EKS-GAG-00388
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00388
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
CMGC/MAPK407.14.1E-12226323298
StatusUnreviewed
Ensembl ProteinENSGALP00000009848
UniProt AccessionE1C1H4;
Protein Name
Protein Synonyms/Alias
Gene NameMAPK8
Gene Synonyms/Alias MAPK8;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000006109ENSGALP00000009848ENSGALT00000009862
OrganismGallus gallus
Functional Description
Protein Length429
Protein Sequence
(FASTA)
MSRSKRDNNF YSVEIGDSTF TVLKRYQNLK PIGSGAQGIV CAAYDAILER NVAIKKLSRP 60
FQNQTHAKRA YRELVLMKCV NHKNIIGLLN VFTPQKSLEE FQDVYIVMEL MDANLCQVIQ 120
MELDHERMSY LLYQMLCGIK HLHSAGIIHR DLKPSNIVVK SDCTLKILDF GLARTAGTSF 180
MMTPYVVTRY YRAPEVILGM GYKENDIVDL WSVGCIMGEM VCHKILFPGR DYIDQWNKVI 240
EQLGTPCPEF MKKLQPTVRT YVENRPKYAG YSFEKLFPDV LFPADSEHNK LKASQARDLL 300
SKMLVIDASK RISVDEALQH PYINVWYDPS EAEAPPPKIP DKQLDEREHT IEEWKELIYK 360
EVMDLEERTK NGVIRGQPAP LGAAMINGSQ HPSSSSSVND VSSMSTDPTL ASDTDSSLET 420
SAGPLGCCR 429
Nucleotide Sequence
(FASTA)
ATGAGCAGAA GCAAGCGTGA CAACAATTTC TACAGTGTTG AAATTGGAGA TTCTACATTC 60
ACTGTATTGA AACGGTATCA AAACTTAAAA CCAATAGGAT CGGGAGCGCA AGGAATAGTA 120
TGTGCAGCCT ATGATGCCAT CCTTGAGCGA AACGTTGCAA TCAAGAAACT AAGCCGACCA 180
TTTCAGAATC AAACCCATGC TAAAAGAGCC TACAGAGAGC TTGTTCTTAT GAAGTGCGTT 240
AATCACAAAA ATATAATCGG CTTACTGAAT GTGTTCACAC CACAGAAATC CCTGGAAGAA 300
TTTCAAGATG TCTACATAGT AATGGAGCTC ATGGATGCAA ATCTCTGCCA AGTGATTCAG 360
ATGGAGCTAG ACCATGAACG AATGTCCTAT CTCCTTTATC AGATGCTGTG TGGTATCAAA 420
CATCTTCACT CAGCTGGAAT TATACATAGG GACTTAAAGC CCAGTAATAT AGTAGTAAAG 480
TCAGACTGCA CTTTGAAGAT TCTTGACTTT GGACTGGCCA GAACTGCAGG AACTAGTTTT 540
ATGATGACGC CTTATGTAGT GACTCGTTAC TACAGAGCAC CAGAGGTCAT CCTAGGGATG 600
GGATACAAAG AAAACGACAT AGTGGATTTA TGGTCTGTGG GGTGCATTAT GGGCGAAATG 660
GTTTGCCACA AAATCCTCTT TCCAGGAAGG GACTATATTG ATCAATGGAA TAAAGTTATA 720
GAGCAGCTAG GAACACCGTG CCCAGAATTT ATGAAGAAAT TACAGCCCAC AGTTCGAACT 780
TATGTGGAGA ACAGACCCAA GTATGCTGGA TACAGCTTTG AGAAACTCTT TCCAGATGTC 840
CTTTTCCCAG CTGATTCTGA ACACAACAAA CTTAAAGCAA GTCAAGCAAG GGATTTGTTA 900
TCAAAAATGC TGGTTATAGA CGCCTCGAAA AGAATTTCTG TGGATGAAGC CCTCCAGCAC 960
CCATACATCA ATGTTTGGTA TGATCCATCA GAAGCCGAAG CTCCTCCACC AAAGATACCA 1020
GATAAGCAGT TAGATGAGAG GGAGCACACA ATAGAAGAAT GGAAAGAATT GATATACAAA 1080
GAAGTCATGG ACCTGGAGGA AAGAACCAAG AATGGGGTTA TACGTGGGCA GCCAGCCCCT 1140
TTAGGTGCAG CAATGATCAA TGGCTCTCAG CATCCATCTT CGTCGTCATC TGTCAACGAT 1200
GTGTCTTCAA TGTCAACGGA TCCAACATTG GCCTCTGATA CAGACAGCAG TCTAGAAACC 1260
TCAGCTGGAC CTCTGGGTTG CTGTAGATGA 1290
Domain Profile
S: 1     yeslkplgeGaygvvvsavdkrteervaikklsrpfqketsakrtlRElkllkelkheNi  60
         y++lkp+g+Ga+g+v++a+d+  e++vaikklsrpfq++t+akr++REl l+k+++h+Ni
Q: 26    YQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNI  85
         899*********************************************************
S: 61    iklldvftpeeeleelkdvYlvtelmetdLkkviksqklsdehiklllyqilrglkylHs  120
         i ll+vftp+++lee++dvY+v+elm+++L++vi+++ l++e++++llyq+l+g+k+lHs
