIHHIDYYK KTTNGRLPVK 660
WMAPEALFDR IYTHQSDVWS FGVLLWEIFT LGGSPYPGVP VEELFKLLKE GHRMDKPSNC 720
TNELYMMMRD CWHAVPSQRP TFKQLVEDLD RIVAMTSNQE YLDLSVPLDQ YSPGFPATRS 780
STCSSGEDSV FSHDPLPDEP CLPRCPPHSH GALKRH 816
Nucleotide Sequence
(FASTA)
AGGTGCCTCA TCCTTTGGGC TGTGCTGGTC ACAGCCACGC TGTCTGCTGC CAGACCGGCC 60
CCCACGCTGC CCGACCAAGC TCTGCCCAAA GCGAACATCG AGGTGGAGTC CCACTCGGCG 120
CACCCCGGCG ATCTCCTCCA GCTGCGCTGC CGGCTGCGCG ATGACGTGCA GAGCATCAAC 180
TGGGTGCGTG ATGGAGTGCA GCTGCCCGAG AACAACCGCA CGCGCATCAC CGGCGAGGAG 240
GTAGAGGTGC GGGACGCGGT GCCCGAGGAC TCGGGGCTCT ATGCCTGCAT GACCAACAGC 300
CCCTCGGGGA GCGAGACCAC CTACTTCTCC GTCAACGTCT CAGACGCACT CCCTTCTGCA 360
GAGGATGATG ATGATGAAGA TGATTCCTCC TCGGAGGAGA AGGAGGCGGA TAACACCAAG 420
CCGAACCAGG CTGTAGCTCC TTACTGGACC TATCCCGAGA AGATGGAGAA GAAGCTGCAT 480
GCCGTCCCCG CTGCCAAAAC AGTGAAATTC AAGTGCCCCT CAGGTGGGAC GCCCAACCCC 540
ACGCTGCGCT GGCTGAAGAA CGGCAAGGAG TTCAAGCCTG ACCACCGCAT CGGGGGGTAC 600
AAGGTCCGCT ATGCCACCTG GAGCATCATC ATGGACTCGG TGGTGCCATC AGATAAGGGC 660
AACTACACGT GCATCGTGGA GAACAAATAC GGGAGCATCA ACCACACCTA CCAGCTGGAT 720
GTCGTGGGTG AGGAGCCCCA CCAGCCCTGC CTGCTCCGCT CTGGGCTGTC CTGGAGGAGC 780
TGGAATGTGA CAGAGGCGGA GAGCGGGGAG TATGTTTGTA AGGTTTCCAA TTATATTGGC 840
GAGGCCAACC AGTCTGCGTG GCTCACTGTC ACCAGACCTC TGGCAAAAGG TGGCCCATTG 900
CCAGCATGCT CCGATGGGCA GACGGCTGGC GTTAACACGA CAGACAAAGA GATGGAAGTC 960
CTTCACTTAA GGAATGTCTC ATTTGAGGAT GCTGGGGAGT ATACATGTTT GGCGGGTAAT 1020
TCTATTGGGA TCTCCCATCA CTCTGCATGG TTGACAGTTC TCGAAGCTAC TGAGCAGTCA 1080
CCAGCCATGA TGACGTCCCC CCTCTACCTG GAGATCATCA TTTACTGCAC CGGCGCCTTC 1140
CTCATCTCCT GCATGGTGGT GACAGTCATC ATCTACAAGA TGAAGAGCAC CACCAAGAAG 1200
ACAGACTTCA ACAGCCAGCT GGCCGTGCAC AAGCTGGCCA AGAGCATCCC ACTGCGCAGA 1260
CAGGTAACAG TGTCAGCAGA TTCCAGCTCC TCCATGAACT CGGGTGTGAT GTTGGTGCGG 1320
CCCTCACGGC TCTCCTCCAG CGGAACCCCC ATGCTGGCCG GCGTCTCCGA GTATGAGCTG 1380
CCCGAGGACC CGCGCTGGGA GCTGCCACGG GACAGGCTGA TCCTGGGCAA GCCGCTGGGA 1440
GAAGGCTGCT TTGGGCAGGT GGTGCTGGCG GAGGCCATCG GCCTGGACAA GGACAAGCCA 1500
AACCGCGTCA CCAAAGTGGC TGTAAAGATG CTCAAGTCCG ATGCCACAGA GAAGGACCTG 1560
TCCGACCTCA TCTCCGAGAT GGAGATGATG AAGATGATCG GCAAGCACAA GAACATCATC 1620
AACCTGCTGG GTGCCTGCAC GCAGGACGGG CCCCTCTATG TCATCGTGGA GTACGCCAGC 1680
AAAGGCAACC TGCGTGAGTA CCTGCAGGCA CGGCGCCCAC CGGGCATGGA GTACTGCTAC 1740
AACCCCACAC GCATCCCCGA GGAGCAGCTC TCCTTCAAGG ACCTGGTGTC CTGCGCGTAC 1800
CAGGTGGCAC GCGGCATGGA GTACCTGGCC TCCAAAAAGT GCATCCACAG GGACCTGGCG 1860
GCCAGGAACG TGCTGGTGAC CGAGGACAAC GTGATGAAGA TCGCTGACTT CGGGCTGGCC 1920
CGCGACATCC ACCACATCGA TTACTACAAG AAGACGACAA ACGGCCGCTT GCCGGTGAAG 1980
TGGATGGCCC CGGAGGCTCT GTTCGACCGA ATATACACCC ATCAGAGTGA TGTTTGGTCC 2040
TTCGGTGTGC TGCTGTGGGA GATCTTCACG CTGGGCGGTT CGCCCTACCC CGGCGTGCCC 2100
GTGGAGGAGC TCTTCAAGCT GCTGAAGGAA GGCCACAGGA TGGACAAGCC CAGCAACTGC 2160
ACCAACGAGC TGTACATGAT GATGCGCGAC TGCTGGCACG CCGTGCCCTC CCAGCGCCCC 2220
ACCTTCAAGC AGCTGGTGGA GGACCTGGAC AGGATCGTGG CCATGACCTC CAATCAGGAG 2280
TACCTGGACC TGTCGGTGCC GTTGGATCAG TACTCGCCCG GCTTCCCGGC CACGCGCAGC 2340
TCCACCTGCT CCTCGGGGGA GGACTCGGTG TTCTCCCACG ACCCGCTGCC CGACGAGCCC 2400
TGCCTGCCGC GCTGCCCCCC GCACAGCCAC GGAGCGCTGA AGCGGCACTG A 2451
Domain Profile
S: 1     lvlgkllGeGafGqvvkaeaigldkdkekkevtvavkmlkedatdkdladlvsemevlkl  60
         l lgk+lGeG+fGqvv aeaigldkdk+++ ++vavkmlk+dat+kdl+dl+seme++k+
