EKS-GAG-00090
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00090
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Tec449.04.3E-135362612251
StatusUnreviewed
Ensembl ProteinENSGALP00000006120
UniProt AccessionE1C6Q5;
Protein Name
Protein Synonyms/Alias
Gene NameITK
Gene Synonyms/Alias ITK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000003857ENSGALP00000006120ENSGALT00000006130
OrganismGallus gallus
Functional Description
Protein Length616
Protein Sequence
(FASTA)
MNNCVLLEEQ LIKKSQQKRR TSPSNFKVRF FVLTKSKLAY YEHRHGKKRT LKGYVELSRI 60
KCVEIVKSDI IIPCQYKYPF QIVHDNYILY VFAPNRESRQ RWVFTLKEET RSNNSLVSKY 120
HPDFWIDGKW RCCAQTEKMA VGCIEYDPTK TASKKPLPPT PEDNWKSLLN TKETLVMAIY 180
DYEAQNPQEL TLQYNEEYHV IDSSEEHWWL IQDKNGHEGY VPSSYLAEKS PENLQIYEWY 240
NKNINRSKAE MLLRDEGREG AFMVRDSRQP GMYTVSVFTK ALRDNNPVIK HYHINETTDF 300
PKRYYLAEKH VFNCIPELIN YHQHNAGGLV TRLRYAVSSW KKKAPITAGL SYGKLVINPS 360
ELTRVQEIGS GQFGVVYLGY WLEKTKVAIK TIREGAMSEE DFIEEAKVLM KLSHPKLVQL 420
YGVCFENTPI CLVFEFMEHG CLSDYLRSQR GSFSKETLLG MCLDVCEGMA YLEQNSVIHR 480
DLAARNCLVG ESQVVKVSDF GMSRIVLDDQ YTSSTGTKFP VKWSAPEVFS YSNYSTKSDV 540
WSFGVLMWEV FSEGKMPYEN RTNGEVVEEI NAGFRLYKPK LASKAIYEVM SHCWSMRKED 600
RPSFSLLLYQ LSEISE 616
Nucleotide Sequence
(FASTA)
ATGAATAACT GTGTGCTCCT GGAAGAGCAG CTGATCAAAA AATCCCAGCA GAAGAGAAGG 60
ACTTCACCCT CCAACTTTAA AGTGCGCTTC TTTGTCTTAA CCAAATCTAA GCTGGCTTAC 120
TATGAACATC GCCATGGGAA AAAAAGGACT TTGAAGGGTT ATGTGGAACT TTCCAGGATT 180
AAATGTGTGG AAATTGTGAA AAGTGACATC ATCATCCCCT GTCAATATAA ATATCCTTTC 240
CAGATTGTCC ATGATAACTA CATCCTCTAC GTGTTTGCAC CCAATCGTGA GAGCCGGCAG 300
AGATGGGTCT TTACACTGAA GGAAGAAACC AGAAGCAACA ACAGCTTGGT CTCAAAGTAT 360
CATCCAGATT TCTGGATAGA CGGCAAGTGG AGATGCTGTG CTCAGACAGA GAAGATGGCA 420
GTTGGCTGTA TAGAGTATGA CCCCACCAAA ACTGCCTCAA AGAAGCCTCT TCCTCCCACC 480
CCTGAAGATA ACTGGAAATC ATTGCTAAAT ACGAAGGAAA CCTTAGTCAT GGCCATATAC 540
GACTATGAAG CCCAGAATCC ACAGGAGCTG ACGTTACAAT ACAATGAGGA ATACCATGTG 600
ATTGACAGCT CTGAGGAACA TTGGTGGCTG ATTCAAGACA AGAATGGGCA TGAAGGCTAT 660
GTGCCAAGTA GCTACCTGGC GGAAAAATCA CCTGAGAACC TGCAAATATA TGAATGGTAC 720
AATAAGAACA TCAACAGAAG CAAAGCAGAA ATGCTCCTCA GGGATGAGGG TAGAGAAGGT 780
GCCTTCATGG TGAGAGATTC GAGGCAGCCT GGCATGTACA CAGTCTCTGT TTTCACCAAA 840
GCATTGAGGG ATAACAATCC TGTTATAAAA CATTACCACA TCAATGAGAC AACTGACTTT 900
CCCAAAAGAT ATTATTTGGC AGAAAAACAC GTCTTCAACT GCATCCCTGA ACTCATCAAC 960
TACCATCAGC ACAATGCAGG AGGTCTTGTT ACTCGTTTGC GGTACGCAGT GTCCTCTTGG 1020
AAGAAGAAGG CCCCAATCAC TGCAGGGCTG AGCTATGGAA AATTGGTCAT TAATCCTTCT 1080
GAGCTCACCC GTGTGCAGGA AATAGGCAGT GGTCAGTTTG GGGTGGTTTA CCTTGGCTAC 1140
TGGCTGGAGA AGACAAAAGT TGCCATAAAG ACCATTCGTG AAGGAGCGAT GTCTGAAGAG 1200
GATTTCATCG AGGAGGCTAA GGTCTTGATG AAGCTGTCTC ACCCCAAACT AGTCCAGCTT 1260
TATGGAGTAT GCTTTGAGAA CACTCCCATA TGCCTAGTGT TCGAGTTCAT GGAGCACGGC 1320
TGCTTGTCTG ACTACCTCAG GAGCCAGAGG GGCAGTTTTT CAAAAGAAAC CCTCCTGGGA 1380
ATGTGCCTGG ATGTGTGCGA AGGAATGGCT TATCTGGAAC AAAATTCTGT CATCCACAGA 1440
GACCTGGCTG CTAGGAACTG CCTGGTGGGG GAATCTCAAG TGGTCAAAGT GTCTGACTTC 1500
GGGATGTCAA GGATTGTTCT TGACGATCAG TATACCAGCT CCACGGGGAC CAAGTTTCCA 1560
GTTAAATGGT CTGCCCCAGA GGTTTTCTCC TACAGTAATT ACAGCACCAA ATCAGACGTT 1620
TGGTCATTTG GAGTGCTCAT GTGGGAGGTC TTCAGTGAAG GCAAAATGCC CTATGAGAAT 1680
