| Tag | Content |
|---|
| EKPD ID | EKS-GAG-00050 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| CMGC/CDK | 375.0 | 2.3E-112 | 19 | 315 | 297 |
|
| Status | Reviewed |
| Ensembl Protein | ENSGALP00000008078 |
| UniProt Accession | Q5ZKN1; |
| Protein Name | Cyclin-dependent kinase 9 |
| Protein Synonyms/Alias | Cell division protein kinase 9; |
| Gene Name | CDK9 |
| Gene Synonyms/Alias | CDK9; RCJMB04_9p8; |
| Ensembl Information | |
| Organism | Gallus gallus |
| Functional Description | Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to production elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II), SUPT5H and RDBP. The CDK9/cyclin-K complex has also a kinase activity toward CTD of RNAP II and can substitute for P-TEFb in vitro (By similarity). |
| Protein Length | 372 |
Protein Sequence
(FASTA) | | MAKQYDMVEC PFCDEVSKYE KLAKIGQGTF GEVFKAKHRQ TGKKVALKKV LMENEKEGFP 60 | | ITALREIKIL QLLKHENVVN LIEICRTKAS PYNRCKGSIY LVFDFCEHDL AGLLSNTHVK 120 | | FTLSEIKKVM QMLLNGLYYI HRNKILHRDM KAANVLITRD GVLKLADFGL ARAFSLAKNS 180 | | QPNRYTNRVV TLWYRPPELL LGERDYGPPI DLWGGGCIMA EMWTRSPIMQ GNTEQHQLTL 240 | | ISQLCGSITP EVWPNVDKYE LYQKLELPKG QKRKVKDRLK AYVKDPYALD LIDKLLVLDP 300 | | AQRIDSDDAL NHDFFWSDPM PSDLKNMLST HNQSMFEYLA PPRRRGGHMP QQPANQGRNP 360 | | AATNQTEFDR VF 372 |
|
Nucleotide Sequence
(FASTA) | | ATGGCCAAGC AGTACGACAT GGTGGAGTGC CCCTTCTGCG ATGAGGTCTC CAAGTACGAG 60 | | AAGCTCGCCA AAATCGGGCA GGGCACCTTC GGGGAAGTGT TCAAAGCCAA GCACCGGCAG 120 | | ACGGGCAAAA AGGTCGCGCT GAAGAAGGTG TTGATGGAAA ATGAGAAGGA GGGGTTCCCC 180 | | ATCACAGCTC TGCGAGAGAT TAAAATCCTC CAGCTGCTCA AGCATGAGAA TGTGGTGAAC 240 | | CTCATAGAAA TCTGTAGGAC CAAAGCCTCT CCATACAACC GCTGCAAGGG AAGTATCTAC 300 | | CTGGTGTTTG ACTTCTGTGA GCACGACCTG GCTGGCCTTC TCAGCAACAC CCACGTCAAG 360 | | TTCACGCTCT CAGAGATCAA GAAAGTTATG CAGATGCTAT TGAATGGACT GTATTACATC 420 | | CACAGGAACA AGATCTTGCA TCGAGATATG AAAGCTGCAA ACGTTCTGAT CACGCGGGAT 480 | | GGAGTCCTGA AGCTTGCAGA CTTTGGGCTG GCTCGAGCTT TCAGCCTGGC TAAGAACAGC 540 | | CAGCCGAACC GCTACACCAA CCGGGTCGTG ACTCTGTGGT ATCGGCCGCC GGAGCTGCTG 600 | | CTAGGGGAGC GGGACTACGG GCCCCCCATT GACCTCTGGG GTGGAGGCTG CATCATGGCA 660 | | GAGATGTGGA CCCGCAGCCC CATCATGCAG GGGAACACGG AGCAGCACCA GCTCACCCTC 720 | | ATTAGCCAGC TCTGCGGATC CATCACACCA GAGGTCTGGC CGAATGTGGA TAAGTACGAG 780 | | CTGTACCAGA AGCTGGAGCT CCCCAAGGGC CAGAAGCGCA AGGTGAAGGA TCGCCTGAAG 840 | | GCCTACGTCA AGGACCCCTA TGCGCTCGAC CTCATCGACA AGCTGCTGGT GCTGGACCCG 900 | | GCCCAACGCA TCGACAGCGA TGATGCGCTG AACCACGACT TCTTCTGGTC AGACCCCATG 960 | | CCCTCGGACC TCAAAAACAT GCTGTCCACC CACAACCAGT CCATGTTCGA GTACCTGGCC 1020 | | CCGCCACGCA GGCGGGGTGG GCACATGCCT CAGCAGCCAG CAAACCAGGG CAGGAACCCT 1080 | | GCGGCTACCA ACCAGACTGA ATTTGACAGG GTGTTTTGA 1119 |
