EKS-GAG-00366

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00366

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/ULK	395.2	1.6E-118	4	266	263

Status

Unreviewed

Ensembl Protein

ENSGALP00000007513

UniProt Accession

F1NHE7;

Protein Name

Protein Synonyms/Alias

Gene Name

ULK2

Gene Synonyms/Alias

ULK2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000004727	ENSGALP00000007513	ENSGALT00000007525

Organism

Gallus gallus

Functional Description

Protein Length

1040

Protein Sequence
(FASTA)

TFEYSKKDLI GHGAFAVVFK GRHRKKTDWE VAIKSINKKN LSKSQILLGK EIKILKELQH 60

ENIVALYDVQ EMPSSVFLVM EYCNGGDLAD YLQAKGTLSE DTIRVFLQQI AAAMRILHSK 120

GIIHRDLKPQ NILLSYASRR KSSVSGIRIK IADFGFARYL HSNMMAATLC GSPMYMAPEV 180

IMSQHYDAKA DLWSIGTVIY QCLVGKPPFQ ANSPQDLRMF YEKNRNLIPS IPRETSTYLA 240

DLLLGLLQRN QKDRMDFEAF FNHPFLDQIS TVKKSCPVPV PTYAGSVSGS SCGSSPSCRF 300

ASPPSLPDMQ HIQEENLSSP PLGPPNYLQV SKDSASTSSK NSSCDTDDFV LVPHNISSDH 360

SYDMPLGAAG RRASSEFLMC GGHCQPSVSP RSETAPIPVP TQLRNYQRIE QNLSSTASPV 420

SNPHGSPRAG VVRRSNTSPM GFMKMGSCSP IPGDTAQGVG RRLSTGSSRP YSPSPLVGTI 480

PEQLGHCCCG QLQGHESRSR NFAGSPIPPS QSPQSLLMGA RLQSAPTLTD IYQNKQKLRK 540

QHSDPVCPSY AGYGYSHSPQ PSRPGSLGTS PTKHMGSSPR SSDWLFKTPL PTIIGSPTKA 600

TTPFKIPKTQ ASSNLLALAN RQGSIDAPLQ PKDITEPRDF SHFHSTQGSE KHAGEQHSKA 660

TFGRSVSTGK LSDQQVKTTL GGQLYQGSTD SLNTERPMDT APAGAYGIAV APPSMGSGAS 720

SRAVMFTVGS PPSSATPPTC THMVLRTRTT SVGSNSSGGS LCSTSGRVYM GSPPGIYMGS 780

SPPGAEAAPS LKYMPYGTSP PSLEGFITFE APELPEETLM EREHTDTLRH LNMMLTFTEC 840

VLDLTALRGG NPDLCTSAVS LYQIQESIVV DQISQLSKEW GQVEQLVLYM KAAQLLASSL 900

HLAKAQVKLG KLNPSTAVKH VVKSLNERYK FCIGMCKKLT EKLNRFFSDK QRFIDEINSV 960

TAEKLIYSCA VEMVQSAALD EMFQQTEDIT YRYHKAALLL EGLTKILQDP ADIENVHKYK 1020

SSIERRLSAL CCSTVAVYEQ 1040

Nucleotide Sequence
(FASTA)

