EKS-GAG-00144
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00144
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC480.12.0E-144274532259
StatusUnreviewed
Ensembl ProteinENSGALP00000009662
UniProt AccessionF1N9K8;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCB
Gene Synonyms/Alias PRKCB;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000006014ENSGALP00000009664ENSGALT00000009678
ENSGALG00000006014ENSGALP00000009663ENSGALT00000009677
ENSGALG00000006014ENSGALP00000009662ENSGALT00000009676
OrganismGallus gallus
Functional Description
Protein Length608
Protein Sequence
(FASTA)
VCCFVVHKRC HEFVTFSCPG ADKGPASDDP RSKHKFKIHT YSSPTFCDHC GSLLYGLIHQ 60
GMKCDTCMMN VHKRCVMNVP SLCGTDHTER RGRIYIRADI EKDVLTVVVR DAKNLVPMDP 120
NGLSDPYVKL KLIPDPKNES KQKTKTIKCS LNPEWNETFR FQLKEADKDR RLSVEIWDWD 180
LTSRNDFMGS LSFGISELQK SGVDGWFKLL SQEEGEYFNV PVPPEGEEGN EELRQKFERA 240
KIGTGSKAAD EKTTNAISKF DNNGSRDRMK LSDFNFLMVL GKGSFGKVML AERKGTDELY 300
AVKILKKDVV IQDDDVECTM VEKRVLALSG KPPFLTQLHS CFQTMDRLYF VMEYVNGGDL 360
MYQIQQVGRF KEPHAVFYAA EIAIGLFFLQ SKGIIYRDLK LDNVMLDSEG HIKIADFGMC 420
KENIWDGVTT KTFCGTPDYI APEIIAYQPY GKSVDWWAFG VLLYEMLAGQ APFEGEDEDE 480
LFQSIMEHNV AYPKSMSKEA VAICKGLMTK HPAKRLGCGP EGERDIKEHA FFRYIDWDKL 540
ERNSVAPPYI PSLCCGRNAE NFDRFFTRHP PVLTPPDQEV IRNIDQSEFE GFSFFNSEFF 600
KPEAKRAA 608
Nucleotide Sequence
(FASTA)
GTTTGCTGCT TCGTGGTGCA CAAGCGGTGC CATGAGTTCG TCACCTTCTC CTGCCCCGGC 60
GCAGACAAGG GCCCCGCTTC CGATGATCCC CGGAGCAAAC ACAAGTTTAA AATCCACACG 120
TACTCCAGCC CCACCTTCTG CGACCACTGC GGCTCACTGC TGTATGGCCT CATCCACCAG 180
GGGATGAAAT GTGACACCTG CATGATGAAC GTGCACAAAC GCTGCGTGAT GAACGTCCCC 240
AGCCTGTGCG GGACCGACCA CACCGAGCGC CGGGGCAGGA TATACATCAG GGCCGACATC 300
GAGAAGGACG TGCTGACTGT CGTGGTAAGA GATGCTAAAA ACCTAGTTCC CATGGATCCC 360
AATGGCTTGT CAGATCCCTA CGTGAAGCTT AAACTAATCC CCGACCCCAA AAATGAAAGC 420
AAACAGAAGA CCAAAACCAT AAAGTGCTCC CTGAATCCTG AGTGGAACGA GACATTCAGA 480
TTCCAGCTGA AGGAGGCAGA CAAGGACAGG CGGTTGTCAG TGGAGATCTG GGATTGGGAC 540
CTGACCAGCA GGAACGACTT CATGGGCTCC TTGTCCTTCG GCATCTCCGA GCTGCAGAAG 600
TCCGGAGTTG ACGGATGGTT CAAGCTGCTG AGCCAGGAGG AGGGGGAGTA CTTCAATGTC 660
CCGGTGCCTC CTGAAGGTGA AGAAGGAAAC GAGGAACTGA GGCAGAAATT TGAGAGAGCC 720
AAGATTGGCA CGGGCTCCAA GGCTGCGGAT GAGAAGACGA CAAACGCCAT TTCTAAGTTC 780
GATAACAACG GGAGCAGAGA TCGGATGAAG CTCTCAGATT TCAATTTCCT GATGGTTCTG 840
GGGAAGGGAA GCTTTGGGAA GGTGATGCTG GCTGAGAGAA AGGGCACGGA TGAACTCTAC 900
GCTGTGAAGA TCCTGAAGAA GGACGTGGTC ATCCAGGATG ACGACGTGGA GTGCACCATG 960
GTTGAGAAGC GTGTGCTGGC ACTCTCTGGG AAGCCCCCAT TCCTGACCCA GCTCCACTCC 1020
TGCTTCCAGA CCATGGATCG CTTGTACTTT GTGATGGAAT ATGTGAACGG AGGGGACTTG 1080
ATGTACCAGA TCCAGCAGGT TGGGAGGTTT AAGGAGCCAC ATGCTGTATT CTACGCAGCA 1140
GAAATAGCCA TTGGCCTCTT CTTCCTGCAA AGCAAAGGCA TCATTTACCG AGACCTGAAG 1200
CTGGATAACG TAATGCTGGA CAGTGAGGGG CACATCAAGA TCGCAGACTT CGGCATGTGC 1260
AAGGAGAACA TTTGGGATGG GGTGACCACC AAGACCTTCT GCGGCACCCC CGACTACATC 1320
GCACCTGAGA TAATTGCTTA TCAGCCCTAT GGGAAGTCGG TGGACTGGTG GGCATTTGGA 1380
GTCCTGCTCT ATGAAATGTT GGCTGGCCAG GCTCCCTTTG AGGGAGAAGA TGAAGACGAG 1440
CTCTTCCAGT CCATCATGGA GCACAACGTG GCCTACCCCA AGTCCATGTC CAAGGAGGCA 1500
