EKS-GAG-00220
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00220
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
Other/PLK387.24.0E-11644295252
StatusUnreviewed
Ensembl ProteinENSGALP00000009850
UniProt AccessionF1NCX7;
Protein Name
Protein Synonyms/Alias
Gene NamePLK1
Gene Synonyms/Alias PLK1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000006110ENSGALP00000009850ENSGALT00000009864
OrganismGallus gallus
Functional Description
Protein Length595
Protein Sequence
(FASTA)
MSAAGGKARP VAAVEPARAG GAAAAGGKEV PKVLLDPRTR RSHVRGRFLG KGGFARCYEL 60
TEAESRAVYA GIVVPQSLLA KPHQKEKMSM EIAIPRSPAH RQVVGFQSFL KDGDFVYVVP 120
ELCRLRSLLE LHKRRKALSE PEVRYYLRQI ILGCQYLHSQ RVIHRDLKLG NLFLSDDMEV 180
KIGDFGLATK VEYDGERKKT LCGTPNYIAP EVLGKKGHSF EVDIWSIGCI MYTLLVGKPP 240
FETSCLKETY IRIKKNEYTI PKHINPVAAN LIQKMLRSDP ATRPAINELL NDEFFTSGYI 300
PSRLPTSCLT VAPRFSIAPS TLELNGRKPL TALNKGPESP ALENLPEKED AAGLREVGDT 360
IECHLADMLQ QLTAVNSAKP SERTAVRQEE AEDPACIPIF WVSKWVDYSD KYGLGYQLCD 420
NSVGVLFNDS TRLIMYNDGD SLQYIEQNNT ESYFTVRSCP SALNKKITLL KYFRNYMSEH 480
LLKAGANITP REGDELARLP YLCTWFRTRS AIILHLSNGT VQINFFQDHT KVILCPLMAA 540
VTYIDEKRDF RTYKLSLIEE HGCCKELASR LRYARTMVEK LLSSKSGSAR VKSST 595
Nucleotide Sequence
(FASTA)
ATGAGCGCGG CGGGCGGCAA AGCCCGGCCG GTGGCGGCGG TGGAGCCGGC ACGAGCGGGC 60
GGCGCGGCGG CGGCGGGGGG CAAGGAGGTG CCGAAGGTGC TGTTGGACCC GCGGACGCGG 120
CGCAGTCACG TGCGGGGCCG CTTCCTGGGC AAGGGCGGGT TCGCGCGGTG TTATGAGCTG 180
ACAGAGGCCG AGAGCCGCGC GGTTTACGCG GGCATAGTGG TGCCCCAATC GTTGCTGGCC 240
AAGCCGCACC AGAAGGAGAA GATGTCCATG GAGATCGCCA TCCCCCGCAG CCCGGCGCAC 300
CGCCAGGTCG TCGGCTTCCA GAGCTTCTTA AAAGACGGCG ATTTCGTCTA CGTGGTGCCG 360
GAGCTGTGCC GCCTCCGGTC GCTGCTGGAG CTGCACAAGC GGCGGAAGGC GCTGAGCGAG 420
CCCGAGGTGC GCTACTACCT GCGGCAGATC ATCCTGGGCT GCCAGTACCT GCACAGCCAG 480
CGCGTCATCC ACCGCGACCT CAAGCTGGGC AACCTCTTCC TCAGCGACGA CATGGAGGTG 540
AAGATCGGTG ACTTTGGCCT GGCCACCAAA GTGGAGTATG ATGGCGAGCG CAAGAAGACC 600
CTGTGTGGGA CCCCCAACTA CATCGCCCCG GAGGTGCTGG GCAAGAAGGG GCACAGCTTT 660
GAGGTGGATA TATGGTCCAT TGGCTGCATC ATGTATACTC TGCTGGTGGG GAAACCACCT 720
TTTGAAACCT CTTGTCTCAA AGAAACATAC ATCCGAATCA AGAAGAATGA GTATACTATT 780
CCCAAGCACA TCAACCCCGT AGCTGCTAAC CTCATTCAGA AGATGCTGAG ATCTGACCCT 840
GCCACACGCC CGGCTATCAA CGAGTTGCTG AACGATGAGT TCTTCACATC AGGGTACATC 900
CCCAGCCGCC TGCCCACCAG CTGTCTCACT GTTGCACCTC GGTTTTCAAT CGCTCCCAGC 960