ACTTTTGAGT ACAGCAAGAA GGACCTGATA GGACACGGAG CCTTCGCTGT GGTCTTCAAA 60

GGTCGCCACC GTAAGAAAAC TGATTGGGAA GTAGCCATAA AGAGCATTAA CAAAAAGAAC 120

TTGTCAAAAT CACAAATCTT ACTTGGAAAA GAAATTAAAA TCTTAAAGGA ACTTCAGCAT 180

GAGAACATTG TAGCTCTCTA TGATGTCCAG GAAATGCCCA GTTCTGTCTT TTTGGTGATG 240

GAGTACTGCA ATGGTGGGGA TCTGGCAGAT TACTTACAAG CTAAAGGAAC TCTTAGTGAA 300

GACACCATCC GAGTGTTCCT CCAGCAGATC GCAGCTGCTA TGCGTATTCT GCACAGTAAA 360

GGAATCATTC ATAGGGACCT TAAGCCACAG AATATTTTAT TGTCTTATGC CAGCCGTAGG 420

AAGTCAAGTG TCAGTGGCAT ACGCATCAAA ATAGCTGACT TTGGTTTTGC TCGTTATCTG 480

CATAGCAACA TGATGGCTGC AACTCTGTGT GGTTCCCCAA TGTACATGGC CCCTGAAGTG 540

ATTATGTCTC AACACTATGA TGCTAAAGCA GATCTGTGGA GCATAGGAAC TGTGATTTAT 600

CAATGTCTTG TTGGAAAACC ACCTTTTCAG GCCAATAGTC CTCAAGATTT GAGAATGTTT 660

TATGAAAAGA ACAGGAATTT GATTCCTAGT ATACCTCGAG AAACGTCAAC TTACCTGGCT 720

GACCTGCTGT TGGGTTTGCT TCAGAGAAAC CAAAAAGATA GAATGGACTT TGAAGCATTT 780

TTCAACCACC CTTTCCTGGA TCAGATTTCA ACAGTCAAAA AATCATGTCC CGTACCGGTG 840

CCCACATATG CAGGCTCAGT CTCTGGCAGT TCCTGTGGCA GCTCACCTTC CTGCCGTTTT 900

GCTTCTCCTC CATCTCTTCC AGACATGCAG CATATTCAAG AAGAAAACTT GTCTTCACCT 960

CCGTTGGGTC CTCCAAACTA TCTTCAAGTG TCTAAGGACT CTGCAAGTAC CAGTAGCAAG 1020

AACTCTTCCT GTGACACAGA TGACTTTGTT CTTGTCCCAC ACAACATCTC TTCAGACCAC 1080

TCATATGATA TGCCATTGGG AGCAGCTGGC AGGCGGGCTT CGAGCGAGTT CTTGATGTGT 1140

GGAGGGCATT GCCAGCCTTC TGTATCCCCT CGCAGCGAAA CAGCACCTAT CCCAGTTCCT 1200

ACTCAGCTAC GGAATTACCA GCGTATAGAA CAGAACCTCT CCTCTACTGC CAGCCCTGTG 1260

TCCAACCCCC ACGGATCACC AAGAGCTGGG GTTGTGAGAC GCTCAAATAC TAGCCCAATG 1320

GGCTTCATGA AGATGGGCTC CTGCTCTCCA ATACCAGGTG ACACTGCACA GGGTGTTGGG 1380

CGCAGGTTAT CCACAGGATC TTCAAGACCG TATTCTCCTT CACCACTAGT TGGAACTATA 1440

CCTGAGCAGC TTGGACACTG TTGTTGTGGA CAGCTTCAAG GACATGAGTC CAGGAGCAGA 1500

AACTTCGCAG GTTCTCCAAT ACCACCATCT CAGTCTCCAC AGTCACTTCT GATGGGAGCT 1560

AGGTTGCAAA GTGCTCCTAC TCTCACGGAT ATTTACCAAA ATAAGCAGAA GCTCAGAAAG 1620

CAACATTCAG ATCCAGTATG CCCATCCTAT GCTGGGTATG GATACAGTCA TTCTCCACAA 1680

CCAAGTAGGC CAGGTAGCCT GGGAACATCA CCCACCAAGC ACATGGGATC ATCACCAAGG 1740

AGTTCAGACT GGCTGTTCAA AACTCCTTTA CCAACAATCA TCGGTTCTCC TACTAAGGCA 1800

ACAACTCCTT TCAAAATACC TAAAACACAA GCATCCTCAA ACTTGCTGGC CCTGGCTAAT 1860

CGCCAGGGAT CTATAGATGC TCCATTGCAG CCTAAAGACA TCACTGAACC GAGGGATTTT 1920

TCACACTTTC ACTCGACACA AGGAAGTGAA AAGCATGCAG GAGAGCAGCA CAGTAAAGCT 1980

ACGTTTGGCA GATCTGTTAG TACTGGGAAA CTATCAGATC AACAGGTCAA GACTACCCTC 2040

GGTGGCCAGT TATACCAAGG CAGTACAGAC AGCCTGAATA CAGAGCGACC AATGGATACA 2100

GCCCCAGCAG GGGCCTATGG CATTGCAGTG GCGCCTCCTT CCATGGGAAG TGGGGCAAGT 2160

TCTCGGGCTG TCATGTTTAC TGTTGGGTCT CCTCCAAGCA GTGCCACCCC TCCTACCTGC 2220

ACCCATATGG TCCTCAGAAC AAGAACCACC TCAGTTGGAT CAAACAGTTC TGGAGGGTCT 2280

CTCTGCTCTA CTAGTGGCCG TGTATATATG GGCTCGCCTC CTGGTATTTA TATGGGTTCT 2340

TCTCCTCCGG GAGCCGAGGC AGCTCCAAGT CTGAAGTACA TGCCTTATGG TACTTCGCCT 2400

CCCAGCTTAG AGGGCTTTAT CACTTTTGAA GCTCCTGAAT TGCCTGAGGA AACTTTAATG 2460

