EKS-GAG-00006
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00006
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Eph513.49.1E-155622881260
StatusUnreviewed
Ensembl ProteinENSGALP00000010654
UniProt AccessionF1P4I4;
Protein Name
Protein Synonyms/Alias Ephrin type-B receptor 1;
Gene NameEPHB1
Gene Synonyms/Alias EPHB1;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000006609ENSGALP00000010654ENSGALT00000010668
OrganismGallus gallus
Functional Description
Protein Length987
Protein Sequence
(FASTA)
FYMLLLSLLL LLLFFFSLYK KTLMDTRTAT AELGWTANPP SGWEEVSGYD ENLNTIRTYQ 60
VCNVFEPNQN NWLLTTFINR RGAHRIYTEM RFTVRDCSSL PNVPGSCKET FNLYYYETDS 120
VIATKKSAFW TEAPYLKVDT IAADESFSQV DFGGRLMKVN TEVRSFGPLT RNGFYLAFQD 180
YGACMSLLSV RVFFKKCPSV VQNFAIFPET MTGAESTSLV TARGTCIPNA EEVDVPIKLY 240
CNGDGEWMVP IGRCTCKAGY EPENNVACKA CPAGTFKASQ GAGLCAPCPP NSRSSAEASP 300
LCACRNGYFR ADLDPPTAAC TSVPSGPRNV ISIVNETSII LEWNPPRETG GRDDVTYNIV 360
CKKCRADRRA CSRCDDNVEF VPRQLGLTET RVFISSLWAH TPYTFEIQAV NGVSNKSPFP 420
PQHVSVNITT NQAAPSTVPI MHQVSATMRS ITLSWPQPEQ PNGIILDYEL RYYEKDHNEY 480
NSSVARSQTN TARLEGLRPG MVYVVQVRAR TVAGYGKYSG KMCFQTLTDD DYKSELREQL 540
PLIAGSAAAG VVFIVSLVAI SIVCSRKRAY SKEAVYSDKL QHYSTGRAQG SPGMKIYIDP 600
FTYEDPNEAV REFAKEIDVS FVKIEEVIGA GEFGEVYKGR LKLPGKREIY VAIKTLKAGY 660
SEKQRRDFLS EASIMGQFDH PNIIRLEGVV TKSRPVMIIT EFMENGALDS FLRQNDGQFT 720
VIQLVGMLRG IAAGMKYLAE MNYVHRDLAA RNILVNSNLV CKVSDFGLSR YLQDDTSDPT 780
YTSSLGGKIP VRWTAPEAIA YRKFTSASDV WSYGIVMWEV MSFGERPYWD MSNQDVINAI 840
EQDYRLPPPM DCPAALHQLM LDCWQKDRNT RPRFAEIVNT LDKMIRNPAS LKTVATITAV 900
PSQPLLDRSI PDFTAFTSVE DWLSAVKMSQ YRDNFLSAGF TSLQLVAQMT SEDLLRIGVT 960
LAGHQKKILN SIQSMRVQMS QSPTSMA 987
Nucleotide Sequence
(FASTA)
TTCTATATGT TGTTGCTCTC ACTGTTATTG TTGTTACTCT TTTTTTTTTC CTTGTACAAG 60
AAAACCCTGA TGGACACACG GACAGCGACA GCTGAGCTGG GCTGGACTGC CAACCCTCCG 120
TCAGGGTGGG AAGAAGTGAG TGGCTACGAC GAGAACCTGA ACACCATCCG TACCTACCAG 180
GTGTGCAACG TCTTCGAGCC AAACCAGAAC AACTGGCTCC TCACCACCTT CATCAACCGG 240
CGCGGAGCCC ACCGCATCTA CACTGAGATG CGCTTCACTG TGCGGGACTG CAGCAGCCTC 300
CCCAACGTCC CCGGCTCCTG CAAGGAGACC TTCAACCTCT ACTACTATGA GACAGACTCT 360
GTCATTGCCA CTAAGAAGTC GGCCTTCTGG ACGGAGGCAC CCTACCTCAA AGTGGACACC 420
