EKS-GAG-00342
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00342
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/PDGFR544.21.6E-163577906330
StatusUnreviewed
Ensembl ProteinENSGALP00000009176
UniProt AccessionF1N869;
Protein Name
Protein Synonyms/Alias
Gene NameCSF1R
Gene Synonyms/Alias CSF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000005725ENSGALP00000009176ENSGALT00000009190
ENSGALG00000005725ENSGALP00000039628ENSGALT00000040427
OrganismGallus gallus
Functional Description
Protein Length959
Protein Sequence
(FASTA)
MGPGDVGPGL LLLLLTTPAV WHGSASPVIS PDISALVVNV SDPVLLRCSG ESEVKWYPEK 60
FANHASSTLS IPRTTHRDTG TYRCAYINSS DKGIASVHLY VRDPNNVWYV PYFRISVTKG 120
GNAEFPCFIT APEYGSNVTL IRNDGSKLSP GTNYSFSPEK GITLYHVEHE QKGQYQCQTV 180
VNGKIEKSSR IRLIVVEGQE KPVQVMVDPA DHVRIVGEPF EVTCVVTAPS HKYDIKWVTA 240
TNSVKSNGKP DIYDGNYIIN DTLSIPAVTM EDSGKYTCIA NNSAGFRNAS TMLRVVERGY 300
VILTPVQATN QEVAEGDSLK LQVHIEAYPK LLHWHWEHTD SLKNSGSNKL NSEMVPKNNW 360
YNNTLFLDHL EGEERGLYTF YAFNSETNSS VTFSVSVKSP PRIGDVMVSA SDSGKLLCTA 420
IGYPAPHIEW YQCPTHSDRY EDYILLLNDS SPHVVNILPF QEVQVESIIP FQDLGTNFTF 480
CCVAVNSEGS TSDILHSVFR SVMAPPNQLF SPILTTCMCT SVLLLLLLLF LLYKYNQKPK 540
YQVRWKIIEA CEGNNYIFID PTQLPYNEKW EFPRNNLQFG KTLGAGAFGK VVEATAFGLG 600
KEDSVLKVAV KMLKSTADTD EQEALMSELK IMSHLGHHAN IVNLLGACTY GGPILVITEY 660
CRYGDLLNFL RKKAEYIIIQ DSALDTSLDS TADYKNIDLE KKYIRSDSGF ASQGLETYVE 720
MRPISSSSSV WKSSEEDETR EDLQPLNLSD LLQFSSQVAQ GMAFLASKNC IHRDLAARNV 780
LVSDGRVAKI CDFGLARDIM NDSNYVVKGN ARLPVKWMAP ESIFDCVYTV QSDVWSYGIL 840
LWEIFSLGKS PYPGMAVNSK FYSMVKRGYQ MARPDFAPLE MYSIMQACWS LEPTQRPTFD 900
QICCFIQKEL DLHKEQDYTN LPSTAEEDSG CDTSGCCEES CEQEESGQPL LKGNNYQFC 959
Nucleotide Sequence
(FASTA)
ATGGGCCCCG GGGATGTTGG TCCTGGCCTG CTGCTGCTGC TGCTGACCAC ACCTGCTGTC 60
TGGCACGGCT CAGCATCCCC TGTGATCAGC CCTGATATCT CTGCTCTGGT TGTCAATGTG 120
AGTGATCCAG TCCTCCTGCG CTGCTCGGGA GAGTCAGAAG TTAAATGGTA CCCTGAAAAG 180
TTTGCCAACC ATGCCAGCAG CACGCTCAGT ATTCCCAGGA CCACTCACAG AGACACAGGC 240
ACCTATAGGT GTGCTTACAT CAACAGCAGC GACAAGGGTA TTGCATCTGT GCATCTGTAC 300
GTGCGAGATC CCAATAACGT GTGGTACGTC CCATACTTCC GGATCTCTGT GACCAAAGGT 360
GGTAATGCTG AGTTCCCCTG CTTCATCACT GCCCCCGAGT ATGGATCCAA TGTGACTCTG 420
ATAAGGAATG ATGGCTCTAA GCTCTCACCT GGAACCAACT ATTCTTTCAG CCCTGAGAAG 480