CGCACCAATG GAGAAGTGGT GGAAGAAATC AATGCAGGGT TTCGGCTCTA CAAGCCCAAG 1740
TTGGCCTCGA AGGCTATTTA TGAGGTGATG AGCCACTGCT GGAGCATGAG GAAAGAAGAC 1800
CGCCCGTCCT TTTCTCTTCT GCTTTATCAG CTGAGTGAAA TCTCTGAG 1848
Domain Profile
S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60
         lt ++e+gsgqfgvv lg+w +k++vaik+i+egamseedfieeakv+mklshpklvqly
Q: 362   LTRVQEIGSGQFGVVYLGYWLEKTKVAIKTIREGAMSEEDFIEEAKVLMKLSHPKLVQLY  421
         5779********************************************************
S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120
         gvc +++pi++v+e++e+gcl++ylr+++++++ke+ll mc dvcegm+yle++s+ihrd
Q: 422   GVCFENTPICLVFEFMEHGCLSDYLRSQRGSFSKETLLGMCLDVCEGMAYLEQNSVIHRD  481
         ************************************************************
S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180
         laarnclv+e++vvkvsdfg++r vlddqy+ss+g+kfpvkws+pev+sys+ys+ksdvw
Q: 482   LAARNCLVGESQVVKVSDFGMSRIVLDDQYTSSTGTKFPVKWSAPEVFSYSNYSTKSDVW  541
         ************************************************************
S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240
         +fgvlmwevfsegk+pye+++n evve+++ g+rly+pklask +yevm +cw+ + e+r
Q: 542   SFGVLMWEVFSEGKMPYENRTNGEVVEEINAGFRLYKPKLASKAIYEVMSHCWSMRKEDR  601
         ************************************************************
S: 241   ptfkellsale  251
         p+f+ ll +l+
Q: 602   PSFSLLLYQLS  612
         *******9885
Domain Sequence
(FASTA)
LTRVQEIGSG QFGVVYLGYW LEKTKVAIKT IREGAMSEED FIEEAKVLMK LSHPKLVQLY 60
GVCFENTPIC LVFEFMEHGC LSDYLRSQRG SFSKETLLGM CLDVCEGMAY LEQNSVIHRD 120
LAARNCLVGE SQVVKVSDFG MSRIVLDDQY TSSTGTKFPV KWSAPEVFSY SNYSTKSDVW 180
SFGVLMWEVF SEGKMPYENR TNGEVVEEIN AGFRLYKPKL ASKAIYEVMS HCWSMRKEDR 240
PSFSLLLYQL S 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-AIM-00101
EKS-ANC-00099
EKS-BOT-00110
EKS-CAJ-00111
EKS-CAF-00112
EKS-CAP-00105
EKS-DAR-00357
EKS-EQC-00108
EKS-FEC-00105
EKS-GAA-00128
EKS-GOG-00111
EKS-HOS-00113
EKS-ICT-00105
EKS-LAC-00114
EKS-LOA-00106
EKS-MAM-00105
EKS-MEG-00085
EKS-MOD-00106
EKS-MUM-00112
EKS-MUP-00113
EKS-MYL-00124
EKS-NOL-00103
EKS-OCP-00072
EKS-ORA-00089
EKS-ORC-00102
EKS-ORL-00125
EKS-OTG-00112
EKS-PAT-00100
EKS-PES-00093
EKS-POA-00103
EKS-RAN-00108
EKS-SAH-00102
EKS-TAG-00138
EKS-TAR-00137
EKS-TEN-00127
EKS-XET-00091
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004715; F:non-membrane spanning protein tyrosine kinase activity
GO:0005543; F:phospholipid binding
GO:0007202; P:activation of phospholipase C activity
GO:0002250; P:adaptive immune response
GO:0035556; P:intracellular signal transduction
GO:0050852; P:T cell receptor signaling pathway
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR011993; PH_like_dom.
IPR001849; Pleckstrin_homology.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR013315; Spectrin_alpha_SH3.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR001562; Znf_Btk_motif.
Pfam
PF00779; BTK; 1.
PF00169; PH; 1.
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00107; BTK; 1.
SM00233; PH; 1.
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS50003; PH_DOMAIN; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
PS51113; ZF_BTK; 1.
Prints
PR00401; SH2DOMAIN.
PR01887; SPECTRNALPHA.
PR00109; TYRKINASE.
Created Date20-Feb-2013