|
| Domain Profile | S: 1 yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni 60 | yekl+kig+Gt+g+v+kak+++tg++vAlKk+ +e+ekeg+pitalrEi++l+ lkh+n+ | Q: 19 YEKLAKIGQGTFGEVFKAKHRQTGKKVALKKVLMENEKEGFPITALREIKILQLLKHENV 78 | 99********************************************************** |
| S: 61 vkLlevva.......kdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqllegl 113 | v+L+e++ + k ++yLvf+f+e+dL+ ll++++ k++l+e+k+++++ll+gl | Q: 79 VNLIEICRtkaspynRCKGSIYLVFDFCEHDLAGLLSNTHV-KFTLSEIKKVMQMLLNGL 137 | ********99999988889********************99.****************** |
| S: 114 aylHsnkilHRDlKpqNlLiskegklklaDfGlaraf....ssplktytkevvTlwYraP 169 | y+H+nkilHRD+K++N+Li+++g+lklaDfGlaraf +s+ ++yt++vvTlwYr+P | Q: 138 YYIHRNKILHRDMKAANVLITRDGVLKLADFGLARAFslakNSQPNRYTNRVVTLWYRPP 197 | *************************************7776555557************* |
| S: 170 elLlgakeYstavDiWsvgcilaelltrkplfqgkseidqlerifkllgtpsekvwpevs 229 | elLlg+++Y+ +D+W+ gci+ae++tr+p++qg++e++ql+ i++l+g+++ +vwp+v | Q: 198 ELLLGERDYGPPIDLWGGGCIMAEMWTRSPIMQGNTEQHQLTLISQLCGSITPEVWPNVD 257 | ************************************************************ |
| S: 230 klpeyk.ksfpkkkkkklkekvkklkek..aldllekllaldpkkRisakealqhkyf 284 | k++ y+ ++pk +k+k+k+++k++ ++ aldl++kll ldp++Ri++++al+h++f | Q: 258 KYELYQkLELPKGQKRKVKDRLKAYVKDpyALDLIDKLLVLDPAQRIDSDDALNHDFF 315 | ******8899**9999******988766579*************************98 |
|
Domain Sequence
(FASTA) | | YEKLAKIGQG TFGEVFKAKH RQTGKKVALK KVLMENEKEG FPITALREIK ILQLLKHENV 60 | | VNLIEICRTK ASPYNRCKGS IYLVFDFCEH DLAGLLSNTH VKFTLSEIKK VMQMLLNGLY 120 | | YIHRNKILHR DMKAANVLIT RDGVLKLADF GLARAFSLAK NSQPNRYTNR VVTLWYRPPE 180 | | LLLGERDYGP PIDLWGGGCI MAEMWTRSPI MQGNTEQHQL TLISQLCGSI TPEVWPNVDK 240 | | YELYQKLELP KGQKRKVKDR LKAYVKDPYA LDLIDKLLVL DPAQRIDSDD ALNHDFF 297 |
|
| Keyword | ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Nucleus; Reference proteome; Serine/threonine-protein kinase; Transcription; Transcription regulation; Transferase. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |