EKS-GAG-00308

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00308

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Lmr	506.3	1.8E-152	98	371	274

Status

Unreviewed

Ensembl Protein

ENSGALP00000005497

UniProt Accession

F1NPU4;

Protein Name

Protein Synonyms/Alias

Gene Name

LMTK2

Gene Synonyms/Alias

LMTK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000003479	ENSGALP00000005497	ENSGALT00000005507

Organism

Gallus gallus

Functional Description

Protein Length

1446

Protein Sequence
(FASTA)

AAEVSSSFAV LSVCALVVLV VLLANCVSCC KDPEIDFKEF EDNFDDEIDF TPPAEDTPSV 60

QSPAEVFTLS VPNIALPTPS QFPSRADGSK SQVARQSLNY IQEIGNGWFG KVLLGEIYTG 120

TSVARVVVKE LKASAGLKEQ EQFLRSGEPY YILQHPNVLQ CIGQCVEAVP YLLVFEFCDL 180

GDLKTYICNE QDHVRGDSQI MLLQRMACEI AAGLAVMHKH NFVHSDLALR NCFLTSDLNV 240

KVGDYGIGFS RYKEDYIETD EKKLVPLRWT APELVTSFQD KLLSAEQNKY SNIWSLGVTL 300

WELFENAAQP YSDFSDREVL THVIKEKQVK LFKPHLEQPY SDRWYEVLQF CWLPPEKRPT 360

AEEVHRLLTY LRMQSQRDSE IDFEQQWNAL KPNTSNRETN NSAFPILDHF TGDRLGHEME 420

EVLTVTETSQ GLSFEYIWEA AKHDHFDECG HVNPDEAMAY TSIFFPVEVF ERSLSEQGPG 480

AQDGSGQEAS LAVPGVLPVF DAHKLSVGND YYIQLEEKGS GCSMNFDNQS VVLTTEVDQE 540

AVQEKSSHFM VLRDLDVEES STDGDFFHYN RDPKEEFLPA TSSPESPFQS IFNDIGRSEE 600

LTNRKIVGFA ETNDIPKDFK PTVLNSKIDI TNVPGFGEKE HSSHGSENKT VSVCENISNQ 660

SELVTLEELS DNFLFLQEKN LLTEILSNKT SRDFGQKTEA VLKSVLDTSS RTSVESEPVL 720

AESVQVFSLI CGNPGTVKDE NFNPVAVDKD MNSRSQTTVE IEASSSPSAA YKLHDKDINL 780

PYLKDEGKLS NVEVNQALFC NTDTFFQELS NNAKNNNVGN NSYYSAAAEA DQSNVQIKQG 840

ILSESDEIAF NKEKCDQEDM ERNLQCKSPI FKKDADLLEE RQETSNNFEN CKDVLEEVTS 900

ASVGASDCAS QDSLLEDSPS PREAVEQVLE TPDSLDSLDV IEVLESLQAQ SPQKLLPPDK 960

PADSGYETEN LESPEWTSHV TVEDASNGDT AHCSVSESSV NDLPSNPVII VSEAAPCLDA 1020

VNSNFEITPL SNQNSYRDSA YFSDNDSEPD KKTEETVNLS RETTCGVSSN RGENNSEKDY 1080

CLEERPQKHN LRNYQDAGTQ NAEPELDRKI EMHELGVRVQ GCPEEWAEAT LNSLEISMED 1140

NAKDEITLSE TCHKSVSCVG TNTSELLSHR DFKSVHNIHN SLDANNSEKP FYHNEGQKLK 1200

EPDIEGKYLG KLDVSGMLDL EDGDDADEED ENSDSEDDMR TFHMHSLSSD SEDETVHQVP 1260

EILTDKDDGK HLRSLLKLPK PPHERQAEHW RNEKKAVTFF DDVTVYLFDQ ETPTKELGNR 1320

VADLNGEGSH STPAPSSGFS YFNRFTNSES STDEQGGGFE WDDDFSSPEP SFISKAANSL 1380

ISSKPPLQSK YFSPPPPART LDQNWSHSSP YSRFSISPAN MASFSLTHLT DSDIEQGGSS 1440

EDGEKD 1446

Nucleotide Sequence
(FASTA)

