EKS-GAG-00016
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00016
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR532.51.7E-160630897268
StatusUnreviewed
Ensembl ProteinENSGALP00000040154
UniProt AccessionF1NJT2;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameINSR
Gene Synonyms/Alias INSR;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003579ENSGALP00000040154ENSGALT00000040949
ENSGALG00000003579ENSGALP00000040146ENSGALT00000040941
ENSGALG00000003579ENSGALP00000005655ENSGALT00000005665
ENSGALG00000003579ENSGALP00000040148ENSGALT00000040943
OrganismGallus gallus
Functional Description
Protein Length989
Protein Sequence
(FASTA)
NIAAELEANL GLIEEISGYL KIRRSYALVS LSFFRKLHLI RGETLEAGNY SFYALDNQNL 60
RQLWDWSKHN LTIARGKLFF HYNPKLCLSE IHKMEEISGT KGRQERNDIA LKTNGDQASC 120
ENELLKFSSI RTSHDKILLK WEPYWPPDFR DLLGFMLFYK EAPYQNVTEF DGQDACGSNS 180
WTVVDVDPPP RSNEPKAQAQ PGWLLRGLKP WTQYAVFVKT LVTFSDERRT YGAKSEIIYV 240
QTNATVPSVP LDPISVSNSS SQIILKWKPP SEPNGNITHY LVYWQQQAED SELYELDYCL 300
KGLKLPSRTW SPPFESEDPQ KYNQSESEDV SGECCSCPKT DSQIQKELEE SAFRKTFENY 360
LHNEVFVPRP SRKRRDLGSI ANATVVIPTI PSSPNSSAAA SESAEEQKPF EKVKFKESLV 420
ISGLRHFTGY RIELHACNHD AQESRCSVAA YVSARTMPEA KADDIVGPVT HELVEKNTVH 480
LKWQEPKEPN GLIVLYEVNY GRLGEAEEAH FCVSRKHFAS EQGCKLRGLQ PGNYSVRIRA 540
TSLAGNGSWT EPTYFYVADY LNAQPNIAVI IVPIIFAIII AGIIGAAYVL VKKRQTEGPT 600
GPLYASSNPE YLSASDVYVP DEWEVPREKI TLLRELGQGS FGMVYEGIAK DIVKGELETR 660
VAVKTVNESA SLRERIEFLN EASVMKGFSC HHVVRLLGVV SKGQPTLVVM ELMAHGDLKS 720
YLRSLRPDAE NNPGRPPPTL REMIQMAAEI ADGMAYLNAK KFVHRDLAAR NCMVAEDFTV 780
KIGDFGMTRD IYETDYYRKG GKGLLPVRWM APESLKDGVF TTYSDVWSFG VVLWEISSLA 840
EQPYQGLSNE QVLKFVMDGG YLDQPDNCPE RLHNLMQMCW QYNPKMRPTF IEVIEMLKED 900
LHPSFQEVSF FYSEENKPLE TEEYEMDFEN MESIPLDPSS YTQRDKALGR DNGPSMALKG 960
NYEEHIPYTH MNGGKKNGRI LSMPRSSPS 989
Nucleotide Sequence
(FASTA)
AACATAGCAG CTGAGCTGGA AGCGAATCTT GGCCTGATAG AAGAAATCTC AGGTTACCTA 60
AAAATCCGCC GGTCGTATGC CTTGGTTTCT CTTTCTTTTT TCCGTAAACT GCATCTGATC 120
AGAGGAGAAA CGTTAGAAGC TGGAAATTAC TCATTTTATG CTTTGGACAA CCAGAATCTT 180
CGCCAGCTCT GGGACTGGAG TAAACACAAC CTCACGATAG CACGAGGCAA ACTCTTCTTC 240
CATTACAATC CCAAACTGTG TTTGTCAGAA ATCCACAAGA TGGAGGAGAT CTCTGGGACT 300
AAGGGGCGTC AGGAGAGGAA CGACATAGCC CTGAAGACAA ACGGTGACCA AGCCTCATGT 360
GAAAACGAAT TGCTGAAGTT CTCTTCCATT AGAACAAGTC ATGACAAGAT CCTGTTGAAG 420
TGGGAGCCCT ATTGGCCTCC TGATTTCCGT GACCTCCTGG GATTTATGCT CTTTTACAAA 480
GAGGCTCCAT ACCAAAACGT GACGGAGTTT GATGGGCAGG ATGCCTGCGG CTCCAACAGC 540
TGGACGGTCG TGGATGTGGA CCCACCACCG CGGTCCAACG AGCCCAAAGC CCAGGCCCAG 600
CCAGGCTGGC TGCTGCGGGG CCTGAAGCCA TGGACACAGT ATGCTGTGTT TGTTAAAACT 660
CTGGTCACCT TCTCAGATGA ACGAAGGACA TACGGTGCAA AGAGTGAGAT CATCTACGTC 720
CAGACCAACG CTACGGTTCC GTCAGTCCCA TTAGATCCAA TTTCTGTTTC CAACTCTTCA 780