ATTGCTGCTG ACGAGAGCTT TTCCCAGGTG GACTTTGGTG GCAGGTTGAT GAAGGTGAAC 480
ACAGAAGTGA GAAGTTTTGG GCCCCTGACC CGCAATGGCT TTTACCTGGC TTTCCAGGAC 540
TACGGGGCTT GCATGTCTTT GCTCTCCGTC AGGGTTTTCT TCAAGAAGTG CCCAAGCGTG 600
GTGCAGAACT TCGCTATCTT CCCTGAGACG ATGACGGGGG CAGAGAGCAC CTCTCTGGTG 660
ACAGCACGGG GCACCTGCAT CCCCAACGCT GAGGAGGTGG ACGTGCCCAT CAAGCTGTAC 720
TGCAACGGGG ATGGGGAGTG GATGGTACCC ATAGGTCGCT GCACCTGCAA GGCTGGTTAT 780
GAGCCGGAAA ACAACGTGGC TTGCAAAGCC TGCCCGGCTG GGACATTCAA AGCCAGTCAG 840
GGTGCGGGGC TGTGTGCCCC GTGTCCCCCC AACAGCCGCT CCAGCGCTGA GGCCTCACCG 900
CTCTGCGCCT GCCGCAATGG CTACTTTCGG GCTGACCTGG ACCCACCGAC AGCTGCCTGC 960
ACCAGCGTCC CCTCTGGTCC ACGCAACGTC ATCTCCATTG TCAACGAGAC CTCCATCATC 1020
CTGGAGTGGA ACCCGCCACG GGAGACAGGA GGCCGGGATG ATGTCACTTA CAACATTGTC 1080
TGCAAGAAGT GCCGGGCAGA CCGGCGTGCC TGCTCCCGCT GCGACGACAA CGTGGAGTTT 1140
GTGCCCCGAC AGCTGGGGCT GACAGAGACC CGCGTCTTCA TCAGCAGCCT CTGGGCACAC 1200
ACACCCTACA CCTTTGAGAT CCAGGCGGTC AACGGGGTTT CCAACAAGAG CCCCTTCCCA 1260
CCCCAGCACG TCTCCGTGAA CATCACCACC AACCAAGCTG CACCCTCCAC TGTCCCCATC 1320
ATGCACCAGG TGAGTGCCAC CATGAGGAGC ATCACGCTGT CCTGGCCGCA GCCGGAGCAG 1380
CCCAACGGCA TCATCCTGGA CTACGAGCTG CGCTACTACG AGAAGGACCA CAACGAGTAC 1440
AACTCCTCTG TGGCCCGCAG TCAGACCAAC ACGGCCCGGC TGGAGGGGCT GCGCCCTGGC 1500
ATGGTGTACG TGGTGCAGGT GCGAGCACGG ACGGTGGCCG GCTATGGGAA GTACAGTGGG 1560
AAGATGTGCT TCCAGACGCT GACCGATGAT GACTACAAGT CTGAGCTGAG GGAGCAGCTG 1620
CCATTGATTG CGGGGTCTGC AGCGGCCGGC GTGGTCTTCA TTGTTTCGCT GGTGGCCATT 1680
TCCATAGTGT GCAGCAGGAA GCGAGCGTAC AGCAAGGAGG CGGTTTACAG CGATAAGCTG 1740
CAGCACTACA GCACCGGGAG AGCACAAGGG TCTCCGGGAA TGAAGATTTA CATCGACCCC 1800
TTCACTTATG AGGACCCCAA CGAGGCAGTG CGTGAGTTTG CCAAGGAGAT TGACGTCTCC 1860
TTTGTGAAGA TTGAAGAGGT CATTGGAGCA GGGGAGTTTG GAGAGGTGTA CAAAGGCCGC 1920
CTGAAGTTGC CTGGCAAGCG GGAGATCTAT GTGGCCATCA AAACACTGAA GGCTGGCTAC 1980
TCAGAGAAGC AGCGCCGGGA TTTCCTGAGC GAAGCCAGCA TCATGGGGCA GTTTGACCAC 2040
CCCAACATCA TCCGGCTGGA AGGGGTGGTG ACCAAGAGCC GACCAGTCAT GATTATCACA 2100
GAGTTCATGG AGAATGGGGC CCTGGACTCG TTCCTGCGGC AAAATGATGG GCAGTTCACA 2160
GTGATCCAGC TGGTGGGGAT GCTCAGAGGG ATTGCTGCTG GGATGAAGTA CCTGGCAGAG 2220
ATGAACTATG TCCACAGGGA TCTGGCGGCC AGGAACATTC TGGTCAACAG CAACCTGGTG 2280
