EKS-GAG-00313
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00313
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Src437.31.6E-131229479251
StatusUnreviewed
Ensembl ProteinENSGALP00000010524
UniProt AccessionE1BXA3;
Protein Name
Protein Synonyms/Alias
Gene NameHCK
Gene Synonyms/Alias HCK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000006522ENSGALP00000010524ENSGALT00000010538
OrganismGallus gallus
Functional Description
Protein Length494
Protein Sequence
(FASTA)
MGCVKSKEDS IQEKMQLGRG KKDPTSGSKQ HDEHRVPVPP PVDGSGDSVV LALYDYEAMH 60
SGDLSFKKGE RLQVLEQLGE WWQARSLLTG RKGFIPSNFV ARANSLEAEE WFFKSISRKD 120
AERQLLGPGN TLGSFMIRDS ETTKGCYSLS VRDGDSLQGG SVKHYRIRTL DSGGFYISSR 180
SSFDTLQELV KHYKGQSDGL CRRLTYPCSV PRPQKPWEKD AWEIPRASLK LEKKLGAGQF 240
GEVWMATYNK HTKVAVKTMK PGSMSVSAFL EEANLMKSLQ HDKLVRLHAV VTREEPIYII 300
TEFMEKGSLL DFLKSEEGNK QPLPKLIDFS AQIAEGMAYI EKRNYIHRDL RAANILVSAM 360
LVCKIADFGL ARIIEDNEYV AREGAKFPIK WTAPEAINYG SFTIKSDVWS FGILLTEIVT 420
YGRIPYPGMS SAEVIRALEH GYRMPRTESC PEELYDVMIR CWKTKPEDRP TFEYMQSILE 480
DFFTATEGQY QKQA 494
Nucleotide Sequence
(FASTA)
ATGGGTTGCG TGAAGTCAAA GGAAGACAGC ATCCAAGAGA AGATGCAGTT AGGCCGTGGT 60
AAGAAGGACC CCACGTCTGG CAGCAAGCAA CATGATGAAC ACAGAGTTCC CGTGCCCCCG 120
CCGGTGGATG GCTCAGGGGA CAGCGTGGTG CTGGCACTGT ACGACTACGA GGCGATGCAC 180
TCTGGGGACC TGAGCTTCAA GAAAGGGGAG AGGCTGCAGG TCCTGGAGCA GCTGGGAGAG 240
TGGTGGCAGG CACGGTCGCT GCTGACAGGG CGCAAGGGCT TCATCCCCAG CAACTTTGTT 300
GCCCGAGCTA ACTCACTGGA GGCAGAAGAG TGGTTCTTCA AGAGTATCAG CAGGAAGGAT 360
GCGGAGCGGC AGCTGCTCGG CCCTGGGAAC ACGTTGGGAT CCTTCATGAT TCGGGACAGT 420
GAGACGACCA AAGGTTGCTA CTCGTTGTCG GTGCGGGATG GGGACAGCCT GCAGGGAGGC 480
AGCGTCAAGC ACTACAGGAT CCGGACACTG GATAGTGGTG GCTTCTATAT CTCCTCACGC 540
AGCAGCTTCG ACACGCTTCA GGAGCTGGTG AAGCACTACA AGGGGCAGAG TGATGGGCTG 600
TGCCGAAGGC TCACCTACCC CTGCAGTGTG CCCAGACCCC AGAAGCCCTG GGAGAAAGAT 660
GCCTGGGAGA TTCCTCGGGC GTCACTGAAG CTGGAGAAGA AGCTGGGAGC CGGGCAGTTC 720
GGAGAAGTGT GGATGGCAAC GTACAACAAG CACACCAAGG TGGCAGTGAA GACAATGAAA 780
CCGGGCAGCA TGTCTGTGAG TGCCTTCCTG GAGGAGGCGA ACCTCATGAA GAGCCTGCAG 840
CATGACAAGC TGGTGAGGCT GCACGCCGTG GTCACCAGGG AGGAGCCCAT ATACATCATC 900
ACCGAGTTCA TGGAGAAAGG GAGCCTGCTG GACTTCCTGA AGAGTGAGGA AGGCAACAAG 960
CAGCCACTGC CAAAGCTGAT CGACTTCTCT GCACAGATTG CAGAAGGAAT GGCTTATATT 1020
GAGAAGAGGA ACTACATTCA CAGAGACCTG AGAGCTGCCA ACATTCTCGT GTCAGCGATG 1080
CTGGTGTGCA AGATTGCAGA CTTTGGGCTG GCCAGGATCA TTGAAGATAA TGAGTACGTA 1140
GCTCGGGAAG GTGCCAAGTT TCCCATTAAA TGGACTGCAC CAGAAGCAAT CAACTATGGA 1200
TCTTTCACTA TAAAATCCGA TGTCTGGTCC TTTGGGATCC TCCTGACTGA GATTGTTACC 1260
TACGGGCGCA TCCCATACCC AGGGATGTCG AGCGCGGAGG TGATCAGGGC CCTGGAGCAC 1320
GGCTACCGCA TGCCCCGCAC AGAAAGCTGC CCTGAGGAGC TTTACGATGT CATGATAAGA 1380
TGCTGGAAGA CCAAACCAGA GGACCGTCCC ACCTTTGAGT ACATGCAGAG CATTTTGGAG 1440
GATTTCTTTA CTGCGACGGA GGGCCAGTAC CAGAAGCAGG CATAG 1485
Domain Profile
S: 1     lklvkklGeGqfGevwlgkwkgsvkvavktlkegtlspeafleeaqilkklrheklvkly  60
         lkl+kklG+GqfGevw++++++++kvavkt+k+g++s +afleea+++k+l+h+klv+l+
Q: 229   LKLEKKLGAGQFGEVWMATYNKHTKVAVKTMKPGSMSVSAFLEEANLMKSLQHDKLVRLH  288
         689*********************************************************
