EKS-GAG-00030
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00030
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CAMK/RAD53400.53.5E-120197463267
StatusUnreviewed
Ensembl ProteinENSGALP00000009122
UniProt AccessionF1N864;
Protein Name
Protein Synonyms/Alias
Gene NameCHEK2
Gene Synonyms/Alias CHEK2;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000005695ENSGALP00000009122ENSGALT00000009136
OrganismGallus gallus
Functional Description
Protein Length523
Protein Sequence
(FASTA)
MSRETRSDAQ PSQGTQPSQG GTSSSSSASQ GASQSSSSSG TLSSLDTVPT QELPSIPEDP 60
EPDELVPQPW GRLFALGKGF SNWDCVNDEY WFGRDKSCDY SFSKLGLSET GFYQNYSKKH 120
FRIFREMGPK NSYVAYIEDH SANGTFINRE LIGKGKRLPL THNSEIALSI QTNKVFVFSD 180
LTVDDQLVFP REFREKYIMS KTLGSGACGE VKLAFEKSTC NKVAVKIINK RKFMASGGRE 240
ANPAFNINTE IEILKKIDHP CLIKIKNFFE AEDYYIVLEL MEGGELYDRV SRPVKMKEAT 300
CKLYFYQMLL AVKYLHDNGI IHRDLKPENV LLSSSEETCL IKITDFGQSK ILGETSLMKT 360
LCGTPTYLAP EVLNSFGTAG YSRAVDCWSL GVILFVCLCG YPPFNEQNTQ LSLKDQITRG 420
EYTFISKEWK HVSNMALDLV KKLLVVDPSK RFTIEEALEH PWLQQDEDMK NTFQQLLAQT 480
SATMNPPQTS KMPVATRKRL HENEDESVSS KRDVPSTSLQ KMR 523
Nucleotide Sequence
(FASTA)
ATGTCTCGAG AGACGAGGAG CGACGCGCAG CCGTCCCAGG GCACCCAGCC GTCCCAGGGC 60
GGCACCAGCT CGTCCTCCAG CGCCTCGCAG GGCGCCAGCC AGTCCTCCTC CAGCTCCGGC 120
ACGCTCAGCT CGCTGGACAC CGTGCCCACG CAGGAGCTGC CCTCCATTCC CGAGGACCCG 180
GAACCCGACG AGCTCGTTCC CCAGCCGTGG GGTCGGCTCT TCGCGCTCGG AAAAGGTTTC 240
AGCAATTGGG ACTGTGTGAA TGATGAGTAC TGGTTTGGAA GAGACAAAAG CTGTGATTAC 300
AGTTTTTCTA AGCTCGGTTT ATCGGAGACG GGGTTTTACC AGAACTACAG CAAGAAGCAC 360
TTCCGAATTT TCAGGGAAAT GGGACCCAAA AATTCATACG TTGCCTACAT TGAAGACCAC 420
AGCGCAAATG GAACTTTCAT TAATAGAGAG CTCATTGGGA AAGGGAAGAG GCTCCCGCTG 480
ACTCATAACT CTGAAATCGC ACTGTCTATT CAGACTAACA AGGTGTTTGT GTTTTCTGAT 540
CTCACGGTGG ATGACCAGTT GGTGTTTCCT AGAGAATTCC GAGAGAAGTA CATCATGTCC 600
AAGACTTTGG GAAGTGGTGC CTGTGGAGAA GTCAAACTGG CATTTGAGAA GAGCACTTGT 660
AATAAAGTTG CGGTAAAGAT AATCAATAAG CGGAAGTTTA TGGCCAGTGG TGGTAGAGAG 720
GCAAACCCAG CTTTTAATAT CAACACAGAA ATAGAGATTT TGAAGAAAAT AGACCACCCC 780
TGCTTAATCA AGATCAAGAA CTTCTTTGAA GCAGAGGATT ACTACATTGT TTTGGAACTG 840
ATGGAAGGAG GAGAACTGTA TGACAGAGTG TCAAGGCCAG TCAAGATGAA AGAAGCTACC 900
TGCAAGTTGT ACTTTTATCA GATGCTGCTG GCTGTGAAGT ATCTTCATGA CAATGGAATC 960
ATACACCGGG ATCTGAAGCC GGAGAATGTG CTGCTTTCAT CTTCTGAAGA GACGTGTCTG 1020
ATAAAGATTA CAGATTTTGG ACAATCCAAG ATTCTTGGAG AAACTTCTCT TATGAAAACA 1080
TTATGTGGTA CTCCCACGTA TCTTGCTCCT GAGGTTCTAA ATTCATTTGG GACTGCTGGA 1140
TACAGCCGAG CTGTGGACTG CTGGAGTTTA GGAGTTATTC TTTTTGTATG CTTGTGTGGA 1200
TATCCACCAT TTAATGAGCA AAATACTCAA CTATCTCTGA AAGACCAAAT CACTCGTGGA 1260
GAATACACAT TCATTTCAAA AGAATGGAAA CACGTATCCA ACATGGCTCT GGATCTTGTG 1320
AAGAAGCTGT TGGTAGTGGA TCCAAGCAAA CGTTTTACAA TAGAGGAAGC CTTAGAGCAT 1380
CCCTGGCTTC AGCAGGATGA GGATATGAAA AATACATTTC AACAACTACT TGCTCAGACA 1440
AGTGCCACTA TGAATCCACC ACAAACATCA AAAATGCCAG TTGCTACGAG AAAACGTCTC 1500
CACGAAAATG AGGATGAATC TGTCTCTTCT AAGCGTGATG TTCCTTCTAC GTCACTGCAG 1560
AAAATGAGGT GA 1572
Domain Profile
S: 1     yilskelGkGafgkvklayekktgkkvavkilskrk.sirssreikkakeveeeveilkk  59
         yi+sk+lG+Ga+g+vkla+ek+t++kvavki++krk  +   re++ a ++++e+eilkk
