EKS-GAG-00196

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00196

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/MAPKAPK	409.6	5.5E-123	23	307	285

Status

Unreviewed

Ensembl Protein

ENSGALP00000007550

UniProt Accession

F1NHB6;

Protein Name

Protein Synonyms/Alias

Gene Name

MAPKAPK5

Gene Synonyms/Alias

MAPKAPK5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000004743	ENSGALP00000038213	ENSGALT00000039003
ENSGALG00000004743	ENSGALP00000007550	ENSGALT00000007562

Organism

Gallus gallus

Functional Description

Protein Length

474

Protein Sequence
(FASTA)

TSGDPEMDKA IQETSILEEY NINWTQKLGA GISGPVSNTR VCVKKSSQER FALKILLDRP 60

KARNEVRLHM MCATHPNIVQ IIEVYANSVQ FPHESSPRAR LLIVMEMMEG GELFHRISQH 120

RHFTEKQASQ VTKQIALALQ HCHSLNIAHR DLKPENLLFK DNSLDAPVKL CDFGFAKVDQ 180

GDLMTPQFTP YYVAPQVLEA QRRHQKEKSG IIPTSPTPYT YNKSCDLWSL GVIIYVMLCG 240

YPPFYSKHHS RTIPKDMRKK IMTGSFEFPE EEWSQISEMA KDIVRKLLKV KPEERLTIEG 300

VLDHPWLNST EALDNILPSA QLMMDKAMVA GIQQAHAEQL ANMRIQDLKV SLKPLHSVNN 360

PILRKRKLLG TKPKDGVYIH DPENGSNDSN VALEKLRDVI AQCILPQAGE NEDEKLNEVM 420

QEAWKYNREC KLLRDTLQSF SWNGRGFTDK VDRLKLAEIV KQVIEEQTNS HDSQ 474

Nucleotide Sequence
(FASTA)