S: 61    avvseeePiyivtelmakGslldflkeeegkklklpklvdlaaqvaeGmayleeknlihr  120
         avv++eePiyi+te+m+kGslldflk+eeg+k++lpkl+d++aq+aeGmay+e++n+ihr
Q: 289   AVVTREEPIYIITEFMEKGSLLDFLKSEEGNKQPLPKLIDFSAQIAEGMAYIEKRNYIHR  348
         ************************************************************
S: 121   dlaarnvlvgeslvvkvadfGlarlieddeytakegaklPikWtaPeaiklgkftiksdv  180
         dl+a+n+lv+  lv+k+adfGlar+ied+ey+a+egak+PikWtaPeai++g+ftiksdv
Q: 349   DLRAANILVSAMLVCKIADFGLARIIEDNEYVAREGAKFPIKWTAPEAINYGSFTIKSDV  408
         ************************************************************
S: 181   WsfGillteivtkGkvPypGmtneevleqvergyrlprpeecpeelyelllecwkkdpee  240
         WsfGillteivt+G++PypGm+++ev++++e+gyr+pr+e+cpeely+++++cwk++pe+
Q: 409   WSFGILLTEIVTYGRIPYPGMSSAEVIRALEHGYRMPRTESCPEELYDVMIRCWKTKPED  468
         ************************************************************
S: 241   rPtfetlqevl  251
         rPtfe++q++l
Q: 469   RPTFEYMQSIL  479
         *******9875
Domain Sequence
(FASTA)
LKLEKKLGAG QFGEVWMATY NKHTKVAVKT MKPGSMSVSA FLEEANLMKS LQHDKLVRLH 60
AVVTREEPIY IITEFMEKGS LLDFLKSEEG NKQPLPKLID FSAQIAEGMA YIEKRNYIHR 120
DLRAANILVS AMLVCKIADF GLARIIEDNE YVAREGAKFP IKWTAPEAIN YGSFTIKSDV 180
WSFGILLTEI VTYGRIPYPG MSSAEVIRAL EHGYRMPRTE SCPEELYDVM IRCWKTKPED 240
RPTFEYMQSI L 251
KeywordATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; SH3 domain; Transferase; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00343
EKS-ANC-00359
EKS-BOT-00369
EKS-CAJ-00373
EKS-CAF-00370
EKS-CAP-00404
EKS-DAR-00749
EKS-DIO-00065
EKS-EQC-00360
EKS-FEC-00356
EKS-GAA-00451
EKS-GOG-00360
EKS-HOS-00375
EKS-ICT-00350
EKS-LOA-00378
EKS-MAM-00369
EKS-MEG-00306
EKS-MIM-00060
EKS-MOD-00358
EKS-MUM-00401
EKS-MUP-00363
EKS-MYL-00369
EKS-NOL-00337
EKS-OCP-00073
EKS-ORN-00478
EKS-ORC-00347
EKS-ORL-00440
EKS-OTG-00371
EKS-PAT-00354
EKS-PEM-00194
EKS-PTV-00094
EKS-RAN-00383
EKS-SAH-00339
EKS-SOA-00006
EKS-SUS-00324
EKS-TAG-00442
EKS-TAR-00474
EKS-XET-00485
EKS-XIM-00467
Gene Ontology
GO:0005884; C:actin filament
GO:0005901; C:caveola
GO:0031234; C:extrinsic to internal side of plasma membrane
GO:0005925; C:focal adhesion
GO:0005764; C:lysosome
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043066; P:negative regulation of apoptotic process
GO:0018108; P:peptidyl-tyrosine phosphorylation
GO:0006909; P:phagocytosis
GO:2000251; P:positive regulation of actin cytoskeleton reorganization
GO:0008284; P:positive regulation of cell proliferation
GO:0046777; P:protein autophosphorylation
GO:0008360; P:regulation of cell shape
GO:0050764; P:regulation of phagocytosis
GO:0071801; P:regulation of podosome assembly
GO:0051090; P:regulation of sequence-specific DNA binding transcription factor activity
KEGG
InterPros
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR000980; SH2.
IPR001452; SH3_domain.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF07714; Pkinase_Tyr; 1.
PF00017; SH2; 1.
PF00018; SH3_1; 1.
SMARTs
SM00252; SH2; 1.
SM00326; SH3; 1.
SM00219; TyrKc; 1.
Prosites
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS50001; SH2; 1.
PS50002; SH3; 1.
Prints
PR00401; SH2DOMAIN.
PR00452; SH3DOMAIN.
PR00109; TYRKINASE.
Created Date20-Feb-2013