GCAGCTGAAG TTTCCTCATC TTTTGCTGTT CTATCTGTCT GTGCTCTGGT AGTACTGGTG 60

GTCCTGCTTG CAAACTGTGT CTCCTGCTGC AAAGACCCGG AGATCGACTT CAAGGAGTTT 120

GAAGATAACT TTGATGATGA AATAGATTTC ACGCCCCCAG CAGAAGATAC TCCGTCTGTT 180

CAGTCTCCAG CAGAAGTTTT TACTCTTTCA GTTCCCAATA TTGCTTTACC AACCCCATCC 240

CAGTTTCCAT CTCGTGCAGA TGGATCAAAG TCTCAAGTTG CACGTCAGAG TCTAAACTAC 300

ATCCAGGAAA TTGGAAATGG CTGGTTTGGA AAGGTTCTGC TTGGAGAAAT CTACACAGGC 360

ACTAGTGTGG CACGAGTGGT AGTGAAGGAG TTGAAGGCAA GTGCAGGTCT CAAGGAGCAA 420

GAACAGTTTT TAAGAAGTGG AGAACCGTAC TACATTCTTC AGCATCCAAA TGTTCTCCAG 480

TGTATTGGGC AATGTGTGGA AGCTGTTCCT TATCTCCTAG TCTTTGAGTT CTGTGACTTG 540

GGTGACCTGA AAACTTATAT CTGCAATGAG CAGGACCACG TTAGAGGAGA TTCACAAATA 600

ATGCTGCTAC AGAGAATGGC ATGTGAGATT GCTGCTGGAC TTGCTGTAAT GCATAAACAT 660

AATTTTGTGC ATAGTGACTT GGCCTTACGA AATTGCTTTC TTACATCTGA TTTAAATGTC 720

AAAGTAGGAG ATTATGGTAT AGGATTCAGT AGGTACAAGG AAGATTATAT TGAGACAGAT 780

GAGAAGAAAC TTGTTCCTCT CCGATGGACT GCACCTGAAT TAGTAACGAG TTTTCAAGAC 840

AAACTATTAT CAGCAGAGCA AAATAAATAC AGTAACATAT GGTCCCTGGG TGTAACATTA 900

TGGGAGCTGT TTGAGAATGC TGCTCAGCCT TACTCAGACT TCTCTGACAG GGAGGTCTTA 960

ACCCACGTCA TAAAGGAGAA GCAGGTTAAA CTTTTTAAGC CACATCTGGA GCAGCCATAC 1020

TCTGATAGAT GGTATGAAGT TCTGCAATTC TGCTGGCTAC CTCCAGAGAA GAGACCAACA 1080

GCAGAAGAAG TGCATAGACT TCTAACTTAC CTTCGCATGC AAAGCCAAAG GGACTCAGAG 1140

ATTGATTTTG AACAGCAGTG GAATGCTCTT AAACCAAACA CCTCAAATAG AGAAACAAAT 1200

AATTCTGCGT TTCCGATCTT AGATCACTTC ACAGGAGATA GACTTGGCCA TGAAATGGAG 1260

GAAGTTCTTA CTGTAACTGA AACAAGCCAA GGTCTCAGCT TTGAATATAT CTGGGAGGCA 1320

GCTAAACATG ATCATTTTGA TGAGTGTGGT CATGTGAATC CTGATGAAGC AATGGCATAC 1380

ACAAGTATTT TCTTTCCAGT GGAGGTTTTT GAGAGGTCCC TTTCAGAGCA AGGGCCGGGA 1440

GCACAGGATG GAAGTGGTCA GGAAGCATCA CTAGCTGTTC CTGGGGTGTT ACCTGTGTTT 1500

GATGCGCACA AACTTTCAGT TGGAAATGAC TACTATATCC AGTTAGAGGA AAAAGGTAGT 1560

GGCTGCAGCA TGAATTTCGA TAACCAATCA GTTGTACTGA CTACAGAAGT TGATCAAGAA 1620

GCTGTACAAG AAAAAAGTTC TCATTTCATG GTTCTCAGGG ATCTTGATGT AGAAGAATCT 1680

AGCACTGATG GGGACTTCTT CCACTACAAT AGAGATCCCA AAGAGGAATT TTTGCCTGCT 1740

ACTAGTAGTC CAGAAAGTCC TTTCCAAAGT ATATTTAATG ACATTGGCAG ATCAGAAGAA 1800

TTAACAAATA GAAAAATAGT TGGTTTTGCT GAAACAAATG ATATTCCTAA AGACTTTAAA 1860

CCAACTGTTT TAAACTCAAA GATAGATATT ACAAATGTCC CAGGTTTTGG TGAGAAAGAG 1920

CATTCTAGTC ATGGTTCTGA AAACAAAACA GTTTCTGTAT GTGAAAACAT CTCTAACCAG 1980

TCTGAGTTGG TAACTTTAGA AGAACTTTCT GATAATTTCT TGTTTCTTCA AGAGAAAAAC 2040

TTACTAACAG AGATACTGTC TAATAAAACC AGCCGTGATT TTGGGCAAAA AACAGAAGCT 2100

GTTCTAAAAA GTGTATTAGA CACCTCAAGT AGGACCTCTG TAGAGTCTGA GCCTGTATTG 2160