GGAATAACAC TTTATCACGT GGAACACGAG CAGAAGGGCC AATACCAATG CCAAACAGTG 540
GTAAATGGAA AAATAGAGAA GTCATCAAGA ATAAGACTGA TTGTGGTTGA AGGACAAGAG 600
AAGCCTGTAC AGGTGATGGT GGACCCTGCA GACCATGTGC GAATCGTGGG TGAACCTTTC 660
GAAGTCACTT GTGTAGTAAC TGCTCCTTCC CATAAGTATG ACATCAAATG GGTGACAGCA 720
ACAAACAGTG TTAAGAGTAA TGGAAAGCCT GACATATATG ACGGGAACTA CATCATCAAT 780
GACACCCTGT CAATTCCAGC AGTGACCATG GAAGACAGTG GGAAATACAC TTGCATAGCT 840
AACAATTCAG CAGGATTCAG GAATGCCTCC ACAATGCTTC GGGTAGTAGA AAGAGGGTAT 900
GTGATCCTGA CCCCAGTGCA AGCCACGAAC CAAGAAGTTG CTGAAGGAGA CAGTTTGAAA 960
CTCCAGGTCC ATATTGAGGC ATATCCCAAA CTTCTACACT GGCACTGGGA GCACACGGAC 1020
TCATTGAAGA ACTCCGGGAG CAACAAACTC AATAGCGAAA TGGTCCCTAA AAACAACTGG 1080
TATAACAACA CGCTCTTCCT GGATCATCTG GAAGGAGAAG AGAGAGGTCT CTATACGTTT 1140
TATGCTTTCA ACAGTGAGAC CAACTCATCA GTTACTTTCA GTGTATCTGT GAAATCTCCT 1200
CCAAGGATAG GCGATGTCAT GGTGTCGGCC AGTGACTCCG GTAAGCTCCT CTGCACGGCC 1260
ATCGGCTACC CTGCCCCACA CATTGAATGG TACCAGTGCC CCACTCACTC TGACAGGTAT 1320
GAGGACTATA TCCTGCTTCT GAATGACTCC AGTCCCCATG TGGTGAACAT ACTACCTTTC 1380
CAAGAGGTGC AGGTGGAGAG CATCATCCCA TTCCAAGATC TGGGGACCAA TTTTACCTTC 1440
TGCTGTGTGG CTGTTAACAG CGAGGGGAGC ACCTCTGACA TCCTTCACTC AGTCTTTAGA 1500
AGTGTCATGG CTCCCCCAAA CCAACTCTTC AGTCCCATTC TCACCACCTG CATGTGCACA 1560
TCGGTCTTGC TGCTCCTGCT GCTCCTCTTC CTCCTCTACA AGTACAACCA GAAACCTAAG 1620
TACCAGGTGC GGTGGAAGAT CATTGAGGCC TGTGAGGGGA ATAACTACAT CTTTATCGAT 1680
CCCACTCAGC TGCCATACAA CGAGAAATGG GAGTTTCCCA GGAATAACCT CCAGTTTGGA 1740
AAAACTCTTG GAGCTGGAGC CTTTGGAAAG GTGGTAGAAG CCACTGCTTT TGGACTGGGA 1800
AAAGAAGATT CAGTCCTCAA AGTGGCTGTG AAGATGTTGA AATCAACGGC AGACACAGAC 1860
GAGCAGGAGG CTCTCATGTC TGAGCTGAAG ATCATGAGTC ATTTGGGGCA CCACGCGAAC 1920
ATTGTTAACC TGCTGGGAGC ATGTACCTAT GGAGGCCCAA TTCTTGTCAT CACCGAGTAC 1980
TGTCGCTATG GAGATCTGCT GAATTTCCTG CGGAAGAAGG CTGAATACAT AATTATCCAG 2040
GACTCAGCTC TGGACACCTC TTTGGACAGC ACTGCTGATT ACAAGAACAT TGACCTGGAG 2100
AAAAAATACA TCCGCAGTGA CAGTGGCTTT GCGAGCCAGG GTTTGGAAAC TTATGTTGAA 2160
ATGAGGCCCA TATCATCATC ATCTTCGGTG TGGAAAAGCT CGGAAGAAGA TGAAACCAGA 2220
GAGGACCTCC AGCCCCTTAA CCTCTCTGAC CTGCTCCAGT TCTCCAGCCA GGTGGCACAG 2280
GGCATGGCAT TCCTTGCATC AAAGAACTGC ATCCATCGTG ACTTAGCAGC CAGGAATGTG 2340