TCCCAAATCA TCCTGAAGTG GAAGCCGCCC TCGGAGCCCA ATGGTAACAT CACGCACTAC 840
CTGGTGTACT GGCAGCAGCA GGCAGAAGAC AGTGAGCTTT ATGAACTCGA TTACTGCTTA 900
AAGGGATTAA AACTGCCCTC GAGGACGTGG TCTCCTCCTT TTGAATCTGA AGACCCTCAG 960
AAGTACAACC AAAGTGAAAG TGAGGACGTC AGTGGAGAGT GTTGTTCCTG TCCTAAAACC 1020
GACTCTCAGA TCCAGAAGGA GCTGGAGGAG TCTGCCTTCC GCAAGACCTT TGAGAACTAC 1080
CTGCACAACG AGGTGTTCGT CCCCAGGCCA TCAAGGAAGA GAAGAGACCT GGGCTCCATT 1140
GCCAATGCCA CCGTGGTGAT CCCCACCATC CCGTCCTCTC CAAACTCTTC CGCAGCCGCA 1200
TCTGAGAGTG CAGAGGAGCA GAAGCCTTTT GAAAAAGTGA AGTTCAAGGA GTCCCTGGTG 1260
ATCTCCGGGC TGCGGCACTT CACGGGGTAC CGCATTGAGC TCCACGCGTG TAACCACGAC 1320
GCGCAGGAAT CCCGGTGCAG CGTTGCAGCT TATGTCAGTG CCAGGACCAT GCCGGAGGCT 1380
AAGGCAGATG ACATCGTTGG TCCAGTCACC CATGAACTGG TTGAAAAAAA CACTGTGCAT 1440
TTGAAGTGGC AGGAGCCCAA GGAGCCGAAT GGCCTTATTG TGCTGTACGA AGTGAATTAC 1500
GGCCGTCTGG GGGAAGCAGA GGAAGCGCAC TTCTGCGTGT CCCGTAAGCA CTTTGCCAGC 1560
GAGCAGGGCT GCAAACTGCG CGGGCTGCAG CCCGGGAACT ACAGCGTGCG GATCCGAGCG 1620
ACGTCGCTGG CTGGGAACGG CTCCTGGACA GAGCCCACCT ACTTCTATGT GGCTGATTAC 1680
TTGAACGCTC AGCCTAATAT TGCTGTTATA ATTGTTCCGA TTATTTTTGC CATAATCATT 1740
GCTGGAATTA TTGGAGCTGC TTACGTGCTC GTGAAAAAGA GACAAACTGA AGGACCAACG 1800
GGGCCACTCT ACGCATCCTC CAACCCCGAA TACCTCAGTG CCAGTGATGT GTACGTTCCC 1860
GATGAGTGGG AGGTGCCACG GGAAAAGATC ACTCTGCTCC GTGAGCTGGG CCAGGGCTCA 1920
TTTGGGATGG TGTACGAGGG GATCGCCAAG GACATCGTGA AGGGAGAGCT GGAGACCCGC 1980
GTGGCTGTGA AAACGGTGAA CGAATCGGCC AGCCTGCGGG AGCGCATTGA GTTCCTCAAT 2040
GAAGCCTCCG TGATGAAAGG CTTCAGCTGC CACCACGTGG TTCGCCTCCT CGGGGTGGTC 2100
TCCAAGGGCC AACCCACACT GGTGGTCATG GAGTTAATGG CACATGGAGA CTTGAAAAGC 2160
TACCTACGCT CTCTGAGACC CGACGCTGAG AATAACCCTG GTCGTCCACC ACCAACACTG 2220
AGAGAAATGA TCCAGATGGC TGCAGAGATC GCTGATGGCA TGGCCTATCT GAATGCCAAG 2280
AAGTTTGTTC ACAGAGACCT GGCAGCTCGG AACTGCATGG TTGCAGAGGA CTTCACTGTA 2340
AAGATTGGAG ACTTCGGCAT GACCAGAGAT ATCTACGAGA CGGATTATTA CCGAAAGGGC 2400
GGCAAAGGAC TTCTGCCTGT GCGGTGGATG GCGCCTGAAT CGCTGAAGGA TGGCGTATTC 2460
ACAACGTACT CAGATGTGTG GTCATTTGGT GTTGTCCTTT GGGAGATAAG CAGCTTAGCA 2520
GAGCAGCCAT ATCAGGGACT CTCCAACGAA CAGGTGCTGA AGTTTGTGAT GGATGGAGGA 2580
TACCTGGATC AGCCGGACAA CTGCCCGGAG AGGCTGCACA ACCTGATGCA GATGTGCTGG 2640
CAGTACAACC CCAAGATGCG CCCCACCTTC ATTGAGGTCA TTGAGATGCT GAAGGAGGAT 2700
TTGCACCCCA GCTTCCAGGA GGTTTCTTTC TTCTACAGCG AGGAGAACAA GCCTCTGGAA 2760
ACAGAGGAGT ATGAGATGGA CTTCGAGAAC ATGGAGAGCA TCCCCCTCGA TCCCTCCTCG 2820
TACACACAGA GGGACAAAGC CCTGGGGCGG GACAATGGGC CCTCCATGGC CCTAAAGGGG 2880
AACTATGAGG AGCACATACC TTACACTCAC ATGAACGGAG GCAAGAAGAA CGGGCGGATC 2940
CTCTCCATGC CCAGGTCAAG TCCTTCCTAA 2970
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i+llrelGqGsfGmvyeG+akd+vkge etrva+ktvne+as reriefl+easvmk f+
Q: 630   ITLLRELGQGSFGMVYEGIAKDIVKGELETRVAVKTVNESASLRERIEFLNEASVMKGFS  689
