EKS-GAG-00141

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00141

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKG	508.8	2.6E-153	375	633	259

Status

Unreviewed

Ensembl Protein

ENSGALP00000006027

UniProt Accession

F1NE85;

Protein Name

cGMP-dependent protein kinase

Protein Synonyms/Alias

Gene Name

PRKG1

Gene Synonyms/Alias

PRKG1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000003805	ENSGALP00000006027	ENSGALT00000006037
ENSGALG00000003805	ENSGALP00000040125	ENSGALT00000040920

Organism

Gallus gallus

Functional Description

Protein Length

685

Protein Sequence
(FASTA)

LGTLRDLQYA LQEKIEELRQ RDALIDELEL ELDQKDDLIP KLQNKLVYRS VIRPAARQAQ 60

QQSARSLQGE QRTKRQAISA EPTAFDIQDL SHVTLPFYPK SPQSKELIKE AILDNDFMKN 120

LELSQIQEIV DCMYPVEYGK DSCIIKEGDV GSLVYVMEDG KVEVTKEGVK LCTMGPGKVF 180

GELAILYNCT RTATVKTLVN VKLWAIDRQC FQTIMMRTGL IKHTEYMEFL KSVPTFQSLP 240

EEILSKLADV LEETHYESGE YIIRQGARGD TFFIISKGKV NVTREDSPSE DPVFLRTLGK 300

GDWFGEKALQ WEDVRTANVI AAEAVTCLVI DRDSFKHLIG GLDDVSNKAY EDAEAKAKYE 360

AEAAFFANLK LSDFNIIDTL GVGGFGRVEL VQLKSEETKT FAMKILKKRH IVDTRQQEHI 420

RSEKQIMQSA HSDFIVRLYR TFKDSKYLYM LMEACLGGEL WTILRDRGSF EDSTTRFYTA 480

CVVEAFAYLH SKGIIYRDLK PENLILDHRG YAKLVDFGFA KKIGFGKKTW TFCGTPEYVA 540

PEIILNKGHD ISADYWSLGI LMYELLTGSP PFSGPDPMKT YNIILRGIDM IEFPKKIAKN 600

AANLIKKLCR DNPSERLGNL KNGVKDIQKH KWFEGFNWEG LRKGTLTPPI IPSVASPTDT 660

SNFDSFPEDN DEPPPDDNSG WDIDF 685

Nucleotide Sequence
(FASTA)