ACACTTGAAC TGAACGGGCG AAAGCCACTG ACAGCACTCA ACAAAGGACC AGAAAGCCCT 1020
GCATTAGAAA ACTTGCCTGA AAAGGAAGAT GCAGCTGGGC TGCGGGAGGT GGGAGACACC 1080
ATTGAGTGTC ACTTAGCAGA CATGTTACAG CAGCTGACTG CAGTCAACTC AGCCAAACCC 1140
TCTGAGAGAA CAGCAGTGAG ACAAGAAGAA GCTGAAGACC CAGCCTGTAT TCCCATCTTC 1200
TGGGTTAGCA AATGGGTGGA CTATTCGGAT AAGTATGGTC TAGGTTATCA GCTGTGTGAC 1260
AACAGTGTTG GAGTTCTCTT CAATGACTCC ACTCGTCTTA TCATGTACAA TGATGGGGAC 1320
AGCTTGCAGT ACATTGAGCA AAACAACACC GAGTCCTATT TCACTGTGAG ATCCTGTCCC 1380
TCTGCCTTGA ACAAGAAGAT AACACTATTG AAATACTTCA GGAACTACAT GAGTGAGCAC 1440
TTGCTGAAGG CAGGTGCTAA CATCACACCT CGGGAAGGAG ACGAGCTGGC ACGTTTACCC 1500
TACCTCTGCA CGTGGTTCCG GACCCGCAGT GCCATCATCC TGCACCTCAG CAATGGCACT 1560
GTGCAGATCA ACTTCTTCCA GGACCACACC AAAGTCATCT TGTGCCCTCT AATGGCTGCT 1620
GTCACATACA TAGATGAGAA ACGGGACTTC CGCACGTACA AGCTGAGCCT CATTGAGGAG 1680
CACGGATGCT GCAAGGAGCT GGCCAGCCGA CTACGCTATG CTCGCACCAT GGTGGAGAAG 1740
CTCCTCAGTT CGAAATCTGG CTCAGCCCGT GTGAAATCCT CCACTTAG 1788
Domain Profile
S: 2     ergkllGkGgfakcyelkdletkevfavkvvpksllakekqrekvekeieihrslkhkni  61
          rg++lGkGgfa+cyel+++e+++v+a  vvp+sllak++q+ek+++ei+i rs +h+++
Q: 44    VRGRFLGKGGFARCYELTEAESRAVYAGIVVPQSLLAKPHQKEKMSMEIAIPRSPAHRQV  103
         589*********************************************************
S: 62    vklyeffedkenvylvlelcsrrslaellkrrkaltepevryylrqivsglkylhekril  121
         v +++f++d ++vy+v elc+ rsl el+krrkal+epevryylrqi+ g++ylh++r++
Q: 104   VGFQSFLKDGDFVYVVPELCRLRSLLELHKRRKALSEPEVRYYLRQIILGCQYLHSQRVI  163
         ************************************************************
S: 122   hrdlklgnlflneelevkigdfGlatrlekeeerkktlcGtPnyiaPevlskkghslevd  181
         hrdlklgnlfl++++evkigdfGlat++e+++erkktlcGtPnyiaPevl kkghs+evd
Q: 164   HRDLKLGNLFLSDDMEVKIGDFGLATKVEYDGERKKTLCGTPNYIAPEVLGKKGHSFEVD  223
         ************************************************************
S: 182   iWslGcilytllvGkPPfetkelketyekikkaeyslPsslskeaksliakllkkePeer  241
         iWs+Gci+ytllvGkPPfet++lkety +ikk+ey++P+++++ a++li+k+l+++P+ r
Q: 224   IWSIGCIMYTLLVGKPPFETSCLKETYIRIKKNEYTIPKHINPVAANLIQKMLRSDPATR  283
         ************************************************************
S: 242   psleevlkdefl  253
         p+++e+l+def+
Q: 284   PAINELLNDEFF  295
         ***********8
Domain Sequence
(FASTA)
VRGRFLGKGG FARCYELTEA ESRAVYAGIV VPQSLLAKPH QKEKMSMEIA IPRSPAHRQV 60