Q: 473   LILGKPLGEGCFGQVVLAEAIGLDKDKPNRVTKVAVKMLKSDATEKDLSDLISEMEMMKM  532
         689*********************************************************
S: 61    iGkhkniinllGactqeGplyviveyaakGnlreflrarrpkgeeaskdkskaseeqlte  120
         iGkhkniinllGactq+Gplyviveya+kGnlre+l+arrp+g+e+++++++++eeql++
Q: 533   IGKHKNIINLLGACTQDGPLYVIVEYASKGNLREYLQARRPPGMEYCYNPTRIPEEQLSF  592
         ************************************************************
S: 121   kdlvsfayqvarGmeylaskkcihrdlaarnvlvtednvlkiadfGlardvheidyykkt  180
         kdlvs+ayqvarGmeylaskkcihrdlaarnvlvtednv+kiadfGlard+h+idyykkt
Q: 593   KDLVSCAYQVARGMEYLASKKCIHRDLAARNVLVTEDNVMKIADFGLARDIHHIDYYKKT  652
         ************************************************************
S: 181   tnGrlpvkwmapealfdrvytsqsdvwsfGvllweiltlGgspypgiaveelfkllkeGh  240
         tnGrlpvkwmapealfdr+yt+qsdvwsfGvllwei+tlGgspypg++veelfkllkeGh
Q: 653   TNGRLPVKWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPGVPVEELFKLLKEGH  712
         ************************************************************
S: 241   rmekpakctkelyvlmrecwhakaserptfkqlvedl  277
         rm+kp++ct+ely++mr+cwha++s+rptfkqlvedl
Q: 713   RMDKPSNCTNELYMMMRDCWHAVPSQRPTFKQLVEDL  749
         ***********************************97
Domain Sequence
(FASTA)
LILGKPLGEG CFGQVVLAEA IGLDKDKPNR VTKVAVKMLK SDATEKDLSD LISEMEMMKM 60
IGKHKNIINL LGACTQDGPL YVIVEYASKG NLREYLQARR PPGMEYCYNP TRIPEEQLSF 120
KDLVSCAYQV ARGMEYLASK KCIHRDLAAR NVLVTEDNVM KIADFGLARD IHHIDYYKKT 180
TNGRLPVKWM APEALFDRIY THQSDVWSFG VLLWEIFTLG GSPYPGVPVE ELFKLLKEGH 240
RMDKPSNCTN ELYMMMRDCW HAVPSQRPTF KQLVEDL 277
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00140
EKS-ANC-00142
EKS-BOT-00147
EKS-CAJ-00152
EKS-CAF-00156
EKS-CAP-00148
EKS-CIS-00182
EKS-DAR-00434
EKS-EQC-00147
EKS-FEC-00138
EKS-GAM-00076
EKS-GAA-00173
EKS-GOG-00148
EKS-HOS-00154
EKS-ICT-00142
EKS-LAC-00157
EKS-LOA-00147
EKS-MAM-00145
EKS-MEG-00116
EKS-MOD-00148
EKS-MUM-00153
EKS-MUP-00152
EKS-MYL-00157
EKS-NOL-00142
EKS-ORA-00126
EKS-ORC-00139
EKS-ORL-00171
EKS-OTG-00153
EKS-PAT-00139
EKS-PES-00133
EKS-POA-00144
EKS-RAN-00147
EKS-SAH-00143
EKS-SUS-00129
EKS-TAG-00177
EKS-TAR-00192
EKS-TEN-00184
EKS-XET-00136
EKS-XIM-00177
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0005007; F:fibroblast growth factor-activated receptor activity
GO:0008201; F:heparin binding
GO:0043066; P:negative regulation of apoptotic process
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0001759; P:organ induction
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0060045; P:positive regulation of cardiac muscle cell proliferation
GO:0045787; P:positive regulation of cell cycle
GO:0043406; P:positive regulation of MAP kinase activity
GO:0090080; P:positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
GO:0002053; P:positive regulation of mesenchymal cell proliferation
GO:0010863; P:positive regulation of phospholipase C activity
GO:0046777; P:protein autophosphorylation
GO:0060665; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling
GO:0048378; P:regulation of lateral mesodermal cell fate specification
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016248; Tyr_kinase_fibroblast_GF_rcpt.
Pfam
PF07679; I-set; 2.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 1.
SM00408; IGc2; 2.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013