EKS-GAG-00145

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00145

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKC	477.3	1.5E-143	341	599	259

Status

Unreviewed

Ensembl Protein

ENSGALP00000006278

UniProt Accession

Q5F3X1;

Protein Name

Protein kinase C

Protein Synonyms/Alias

Gene Name

PRKCA

Gene Synonyms/Alias

PRKCA; RCJMB04_5a10;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000003943	ENSGALP00000006278	ENSGALT00000006288

Organism

Gallus gallus

Functional Description

Protein Length

674

Protein Sequence
(FASTA)

MADVFPGSEP GAAPDAARRF ARKGALRQKN VHEVKEHKFI ARFFKQPTFC SHCTDFIWGF 60

GKQGFQCQVC CFVVHKRCHE FVTFSCPGAD KGPDTDDPRS KHKFKIHTYG SPTFCDHCGS 120

LLYGLLHQGM KCDTCDMNVH KQCVINVPSL CGMDHTEKRG RIYLKAEVTG DKLEVTVREA 180

KNLIPMDPNG LSDPYVKLKL IPDPKNESKQ KTKTFRSTLN PHWNESFTFK LKPTDKDRRL 240

SVEVWDWDRT TRNDFMGSLS FGVSELMKMP ASGWYKLLNQ EEGEYYNVPI PDADEDGNAE 300

LRQKFEKAKL GPAGNKVITP SEDRNSSVPS NNLDRVKLTD FNFLMVLGKG SFGKVMLADR 360

KNTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALQDKPP FLTQLHSCFQ TVDRLYFVME 420

YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS VGLFFLHNRG IVYRDLKLDN VMLDSEGHIK 480

IADFGMCKEH MLDGVTTRTF CGTPDYIAPE IIAYQPYGKS VDWWAYGVLL YEMLAGQPPF 540

DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA KRLGCGLEGE RDIREHAFFR 600

RIDWEKLENR EIQPPFKPKV CGKGAENFDK FFTRGQPVLT PPDQLVIANI DQSDFEGFSY 660

VNPQFVHPLL ENVA 674

Nucleotide Sequence
(FASTA)