GCTGAAAGTG TGCAGGTCTT TTCTTTAATA TGTGGAAATC CTGGAACTGT GAAAGATGAA 2220

AACTTTAACC CAGTAGCAGT GGATAAAGAT ATGAATTCTC GGTCTCAGAC TACTGTAGAG 2280

ATAGAGGCAT CCTCTAGTCC ATCTGCAGCA TATAAGTTGC ATGATAAAGA TATAAATCTT 2340

CCTTATTTGA AGGATGAGGG GAAACTTTCA AATGTGGAAG TCAACCAAGC CTTGTTCTGT 2400

AACACTGATA CTTTCTTTCA AGAGCTGTCC AATAATGCAA AAAATAATAA CGTTGGAAAC 2460

AATTCATATT ACAGCGCTGC TGCTGAAGCA GATCAGAGTA ATGTACAAAT AAAACAGGGA 2520

ATACTTTCCG AGTCTGATGA AATAGCTTTT AATAAGGAAA AATGTGATCA GGAAGATATG 2580

GAAAGAAACT TGCAATGTAA GTCTCCCATA TTTAAAAAAG ATGCAGATTT GTTAGAGGAA 2640

AGACAAGAAA CGTCAAATAA TTTTGAGAAC TGTAAGGATG TTCTGGAAGA GGTGACCTCA 2700

GCTTCTGTTG GCGCTTCAGA CTGTGCGAGT CAGGACAGTC TTTTGGAAGA TAGCCCGTCT 2760

CCAAGAGAAG CTGTAGAGCA AGTCTTGGAG ACGCCTGATT CATTGGATTC TTTAGATGTA 2820

ATCGAAGTTT TAGAATCCTT ACAGGCTCAA AGTCCACAAA AACTTTTGCC TCCTGATAAG 2880

CCTGCTGACA GCGGCTATGA AACAGAGAAT CTGGAGTCTC CAGAATGGAC TTCCCATGTT 2940

ACTGTTGAGG ATGCTTCTAA TGGGGATACC GCTCACTGTA GTGTCAGTGA GAGCAGTGTC 3000

AACGATCTGC CTTCTAATCC AGTCATAATT GTTTCAGAAG CAGCACCTTG CTTAGATGCA 3060

GTGAACAGCA ATTTTGAAAT AACCCCATTA TCAAATCAGA ATTCATATAG AGACTCTGCC 3120

TATTTCTCTG ACAATGACTC CGAGCCAGAT AAAAAAACAG AAGAGACTGT AAATCTATCA 3180

AGGGAGACTA CGTGTGGTGT TTCTTCAAAT AGAGGAGAGA ATAATAGTGA GAAGGATTAC 3240

TGTTTGGAAG AGAGACCACA AAAGCACAAT CTAAGGAATT ACCAGGATGC CGGTACTCAG 3300

AATGCAGAAC CAGAACTGGA TCGTAAGATA GAGATGCACG AGCTGGGTGT AAGGGTGCAG 3360

GGGTGTCCCG AGGAGTGGGC TGAGGCAACT CTGAATTCCC TGGAGATATC AATGGAAGAC 3420

AATGCGAAGG ATGAAATAAC GCTCTCTGAG ACCTGCCATA AAAGTGTCTC TTGCGTTGGC 3480

ACTAACACTT CAGAGCTTCT CTCACACAGA GACTTTAAGT CTGTGCATAA CATACACAAT 3540

TCTTTAGATG CCAATAATAG CGAGAAGCCC TTCTACCATA ATGAAGGACA AAAGCTGAAA 3600

GAGCCAGATA TTGAAGGAAA ATACCTTGGC AAGCTTGACG TTTCTGGAAT GCTTGATTTA 3660

GAAGACGGTG ATGATGCAGA CGAGGAAGAT GAAAACAGTG ATTCTGAGGA TGACATGAGG 3720

ACTTTTCATA TGCACAGCCT GAGTTCTGAC AGTGAGGATG AAACTGTTCA CCAGGTTCCC 3780

GAGATACTTA CTGACAAGGA TGATGGAAAA CATCTGAGAA GCTTACTGAA ACTTCCAAAA 3840

CCTCCTCATG AAAGGCAAGC TGAGCACTGG AGAAACGAGA AGAAGGCTGT CACGTTCTTC 3900

GATGATGTCA CGGTCTATTT GTTTGATCAG GAAACACCAA CTAAGGAATT GGGAAACCGT 3960

GTGGCAGACT TGAATGGCGA AGGCTCTCAC AGCACTCCTG CTCCATCCTC GGGTTTTAGT 4020

TACTTCAACA GATTTACCAA TTCAGAAAGC TCAACAGATG AACAAGGTGG AGGTTTTGAA 4080

TGGGATGATG ACTTCTCTTC CCCAGAGCCA TCCTTTATAT CAAAGGCAGC TAATAGCCTT 4140

ATTAGCTCTA AACCACCTCT TCAGTCAAAG TACTTCTCTC CACCTCCTCC TGCCCGGACT 4200

CTCGACCAGA ACTGGTCACA TTCATCCCCT TACTCCAGAT TCTCTATTTC TCCTGCAAAC 4260

ATGGCAAGCT TTTCCCTTAC GCATCTTACA GATTCAGATA TAGAGCAAGG AGGAAGCAGT 4320

GAAGATGGAG AGAAAGATTA A 4341

