EKS-GAG-00132

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00132

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/RSK	368.2	2.8E-110	68	329	262

Status

Unreviewed

Ensembl Protein

ENSGALP00000008334

UniProt Accession

F1P4J0;

Protein Name

Protein Synonyms/Alias

Gene Name

RPS6KB1

Gene Synonyms/Alias

RPS6KB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000005198	ENSGALP00000008334	ENSGALT00000008348

Organism

Gallus gallus

Functional Description

Protein Length

502

Protein Sequence
(FASTA)

MAGVFDIDLD QPEDAGSDEE LEEGGQLSES MDHGGVGQYD LGMEHCEKFE ISETSVNRGP 60

EKIRPECFEL LRVLGKGGYG KVFQVRKVTG ANTGKIFAMK VLKKAMIVRN AKDTAHTKAE 120

RNILEEVKHP FIVDLIYAFQ TGGKLYLILE YLSGGELFMQ LEREGIFMED TACFYLAEIS 180

MALGHLHQKG IIYRDLKPEN IMLNHQGHVK LTDFGLCKES IHDGTVTHTF CGTIEYMAPE 240

ILMRSGHNRA VDWWSLGALM YDMLTGAPPF TGENRKKTID KILKCKLNLP PYLTQEARDL 300

LKKLLKRNAA SRLGAGPGDA GEVQAHPFFR HINWDELLAR KVEPPFKPLL QSEEDVSQFD 360

SKFTRQTPVD SPDDSTLSES ANQVFLGFTY VAPSVLESVK EKFSFEPKIR SPRRFIGSPR 420

TPVSPVKFSP GEFWGRGASA SASNTQTPVE YPMETSGIEQ MDVTVCGEAS APLPIRQPNS 480

GPYKKQAFPM ISKRPEHLRM NL 502

Nucleotide Sequence
(FASTA)