TGCAAAGTGT CAGACTTTGG CCTCTCGCGC TACCTGCAGG ACGACACCTC TGATCCCACC 2340
TACACCAGCT CCTTGGGTGG GAAGATCCCT GTGCGATGGA CAGCACCAGA GGCCATTGCG 2400
TACCGCAAGT TCACGTCAGC CAGTGACGTC TGGAGCTATG GCATCGTCAT GTGGGAGGTG 2460
ATGTCGTTCG GAGAGAGGCC CTACTGGGAC ATGTCCAACC AGGACGTCAT CAATGCCATC 2520
GAGCAGGACT ACCGGCTCCC GCCGCCCATG GACTGCCCAG CTGCCCTGCA CCAACTGATG 2580
CTGGACTGCT GGCAGAAGGA CCGCAACACC CGGCCTCGCT TCGCCGAGAT TGTCAACACC 2640
CTGGACAAAA TGATCCGCAA CCCGGCAAGC CTCAAAACTG TGGCTACCAT CACCGCTGTG 2700
CCTTCTCAGC CCCTCCTCGA CCGCTCTATC CCTGATTTCA CTGCCTTTAC CTCAGTAGAA 2760
GACTGGCTGA GTGCCGTCAA GATGAGCCAG TATAGAGACA ACTTCCTGAG CGCTGGATTC 2820
ACCTCCCTCC AGCTGGTCGC CCAGATGACA TCTGAAGACC TCCTGAGAAT AGGAGTAACG 2880
CTGGCTGGGC ACCAGAAGAA GATCCTGAAC AGCATCCAGT CCATGCGCGT GCAGATGAGT 2940
CAGTCTCCGA CCTCGATGGC GTGA 2964
Domain Profile
S: 1     vkiekviGaGefGevcsGrlklpgkreiavaiktlkagstekqrrdflseasilGqfdhp  60
         vkie+viGaGefGev++Grlklpgkrei+vaiktlkag++ekqrrdflseasi+Gqfdhp
Q: 622   VKIEEVIGAGEFGEVYKGRLKLPGKREIYVAIKTLKAGYSEKQRRDFLSEASIMGQFDHP  681
         79**********************************************************
S: 61    niirleGvvtkskpvmivteymengaldsflrkkdgqftviqlvgmlrGiasgmkylsdm  120
         niirleGvvtks+pvmi+te+mengaldsflr++dgqftviqlvgmlrGia+gmkyl++m
Q: 682   NIIRLEGVVTKSRPVMIITEFMENGALDSFLRQNDGQFTVIQLVGMLRGIAAGMKYLAEM  741
         ************************************************************
S: 121   gyvhrdlaarnilvnsnlvckvsdfGlsrvledds.eaaytts.ggkipirwtapeaiay  178
         +yvhrdlaarnilvnsnlvckvsdfGlsr l+dd+ +++yt+s ggkip+rwtapeaiay
Q: 742   NYVHRDLAARNILVNSNLVCKVSDFGLSRYLQDDTsDPTYTSSlGGKIPVRWTAPEAIAY  801
         *******************************99999*****999****************
S: 179   rkftsasdvwsyGivlwevlsyGerpywdmsnqdvikaieegyrlpppmdcpaalyqlml  238
         rkftsasdvwsyGiv+wev+s+Gerpywdmsnqdvi+aie++yrlpppmdcpaal+qlml
Q: 802   RKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQDVINAIEQDYRLPPPMDCPAALHQLML  861
         ************************************************************
S: 239   dcwqkdraerpkfeqivsil  258
         dcwqkdr++rp+f++iv++l
Q: 862   DCWQKDRNTRPRFAEIVNTL  881
         *****************975
Domain Sequence
(FASTA)
VKIEEVIGAG EFGEVYKGRL KLPGKREIYV AIKTLKAGYS EKQRRDFLSE ASIMGQFDHP 60