ATGGCCGACG TGTTCCCGGG CTCCGAGCCC GGCGCGGCCC CGGACGCGGC GCGGCGCTTT 60

GCTCGCAAAG GGGCCCTGAG GCAGAAGAAC GTGCACGAGG TGAAGGAGCA CAAATTCATC 120

GCGCGCTTCT TCAAGCAGCC CACCTTCTGC AGCCACTGCA CCGACTTCAT CTGGGGATTT 180

GGGAAACAAG GATTTCAGTG CCAAGTTTGC TGTTTTGTGG TTCATAAGAG ATGCCATGAG 240

TTCGTTACCT TCTCCTGTCC TGGAGCTGAC AAGGGACCTG ACACCGATGA CCCCAGGAGC 300

AAGCACAAAT TTAAGATCCA CACCTATGGG AGCCCAACCT TCTGTGACCA CTGTGGGTCC 360

CTTCTTTATG GGCTCCTACA CCAAGGGATG AAATGTGACA CTTGTGATAT GAATGTGCAT 420

AAGCAATGTG TGATAAACGT CCCGAGCCTC TGTGGCATGG ATCACACTGA GAAAAGGGGA 480

AGGATTTATC TGAAGGCTGA AGTCACTGGT GACAAACTGG AAGTAACAGT GCGAGAAGCA 540

AAAAACCTAA TTCCCATGGA TCCAAATGGG CTTTCAGATC CTTATGTTAA ACTGAAACTT 600

ATCCCAGATC CCAAGAATGA AAGTAAACAA AAAACAAAAA CCTTCCGTTC TACCCTGAAT 660

CCACACTGGA ATGAGTCATT CACATTTAAA TTAAAACCTA CAGACAAAGA TCGACGGCTC 720

TCTGTAGAGG TCTGGGACTG GGATCGAACA ACCAGGAATG ATTTTATGGG CTCTCTTTCA 780

TTTGGGGTGT CAGAGCTCAT GAAGATGCCA GCCAGTGGAT GGTACAAGCT GCTGAATCAA 840

GAAGAAGGTG AATATTATAA TGTTCCAATT CCAGATGCTG ACGAGGATGG AAATGCAGAG 900

CTCCGGCAGA AGTTCGAGAA AGCCAAACTT GGGCCAGCTG GTAACAAAGT CATTACTCCA 960

TCAGAAGACA GGAATTCAAG TGTGCCATCC AACAATCTGG ACAGGGTGAA GCTGACAGAT 1020

TTCAACTTTC TTATGGTTCT TGGAAAAGGA AGCTTTGGAA AGGTGATGCT GGCGGACAGG 1080

AAGAATACAG AGGAGCTCTA TGCAATCAAA ATACTGAAAA AAGATGTGGT GATTCAGGAT 1140

GATGATGTTG AGTGTACAAT GGTTGAAAAA CGAGTGCTAG CACTGCAGGA TAAACCACCA 1200

TTCCTGACAC AGCTTCACTC ATGTTTCCAA ACAGTTGACC GCCTGTATTT TGTTATGGAG 1260

TATGTGAATG GTGGGGATCT CATGTACCAC ATTCAGCAAG TAGGAAAATT TAAGGAGCCA 1320

CAAGCAGTGT TCTATGCAGC TGAGATCTCA GTTGGGTTAT TCTTTCTCCA TAATAGAGGG 1380

ATTGTTTATA GAGATCTGAA ATTGGATAAT GTGATGTTGG ATTCAGAAGG ACACATTAAA 1440

ATTGCTGACT TTGGAATGTG CAAAGAACAT ATGTTAGATG GAGTAACAAC CAGGACCTTC 1500

TGTGGCACCC CAGATTACAT CGCACCGGAG ATCATTGCTT ATCAGCCCTA TGGGAAGTCT 1560

GTGGATTGGT GGGCATATGG AGTGCTGCTC TACGAGATGT TAGCTGGCCA GCCTCCATTT 1620

GATGGAGAAG ACGAAGATGA ACTTTTCCAG TCCATAATGG AACATAATGT TTCCTATCCA 1680

AAATCGCTGT CCAAAGAAGC TGTCTCCATC TGCAAGGGGC TAATGACTAA ACATCCCGCA 1740

AAGCGCCTTG GCTGCGGCCT CGAAGGTGAA AGAGACATCA GGGAACACGC TTTCTTCAGG 1800

AGAATTGACT GGGAGAAACT GGAAAACAGA GAGATCCAGC CACCTTTCAA GCCCAAAGTG 1860

TGTGGCAAAG GTGCTGAAAA CTTCGATAAA TTCTTCACGC GAGGACAGCC GGTGTTGACC 1920

CCGCCAGACC AGCTGGTTAT TGCTAACATA GATCAATCCG ATTTTGAAGG GTTCTCCTAT 1980

GTCAACCCCC AGTTTGTACA TCCCCTCCTA GAAAATGTAG CATGA 2025

Domain Profile

S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60

         f++l+vlGkGsfgkv+la++k+t+elyaik+lkkdvv+qdddve+t+vekrvlal++k+p

Q: 341   FNFLMVLGKGSFGKVMLADRKNTEELYAIKILKKDVVIQDDDVECTMVEKRVLALQDKPP  400

         99**********************************************************

S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120

         fl+ql+scfqt drl+fv+eyvnGGdlm+hiq+++k+ke++a+fyaaei+++l+flh++g

Q: 401   FLTQLHSCFQTVDRLYFVMEYVNGGDLMYHIQQVGKFKEPQAVFYAAEISVGLFFLHNRG  460

         ************************************************************

S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180

         i+yrdlkldnv+ld+eGhik+adfG+cke++l+g tt+tfcGtPdyiaPei+++++ygks

Q: 461   IVYRDLKLDNVMLDSEGHIKIADFGMCKEHMLDGVTTRTFCGTPDYIAPEIIAYQPYGKS  520