         789*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvskgqp+lvvmelm++Gdlksylrslrp++en+++++pp+l ++iqmaae
Q: 690   CHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPDAENNPGRPPPTLREMIQMAAE  749
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+akkfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 750   IADGMAYLNAKKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  809
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         m+peslkdGvft+ sdvwsfGvvlwei +laeqpyqGlsneqvlkfv+dgg+l++p+ncp
Q: 810   MAPESLKDGVFTTYSDVWSFGVVLWEISSLAEQPYQGLSNEQVLKFVMDGGYLDQPDNCP  869
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         e+l++lm++cwqynpk+rp+f+e++e+l
Q: 870   ERLHNLMQMCWQYNPKMRPTFIEVIEML  897
         *************************975
Domain Sequence
(FASTA)
ITLLRELGQG SFGMVYEGIA KDIVKGELET RVAVKTVNES ASLRERIEFL NEASVMKGFS 60
CHHVVRLLGV VSKGQPTLVV MELMAHGDLK SYLRSLRPDA ENNPGRPPPT LREMIQMAAE 120
IADGMAYLNA KKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MAPESLKDGV FTTYSDVWSF GVVLWEISSL AEQPYQGLSN EQVLKFVMDG GYLDQPDNCP 240
ERLHNLMQMC WQYNPKMRPT FIEVIEML 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>
EKS-AIM-00014
EKS-BOT-00015
EKS-CAF-00017
EKS-CAP-00016
EKS-CIS-00008
EKS-FEC-00016
EKS-GOG-00019
EKS-HOS-00018
EKS-ICT-00017
EKS-LAC-00018
EKS-LOA-00015
EKS-MEG-00014
EKS-MOD-00015
EKS-MUM-00015
EKS-MUP-00018
EKS-MYL-00018
EKS-ORA-00016
EKS-ORC-00014
EKS-OTG-00016
EKS-PAT-00017
EKS-PES-00017
EKS-POA-00016
EKS-RAN-00017
EKS-TAG-00016
EKS-TAR-00026
EKS-TEN-00026
Gene Ontology
GO:0005901; C:caveola
GO:0005899; C:insulin receptor complex
GO:0005524; F:ATP binding
GO:0005525; F:GTP binding
GO:0004716; F:receptor signaling protein tyrosine kinase activity
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0032148; P:activation of protein kinase B activity
GO:0071363; P:cellular response to growth factor stimulus
GO:0007186; P:G-protein coupled receptor signaling pathway
GO:0008286; P:insulin receptor signaling pathway
GO:0030335; P:positive regulation of cell migration
GO:0048639; P:positive regulation of developmental growth
GO:0045740; P:positive regulation of DNA replication
GO:0045725; P:positive regulation of glycogen biosynthetic process
GO:0045821; P:positive regulation of glycolysis
GO:0043410; P:positive regulation of MAPK cascade
GO:0045840; P:positive regulation of mitosis
GO:0045429; P:positive regulation of nitric oxide biosynthetic process
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0060267; P:positive regulation of respiratory burst
GO:0046777; P:protein autophosphorylation
GO:0045995; P:regulation of embryonic development
GO:0006355; P:regulation of transcription, DNA-dependent
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 2.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013