EKS-GAG-00088

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00088

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Tec	473.2	1.8E-142	400	650	251

Status

Unreviewed

Ensembl Protein

ENSGALP00000007936

UniProt Accession

Q5ZLF2;

Protein Name

Protein Synonyms/Alias

Tyrosine-protein kinase BTK;

Gene Name

BTK

Gene Synonyms/Alias

BTK; RCJMB04_6h8;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000004958	ENSGALP00000007936	ENSGALT00000007950

Organism

Gallus gallus

Functional Description

Protein Length

657

Protein Sequence
(FASTA)

MASIILESIF LKRSQQKKKT SPLNFKKRLF LLTESKLSYY EYDFERGRRG SKKGSVDIEK 60

ITCVETVVPE NNPPPERQVP KKGEDYNMEQ ISIIERFPYP FQVVYDEGPL YVFSPTEELR 120

KRWIHQLKSV IRYNSDLVQK YHPCFWIDGQ YLCCSQTAKN AMGCKILESR NGSLKAGRSH 180

RKTKKPLPPT PEEDTMVMKP LPPEPAPSAA GEMKKVVALY NYVPMNVQDL QLQKGEEYLI 240

LEESHLPWWK ARDKNGREGY IPSNYVTATS NSLEIYEWYS KNITRSQAEQ LLKQEGKEGG 300

FIVRDSTSKT GKYTVSVYAK SAVDPQGMIR HYVVCCTPQN QYYLAEKHLF NTIPELITYH 360

QHNSAGLISR LKYPVSRHQK SAPSTAGLGY GSWEIDPKDL TFLKELGTGQ FGVVKYGKWR 420

GQYNVAIKMI REGSMSEDEF IDEAKVMMNL SHEKLVQLYG VCTKQRPIFI ITEYMANGCL 480

LNFLRETQRR FQPAELLEMC KDVCEAMEYL ESKQFLHRDL AARNCLVNDQ GIVKVSDFGL 540

SRYVLDDEYT SSMGSKFPVR WSPPEVLLYS KFSSKSDVWS FGVLMWEVYS LGKMPYERFN 600

NSETTEHVIQ GLRLYRPQQA SERVYAIMYS CWHEKAEERP TFSALLGSIV DITDEEP 657

Nucleotide Sequence
(FASTA)