GTGGCGATCT GCAAAGGGCT CATGACCAAG CACCCTGCCA AGCGACTGGG CTGCGGCCCG 1560
GAGGGGGAGC GCGACATCAA GGAGCACGCC TTCTTCCGCT ACATCGACTG GGACAAGCTG 1620
GAGCGCAACT CTGTAGCACC GCCCTACATA CCCTCGCTCT GCTGTGGACG CAATGCTGAA 1680
AACTTCGACC GGTTTTTCAC TCGCCATCCA CCCGTGTTAA CACCTCCTGA CCAGGAAGTC 1740
ATCAGGAACA TTGACCAGTC AGAATTCGAA GGATTTTCCT TTTTTAACTC TGAGTTTTTT 1800
AAACCTGAAG CCAAGAGAGC TGCT 1824
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f++l+vlGkGsfgkv+lae+k+tdelya+k+lkkdvv+qdddve+t+vekrvlal+ k+p
Q: 274   FNFLMVLGKGSFGKVMLAERKGTDELYAVKILKKDVVIQDDDVECTMVEKRVLALSGKPP  333
         99**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         fl+ql+scfqt+drl+fv+eyvnGGdlm++iq+++++ke++a+fyaaei+++l+fl++kg
Q: 334   FLTQLHSCFQTMDRLYFVMEYVNGGDLMYQIQQVGRFKEPHAVFYAAEIAIGLFFLQSKG  393
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnv+ld+eGhik+adfG+cke+i++g tt+tfcGtPdyiaPei+++++ygks
Q: 394   IIYRDLKLDNVMLDSEGHIKIADFGMCKENIWDGVTTKTFCGTPDYIAPEIIAYQPYGKS  453
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfegededelfesilekevlyPkslskeaveilkglltkdpe  240
         vdwwa+Gvllyemlagq+Pfegededelf+si+e++v+yPks+skeav+i+kgl+tk+p+
Q: 454   VDWWAFGVLLYEMLAGQAPFEGEDEDELFQSIMEHNVAYPKSMSKEAVAICKGLMTKHPA  513
         ************************************************************
S: 241   krlGvkeegeedikehaff  259
         krlG+ +ege+dikehaff
Q: 514   KRLGCGPEGERDIKEHAFF  532
         ******************9
Domain Sequence
(FASTA)
FNFLMVLGKG SFGKVMLAER KGTDELYAVK ILKKDVVIQD DDVECTMVEK RVLALSGKPP 60
FLTQLHSCFQ TMDRLYFVME YVNGGDLMYQ IQQVGRFKEP HAVFYAAEIA IGLFFLQSKG 120
IIYRDLKLDN VMLDSEGHIK IADFGMCKEN IWDGVTTKTF CGTPDYIAPE IIAYQPYGKS 180
VDWWAFGVLL YEMLAGQAPF EGEDEDELFQ SIMEHNVAYP KSMSKEAVAI CKGLMTKHPA 240
KRLGCGPEGE RDIKEHAFF 259
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Repeat; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Equus caballus"; ?>Felis catus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-BOT-00168
EKS-CAJ-00172
EKS-CAF-00175
EKS-CAP-00168
EKS-EQC-00173
EKS-FEC-00158
EKS-GOG-00171
EKS-HOS-00174
EKS-ICT-00163
EKS-LAC-00180
EKS-LOA-00167
EKS-MAM-00166
EKS-MOD-00167
EKS-MUM-00173
EKS-MUP-00172
EKS-MYL-00177
EKS-NOL-00161
EKS-OCP-00107
EKS-ORC-00156
EKS-OTG-00174
EKS-PAT-00159
EKS-PES-00148
EKS-POA-00165
EKS-RAN-00164
EKS-SAH-00162
EKS-XET-00157
EKS-SAC-00081
EKS-SCP-00080
Gene Ontology
GO:0005622; C:intracellular
GO:0005524; F:ATP binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0035556; P:intracellular signal transduction
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR000008; C2_Ca-dep.
IPR008973; C2_Ca/lipid-bd_dom_CaLB.
IPR020477; C2_dom.
IPR018029; C2_membr_targeting.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR014375; Protein_kinase_C_a/b/g.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00168; C2; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00239; C2; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS50004; C2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00360; C2DOMAIN.
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013