Domain Profile

S: 1     lsylkeigsgwfgkvllgevfsdvssaqvvvkelkasaspkeqrkfleeaqpyralqhpn  60

         l+y++eig+gwfgkvllge+++++s+a+vvvkelkasa+ keq++fl++++py++lqhpn

Q: 98    LNYIQEIGNGWFGKVLLGEIYTGTSVARVVVKELKASAGLKEQEQFLRSGEPYYILQHPN  157

         79**********************************************************

S: 61    vlqclgqcvealpyllvlefcdlgdlkaylraereaeslspdlrtlqrmalevaaglahl  120

         vlqc+gqcvea+pyllv+efcdlgdlk+y+ +e+++++ ++++++lqrma+e+aagla +

Q: 158   VLQCIGQCVEAVPYLLVFEFCDLGDLKTYICNEQDHVRGDSQIMLLQRMACEIAAGLAVM  217

         ************************************************************

S: 121   hklnyvhsdlalrnclltsdltvkvgdyglahskykedylltadklvvplrwaapelvde  180

         hk+n+vhsdlalrnc+ltsdl+vkvgdyg+++s+ykedy++t++k++vplrw+apelv++

Q: 218   HKHNFVHSDLALRNCFLTSDLNVKVGDYGIGFSRYKEDYIETDEKKLVPLRWTAPELVTS  277

         ************************************************************

S: 181   lhdrllvvdqtkesnvwslgvtlwelfelgaqpyrklsdeevlafvvreqdvklakprlk  240

         ++d+ll ++q k+sn+wslgvtlwelfe++aqpy+++sd+evl++v++e++vkl kp+l+

Q: 278   FQDKLLSAEQNKYSNIWSLGVTLWELFENAAQPYSDFSDREVLTHVIKEKQVKLFKPHLE  337

         ************************************************************

S: 241   lpysdrwyevlqfcwlppekrpaaedvhllltyl  274

         +pysdrwyevlqfcwlppekrp+ae+vh+lltyl

Q: 338   QPYSDRWYEVLQFCWLPPEKRPTAEEVHRLLTYL  371

         *********************************8

Domain Sequence
(FASTA)

LNYIQEIGNG WFGKVLLGEI YTGTSVARVV VKELKASAGL KEQEQFLRSG EPYYILQHPN 60

VLQCIGQCVE AVPYLLVFEF CDLGDLKTYI CNEQDHVRGD SQIMLLQRMA CEIAAGLAVM 120

HKHNFVHSDL ALRNCFLTSD LNVKVGDYGI GFSRYKEDYI ETDEKKLVPL RWTAPELVTS 180

FQDKLLSAEQ NKYSNIWSLG VTLWELFENA AQPYSDFSDR EVLTHVIKEK QVKLFKPHLE 240

QPYSDRWYEV LQFCWLPPEK RPTAEEVHRL LTYL 274

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005769	; C:early endosome
GO:0005794	; C:Golgi apparatus
GO:0016021	; C:integral to membrane
GO:0048471	; C:perinuclear region of cytoplasm
GO:0055037	; C:recycling endosome
GO:0005524	; F:ATP binding
GO:0004864	; F:protein phosphatase inhibitor activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004713	; F:protein tyrosine kinase activity
GO:0045022	; P:early endosome to late endosome transport
GO:0032456	; P:endocytic recycling
GO:0018105	; P:peptidyl-serine phosphorylation
GO:0018107	; P:peptidyl-threonine phosphorylation
GO:0046777	; P:protein autophosphorylation
GO:0001881	; P:receptor recycling
GO:0033572	; P:transferrin transport

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.

Pfam

PF07714

; Pkinase_Tyr; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013