GAGAGGGAAC ACACAGATAC CCTGCGTCAT CTAAACATGA TGCTGACATT CACAGAATGT 2520

GTTCTGGATC TGACAGCATT ACGGGGAGGA AACCCAGACC TGTGTACTTC TGCAGTGTCA 2580

CTGTACCAAA TCCAAGAGAG CATAGTTGTT GATCAGATCA GCCAACTAAG CAAAGAATGG 2640

GGACAAGTAG AGCAGCTTGT GTTATATATG AAAGCAGCCC AGTTACTGGC ATCTTCTCTG 2700

CATCTTGCCA AAGCACAGGT CAAATTGGGG AAACTGAACC CATCCACTGC TGTTAAGCAC 2760

GTTGTGAAAA GCCTCAATGA GAGATACAAA TTCTGTATTG GTATGTGCAA GAAACTGACT 2820

GAGAAGCTGA ATCGTTTCTT TTCGGACAAG CAAAGGTTCA TTGATGAAAT CAACAGTGTA 2880

ACTGCAGAAA AACTCATCTA CAGCTGTGCT GTAGAAATGG TTCAATCAGC AGCTCTAGAT 2940

GAGATGTTTC AGCAAACTGA AGATATTACA TATCGATACC ACAAGGCAGC CTTGCTGCTG 3000

GAAGGACTGA CTAAAATACT GCAAGACCCT GCGGATATAG AAAATGTGCA CAAATATAAA 3060

TCTAGCATTG AGCGAAGGCT TTCTGCACTC TGCTGCAGCA CAGTGGCTGT ATATGAGCAG 3120

TAG 3123

Domain Profile

S: 1     ysleeeiGkGsfavvykgrlrkktsqvvAikvvekkklkkslenlekeikilkelkheni  60

         ys+++ iG+G+favv+kgr+rkkt+++vAik+++kk+l+ks+  l keikilkel+heni

Q: 4     YSKKDLIGHGAFAVVFKGRHRKKTDWEVAIKSINKKNLSKSQILLGKEIKILKELQHENI  63

         899*********************************************************

S: 61    valldveetskevylvmeycaggdLakllkqkkeLsedtvreflqqlasalkaLhskkiv  120

         val+dv+e+ ++v+lvmeyc+ggdLa++l++k++Lsedt+r+flqq+a+a+++Lhsk+i+

Q: 64    VALYDVQEMPSSVFLVMEYCNGGDLADYLQAKGTLSEDTIRVFLQQIAAAMRILHSKGII  123

         ************************************************************

S: 121   hrDlkPqniLlsyadakk.elkkvtlkladFglarvlkeesmaatlkGsplYmaPEvvke  179

         hrDlkPqniLlsya+++k +++ +++k+adFg+ar+l++++maatl+Gsp+YmaPEv+++

Q: 124   HRDLKPQNILLSYASRRKsSVSGIRIKIADFGFARYLHSNMMAATLCGSPMYMAPEVIMS  183

         **************999989****************************************

S: 180   qqydakaDlWSiGtilyellvGkpPfaaesiseLvekiekndvleppipkeisselkdll  239

         q+ydakaDlWSiGt++y++lvGkpPf+a+s+++L++++ekn++l p+ip+e+s+ l+dll

Q: 184   QHYDAKADLWSIGTVIYQCLVGKPPFQANSPQDLRMFYEKNRNLIPSIPRETSTYLADLL  243

         ************************************************************

S: 240   qsLLqrdpkkRisfeelfahpfl  262

          +LLqr++k+R++fe +f+hpfl

Q: 244   LGLLQRNQKDRMDFEAFFNHPFL  266

         *********************96

Domain Sequence
(FASTA)

YSKKDLIGHG AFAVVFKGRH RKKTDWEVAI KSINKKNLSK SQILLGKEIK ILKELQHENI 60

VALYDVQEMP SSVFLVMEYC NGGDLADYLQ AKGTLSEDTI RVFLQQIAAA MRILHSKGII 120

HRDLKPQNIL LSYASRRKSS VSGIRIKIAD FGFARYLHSN MMAATLCGSP MYMAPEVIMS 180

QHYDAKADLW SIGTVIYQCL VGKPPFQANS PQDLRMFYEK NRNLIPSIPR ETSTYLADLL 240

LGLLQRNQKD RMDFEAFFNH PFL 263

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0034045	; C:pre-autophagosomal structure membrane
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0046777	; P:protein autophosphorylation
GO:0010506	; P:regulation of autophagy
GO:0042594	; P:response to starvation

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR022708	; Ser/Thr_kinase_C.

Pfam

PF12063	; DUF3543; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013