CTGGGCACGT TGCGGGATTT ACAGTACGCG CTGCAGGAGA AGATCGAGGA GCTGCGGCAG 60

CGGGATGCGC TGATCGACGA GCTGGAGCTG GAGCTGGACC AGAAGGACGA TTTGATCCCC 120

AAGCTGCAAA ACAAACTGGT TTACCGCTCG GTGATCCGGC CCGCCGCGCG GCAGGCGCAA 180

CAGCAGAGCG CCCGCAGCCT GCAGGGCGAG CAGCGGACGA AGCGGCAGGC GATCTCGGCC 240

GAGCCCACCG CCTTCGACAT CCAGGACCTC AGCCACGTCA CGCTCCCCTT CTACCCCAAG 300

AGCCCGCAGT CCAAGGAGCT AATAAAGGAA GCAATCCTTG ACAATGACTT CATGAAGAAT 360

CTGGAGCTGT CTCAGATCCA GGAGATTGTG GATTGTATGT ATCCTGTGGA GTATGGCAAA 420

GACAGCTGTA TCATCAAGGA GGGAGATGTG GGTTCCCTGG TGTACGTCAT GGAAGATGGG 480

AAGGTTGAAG TGACAAAAGA AGGCGTGAAG CTGTGCACCA TGGGACCGGG CAAGGTGTTC 540

GGGGAGTTGG CCATCCTCTA CAACTGCACT CGAACAGCAA CTGTCAAAAC TCTCGTAAAT 600

GTGAAACTTT GGGCTATTGA TCGGCAATGT TTTCAAACAA TAATGATGAG GACAGGCCTC 660

ATCAAGCATA CTGAGTATAT GGAATTTTTA AAAAGTGTTC CCACATTCCA GAGCCTTCCT 720

GAGGAGATAC TCAGTAAGCT TGCAGATGTC CTTGAAGAGA CACACTATGA AAGTGGGGAG 780

TATATTATCC GACAGGGTGC TCGAGGGGAC ACCTTCTTTA TAATCAGCAA AGGAAAGGTG 840

AACGTCACTC GTGAAGATTC CCCCAGTGAG GATCCAGTCT TTCTCCGTAC TTTAGGAAAA 900

GGAGATTGGT TTGGAGAAAA AGCACTGCAA TGGGAGGATG TCAGAACTGC CAACGTCATT 960

GCGGCTGAAG CAGTAACTTG TCTGGTCATA GACAGAGACT CCTTCAAACA TCTGATTGGC 1020

GGCCTAGATG ATGTTTCCAA TAAAGCCTAT GAAGATGCAG AAGCAAAAGC AAAATATGAA 1080

GCCGAAGCTG CCTTCTTCGC CAACCTGAAA CTGTCTGATT TCAACATCAT TGACACCCTT 1140

GGAGTCGGAG GTTTCGGACG AGTTGAACTG GTCCAGTTGA AAAGTGAAGA GACGAAGACG 1200

TTTGCGATGA AGATCCTGAA GAAACGTCAC ATAGTGGACA CAAGGCAGCA GGAGCACATC 1260

CGCTCGGAGA AGCAGATCAT GCAGAGCGCT CACTCAGACT TCATCGTGAG GCTCTACAGG 1320

ACGTTCAAGG ACAGCAAGTA CCTGTACATG CTGATGGAAG CCTGTCTAGG TGGAGAGCTC 1380

TGGACAATTC TCAGGGACAG AGGTTCATTT GAGGATTCAA CAACCAGGTT TTACACGGCG 1440

TGCGTAGTTG AAGCTTTTGC CTATTTGCAT TCCAAAGGAA TCATTTATAG GGACCTCAAG 1500

CCAGAAAACC TCATTCTGGA TCATCGAGGT TATGCCAAAC TGGTTGATTT TGGCTTTGCA 1560

AAGAAAATAG GATTTGGAAA GAAAACATGG ACTTTTTGTG GAACTCCAGA GTACGTAGCC 1620

CCCGAGATCA TCCTGAACAA AGGTCACGAT ATTTCAGCAG ACTACTGGTC ACTGGGAATC 1680

CTAATGTATG AACTCCTGAC TGGCAGTCCC CCTTTCTCAG GCCCAGACCC TATGAAGACC 1740

TATAACATAA TATTAAGGGG AATTGATATG ATTGAATTTC CAAAGAAGAT TGCCAAAAAT 1800

GCTGCTAATT TAATTAAAAA ACTATGCAGG GACAATCCAT CAGAAAGATT AGGGAACTTG 1860

AAAAATGGAG TGAAAGACAT CCAAAAGCAC AAATGGTTTG AAGGCTTTAA CTGGGAAGGG 1920

TTACGAAAAG GGACACTGAC ACCTCCTATA ATACCAAGTG TTGCATCTCC AACAGACACA 1980

AGCAATTTCG ACAGCTTCCC TGAGGACAAT GATGAACCAC CCCCTGATGA CAACTCAGGA 2040

TGGGACATAG ATTTT 2055

Domain Profile

S: 2     kviatlgvggfgrvelvkvksdeskafalkilkkkhivdtkqqehvlsekrileeaksdf  61

         ++i+tlgvggfgrvelv++ks+e+k+fa+kilkk+hivdt+qqeh++sek+i+++a+sdf

Q: 375   NIIDTLGVGGFGRVELVQLKSEETKTFAMKILKKRHIVDTRQQEHIRSEKQIMQSAHSDF  434

         79**********************************************************

S: 62    ivklyrtfkdekyvyllleaclggelwtilrdrgsfddktakfivacvvealeylhskni  121

         iv+lyrtfkd+ky+y+l+eaclggelwtilrdrgsf+d+t++f++acvvea++ylhsk+i

Q: 435   IVRLYRTFKDSKYLYMLMEACLGGELWTILRDRGSFEDSTTRFYTACVVEAFAYLHSKGI  494

         ************************************************************

S: 122   iyrdlkpenllldeegylklvdfgfakklksgkktwtfcgtpeyvapeiilnkghdlsvd  181

         iyrdlkpenl+ld++gy+klvdfgfakk++ gkktwtfcgtpeyvapeiilnkghd+s+d

Q: 495   IYRDLKPENLILDHRGYAKLVDFGFAKKIGFGKKTWTFCGTPEYVAPEIILNKGHDISAD  554

         ************************************************************

S: 182   ywalgilvyelltgkppfsgvdplktynlilkgidklelprkitkeaedlikklcrdnpa  241

         yw+lgil+yelltg+ppfsg+dp+ktyn+il+gid++e+p+ki+k+a++likklcrdnp+

Q: 555   YWSLGILMYELLTGSPPFSGPDPMKTYNIILRGIDMIEFPKKIAKNAANLIKKLCRDNPS  614

         ************************************************************

S: 242   erlgylkggikdikkhkwf  260

         erlg+lk+g+kdi+khkwf

Q: 615   ERLGNLKNGVKDIQKHKWF  633

         ******************9

Domain Sequence
(FASTA)

NIIDTLGVGG FGRVELVQLK SEETKTFAMK ILKKRHIVDT RQQEHIRSEK QIMQSAHSDF 60

IVRLYRTFKD SKYLYMLMEA CLGGELWTIL RDRGSFEDST TRFYTACVVE AFAYLHSKGI 120

IYRDLKPENL ILDHRGYAKL VDFGFAKKIG FGKKTWTFCG TPEYVAPEII LNKGHDISAD 180

YWSLGILMYE LLTGSPPFSG PDPMKTYNII LRGIDMIEFP KKIAKNAANL IKKLCRDNPS 240

ERLGNLKNGV KDIQKHKWF 259

Keyword

ATP-binding; cGMP; cGMP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005794	; C:Golgi apparatus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005246	; F:calcium channel regulator activity
GO:0030553	; F:cGMP binding
GO:0004692	; F:cGMP-dependent protein kinase activity
GO:0090331	; P:negative regulation of platelet aggregation
GO:0043087	; P:regulation of GTPase activity
GO:0007165	; P:signal transduction

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR016232	; cGMP-dependent_protein_kinase.
IPR002374	; cGMP_dep_kinase.
IPR018490	; cNMP-bd-like.
IPR018488	; cNMP-bd_CS.
IPR000595	; cNMP-bd_dom.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014710	; RmlC-like_jellyroll.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00027	; cNMP_binding; 2.
PF00069	; Pkinase; 1.

SMARTs

SM00100	; cNMP; 2.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00888	; CNMP_BINDING_1; 2.
PS00889	; CNMP_BINDING_2; 2.
PS50042	; CNMP_BINDING_3; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00104

; CGMPKINASE.

Created Date

20-Feb-2013