| Tag | Content |
|---|
| EKPD ID | EPS-GAG-00072 |
| Classification | | Group/Family | Score | E-Value | Start | End | Domain Length |
|---|
| Asp-Based PTP/FCP | 166.2 | 6.0E-49 | 106 | 264 | 159 |
|
| Status | Reviewed |
| Ensembl Protein | ENSGALP00000009144 |
| UniProt Accession | Q9PTJ6; Q9PTJ7; Q9PTJ8; Q9PTJ9; |
| Protein Name | CTD small phosphatase-like protein |
| Protein Synonyms/Alias | CTDSP-like; Nuclear LIM interactor-interacting factor 1; NLI-interacting factor 1; Small C-terminal domain phosphatase 3; |
| Gene Name | NFI1 |
| Gene Synonyms/Alias | NFI1; NIF; |
| Ensembl Information | |
| Organism | Gallus gallus |
| Functional Description | Preferentially catalyzes the dephosphorylation of 'Ser-5' within the tandem 7 residues repeats in the C-terminal domain (CTD) of the largest RNA polymerase II subunit POLR2A. Negatively regulates RNA polymerase II transcription, possibly by controlling the transition from initiation/capping to processive transcript elongation. Recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells (By similarity). |
| Protein Length | 275 |
Protein Sequence
(FASTA) | | MDNPSIITQV TNPKEEEILS CTQDKVSQCN ISLKKQRSRS IFSTLFCCFR DYNVEPPSTN 60 | | STSALPPLVE ENGGLQKGDQ MQVMPIPSPP AKYLLPELTA SDYGKKCVVI DLDETLVHSS 120 | | FKPISNADFI VPVEIDGTIH QVYVLKRPHV DEFLQRMGEL FECVLFTASL AKYADPVADL 180 | | LDRWGVFRAR LFRESCVFHR GNYVKDLSRL GRELSKVIIV DNSPASYIFH PENAVPVQSW 240 | | FDDMTDTELL DLIPFFEGLS KEEEVYSMLH KLCNR 275 |
|
Nucleotide Sequence
(FASTA) | | ATGGACAACC CGTCCATTAT CACCCAGGTG ACTAACCCCA AAGAGGAGGA GATCCTGTCC 60 | | TGCACTCAGG ATAAAGTGTC CCAATGTAAT ATCAGCTTGA AGAAGCAGAG AAGTCGGAGT 120 | | ATCTTTAGCA CCTTATTCTG CTGCTTTCGT GACTACAATG TCGAACCACC ATCTACCAAC 180 | | AGCACCAGTG CTCTTCCTCC TTTGGTGGAG GAGAATGGAG GACTTCAGAA GGGTGACCAG 240 | | ATGCAGGTCA TGCCTATACC AAGTCCACCA GCTAAATACC TCCTGCCAGA ACTGACAGCA 300 | | TCAGACTATG GGAAGAAGTG TGTGGTCATT GATTTAGATG AAACTTTAGT GCACAGTTCA 360 | | TTTAAGCCAA TTAGCAATGC TGATTTCATC GTTCCCGTTG AAATCGATGG AACCATACAT 420 | | CAGGTTTATG TATTGAAACG ACCACATGTG GATGAATTTC TTCAAAGGAT GGGAGAGCTC 480 | | TTTGAATGTG TTCTCTTCAC AGCAAGTCTA GCCAAGTATG CAGACCCAGT AGCCGACTTA 540 | | CTGGATCGCT GGGGTGTGTT CAGGGCAAGG CTATTTAGAG AATCCTGTGT TTTCCACCGG 600 | | GGCAATTACG TGAAGGATCT GAGTCGGCTG GGACGTGAGC TGAGTAAAGT TATCATAGTG 660 | | GATAATTCTC CTGCATCTTA CATCTTCCAT CCTGAAAATG CAGTGCCTGT GCAGTCCTGG 720 | | TTTGATGACA TGACAGACAC AGAGCTGCTA GATCTTATTC CTTTCTTTGA AGGACTAAGC 780 | | AAAGAGGAAG AAGTTTACAG TATGCTTCAT AAACTCTGCA ACAGGTAG 828 |
|
| Domain Profile | S: 1 ktLVLDLDetLvhsksekdee........e..ektkasvkkRPgldeFLkelskayevvi 50 | k++V+DLDetLvhs++++ ++ + ++++v kRP++deFL+++ + +e v+ | Q: 106 KCVVIDLDETLVHSSFKPISNadfivpveIdgTIHQVYVLKRPHVDEFLQRMGELFECVL 165 | 89*************8777634577776515799************************** |
| S: 51 ftasskeyadavldkldpkkklfkkrlyresctlengkyvKdLsllgrdlskvvivDdsp 110 | ftas +yad+v d ld+ +f++rl+resc++++g+yvKdLs lgr+lskv+ivD+sp | Q: 166 FTASLAKYADPVADLLDR-WGVFRARLFRESCVFHRGNYVKDLSRLGRELSKVIIVDNSP 224 | *****************8.779************************************** |
| S: 111 rsfelqpdnlipiepfygdsdkdtellkllpflealeksdd 151 | s+ ++p+n++p++++++d +dtell+l+pf+e l+k+++ | Q: 225 ASYIFHPENAVPVQSWFDD-MTDTELLDLIPFFEGLSKEEE 264 | *******************.999**********99997765 |
|
Domain Sequence
(FASTA) | | KCVVIDLDET LVHSSFKPIS NADFIVPVEI DGTIHQVYVL KRPHVDEFLQ RMGELFECVL 60 | | FTASLAKYAD PVADLLDRWG VFRARLFRES CVFHRGNYVK DLSRLGRELS KVIIVDNSPA 120 | | SYIFHPENAV PVQSWFDDMT DTELLDLIPF FEGLSKEEE 159 |
|
| Keyword | Alternative splicing; Complete proteome; Hydrolase; Magnesium; Metal-binding; Nucleus; Protein phosphatase; Reference proteome. |
| Sequence Source | Ensembl |
| Orthology | |
| Gene Ontology | |
| KEGG | |
| InterPros | |
| Pfam | |
| SMARTs | |
| Prosites | |
| Prints | |
| Created Date | 20-Feb-2013 |