CTCGTATCAG ATGGACGGGT AGCCAAGATT TGTGACTTTG GCCTGGCCCG TGACATCATG 2400
AATGACTCAA ACTACGTTGT AAAAGGCAAT GCCCGCCTAC CCGTGAAGTG GATGGCCCCA 2460
GAGAGCATCT TCGACTGTGT TTATACAGTG CAGAGTGATG TGTGGTCCTA CGGCATTCTT 2520
CTCTGGGAGA TCTTTTCCCT TGGTAAAAGT CCCTATCCTG GCATGGCGGT GAACAGCAAG 2580
TTCTACAGCA TGGTGAAGAG GGGCTACCAG ATGGCCAGGC CTGACTTTGC TCCCTTGGAA 2640
ATGTATAGCA TCATGCAGGC ATGCTGGAGC CTGGAGCCCA CACAGAGACC TACCTTTGAT 2700
CAGATCTGCT GCTTTATTCA GAAAGAACTG GATTTGCATA AGGAACAGGA CTATACAAAC 2760
CTCCCATCCA CTGCTGAGGA AGACAGTGGC TGTGATACCT CTGGCTGCTG TGAGGAGTCC 2820
TGTGAACAAG AGGAGAGCGG GCAGCCCCTT CTCAAAGGCA ACAACTATCA GTTCTGTTAG 2880
Domain Profile
S: 1     lelGkvlGsGafGkvveatayGlsksdavlkvavkmlkstarssekealmselkilshlG  60
         l++Gk+lG+GafGkvveata+Gl+k+d+vlkvavkmlksta+++e+ealmselki+shlG
Q: 577   LQFGKTLGAGAFGKVVEATAFGLGKEDSVLKVAVKMLKSTADTDEQEALMSELKIMSHLG  636
         79**********************************************************
S: 61    ehenivnllGactkgGpiyviteyccyGdllnylrrkresflkkslekkkekeeeldska  120
         +h nivnllGact gGpi+viteyc+yGdlln+lr+k+e ++ + +   +  ++ +d+k+
Q: 637   HHANIVNLLGACTYGGPILVITEYCRYGDLLNFLRKKAEYIIIQDSALDTSLDSTADYKN  696
         ******************************************9999999999999*****
S: 121   l.ladkslrsksslssesseeyvdlkkdvsdvssskadklasekkksalerevkaaleee  179
         + l++k++rs+s ++s++ e+yv++++    +sss++  ++se+            ++ e
Q: 697   IdLEKKYIRSDSGFASQGLETYVEMRP----ISSSSSVWKSSEE------D-----ETRE  741
         *999***********************....6655544433333......2.....3457
S: 180   dsevleledllsfsyqvakGmeflaskncvhrdlaarnvllteGkvvkicdfGlardimk  239
         d ++l+l+dll+fs+qva+Gm+flasknc+hrdlaarnvl+++G+v+kicdfGlardim+
Q: 742   DLQPLNLSDLLQFSSQVAQGMAFLASKNCIHRDLAARNVLVSDGRVAKICDFGLARDIMN  801
         89**********************************************************
S: 240   dsnyvvkGnarlpvkwmapesifdslytvksdvwsyGillweifslGstpypgllvdskf  299
         dsnyvvkGnarlpvkwmapesifd++ytv+sdvwsyGillweifslG +pypg+ v+skf
Q: 802   DSNYVVKGNARLPVKWMAPESIFDCVYTVQSDVWSYGILLWEIFSLGKSPYPGMAVNSKF  861
         ************************************************************
S: 300   yklikeGyrmaqpayateeiyeimqkcweaepekrpsfkqlvell  344
         y ++k+Gy+ma+p++a+ e+y+imq+cw  ep++rp+f q++ ++