VGFQSFLKDG DFVYVVPELC RLRSLLELHK RRKALSEPEV RYYLRQIILG CQYLHSQRVI 120
HRDLKLGNLF LSDDMEVKIG DFGLATKVEY DGERKKTLCG TPNYIAPEVL GKKGHSFEVD 180
IWSIGCIMYT LLVGKPPFET SCLKETYIRI KKNEYTIPKH INPVAANLIQ KMLRSDPATR 240
PAINELLNDE FF 252
KeywordComplete proteome; Reference proteome.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00244
EKS-ANC-00253
EKS-BOT-00261
EKS-CAE-00235
EKS-CAJ-00267
EKS-CAF-00268
EKS-CAP-00296
EKS-CII-00158
EKS-CIS-00035
EKS-DAR-00596
EKS-DRM-00134
EKS-ECT-00012
EKS-EQC-00256
EKS-FEC-00247
EKS-GAM-00161
EKS-GAA-00322
EKS-GOG-00259
EKS-HOS-00268
EKS-ICT-00246
EKS-LAC-00273
EKS-LOA-00271
EKS-MAM-00263
EKS-MAE-00014
EKS-MEG-00209
EKS-MIM-00017
EKS-MOD-00258
EKS-MUM-00291
EKS-MUP-00258
EKS-MYL-00262
EKS-ORN-00340
EKS-ORA-00231
EKS-ORC-00247
EKS-ORL-00317
EKS-OTG-00267
EKS-PAT-00248
EKS-PES-00234
EKS-POA-00254
EKS-RAN-00276
EKS-SAH-00247
EKS-TAG-00279
EKS-TAR-00335
EKS-TEN-00331
EKS-TUB-00014
EKS-TUT-00029
EKS-XET-00336
EKS-XIM-00332
Gene Ontology
GO:0005813; C:centrosome
GO:0000942; C:condensed nuclear chromosome outer kinetochore
GO:0030496; C:midbody
GO:0005876; C:spindle microtubule
GO:0005524; F:ATP binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0007092; P:activation of mitotic anaphase-promoting complex activity
GO:0051297; P:centrosome organization
GO:0000910; P:cytokinesis
GO:0031572; P:G2/M transition DNA damage checkpoint
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0001578; P:microtubule bundle formation
GO:0043066; P:negative regulation of apoptotic process
GO:0045736; P:negative regulation of cyclin-dependent protein kinase activity
GO:0000122; P:negative regulation of transcription from RNA polymerase II promoter
GO:0018105; P:peptidyl-serine phosphorylation
GO:0010800; P:positive regulation of peptidyl-threonine phosphorylation
GO:0031648; P:protein destabilization
GO:0071168; P:protein localization to chromatin
GO:0016567; P:protein ubiquitination
GO:0090007; P:regulation of mitotic anaphase
GO:0043393; P:regulation of protein binding
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000959; POLO_box_duplicated_dom.
IPR000719; Prot_kinase_cat_dom.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 1.
PF00659; POLO_box; 2.
SMARTs
SM00220; S_TKc; 1.
Prosites
PS50078; POLO_BOX; 2.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013