EKS-GAG-00236

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00236

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	412.4	1.0E-123	174	462	289

Status

Unreviewed

Ensembl Protein

ENSGALP00000009931

UniProt Accession

F1N8I2;

Protein Name

Protein Synonyms/Alias

Activin receptor type-2B;

Gene Name

ACVR2B

Gene Synonyms/Alias

ACVR2B;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000006158	ENSGALP00000009931	ENSGALT00000009945
ENSGALG00000006158	ENSGALP00000038024	ENSGALT00000038816
ENSGALG00000006158	ENSGALP00000030643	ENSGALT00000031280

Organism

Gallus gallus

Functional Description

Protein Length

496

Protein Sequence
(FASTA)

SGPGHGEAET RECIYYNANW ELEKTNQSGV ERCEGEKDKR LHCYASWRNN SGSIELVKKG 60

CWLDDFNCYD RQECVATEEN PQVFFCCCEG NYCNEKFTHL PEVTGPEVIY EPPPPTPSLL 120

NILVYSLLPI AVLSVAILLA FWMYRHRKPP YGHVDINEDP GPPPPSPLVG LKPLQLLEIK 180

ARGRFGCVWK AQLMNDYVAV KIFPIQDKQS WQSEREIFNT PGMKHENLLQ FIAAEKRGTN 240

LETELWLITA FHDKGSLTDY LKGNIISWNE LCHVAETMAR GLSYLHEDVP WCKGEGHKPA 300

IAHRDFKSKN VLLKNDLTAV LADFGLAVRF EPGKPPGDTH GQVGTRRYMA PEVLEGAINF 360

QRDAFLRIDM YAMGLVLWEL VSRCRAVDGP VDEYMLPFEE EIGQHPSLED LQEVVVHKKM 420

RPVFKDHWLK HPGLAQLCVT IEECWDHDAE ARLSAGCVEE RIAQIRKSVN GSTSDCLVSI 480

VTSVTNVDLP PKESSI 496

Nucleotide Sequence
(FASTA)

