EPS-GAG-00030

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EPS-GAG-00030

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
PPM/PP2C	191.8	2.0E-56	165	418	254

Status

Unreviewed

Ensembl Protein

ENSGALP00000008100

UniProt Accession

F1NZC9;

Protein Name

Protein Synonyms/Alias

Gene Name

PPM1E

Gene Synonyms/Alias

PPM1E;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000005061	ENSGALP00000008100	ENSGALT00000008114
ENSGALG00000005061	ENSGALP00000008101	ENSGALT00000008115

Organism

Gallus gallus

Functional Description

Protein Length

548

Protein Sequence
(FASTA)

GAEPAPAPPP PAADTVDTAA SEEDPAAEGE AAAAEAEEGD SADPRPPTPP PPPPPLPPLP 60

RPLSEYITEE EVEGECLDLC LQQLYKYNCP SFLAAALARA TSDEVLQSDL SAHYLPKHVD 120

NADGIIQIET VKLARLVFSK LHEICSNWVK EFPLQPKPHR YYETSIHAIK NMRRKMEDKH 180

VCIPDFNMLF NLEDQEEQAY FAVFDGHGGV DAAIYASIHL HVNMVHQEMF QHDPAEALCR 240

AFRVTDERFV QKAARESLRC GTTGVVTFIR GNMLHVAWLG DSQVMLVRKG QAVELMKPHK 300

PDREDEKKRI EALGGCVVWF GAWRVNGSLS VSRAIGDAEH KPYICGDADS ASTVLDGSED 360

YLILACDGFY DTVNPDEAVK VVADHLKENN GDSSMVAHKL VASARDAGSS DNITVIVVFL 420

RDMNAAVSVS EESDWTENSF QGGQEDNGED KENHGECKRP WPQHQCSAPA DLGYEGRVDS 480

FTDRTSLSIG SGINPFDDQG YLDLTKTETS MPNSAKYLPP IQVFSPGIPK NASLINGLTV 540

KNESPEST 548

Nucleotide Sequence
(FASTA)

