EPS-GAG-00064
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEPS-GAG-00064
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
DSP/PTEN268.73.4E-801158158
StatusUnreviewed
Ensembl ProteinENSGALP00000005747
UniProt AccessionF1NT98;
Protein Name
Protein Synonyms/Alias
Gene NamePTEN
Gene Synonyms/Alias PTEN;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003634ENSGALP00000005747ENSGALT00000005757
OrganismGallus gallus
Functional Description
Protein Length376
Protein Sequence
(FASTA)
IYPNIIAMGF PAERLEGVYR NNIDDVLRFL DSKHKNHYKI YNLCAERHYD TAKFNCRVAQ 60
YPFEDHNPPQ LELIKPFCED LDQWLSEDDN HVAAIHCKAG KGRTGVMICA YLLHRGKFLK 120
AQEALDFYGE VRTRDKKGVT IPSQRRYVYY YSYLLKNHLD YRPVALLFHK MMFETIPMFS 180
GGTCNPQFVV YQLKVKIFTS PSGPSRREDK YMYFEFPQPL PVCGDIKVEF FHKQNKMLKK 240
DKMFHFWVNT FFIGLDENSD KVENGSLVAD QELDGIFSTE RSDNDKEYLI LTLTKNDLDK 300
ANKDKANRYF SPNFKVKLFF TKTVEEPSNP EASSSTSVTP DVSDNEPDHY RYSDTTDSDP 360
ENEPFDEDQH TQITKV 376
Nucleotide Sequence
(FASTA)
ATTTATCCAA ACATAATTGC TATGGGTTTT CCTGCGGAGA GGCTTGAAGG AGTATACCGG 60
AACAATATTG ATGATGTATT AAGGTTTTTG GATTCAAAGC ATAAAAACCA TTACAAGATA 120
TACAATCTAT GTGCTGAAAG ACATTATGAC ACCGCCAAAT TTAACTGCAG AGTTGCACAG 180
TACCCCTTTG AAGACCATAA CCCACCACAG TTAGAGCTTA TCAAACCTTT TTGTGAAGAT 240
CTTGACCAAT GGCTAAGTGA AGATGACAAT CATGTTGCAG CAATCCACTG TAAAGCTGGA 300
AAGGGACGAA CTGGTGTAAT GATATGTGCA TATTTGTTGC ATCGAGGCAA GTTTTTAAAG 360
GCTCAAGAAG CCCTAGATTT CTATGGGGAA GTAAGGACCA GAGACAAGAA GGGAGTCACA 420
ATTCCCAGTC AGAGACGCTA CGTGTACTAC TATAGCTACC TGTTAAAGAA TCACCTTGAT 480
TACAGACCAG TGGCACTGCT GTTTCACAAG ATGATGTTTG AAACAATTCC CATGTTCAGT 540
GGCGGAACTT GCAATCCTCA GTTTGTGGTG TACCAGCTAA AGGTAAAGAT ATTCACCTCC 600
CCTTCAGGAC CCTCAAGACG TGAAGACAAG TATATGTACT TTGAATTCCC TCAACCTTTG 660
CCGGTATGCG GTGATATCAA AGTGGAGTTC TTCCACAAAC AGAACAAGAT GTTGAAAAAG 720
GACAAAATGT TTCACTTTTG GGTAAATACA TTCTTCATAG GACTGGATGA AAATTCAGAC 780
AAAGTAGAAA ATGGAAGTCT AGTTGCAGAT CAGGAACTTG ATGGTATTTT CAGTACAGAG 840
CGCTCAGATA ATGACAAGGA ATATTTAATC CTTACATTAA CAAAAAATGA TCTAGACAAA 900
GCAAATAAAG ACAAAGCCAA CAGATATTTT TCTCCAAACT TCAAGGTGAA GCTATTTTTC 960
ACAAAAACAG TAGAAGAGCC ATCAAATCCC GAGGCTAGCA GTTCAACTTC TGTAACACCA 1020
GATGTTAGTG ACAATGAACC TGATCATTAC AGATACTCTG ACACCACTGA CTCTGATCCA 1080
GAGAATGAAC CTTTTGATGA AGATCAGCAT ACACAGATTA CAAAAGTCTG A 1131
Domain Profile
S: 15    vteriiavsfPaeareevyrnnlrevvrlldskhrnkyklynlcserrydltklnakvae  74
         ++++iia++fPae+ e+vyrnn+++v r+ldskh+n+yk+ynlc+er+yd++k+n++va+
Q: 1     IYPNIIAMGFPAERLEGVYRNNIDDVLRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQ  60
         799*********************************************************
S: 75    fgiedlnaPaleklvsickeldeWlseddenvvvlhckggkgrlGvivcayllaseisak  134
         +++ed+n+P+le ++++c++ld+Wlsedd++v+++hck+gkgr+Gv++cayll++++++k
Q: 61    YPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLK  120
         ************************************************************
S: 135   adealdtfgerrtredkvagvkqPsqrryvsyfsqllkgs  174
         a+eald++ge+rtr++k  gv++Psqrryv+y+s+llk++
Q: 121   AQEALDFYGEVRTRDKK--GVTIPSQRRYVYYYSYLLKNH  158
         *****************..******************986
Domain Sequence
(FASTA)
IYPNIIAMGF PAERLEGVYR NNIDDVLRFL DSKHKNHYKI YNLCAERHYD TAKFNCRVAQ 60
YPFEDHNPPQ LELIKPFCED LDQWLSEDDN HVAAIHCKAG KGRTGVMICA YLLHRGKFLK 120
AQEALDFYGE VRTRDKKGVT IPSQRRYVYY YSYLLKNH 158
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>
EPS-AIM-00070
EPS-ANC-00070
EPS-BOT-00060
EPS-CAE-00090
EPS-CAJ-00060
EPS-CAF-00075
EPS-CAP-00056
EPS-CHH-00018
EPS-CII-00031
EPS-CIS-00020
EPS-DAR-00104
EPS-DIO-00023
EPS-DRM-00027
EPS-EQC-00058
EPS-ERE-00015
EPS-FEC-00070
EPS-GAM-00057
EPS-GAA-00095
EPS-GOG-00071
EPS-HOS-00056
EPS-ICT-00059
EPS-LAC-00074
EPS-LOA-00054
EPS-MAM-00059
EPS-MEG-00066
EPS-MOD-00058
EPS-MUM-00056
EPS-MYL-00058
EPS-NOL-00066
EPS-ORN-00073
EPS-ORA-00063
EPS-ORC-00054
EPS-ORL-00083
EPS-OTG-00058
EPS-PAT-00053
EPS-PES-00071
EPS-POA-00072
EPS-RAN-00059
EPS-SAH-00057
EPS-SUS-00058
EPS-TAG-00068
EPS-TAR-00092
EPS-TAS-00020
EPS-TEN-00069
EPS-VIP-00021
EPS-XET-00068
EPS-XIM-00102
EPS-SCP-00017
Gene Ontology
GO:0042995; C:cell projection
GO:0005737; C:cytoplasm
GO:0009898; C:internal side of plasma membrane
GO:0035749; C:myelin sheath adaxonal region
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0051717; F:inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity
GO:0000287; F:magnesium ion binding
GO:0016314; F:phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity
GO:0051800; F:phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity
GO:0004438; F:phosphatidylinositol-3-phosphatase activity
GO:0004722; F:protein serine/threonine phosphatase activity
GO:0004725; F:protein tyrosine phosphatase activity
GO:0008138; F:protein tyrosine/serine/threonine phosphatase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0060070; P:canonical Wnt receptor signaling pathway
GO:0043542; P:endothelial cell migration
GO:0006917; P:induction of apoptosis
GO:0046855; P:inositol phosphate dephosphorylation
GO:0060291; P:long-term synaptic potentiation
GO:0043066; P:negative regulation of apoptotic process
GO:0090344; P:negative regulation of cell aging
GO:0030336; P:negative regulation of cell migration
GO:0045792; P:negative regulation of cell size
GO:0031658; P:negative regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0050680; P:negative regulation of epithelial cell proliferation
GO:0051895; P:negative regulation of focal adhesion assembly
GO:2000134; P:negative regulation of G1/S transition of mitotic cell cycle
GO:0031642; P:negative regulation of myelination
GO:0046621; P:negative regulation of organ growth
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0090071; P:negative regulation of ribosome biogenesis
GO:2000808; P:negative regulation of synaptic vesicle clustering
GO:0046856; P:phosphatidylinositol dephosphorylation
GO:0008284; P:positive regulation of cell proliferation
GO:2000060; P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0051091; P:positive regulation of sequence-specific DNA binding transcription factor activity
GO:0043491; P:protein kinase B signaling cascade
GO:0050821; P:protein stabilization
GO:0002902; P:regulation of B cell apoptotic process
GO:0033032; P:regulation of myeloid cell apoptotic process
GO:0060024; P:rhythmic synaptic transmission
KEGG
InterPros
IPR017361; Bifunc_PIno_P3_Pase/Pase_PTEN.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR000340; Dual-sp_phosphatase_cat-dom.
IPR014019; Phosphatase_tensin-typ.
IPR014020; Tensin_phosphatase_C2-dom.
IPR016130; Tyr_Pase_AS.
Pfam
PF00782; DSPc; 1.
PF10409; PTEN_C2; 1.
SMARTs
Prosites
PS51182; C2_TENSIN; 1.
PS51181; PPASE_TENSIN; 1.
PS00383; TYR_PHOSPHATASE_1; 1.
Prints
Created Date20-Feb-2013