EKS-GAG-00267
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00267
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
STE/STE20348.03.5E-10429280252
StatusUnreviewed
Ensembl ProteinENSGALP00000006511
UniProt AccessionF1P4Y3;
Protein Name
Protein Synonyms/Alias Serine/threonine-protein kinase 4 18kDa subunit;
Gene NameSTK4
Gene Synonyms/Alias STK4;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000004098ENSGALP00000006511ENSGALT00000006521
OrganismGallus gallus
Functional Description
Protein Length486
Protein Sequence
(FASTA)
METVQLRNPR RQLKKLDEDS LTKQPEEVFD VLEKLGEGSY GSVFKAIHKE TGQVVAIKQV 60
PVESDLQEII KEISIMQQCD SPHVVKYYGS YFKNTDLWIV MEYCGAGSVS DIIRLRNKTL 120
TEEEIATIVQ STLKGLEYLH FMRKIHRDIK AGNILLNTEG HAKLADFGVA GQLTDTMAKR 180
NTVIGTPFWM APEVIQEIGY NCVADIWSLG ITAIEMAEGK PPYADIHPMR AIFMIPTNPP 240
PTFRKPELWS DAFTDFVKQC LVKSPEQRAT ATQLLQHPFV KSAKGASILR DLINEAMDIK 300
LKRQEAQQRE LDQEDEENSE EDETDSGTMV RASGDETGTI RVVNTMSDGA NTMIEHDGTL 360
ESQLGTMVIN TEDEEEEGTM KRRDETMQPA RPSFLEYFEQ KAKENQVNSF GKNVSGQTKN 420
SSDWKVPQDG DYEFLKTWSV DELQRRLSAL DPMMEQEIEE IRQKYQSKRQ PILDAIEAKK 480
RRQQNF 486
Nucleotide Sequence
(FASTA)
ATGGAGACGG TGCAGCTGCG GAACCCGCGG CGGCAGCTGA AGAAGTTAGA TGAAGACAGC 60
TTAACCAAAC AGCCTGAAGA AGTGTTTGAT GTATTGGAGA AGCTTGGAGA AGGTTCCTAT 120
GGCAGCGTGT TCAAAGCTAT TCATAAGGAG ACGGGGCAGG TTGTTGCAAT CAAACAGGTT 180
CCCGTGGAGT CTGACCTGCA AGAGATTATA AAGGAAATAT CCATAATGCA GCAGTGTGAC 240
AGCCCTCACG TGGTGAAATA TTATGGCAGC TACTTTAAGA ACACAGACCT GTGGATCGTC 300
ATGGAATACT GCGGCGCTGG ATCCGTGTCT GATATTATTC GGTTACGAAA TAAAACTCTT 360
ACAGAGGAGG AAATTGCCAC GATAGTACAA TCAACACTGA AAGGACTGGA GTACCTGCAT 420
TTTATGAGGA AAATACATAG AGATATCAAA GCTGGAAATA TATTGCTAAA CACGGAGGGA 480
CATGCTAAGC TTGCAGATTT TGGAGTGGCA GGACAGCTCA CAGATACCAT GGCAAAACGG 540
AACACAGTCA TAGGGACCCC ATTTTGGATG GCTCCAGAAG TGATTCAGGA GATTGGATAT 600
AATTGTGTTG CAGACATCTG GTCGCTGGGA ATCACTGCAA TAGAAATGGC TGAAGGCAAA 660
CCACCATATG CAGATATTCA TCCTATGAGG GCAATCTTCA TGATTCCTAC CAATCCGCCT 720
CCAACGTTTC GGAAGCCCGA GCTCTGGTCA GATGCTTTCA CAGACTTCGT GAAGCAGTGT 780
CTTGTGAAGA GCCCCGAGCA GCGTGCCACT GCAACACAGC TTCTGCAGCA TCCATTTGTT 840
AAAAGTGCCA AAGGAGCATC AATTCTGCGT GATTTGATTA ACGAAGCAAT GGATATCAAA 900
CTGAAACGCC AAGAGGCACA GCAGCGTGAG CTGGATCAGG AAGATGAAGA AAATTCAGAG 960
GAAGATGAAA CTGATTCGGG TACCATGGTG AGGGCGAGTG GAGATGAGAC TGGTACCATC 1020
AGGGTGGTCA ACACGATGAG CGACGGAGCC AACACAATGA TAGAACACGA TGGCACCTTG 1080
GAATCCCAGT TGGGTACAAT GGTCATAAAC ACTGAAGATG AAGAGGAGGA GGGCACCATG 1140
AAAAGGAGGG ATGAAACGAT GCAGCCAGCC AGGCCATCAT TCCTGGAATA TTTTGAGCAG 1200
AAAGCGAAGG AGAATCAAGT CAATAGCTTT GGGAAGAATG TGTCTGGCCA GACAAAAAAC 1260
TCATCTGATT GGAAAGTGCC ACAGGATGGA GACTACGAGT TTCTGAAGAC GTGGAGCGTG 1320
GATGAGCTGC AGAGGAGGCT GTCGGCGCTG GACCCCATGA TGGAGCAGGA GATTGAGGAG 1380
ATCCGCCAGA AGTACCAGTC CAAGCGGCAG CCCATCCTCG ATGCCATCGA AGCCAAGAAG 1440
CGGCGGCAGC AGAACTTCTG A 1461
Domain Profile
S: 1     yelleeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpnive  60
         +++le++g+G++g+v++a +k+tg++vaik++ +e+  +l+e++keis+++++++p++v+