ATGGCCAGCA TCATCCTGGA GAGCATCTTC TTGAAGCGCT CACAGCAGAA GAAGAAAACA 60

TCTCCCCTCA ACTTCAAGAA GCGCCTGTTT CTGCTGACAG AGAGCAAGCT GTCCTACTAC 120

GAGTATGACT TTGAGCGTGG GCGCCGAGGC AGCAAGAAGG GCTCGGTGGA CATTGAGAAG 180

ATCACCTGTG TGGAGACGGT GGTGCCTGAA AACAACCCTC CCCCTGAGCG GCAGGTCCCG 240

AAGAAAGGGG AGGATTACAA CATGGAGCAG ATCTCCATCA TTGAGCGGTT CCCCTACCCC 300

TTTCAGGTGG TGTACGATGA GGGGCCCCTC TACGTCTTCT CCCCGACAGA GGAGCTGCGC 360

AAACGCTGGA TCCATCAGCT GAAGAGTGTG ATCCGATACA ACAGCGACCT GGTGCAGAAG 420

TACCACCCCT GCTTCTGGAT TGATGGCCAG TACCTGTGCT GCTCCCAGAC AGCCAAGAAC 480

GCCATGGGCT GCAAGATCCT GGAGAGCAGG AATGGCAGTT TAAAAGCTGG GCGGTCACAT 540

CGCAAAACAA AGAAGCCTCT TCCCCCTACT CCTGAGGAGG ACACGATGGT GATGAAGCCC 600

CTGCCCCCTG AGCCAGCCCC CAGTGCAGCA GGTGAAATGA AGAAGGTGGT GGCCCTGTAC 660

AACTATGTGC CAATGAATGT GCAGGACCTG CAGCTTCAGA AGGGTGAGGA GTACCTCATC 720

CTGGAGGAAA GCCACCTGCC TTGGTGGAAA GCACGTGACA AAAATGGAAG GGAAGGATAC 780

ATCCCCAGCA ACTATGTCAC TGCAACCAGC AATTCGCTGG AGATTTATGA GTGGTACTCA 840

AAGAATATCA CTCGGAGCCA AGCAGAGCAA CTGCTGAAGC AGGAGGGTAA GGAAGGGGGC 900

TTCATTGTTC GAGATTCTAC CAGCAAGACA GGGAAATACA CTGTCTCTGT TTATGCCAAG 960

TCCGCTGTAG ACCCCCAGGG GATGATCCGC CATTACGTTG TATGCTGCAC CCCTCAGAAT 1020

CAATATTACC TGGCAGAAAA ACACCTGTTC AACACCATCC CAGAGCTCAT CACGTACCAT 1080

CAGCACAACT CTGCCGGGCT CATATCCAGA CTGAAGTATC CCGTGTCTCG ACACCAGAAA 1140

AGTGCCCCTT CCACAGCTGG CCTGGGCTAT GGGTCGTGGG AGATTGACCC GAAGGACCTG 1200

ACCTTCCTGA AGGAACTGGG GACAGGGCAG TTTGGCGTAG TGAAGTACGG GAAATGGAGA 1260

GGCCAATACA ACGTTGCCAT CAAGATGATC AGGGAGGGAT CCATGTCAGA GGACGAGTTT 1320

ATTGATGAAG CCAAAGTCAT GATGAACCTA TCTCATGAGA AGCTGGTGCA GCTCTATGGG 1380

GTCTGCACAA AGCAGCGTCC CATCTTCATC ATCACTGAGT ACATGGCCAA TGGCTGTCTC 1440

CTGAACTTCC TGAGGGAAAC TCAGCGGCGG TTCCAGCCTG CTGAGCTGCT GGAAATGTGC 1500

AAAGATGTCT GTGAAGCTAT GGAGTACCTG GAATCCAAGC AGTTCCTGCA CCGAGACCTG 1560

GCTGCTCGCA ACTGCTTGGT GAATGACCAA GGGATTGTGA AAGTCTCGGA TTTTGGCCTT 1620

TCCAGATACG TCCTGGATGA TGAGTACACA AGCTCCATGG GGTCAAAGTT TCCAGTTCGG 1680

TGGTCTCCTC CTGAAGTGCT TCTGTACAGC AAGTTCAGCA GCAAATCCGA TGTGTGGTCG 1740

TTTGGCGTGC TGATGTGGGA GGTTTACTCT TTGGGAAAGA TGCCTTACGA GAGGTTTAAC 1800

AACAGTGAGA CCACAGAACA CGTCATTCAA GGCCTGCGCC TCTACAGGCC CCAGCAGGCC 1860

TCGGAGCGGG TCTACGCCAT CATGTACAGC TGCTGGCACG AGAAGGCCGA GGAGCGCCCC 1920

ACCTTCAGCG CGCTGCTGGG CAGCATCGTG GACATCACAG ACGAAGAGCC GTGA 1974

Domain Profile

S: 1     ltllkelgsgqfgvvklgkwrakidvaikaikegamseedfieeakvmmklshpklvqly  60

         lt+lkelg+gqfgvvk+gkwr++++vaik+i+eg+mse++fi+eakvmm+lsh+klvqly

Q: 400   LTFLKELGTGQFGVVKYGKWRGQYNVAIKMIREGSMSEDEFIDEAKVMMNLSHEKLVQLY  459

         79**********************************************************

S: 61    gvclkqkpiyivteylengcllnylrekkkklekelllemckdvcegmeylerksfihrd  120

         gvc+kq+pi+i+tey++ngclln+lre++++++ + llemckdvce+meyle+k+f+hrd

Q: 460   GVCTKQRPIFIITEYMANGCLLNFLRETQRRFQPAELLEMCKDVCEAMEYLESKQFLHRD  519

         ************************************************************

S: 121   laarnclvdeelvvkvsdfglaryvlddqyvssvgakfpvkwsppevlsyskyssksdvw  180

         laarnclv+++ +vkvsdfgl+ryvldd+y+ss+g+kfpv+wsppevl ysk+ssksdvw

Q: 520   LAARNCLVNDQGIVKVSDFGLSRYVLDDEYTSSMGSKFPVRWSPPEVLLYSKFSSKSDVW  579

         ************************************************************

S: 181   afgvlmwevfsegklpyekksnsevvekvsrglrlyrpklaskkvyevmkscwkekpeer  240

         +fgvlmwev+s+gk+pye+++nse+ e+v +glrlyrp+ as++vy +m+scw+ek+eer

Q: 580   SFGVLMWEVYSLGKMPYERFNNSETTEHVIQGLRLYRPQQASERVYAIMYSCWHEKAEER  639

         ************************************************************

S: 241   ptfkellsale  251

         ptf+ ll +++

Q: 640   PTFSALLGSIV  650

         *******9885

Domain Sequence
(FASTA)

LTFLKELGTG QFGVVKYGKW RGQYNVAIKM IREGSMSEDE FIDEAKVMMN LSHEKLVQLY 60

GVCTKQRPIF IITEYMANGC LLNFLRETQR RFQPAELLEM CKDVCEAMEY LESKQFLHRD 120

LAARNCLVND QGIVKVSDFG LSRYVLDDEY TSSMGSKFPV RWSPPEVLLY SKFSSKSDVW 180

SFGVLMWEVY SLGKMPYERF NNSETTEHVI QGLRLYRPQQ ASERVYAIMY SCWHEKAEER 240

PTFSALLGSI V 251

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0031410	; C:cytoplasmic vesicle
GO:0005829	; C:cytosol
GO:0045121	; C:membrane raft
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0005547	; F:phosphatidylinositol-3,4,5-trisphosphate binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0007249	; P:I-kappaB kinase/NF-kappaB cascade
GO:0018108	; P:peptidyl-tyrosine phosphorylation

KEGG

gga:374075

;

InterPros

IPR011009	; Kinase-like_dom.
IPR011993	; PH_like_dom.
IPR001849	; Pleckstrin_homology.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980	; SH2.
IPR001452	; SH3_domain.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR001562	; Znf_Btk_motif.

Pfam

PF00779	; BTK; 1.
PF00169	; PH; 1.
PF07714	; Pkinase_Tyr; 1.
PF00017	; SH2; 1.
PF00018	; SH3_1; 1.

SMARTs

SM00107	; BTK; 1.
SM00233	; PH; 1.
SM00252	; SH2; 1.
SM00326	; SH3; 1.
SM00219	; TyrKc; 1.

Prosites

PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS50001	; SH2; 1.
PS50002	; SH3; 1.
PS51113	; ZF_BTK; 1.

Prints

PR00401	; SH2DOMAIN.
PR00452	; SH3DOMAIN.
PR00402	; TECBTKDOMAIN.
PR00109	; TYRKINASE.

Created Date

20-Feb-2013