TCAGGACCAG GTCACGGGGA GGCAGAGACG AGGGAATGCA TTTACTACAA CGCCAACTGG 60

GAGCTGGAGA AGACCAACCA GAGTGGCGTG GAGCGCTGCG AGGGGGAGAA GGACAAGCGG 120

CTCCACTGCT ACGCCTCCTG GAGAAACAAC TCGGGATCCA TTGAGCTGGT GAAGAAAGGC 180

TGCTGGTTAG ATGACTTCAA CTGTTATGAC AGGCAGGAGT GCGTAGCCAC AGAAGAAAAC 240

CCTCAAGTGT TTTTCTGCTG CTGCGAGGGC AACTACTGCA ATGAGAAATT CACCCACTTG 300

CCTGAAGTAA CTGGCCCAGA AGTCATATAT GAGCCGCCAC CACCAACACC CTCCCTGCTT 360

AACATCCTGG TGTACTCTCT GCTGCCCATC GCTGTCCTGT CAGTGGCCAT CCTCTTGGCC 420

TTCTGGATGT ATCGGCACCG CAAGCCTCCC TACGGGCACG TTGACATCAA TGAGGACCCC 480

GGCCCACCAC CTCCTTCTCC CCTGGTTGGC CTAAAACCTC TACAGCTCCT GGAGATCAAA 540

GCCAGGGGAC GCTTTGGCTG CGTGTGGAAG GCTCAGCTGA TGAATGACTA CGTAGCAGTG 600

AAAATCTTCC CAATTCAGGA TAAGCAATCT TGGCAGAGTG AGAGGGAGAT TTTCAATACT 660

CCTGGCATGA AGCATGAAAA CCTTTTGCAA TTTATCGCAG CAGAAAAGAG AGGGACAAAC 720

CTAGAGACAG AGCTCTGGCT GATCACAGCG TTCCACGACA AGGGCTCTCT CACGGATTAC 780

CTGAAGGGCA ATATCATCAG CTGGAACGAG CTCTGCCATG TTGCAGAAAC CATGGCCCGT 840

GGCTTGTCTT ACCTCCATGA GGACGTCCCG TGGTGCAAGG GTGAAGGACA CAAACCTGCT 900

ATAGCACACA GGGACTTCAA GAGTAAAAAC GTCTTGCTGA AGAACGACTT AACGGCGGTG 960

CTAGCCGATT TTGGTCTTGC TGTACGGTTT GAACCTGGAA AACCTCCAGG GGACACCCAT 1020

GGACAGGTGG GAACAAGGAG GTATATGGCT CCTGAAGTGT TAGAGGGAGC AATCAACTTC 1080

CAACGAGACG CCTTCCTGAG AATAGACATG TACGCAATGG GACTGGTATT GTGGGAGTTA 1140

GTCTCCAGAT GTAGAGCAGT TGATGGTCCA GTGGATGAAT ACATGCTGCC TTTTGAAGAA 1200

GAAATAGGTC AGCACCCATC CCTTGAGGAC CTGCAAGAAG TGGTGGTTCA CAAGAAGATG 1260

CGCCCCGTCT TCAAGGATCA TTGGCTGAAA CACCCTGGCT TGGCGCAGCT CTGCGTGACC 1320

ATCGAAGAGT GCTGGGACCA CGACGCAGAG GCTCGGCTCT CGGCAGGCTG TGTCGAGGAG 1380

CGCATTGCTC AGATCCGCAA ATCCGTAAAC GGCTCTACCT CGGACTGCCT TGTCTCCATC 1440

GTGACGTCCG TCACCAACGT GGACTTGCCG CCCAAAGAGT CCAGTATCTA A 1491

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         l+lle+ ++Gr+g+Vwka+l++++vAvKif+ +d++sw++E+ei++t+ ++hen+lqfia

Q: 174   LQLLEIKARGRFGCVWKAQLMNDYVAVKIFPIQDKQSWQSEREIFNTPGMKHENLLQFIA  233

         6899********************************************************

S: 61    adkkeedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgtk  120

         a+k+ ++++tel+l+t++h+kgsL+dyLk ++++++el+++a+++a+Gl++LHe+++++k

Q: 234   AEKRGTNLETELWLITAFHDKGSLTDYLKGNIISWNELCHVAETMARGLSYLHEDVPWCK  293

         ************************************************************

S: 121   g.kkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekeeldlaansqvGtkRYmaP  179

         g  +KpaiaHRD+kskN+l+k+dlt+++aD+GLa+++e  k   d  ++ qvGt+RYmaP

Q: 294   GeGHKPAIAHRDFKSKNVLLKNDLTAVLADFGLAVRFEPGKPPGD--THGQVGTRRYMAP  351

         *99***************************************888..79***********

S: 180   EvleealnlkdfeafkraDvYslgLvlWEvasRceevdeeveeyklpfeevvgsdPslee  239

         Evle+a+n+++ +af r+D+Y++gLvlWE++sRc++vd+ v+ey+lpfee++g++Psle+

Q: 352   EVLEGAINFQR-DAFLRIDMYAMGLVLWELVSRCRAVDGPVDEYMLPFEEEIGQHPSLED  410

         **********9.9***********************************************

S: 240   mkevvvekklrPkipeawkkkealkelsklleecWdadpeaRltalrvkkrl  291

         ++evvv+kk+rP ++++w k++ l++l+ ++eecWd+d+eaRl+a +v++r+

Q: 411   LQEVVVHKKMRPVFKDHWLKHPGLAQLCVTIEECWDHDAEARLSAGCVEERI  462

         *************************************************985

Domain Sequence
(FASTA)

LQLLEIKARG RFGCVWKAQL MNDYVAVKIF PIQDKQSWQS EREIFNTPGM KHENLLQFIA 60

AEKRGTNLET ELWLITAFHD KGSLTDYLKG NIISWNELCH VAETMARGLS YLHEDVPWCK 120

GEGHKPAIAH RDFKSKNVLL KNDLTAVLAD FGLAVRFEPG KPPGDTHGQV GTRRYMAPEV 180

LEGAINFQRD AFLRIDMYAM GLVLWELVSR CRAVDGPVDE YMLPFEEEIG QHPSLEDLQE 240

VVVHKKMRPV FKDHWLKHPG LAQLCVTIEE CWDHDAEARL SAGCVEERI 289

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Choloepus hoffmanni"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009986	; C:cell surface
GO:0005737	; C:cytoplasm
GO:0016020	; C:membrane
GO:0017002	; F:activin-activated receptor activity
GO:0005524	; F:ATP binding
GO:0004712	; F:protein serine/threonine/tyrosine kinase activity
GO:0004702	; F:receptor signaling protein serine/threonine kinase activity
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0032147	; P:activation of protein kinase activity
GO:0030509	; P:BMP signaling pathway
GO:0030073	; P:insulin secretion
GO:0035265	; P:organ growth
GO:0032927	; P:positive regulation of activin receptor signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0009749	; P:response to glucose stimulus
GO:0023014	; P:signal transduction by phosphorylation

KEGG

InterPros

IPR000333	; Activin_II/TGFBeta-II_recpt.
IPR015768	; Activin_II_recpt.
IPR000472	; Activin_rcpt.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

PR00653

; ACTIVIN2R.

Created Date

20-Feb-2013