Q: 29    FDVLEKLGEGSYGSVFKAIHKETGQVVAIKQVPVES--DLQEIIKEISIMQQCDSPHVVK  86
         7899*******************************7..9*********************
S: 61    ylesflkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkvi  120
         y++s++k+++lw+vmey+ +Gs+sd+++  ++++l+Ee+ia+i++++lk+LeylH +++i
Q: 87    YYGSYFKNTDLWIVMEYCGAGSVSDIIR-LRNKTLTEEEIATIVQSTLKGLEYLHFMRKI  145
         ****************************.99*****************************
S: 121   HrdikakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdek  180
         Hrdika+niLl++eg+ kL+dfgva ql++t++kr+tv+gtp+wmAPEvi+  e gY++ 
Q: 146   HRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQ--EIGYNCV  203
         ***************************************************..9******
S: 181   aDiwslGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqk  240
         aDiwslGItaie+aeg+pP++d++p++a+++i++n+pp++++++ +s++f++fv++cl k
Q: 204   ADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDAFTDFVKQCLVK  263
         ************************************************************
S: 241   npekRpsasellkhkFl  257
         +pe+R++a++ll+h+F+
Q: 264   SPEQRATATQLLQHPFV  280
         ****************7
Domain Sequence
(FASTA)
FDVLEKLGEG SYGSVFKAIH KETGQVVAIK QVPVESDLQE IIKEISIMQQ CDSPHVVKYY 60
GSYFKNTDLW IVMEYCGAGS VSDIIRLRNK TLTEEEIATI VQSTLKGLEY LHFMRKIHRD 120
IKAGNILLNT EGHAKLADFG VAGQLTDTMA KRNTVIGTPF WMAPEVIQEI GYNCVADIWS 180
LGITAIEMAE GKPPYADIHP MRAIFMIPTN PPPTFRKPEL WSDAFTDFVK QCLVKSPEQR 240
ATATQLLQHP FV 252
KeywordATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00294
EKS-ANC-00306
EKS-BOT-00313
EKS-CAE-00261
EKS-CAJ-00321
EKS-CAF-00316
EKS-CAP-00348
EKS-CII-00180
EKS-CIS-00082
EKS-DAR-00665
EKS-EQC-00306
EKS-FEC-00300
EKS-GAM-00197
EKS-GAA-00391
EKS-GOG-00309
EKS-HOS-00321
EKS-ICT-00294
EKS-LAC-00325
EKS-LOA-00325
EKS-MAM-00328
EKS-MEG-00256
EKS-MOD-00310
EKS-MUM-00346
EKS-MUP-00308
EKS-MYL-00313
EKS-NOL-00288
EKS-ORN-00415
EKS-ORA-00276
EKS-ORC-00297
EKS-ORL-00377
EKS-OTG-00323
EKS-PAT-00297
EKS-PES-00280
EKS-POA-00303
EKS-PRC-00047
EKS-RAN-00329
EKS-SAH-00293
EKS-SOA-00034
EKS-TAG-00330
EKS-TAR-00411
EKS-TEN-00410
EKS-TUT-00072
EKS-XET-00388
EKS-XIM-00408
Gene Ontology
GO:0005737; C:cytoplasm
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0000287; F:magnesium ion binding
GO:0043539; F:protein serine/threonine kinase activator activity
GO:0004674; F:protein serine/threonine kinase activity
GO:0035329; P:hippo signaling cascade
GO:0006917; P:induction of apoptosis
GO:0007243; P:intracellular protein kinase cascade
GO:0090090; P:negative regulation of canonical Wnt receptor signaling pathway
GO:0008285; P:negative regulation of cell proliferation
GO:0046621; P:negative regulation of organ growth
GO:0018105; P:peptidyl-serine phosphorylation
GO:0046777; P:protein autophosphorylation
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR011524; SARAH.
IPR024205; SARAH_domain.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
Pfam
PF11629; Mst1_SARAH; 1.
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS50951; SARAH; 1.
Prints
Created Date20-Feb-2013