GGGGCAGAGC CGGCGCCGGC TCCCCCCCCT CCCGCCGCCG ACACCGTCGA CACCGCCGCC 60

TCCGAGGAGG ACCCCGCGGC TGAGGGAGAG GCGGCGGCCG CCGAGGCGGA GGAAGGAGAC 120

AGCGCGGACC CTCGGCCGCC CACCCCGCCG CCGCCCCCCC CGCCGCTGCC CCCGCTGCCC 180

CGGCCGCTGT CGGAGTACAT CACGGAGGAG GAGGTGGAGG GCGAGTGCCT GGACCTCTGC 240

CTGCAGCAGC TCTACAAGTA TAATTGCCCT TCATTTCTGG CTGCTGCTTT AGCTAGAGCA 300

ACTTCAGATG AAGTCCTTCA GAGTGATCTT TCAGCACACT ACTTACCAAA GCATGTGGAC 360

AACGCCGATG GGATTATACA GATTGAGACA GTGAAACTAG CCCGCTTAGT TTTTAGCAAA 420

CTCCATGAGA TCTGCAGCAA CTGGGTGAAA GAATTCCCAC TCCAGCCGAA GCCACACCGC 480

TATTATGAGA CGTCCATCCA TGCCATCAAG AATATGCGGA GGAAAATGGA AGACAAGCAT 540

GTCTGCATTC CAGACTTCAA CATGCTCTTC AACCTTGAGG ACCAAGAAGA GCAAGCCTAT 600

TTTGCGGTGT TCGATGGCCA TGGGGGAGTG GATGCTGCCA TCTATGCCTC CATCCATCTC 660

CATGTGAACA TGGTCCATCA GGAGATGTTT CAGCACGACC CGGCAGAGGC GCTGTGCCGA 720

GCTTTCCGGG TGACGGATGA GCGCTTTGTC CAGAAGGCAG CCAGAGAGAG CCTGCGTTGT 780

GGAACCACCG GGGTGGTGAC TTTCATCCGA GGGAATATGT TACATGTGGC TTGGCTTGGG 840

GACTCCCAGG TTATGCTTGT GAGGAAAGGC CAAGCTGTGG AACTGATGAA ACCCCACAAA 900

CCAGATCGAG AGGATGAGAA GAAACGCATC GAGGCACTTG GTGGCTGTGT GGTCTGGTTT 960

GGAGCGTGGA GGGTAAATGG GAGCCTGTCA GTCTCCAGAG CTATTGGGGA CGCTGAGCAC 1020

AAGCCATACA TCTGTGGGGA CGCAGACTCT GCCTCCACTG TACTAGATGG CTCTGAAGAC 1080

TACCTCATTT TAGCCTGCGA TGGTTTCTAT GACACGGTCA ATCCCGATGA GGCAGTCAAA 1140

GTGGTGGCTG ACCATCTAAA GGAAAATAAT GGTGACAGCA GCATGGTAGC ACATAAATTA 1200

GTGGCATCCG CTCGGGATGC TGGTTCCAGC GACAACATTA CTGTCATTGT GGTATTTCTC 1260

AGGGACATGA ATGCAGCAGT CAGCGTTAGT GAGGAGTCGG ACTGGACAGA GAACTCTTTT 1320

CAAGGTGGGC AAGAAGACAA TGGGGAGGAT AAGGAAAACC ATGGAGAATG CAAGCGACCG 1380

TGGCCCCAGC ACCAGTGCTC AGCACCTGCT GACCTAGGCT ATGAAGGACG AGTGGATTCC 1440

TTCACTGATA GAACTAGCTT AAGCATAGGG TCCGGCATTA ACCCATTTGA TGATCAAGGT 1500

TATTTAGACC TGACAAAAAC AGAAACTAGT ATGCCTAATA GTGCCAAATA CCTGCCACCA 1560

ATTCAAGTGT TTAGTCCTGG TATACCAAAG AATGCAAGTT TGATTAATGG TTTAACAGTG 1620

AAGAATGAGT CACCAGAGAG CACA 1644

Domain Profile

S: 4     gvvsvngrrnemedavtsspnflkspekkdr..laffgvyDGhggsevakfcseklheil  61

         ++ +++++r++med++   p+f    + +d+   a+f+v+DGhgg ++a ++s +lh  +

Q: 165   SIHAIKNMRRKMEDKHVCIPDFNMLFNLEDQeeQAYFAVFDGHGGVDAAIYASIHLHVNM  224

         567899**************99766555544459***********************888

S: 62    aeelesseseerkvkkalakaFlstdeelkvleeksldidksGstavvalikdsklyvan  121

           +       + +  +al +aF  tde++  ++++  ++ ++G+t vv  i+++ l+va

Q: 225   VHQEM----FQHDPAEALCRAFRVTDERF--VQKAARESLRCGTTGVVTFIRGNMLHVAW  278

         88855....5777888999**********..7777788888*******************

S: 122   vGdSravLcrngkavelssdHkpsredEleRieeaggsvilkdga.RvlGvLavsRalGd  180

         +GdS+++L r+g+avel + Hkp+redE++Rie+ gg v+ + ga Rv+G+L vsRa+Gd

Q: 279   LGDSQVMLVRKGQAVELMKPHKPDREDEKKRIEALGGCVV-WFGAwRVNGSLSVSRAIGD  337

         *************************************999.55899**************

S: 181   lylkpyvtpePevtshrltsedefliLasDGlwdvvsneeavslvrdvle.kkeaeqeaa  239

          + kpy+  + +  s+ l+ ++++liLa+DG +d+v++ eav++v d+l+ ++ + + +a

Q: 338   AEHKPYICGDADSASTVLDGSEDYLILACDGFYDTVNPDEAVKVVADHLKeNNGDSSMVA  397

         ************************************************9966778899**

S: 240   kkLvklalargskdnvsaivv  260

         +kLv+ a++ gs+dn+++ivv

Q: 398   HKLVASARDAGSSDNITVIVV  418

         *****************9997

Domain Sequence
(FASTA)

SIHAIKNMRR KMEDKHVCIP DFNMLFNLED QEEQAYFAVF DGHGGVDAAI YASIHLHVNM 60

VHQEMFQHDP AEALCRAFRV TDERFVQKAA RESLRCGTTG VVTFIRGNML HVAWLGDSQV 120

MLVRKGQAVE LMKPHKPDRE DEKKRIEALG GCVVWFGAWR VNGSLSVSRA IGDAEHKPYI 180

CGDADSASTV LDGSEDYLIL ACDGFYDTVN PDEAVKVVAD HLKENNGDSS MVAHKLVASA 240

RDAGSSDNIT VIVV 254

Keyword

Complete proteome; Hydrolase; Magnesium; Metal-binding; Protein phosphatase; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005730	; C:nucleolus
GO:0043234	; C:protein complex
GO:0046872	; F:metal ion binding
GO:0004722	; F:protein serine/threonine phosphatase activity
GO:0035690	; P:cellular response to drug
GO:0006469	; P:negative regulation of protein kinase activity
GO:0035970	; P:peptidyl-threonine dephosphorylation
GO:0051496	; P:positive regulation of stress fiber assembly

KEGG

InterPros

IPR001932	; PP2C-like.
IPR000222	; PP2C_Mn2_Asp60_BS.
IPR015655	; Protein_Pase_2C.

Pfam

PF00481

; PP2C; 1.

SMARTs

SM00331	; PP2C_SIG; 1.
SM00332	; PP2Cc; 1.

Prosites

PS01032

; PP2C; 1.

Prints

Created Date

20-Feb-2013