ACGTCGGGGG ATCCCGAGAT GGATAAAGCG ATCCAGGAAA CCTCCATTTT AGAGGAGTAC 60

AACATTAACT GGACTCAGAA GCTGGGAGCT GGGATCAGTG GCCCTGTTAG TAATACCAGA 120

GTCTGCGTGA AAAAATCCTC TCAAGAACGC TTTGCACTGA AAATCCTTCT TGATCGTCCA 180

AAAGCTAGAA ATGAGGTACG TCTGCACATG ATGTGTGCAA CACATCCAAA TATTGTTCAA 240

ATTATTGAAG TTTATGCTAA CAGTGTGCAG TTCCCACATG AATCCAGCCC AAGGGCTCGG 300

CTCCTAATTG TAATGGAGAT GATGGAAGGG GGAGAGCTAT TTCACAGAAT CAGCCAGCAC 360

CGGCACTTTA CTGAGAAGCA AGCAAGCCAA GTAACAAAGC AGATAGCTTT GGCTTTGCAG 420

CATTGCCACT CACTAAACAT TGCACATAGA GACCTCAAGC CCGAGAATCT CCTCTTCAAG 480

GATAACTCTT TGGATGCACC TGTTAAATTG TGTGACTTTG GGTTTGCCAA AGTAGACCAA 540

GGTGACTTGA TGACACCACA GTTCACTCCA TATTACGTAG CACCTCAGGT ATTGGAGGCA 600

CAAAGGCGGC ATCAGAAAGA AAAATCTGGT ATTATCCCCA CCTCTCCAAC ACCGTACACA 660

TATAACAAGA GCTGTGACTT GTGGTCCCTG GGTGTCATTA TTTACGTCAT GCTGTGTGGA 720

TACCCTCCGT TTTACTCCAA ACACCACAGT CGGACAATTC CAAAGGACAT GCGGAAAAAG 780

ATCATGACAG GAAGTTTTGA ATTTCCAGAG GAAGAGTGGA GCCAGATCTC AGAAATGGCG 840

AAAGACATTG TGCGAAAGTT GCTGAAGGTC AAACCAGAGG AGCGGCTGAC CATCGAAGGT 900

GTGCTGGACC ATCCCTGGCT CAACTCCACT GAGGCACTGG ATAACATCCT ACCCTCTGCC 960

CAGCTGATGA TGGACAAGGC AATGGTTGCA GGGATACAAC AGGCTCATGC AGAACAGCTT 1020

GCAAACATGA GAATCCAAGA CCTCAAAGTC AGTCTCAAAC CCCTTCACTC CGTCAACAAC 1080

CCTATCCTGC GCAAAAGGAA ATTACTGGGC ACAAAGCCAA AGGATGGTGT TTACATCCAC 1140

GACCCGGAGA ATGGAAGTAA TGATTCCAAT GTGGCTCTGG AAAAGCTCAG AGATGTGATT 1200

GCTCAGTGCA TTCTACCACA GGCTGGAGAG AATGAGGATG AGAAGCTGAA TGAAGTGATG 1260

CAGGAGGCGT GGAAGTATAA TCGGGAGTGT AAGTTGCTGC GAGATACTCT TCAGAGCTTC 1320

AGCTGGAATG GCAGAGGATT TACAGATAAA GTGGATCGAC TAAAACTGGC AGAAATAGTA 1380

AAACAAGTTA TTGAAGAGCA GACAAACTCC CATGACTCTC AATAG 1425

Domain Profile

S: 2     lteevlGeGisgkv...lecvkkktgekyalkilkdrkkvrrevelhvqasghkniveli  58

         +++++lG+Gisg v   + cvkk+++e++alkil dr+k+r+ev+lh+++++h+niv++i

Q: 23    NWTQKLGAGISGPVsntRVCVKKSSQERFALKILLDRPKARNEVRLHMMCATHPNIVQII  82

         689*********9933346*****************************************

S: 59    dvfensfe......dekrlllvlekleGGellsriqerkaftekeasevvkdiasalkfl  112

         +v++ns++      +++rll+v+e++eGGel++ri+++++ftek+as+v+k+ia al+++

Q: 83    EVYANSVQfphessPRARLLIVMEMMEGGELFHRISQHRHFTEKQASQVTKQIALALQHC  142

         *******99999999*********************************************

S: 113   hskniahrDlkpenlLyeskeknapvklcDfglaketeeeeelktpcltaeyvaPevlea  172

         hs niahrDlkpenlL+++++ +apvklcDfg+ak   ++ +l+tp++t++yvaP+vlea

Q: 143   HSLNIAHRDLKPENLLFKDNSLDAPVKLCDFGFAK--VDQGDLMTPQFTPYYVAPQVLEA  200

         ***********************************..89*********************

S: 173   ekee.............allydksCDlWslGvilyillcGypPfyskk.graiskklker  218

         ++++             +++y+ksCDlWslGvi+y++lcGypPfysk+ +r+i+k+++++

Q: 201   QRRHqkeksgiiptsptPYTYNKSCDLWSLGVIIYVMLCGYPPFYSKHhSRTIPKDMRKK  260

         **999*****************************************9979**********

S: 219   iqegkyefPeeeWsevseeakdlirklLkrdpkerltieevlnhpwv  265

         i++g++efPeeeWs++se+akd++rklLk++p+erltie vl+hpw+

Q: 261   IMTGSFEFPEEEWSQISEMAKDIVRKLLKVKPEERLTIEGVLDHPWL  307

         **********************************************6

Domain Sequence
(FASTA)

NWTQKLGAGI SGPVSNTRVC VKKSSQERFA LKILLDRPKA RNEVRLHMMC ATHPNIVQII 60

EVYANSVQFP HESSPRARLL IVMEMMEGGE LFHRISQHRH FTEKQASQVT KQIALALQHC 120

HSLNIAHRDL KPENLLFKDN SLDAPVKLCD FGFAKVDQGD LMTPQFTPYY VAPQVLEAQR 180

RHQKEKSGII PTSPTPYTYN KSCDLWSLGV IIYVMLCGYP PFYSKHHSRT IPKDMRKKIM 240

TGSFEFPEEE WSQISEMAKD IVRKLLKVKP EERLTIEGVL DHPWL 285

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005634	; C:nucleus
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0032007	; P:negative regulation of TOR signaling cascade
GO:0046777	; P:protein autophosphorylation
GO:0007265	; P:Ras protein signal transduction
GO:0006417	; P:regulation of translation
GO:0090400	; P:stress-induced premature senescence

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013