Q: 197   YIMSKTLGSGACGEVKLAFEKSTCNKVAVKIINKRKfMASGGREANPAFNINTEIEILKK  256
         89**********************************6688899*****************
S: 60    lshPnivklkdvfeeeeskylvlelvegGelldkvvakkllkedlskllfkqlltavkyl  119
         ++hP+++k+k++fe+e++ y+vlel+egGel+d+v +   +ke+++kl+f+q+l avkyl
Q: 257   IDHPCLIKIKNFFEAEDY-YIVLELMEGGELYDRVSRPVKMKEATCKLYFYQMLLAVKYL  315
         *****************9.*****************************************
S: 120   hekgiihrDlkPeniLlsekeedvlvkitDfGlakvlgevslmktlCGtpsyvaPevlvk  179
         h++giihrDlkPen+Lls+ ee +l+kitDfG++k+lge+slmktlCGtp+y+aPevl +
Q: 316   HDNGIIHRDLKPENVLLSSSEETCLIKITDFGQSKILGETSLMKTLCGTPTYLAPEVLNS  375
         ************************************************************
S: 180   kgraeytskvDiWslGvvlfvilsGypPfseeltqvslkeqilkgkyafieekwkkisee  239
          g+a+y+++vD+WslGv+lfv+l+GypPf e+ tq slk+qi++g+y+fi+++wk++s+ 
Q: 376   FGTAGYSRAVDCWSLGVILFVCLCGYPPFNEQNTQLSLKDQITRGEYTFISKEWKHVSNM  435
         ************************************************************
S: 240   akdlikklLvvdPeerlsieealnhpWl  267
         a+dl+kklLvvdP++r++ieeal+hpWl
Q: 436   ALDLVKKLLVVDPSKRFTIEEALEHPWL  463
         ***************************8
Domain Sequence
(FASTA)
YIMSKTLGSG ACGEVKLAFE KSTCNKVAVK IINKRKFMAS GGREANPAFN INTEIEILKK 60
IDHPCLIKIK NFFEAEDYYI VLELMEGGEL YDRVSRPVKM KEATCKLYFY QMLLAVKYLH 120
DNGIIHRDLK PENVLLSSSE ETCLIKITDF GQSKILGETS LMKTLCGTPT YLAPEVLNSF 180
GTAGYSRAVD CWSLGVILFV CLCGYPPFNE QNTQLSLKDQ ITRGEYTFIS KEWKHVSNMA 240
LDLVKKLLVV DPSKRFTIEE ALEHPWL 267
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00032
EKS-BOT-00037
EKS-CAE-00032
EKS-CAJ-00036
EKS-CAF-00037
EKS-CAP-00037
EKS-CII-00014
EKS-CIS-00038
EKS-DAR-00048
EKS-DRM-00013
EKS-EQC-00034
EKS-FEC-00034
EKS-GOG-00035
EKS-HOS-00037
EKS-ICT-00032
EKS-LAC-00038
EKS-LOA-00036
EKS-MAM-00036
EKS-MEG-00032
EKS-MOD-00036
EKS-MUM-00038
EKS-MUP-00038
EKS-MYL-00038
EKS-NOL-00035
EKS-ORN-00053
EKS-ORA-00032
EKS-ORC-00035
EKS-ORL-00049
EKS-OTG-00038
EKS-PAT-00034
EKS-PES-00033
EKS-POA-00034
EKS-RAN-00038
EKS-SAH-00035
EKS-TAG-00034
EKS-TAR-00053
EKS-TEN-00057
EKS-XET-00037
EKS-XIM-00051
EKS-SAC-00050
EKS-SCP-00037
Gene Ontology
GO:0000781; C:chromosome, telomeric region
GO:0016605; C:PML body
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0044257; P:cellular protein catabolic process
GO:0006975; P:DNA damage induced protein phosphorylation
GO:0006302; P:double-strand break repair
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0008630; P:intrinsic apoptotic signaling pathway in response to DNA damage response
GO:0045893; P:positive regulation of transcription, DNA-dependent
GO:0046777; P:protein autophosphorylation
GO:0042176; P:regulation of protein catabolic process
GO:0010332; P:response to gamma radiation
GO:0072428; P:signal transduction involved in intra-S DNA damage checkpoint
GO:0090307; P:spindle assembly involved in mitosis
KEGG
InterPros
IPR000253; FHA_dom.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
IPR008984; SMAD_FHA_domain.
Pfam
PF00498; FHA; 1.
PF00069; Pkinase; 1.
SMARTs
SM00240; FHA; 1.
SM00220; S_TKc; 1.
Prosites
PS50006; FHA_DOMAIN; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013