         ************************************************************

S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240

         vdwwa+Gvllyemlagq+Pf+gededelf+si+e++v+yPkslskeav+i+kgl+tk+p+

Q: 521   VDWWAYGVLLYEMLAGQPPFDGEDEDELFQSIMEHNVSYPKSLSKEAVSICKGLMTKHPA  580

         ************************************************************

S: 241   krlGvkeegeedikehaff  259

         krlG+  ege+di+ehaff

Q: 581   KRLGCGLEGERDIREHAFF  599

         ******************9

Domain Sequence
(FASTA)

FNFLMVLGKG SFGKVMLADR KNTEELYAIK ILKKDVVIQD DDVECTMVEK RVLALQDKPP 60

FLTQLHSCFQ TVDRLYFVME YVNGGDLMYH IQQVGKFKEP QAVFYAAEIS VGLFFLHNRG 120

IVYRDLKLDN VMLDSEGHIK IADFGMCKEH MLDGVTTRTF CGTPDYIAPE IIAYQPYGKS 180

VDWWAYGVLL YEMLAGQPPF DGEDEDELFQ SIMEHNVSYP KSLSKEAVSI CKGLMTKHPA 240

KRLGCGLEGE RDIREHAFF 259

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005829	; C:cytosol
GO:0030425	; C:dendrite
GO:0005783	; C:endoplasmic reticulum
GO:0005739	; C:mitochondrion
GO:0043025	; C:neuronal cell body
GO:0005634	; C:nucleus
GO:0001750	; C:photoreceptor outer segment
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004698	; F:calcium-dependent protein kinase C activity
GO:0035403	; F:histone kinase activity (H3-T6 specific)
GO:0008270	; F:zinc ion binding
GO:0006874	; P:cellular calcium ion homeostasis
GO:0071322	; P:cellular response to carbohydrate stimulus
GO:0000188	; P:inactivation of MAPK activity
GO:0050930	; P:induction of positive chemotaxis
GO:0035556	; P:intracellular signal transduction
GO:0008285	; P:negative regulation of cell proliferation
GO:0034351	; P:negative regulation of glial cell apoptotic process
GO:0046325	; P:negative regulation of glucose import
GO:0046627	; P:negative regulation of insulin receptor signaling pathway
GO:0030593	; P:neutrophil chemotaxis
GO:0045766	; P:positive regulation of angiogenesis
GO:0043536	; P:positive regulation of blood vessel endothelial cell migration
GO:0045785	; P:positive regulation of cell adhesion
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0050729	; P:positive regulation of inflammatory response
GO:0031666	; P:positive regulation of lipopolysaccharide-mediated signaling pathway
GO:0045931	; P:positive regulation of mitotic cell cycle
GO:0001934	; P:positive regulation of protein phosphorylation
GO:0006937	; P:regulation of muscle contraction
GO:0050730	; P:regulation of peptidyl-tyrosine phosphorylation
GO:0090330	; P:regulation of platelet aggregation
GO:0002026	; P:regulation of the force of heart contraction
GO:0070555	; P:response to interleukin-1

KEGG

gga:417430

;

InterPros

IPR000961	; AGC-kinase_C.
IPR000008	; C2_Ca-dep.
IPR008973	; C2_Ca/lipid-bd_dom_CaLB.
IPR020477	; C2_dom.
IPR018029	; C2_membr_targeting.
IPR020454	; DAG/PE-bd.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR014375	; Protein_kinase_C_a/b/g.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00130	; C1_1; 2.
PF00168	; C2; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 2.
SM00239	; C2; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50004	; C2; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS00479	; ZF_DAG_PE_1; 2.
PS50081	; ZF_DAG_PE_2; 2.

Prints

PR00360	; C2DOMAIN.
PR00008	; DAGPEDOMAIN.

Created Date

20-Feb-2013