ATGGCGGGCG TGTTCGACAT CGATTTGGAC CAGCCCGAGG ACGCGGGTTC GGATGAGGAG 60

CTGGAGGAGG GGGGTCAGTT AAGTGAGAGC ATGGACCATG GAGGAGTTGG CCAATATGAC 120

CTTGGCATGG AACATTGTGA AAAATTTGAG ATTTCAGAAA CTAGTGTAAA CAGAGGTCCA 180

GAAAAGATCC GACCGGAGTG CTTTGAGTTA CTGCGCGTAC TGGGCAAAGG TGGCTATGGA 240

AAGGTATTTC AAGTACGAAA AGTAACTGGA GCAAATACTG GGAAAATTTT TGCCATGAAA 300

GTTCTTAAAA AGGCAATGAT TGTAAGGAAT GCAAAAGATA CAGCTCACAC AAAAGCAGAG 360

CGGAATATAC TAGAGGAAGT GAAACATCCC TTCATTGTAG ACTTAATTTA TGCCTTTCAG 420

ACTGGTGGAA AACTCTACCT CATCCTTGAG TATCTCAGCG GAGGAGAACT ATTTATGCAG 480

TTAGAGAGAG AAGGGATATT TATGGAAGAC ACGGCTTGCT TTTACCTAGC AGAAATCTCA 540

ATGGCACTGG GGCACTTGCA TCAAAAAGGA ATCATTTATC GTGATCTGAA GCCAGAAAAT 600

ATCATGCTTA ATCATCAAGG TCATGTAAAA TTGACAGACT TCGGATTATG TAAAGAATCA 660

ATTCATGATG GAACAGTCAC ACACACGTTC TGTGGAACAA TTGAATACAT GGCCCCTGAA 720

ATCTTGATGA GGAGTGGGCA TAATCGTGCT GTGGACTGGT GGAGTTTGGG GGCATTAATG 780

TATGACATGC TGACTGGAGC ACCTCCTTTC ACCGGGGAGA ACAGGAAGAA AACAATTGAC 840

AAGATTCTCA AGTGTAAACT CAATTTGCCT CCCTACCTCA CACAAGAAGC CAGAGATCTG 900

CTTAAAAAGC TGCTAAAAAG AAACGCTGCC TCACGTCTAG GAGCTGGTCC TGGAGATGCT 960

GGAGAAGTTC AGGCTCACCC GTTCTTCAGA CACATTAACT GGGATGAGCT GTTGGCACGA 1020

AAGGTGGAAC CTCCTTTTAA GCCCTTATTG CAATCTGAAG AGGATGTGAG CCAGTTTGAT 1080

TCAAAGTTTA CACGTCAGAC ACCTGTTGAT AGCCCAGATG ACTCTACTCT CAGTGAAAGT 1140

GCCAACCAGG TCTTTCTGGG TTTTACGTAT GTGGCTCCAT CTGTACTTGA AAGTGTAAAA 1200

GAGAAATTTT CTTTTGAACC AAAAATTCGA TCACCTCGCA GATTCATAGG TAGCCCTAGG 1260

ACACCAGTCA GCCCTGTAAA GTTTTCCCCT GGGGAATTCT GGGGAAGAGG TGCTTCTGCC 1320

AGCGCATCAA ATACTCAGAC ACCTGTGGAA TATCCAATGG AGACCAGTGG AATAGAACAA 1380

ATGGATGTGA CAGTTTGTGG AGAGGCTTCG GCACCGCTTC CAATCCGACA ACCAAACTCT 1440

GGGCCATACA AAAAACAAGC TTTCCCCATG ATTTCCAAAC GACCAGAGCA CTTGCGCATG 1500

AATCTATGA 1509

Domain Profile

S: 1     fellkvlgkGaygkvflvrkvekkdtgklyavKvlkkaelvk..kkkertkeereiLeev  58

         fell+vlgkG+ygkvf+vrkv++ +tgk++a+Kvlkka +v+  k++++tk+er+iLeev

Q: 68    FELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRnaKDTAHTKAERNILEEV  127

         89***********************************9999999****************

S: 59    ehpfivklheafqdekklylvlellkGgeLlerlkkkklfseeeasfilaelvlaleylH  118

         +hpfiv+l +afq+  klyl+le+l+GgeL+++l+++++f+e++a+f+lae+++al +lH

Q: 128   KHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLH  187

         ************************************************************

S: 119   skgvvyrDLkpeNilldeeghvkltDfglakekiaeneekaysfcgTleyvaPevlkrkg  178

         +kg++yrDLkpeNi+l+++ghvkltDfgl+ke+i ++++ +++fcgT+ey+aPe+l+r+g

Q: 188   QKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESI-HDGTVTHTFCGTIEYMAPEILMRSG  246

         *********************************9.9999999******************

S: 179   ydeavDlwslGvllyemLtGktPftgeerketlarilkgkfslklpaweelseeakdlvk  238

         +++avD+wslG+l+y+mLtG++Pftge+rk+t+++ilk+k  l+lp +  l++ea+dl+k

Q: 247   HNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCK--LNLPPY--LTQEARDLLK  302

         ****************************************..9*****..**********

S: 239   klLkkdpakRlga...taeeikehkfl  262

         klLk++ a+Rlga   +a e+++h+f+

Q: 303   KLLKRNAASRLGAgpgDAGEVQAHPFF  329

         *************9*9*********97

Domain Sequence
(FASTA)

FELLRVLGKG GYGKVFQVRK VTGANTGKIF AMKVLKKAMI VRNAKDTAHT KAERNILEEV 60

KHPFIVDLIY AFQTGGKLYL ILEYLSGGEL FMQLEREGIF MEDTACFYLA EISMALGHLH 120

QKGIIYRDLK PENIMLNHQG HVKLTDFGLC KESIHDGTVT HTFCGTIEYM APEILMRSGH 180

NRAVDWWSLG ALMYDMLTGA PPFTGENRKK TIDKILKCKL NLPPYLTQEA RDLLKKLLKR 240

NAASRLGAGP GDAGEVQAHP FF 262

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005524	; F:ATP binding
GO:0004435	; F:phosphatidylinositol phospholipase C activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0071363	; P:cellular response to growth factor stimulus
GO:0000082	; P:G1/S transition of mitotic cell cycle
GO:0006629	; P:lipid metabolic process
GO:0045931	; P:positive regulation of mitotic cell cycle
GO:0045948	; P:positive regulation of translational initiation
GO:0043491	; P:protein kinase B signaling cascade
GO:0031929	; P:TOR signaling cascade

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR017892	; Pkinase_C.
IPR001711	; PLipase_C_Pinositol-sp_Y.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR016238	; Ribosomal_S6_kinase.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50008	; PIPLC_Y_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013