Q: 862   YSMVKRGYQMARPDFAPLEMYSIMQACWSLEPTQRPTFDQICCFI  906
         *****************************************9876
Domain Sequence
(FASTA)
LQFGKTLGAG AFGKVVEATA FGLGKEDSVL KVAVKMLKST ADTDEQEALM SELKIMSHLG 60
HHANIVNLLG ACTYGGPILV ITEYCRYGDL LNFLRKKAEY IIIQDSALDT SLDSTADYKN 120
IDLEKKYIRS DSGFASQGLE TYVEMRPISS SSSVWKSSEE DETREDLQPL NLSDLLQFSS 180
QVAQGMAFLA SKNCIHRDLA ARNVLVSDGR VAKICDFGLA RDIMNDSNYV VKGNARLPVK 240
WMAPESIFDC VYTVQSDVWS YGILLWEIFS LGKSPYPGMA VNSKFYSMVK RGYQMARPDF 300
APLEMYSIMQ ACWSLEPTQR PTFDQICCFI 330
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00376
EKS-ANC-00391
EKS-BOT-00405
EKS-CAJ-00409
EKS-CAF-00405
EKS-CAP-00434
EKS-DAR-00788
EKS-EQC-00397
EKS-FEC-00389
EKS-GAA-00492
EKS-GOG-00397
EKS-HOS-00411
EKS-ICT-00384
EKS-LAC-00420
EKS-LOA-00414
EKS-MAM-00404
EKS-MEG-00336
EKS-MOD-00393
EKS-MUM-00437
EKS-MUP-00398
EKS-MYL-00400
EKS-ORN-00515
EKS-ORC-00380
EKS-ORL-00473
EKS-OTG-00407
EKS-PAT-00383
EKS-PES-00359
EKS-PTV-00115
EKS-RAN-00419
EKS-SAH-00375
EKS-SUS-00355
EKS-TAG-00474
EKS-TAR-00511
EKS-TEN-00512
EKS-TUT-00118
EKS-XET-00514
EKS-XIM-00507
Gene Ontology
GO:0009986; C:cell surface
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0043235; C:receptor complex
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0008283; P:cell proliferation
GO:0045217; P:cell-cell junction maintenance
GO:0038145; P:macrophage colony-stimulating factor signaling pathway
GO:0046488; P:phosphatidylinositol metabolic process
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0090197; P:positive regulation of chemokine secretion
GO:0070374; P:positive regulation of ERK1 and ERK2 cascade
GO:0071902; P:positive regulation of protein serine/threonine kinase activity
GO:0061098; P:positive regulation of protein tyrosine kinase activity
GO:0042517; P:positive regulation of tyrosine phosphorylation of Stat3 protein
GO:2000249; P:regulation of actin cytoskeleton reorganization
GO:0031529; P:ruffle organization
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016243; Tyr_kinase_CSF1/PDGF_rcpt.
IPR001824; Tyr_kinase_rcpt_3_CS.
Pfam
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00409; IG; 3.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00240; RECEPTOR_TYR_KIN_III; 1.
Prints
Created Date20-Feb-2013