Q: 86    IGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQME-LDHERMSYLLYQMLCGIKHLHS  144
         ************************************9.**********************
S: 121   anviHrDlKPsNllvnedcelkildFGlarsadkekekklteyvatrwYraPeillslk.  179
         a++iHrDlKPsN++v++dc+lkildFGlar+a ++ +  +t+yv+tr+YraPe++l +  
Q: 145   AGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFM--MTPYVVTRYYRAPEVILGMGy  202
         **********************************976..*****************8541
S: 180   eytkavDiWsvGCIlaElltgkplfpgkdeidqlekilevlgtpseeflkkieseearny  239
         + ++ vD+WsvGCI++E++ +k+lfpg+d+idq++k++e+lgtp  ef+kk++  ++r+y
Q: 203   KENDIVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQP-TVRTY  261
         334569************************************************.5****
S: 240   ikslpkkkkkdfeelfpk............aseealdLleklLvldpdkRisveeaLehp  287
         ++++pk++  +fe+lfp+            + ++a+dLl+k+Lv+d++kRisv+eaL+hp
Q: 262   VENRPKYAGYSFEKLFPDvlfpadsehnklKASQARDLLSKMLVIDASKRISVDEALQHP  321
         ******************************99****************************
S: 288   Yl  289
         Y+
Q: 322   YI  323
         *7
Domain Sequence
(FASTA)
YQNLKPIGSG AQGIVCAAYD AILERNVAIK KLSRPFQNQT HAKRAYRELV LMKCVNHKNI 60
IGLLNVFTPQ KSLEEFQDVY IVMELMDANL CQVIQMELDH ERMSYLLYQM LCGIKHLHSA 120
GIIHRDLKPS NIVVKSDCTL KILDFGLART AGTSFMMTPY VVTRYYRAPE VILGMGYKEN 180
DIVDLWSVGC IMGEMVCHKI LFPGRDYIDQ WNKVIEQLGT PCPEFMKKLQ PTVRTYVENR 240
PKYAGYSFEK LFPDVLFPAD SEHNKLKASQ ARDLLSKMLV IDASKRISVD EALQHPYI 298
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tupaia belangeri"; ?>Vicugna pacos"; ?>
EKS-AIM-00433
EKS-ANC-00452
EKS-CAJ-00470
EKS-CAF-00466
EKS-CAP-00497
EKS-DAR-00873
EKS-EQC-00453
EKS-FEC-00443
EKS-GAM-00270
EKS-GOG-00455
EKS-ICT-00440
EKS-LAC-00476
EKS-LOA-00470
EKS-MAM-00462
EKS-MEG-00380
EKS-MOD-00457
EKS-MUM-00498
EKS-MUP-00455
EKS-MYL-00456
EKS-ORC-00439
EKS-OTG-00472
EKS-PAT-00438
EKS-PES-00409
EKS-POA-00453
EKS-TAG-00527
EKS-TAS-00066
EKS-TUB-00050
EKS-VIP-00088
Gene Ontology
GO:0005829; C:cytosol
GO:0005739; C:mitochondrion
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0035033; F:histone deacetylase regulator activity
GO:0004705; F:JUN kinase activity
GO:0071260; P:cellular response to mechanical stimulus
GO:0043066; P:negative regulation of apoptotic process
GO:0032091; P:negative regulation of protein binding
GO:0018105; P:peptidyl-serine phosphorylation
GO:0018107; P:peptidyl-threonine phosphorylation
GO:0090045; P:positive regulation of deacetylase activity
GO:2000017; P:positive regulation of determination of dorsal identity
GO:0010628; P:positive regulation of gene expression
GO:0032880; P:regulation of protein localization
GO:0046686; P:response to cadmium ion
GO:0009411; P:response to UV
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR003527; MAP_kinase_CS.
IPR008351; MAPK_JNK.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS01351; MAPK; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
PR01772; JNKMAPKINASE.
Created Date20-Feb-2013