NIIRLEGVVT KSRPVMIITE FMENGALDSF LRQNDGQFTV IQLVGMLRGI AAGMKYLAEM 120
NYVHRDLAAR NILVNSNLVC KVSDFGLSRY LQDDTSDPTY TSSLGGKIPV RWTAPEAIAY 180
RKFTSASDVW SYGIVMWEVM SFGERPYWDM SNQDVINAIE QDYRLPPPMD CPAALHQLML 240
DCWQKDRNTR PRFAEIVNTL 260
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Drosophila melanogaster"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00006
EKS-BOT-00012
EKS-CAJ-00005
EKS-CAF-00006
EKS-CAP-00013
EKS-CIS-00001
EKS-DRM-00001
EKS-FEC-00003
EKS-GAM-00002
EKS-GAA-00007
EKS-GOG-00005
EKS-ICT-00005
EKS-MAM-00005
EKS-MEG-00005
EKS-MIM-00001
EKS-MOD-00007
EKS-MUM-00006
EKS-MUP-00006
EKS-MYL-00006
EKS-NOL-00005
EKS-ORN-00008
EKS-ORC-00006
EKS-ORL-00006
EKS-OTG-00004
EKS-PAT-00006
EKS-PES-00006
EKS-POA-00004
EKS-RAN-00006
EKS-TAG-00013
EKS-TAR-00007
EKS-XET-00003
EKS-XIM-00006
Gene Ontology
GO:0030424; C:axon
GO:0031901; C:early endosome membrane
GO:0005887; C:integral to plasma membrane
GO:0045121; C:membrane raft
GO:0005524; F:ATP binding
GO:0008046; F:axon guidance receptor activity
GO:0005005; F:transmembrane-ephrin receptor activity
GO:0007411; P:axon guidance
GO:0031589; P:cell-substrate adhesion
GO:0030010; P:establishment of cell polarity
GO:0061351; P:neural precursor cell proliferation
GO:0070372; P:regulation of ERK1 and ERK2 cascade
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR001090; Ephrin_rcpt_lig-bd_dom.
IPR003961; Fibronectin_type3.
IPR008979; Galactose-bd-like.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001660; SAM.
IPR013761; SAM/pointed.
IPR021129; SAM_type1.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR011641; Tyr-kin_ephrin_A/B_rcpt-like.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016257; Tyr_kinase_ephrin_rcpt.
IPR001426; Tyr_kinase_rcpt_V_CS.
Pfam
PF01404; Ephrin_lbd; 1.
PF00041; fn3; 2.
PF07699; GCC2_GCC3; 1.
PF07714; Pkinase_Tyr; 1.
PF00536; SAM_1; 1.
SMARTs
SM00615; EPH_lbd; 1.
SM00060; FN3; 2.
SM00454; SAM; 1.
SM00219; TyrKc; 1.
Prosites
PS51550; EPH_LBD; 1.
PS50853; FN3; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00790; RECEPTOR_TYR_KIN_V_1; 1.
PS00791; RECEPTOR_TYR_KIN_V_2; 1.
PS50105; SAM_DOMAIN; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013