EKS-GAG-00015
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00015
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/InsR535.81.7E-1619991266268
StatusUnreviewed
Ensembl ProteinENSGALP00000011384
UniProt AccessionF1NG99;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameIGF1R
Gene Synonyms/Alias IGF1R;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000007039ENSGALP00000037696ENSGALT00000038491
ENSGALG00000007039ENSGALP00000037693ENSGALT00000038488
ENSGALG00000007039ENSGALP00000013783ENSGALT00000013798
ENSGALG00000007039ENSGALP00000011387ENSGALT00000011401
ENSGALG00000007039ENSGALP00000011384ENSGALT00000011398
OrganismGallus gallus
Functional Description
Protein Length1362
Protein Sequence
(FASTA)
MKSGAGGGTL AVFCGLLLAF AALCLGTNGE ICGPNVDIRN DIHELKRLEN CTVVEGFLQI 60
LLISKAEDYR NFRFPKLTVI TDYLLLFRVA GLESLSDLFP NLTVIRGRNL FYNYALVIFE 120
MTNLKEIGLH NLRNITRGAI RIEKNSDLCY LSTVDWSLIL DAVSNNYIVG NKPPKECGDL 180
CPGTMEEKPL CEKTSINNEY NYRCWTTNHC QKMCPSSCGK RACTDQNECC HPECLGSCTA 240
PDNNTACVAC RNYYYEGVCM PTCPPNTYKF EGWRCVTKEF CSKVPATETS DYERFVIHND 300
ECMAECPSGF IRNGSQSMFC SPCEGPCPKI CEDGKTKTID SVTSAQMLQG CTILKGNLLI 360
NIRRGNNIAS ELENFMGLIE TVTGYVKIRH SHALVSLSFL KNLRYILGEE QVDGNYSFYV 420
LDNHNLQQLW DWNHHNLTIK EGKMYFAFNP KLCVSEIYRM EEVSGTKGRQ SKGDINPRNN 480
GERASCESHI LRFVSNTTLK NRIKLTWERY RPPDYRDLIS FTVYYKEAPF KNVTEYDGQD 540
ACGSNSWNMV DVDLPPNKEN DPGILLQGLK PWTQYAIYVK AVTLTMMENH HIHGAKSEIV 600
YIRTNAAVPS IPLDVISASN SSSQLIVKWN PPSLPNGNLS YYIVRWQQQP QDSYLYRHNY 660
CSKDKVPIRR YADGTIDTEE ATEPTKPEGC GGEKGPCCAC PKTEAEKQAE KEEAEYRKVF 720
ENFLHNSIFV PRPDRKRRDV FRIANATLAT RNRNITGADH FTNASDAEES EVEYPFFETK 780
VDGKERTVIS HLQPFTLYRI DIHSCNHEAD TLGCSASNFV FARTMPSEGA DNIPGTVAWE 840
AKEENTVYLK WLEPTNPNGL ILMYEIKYGQ HGEEKRECVS RQEYKKLGGA KLTHLNPGNY 900
SARVQATSLA GNGSWTEPVS FYVQPKSANY DNFLHLIIVL PIAFLLIIGG LLIMLYVFNK 960
KRNSDRLGNG VLYASVNPEY FSASDVYVPD EWEVPREKIT MCRELGQGSF GMVYEGIAKG 1020
VVKDEPETRV AIKTVNESAS MRERIEFLNE ASVMKEFNCH HVVRLLGVVS QGQPTLVIME 1080
LMTRGDLKSY LRSLRPDTES NPGQAPPTLK KMIQMAGEIA DGMAYLNANK FVHRDLAARN 1140
CMVAEDFTVK IGDFGMTRDI YETDYYRKGG KGLLPVRWMS PESLKDGVFT THSDVWSFGV 1200
VLWEIATLAE QPYQGMTNEQ VLRFVMEGGL LEKPDNCPDM LFELMRMCWQ YNPKMRPSFL 1260
EIISSIKDEL DPAFKEVSFF YSEENKPPDT EELDLETENM ESIPLDPSST LQPTDKHSGH 1320
KAENGPGVVV LRASFEERQP YAHMNGGRKN ERALPLPQSS AC 1362
Nucleotide Sequence
(FASTA)
ATGAAGTCTG GCGCTGGAGG AGGGACCCTC GCCGTCTTCT GCGGGTTGCT GCTCGCCTTC 60
GCCGCGCTCT GCCTGGGGAC AAATGGGGAA ATTTGTGGGC CAAACGTTGA CATTCGCAAT 120
GATATCCATG AGCTGAAACG CCTGGAGAAC TGTACGGTCG TTGAGGGTTT CCTTCAGATC 180
CTGCTCATCT CTAAAGCAGA GGATTACCGC AACTTCCGCT TCCCGAAGCT GACCGTCATA 240
ACTGACTACT TGCTGCTGTT CCGTGTGGCG GGCTTGGAAA GCCTCAGCGA TCTCTTCCCC 300
AACCTCACGG TCATTCGCGG GAGGAACCTC TTCTACAACT ATGCCTTGGT GATCTTCGAA 360
ATGACAAATC TGAAGGAGAT CGGGCTTCAC AACTTGAGGA ACATAACCCG CGGGGCCATA 420
CGGATTGAGA AGAACTCTGA CCTGTGTTAC CTCTCCACAG TGGACTGGTC TCTCATCCTA 480
GATGCGGTCT CTAATAACTA CATTGTTGGA AATAAGCCTC CGAAGGAGTG CGGGGACTTG 540
TGTCCAGGAA CGATGGAGGA GAAGCCGTTG TGCGAGAAGA CCTCCATTAA CAACGAGTAC 600
AACTACCGCT GCTGGACCAC CAACCACTGC CAGAAAATGT GCCCCAGCTC ATGTGGCAAG 660
AGAGCCTGCA CAGACCAGAA TGAGTGTTGC CATCCTGAGT GCCTGGGGAG CTGCACAGCA 720
CCCGACAACA ACACTGCTTG CGTGGCCTGC CGGAATTACT ACTACGAAGG CGTCTGCATG 780
CCCACCTGCC CTCCCAACAC GTACAAGTTT GAGGGCTGGC GCTGTGTGAC CAAGGAGTTC 840
TGCTCCAAAG TCCCTGCCAC TGAAACAAGT GACTACGAGA GGTTTGTGAT TCACAACGAT 900
GAGTGCATGG CAGAGTGCCC CTCTGGATTC ATACGCAATG GGAGCCAAAG TATGTTCTGC 960
AGTCCTTGTG AGGGGCCTTG CCCCAAAATT TGTGAGGATG GGAAAACGAA GACCATTGAC 1020
TCTGTCACGT CAGCACAAAT GTTGCAGGGA TGCACAATTC TCAAGGGAAA TTTGCTGATC 1080
AACATCCGTC GTGGAAATAA CATCGCTTCA GAACTGGAGA ATTTCATGGG TCTGATTGAG 1140
ACCGTGACGG GATATGTGAA GATTCGCCAT TCCCATGCAT TAGTTTCCCT GTCCTTCTTG 1200
AAGAACCTGC GGTATATTCT GGGAGAGGAG CAGGTGGATG GGAATTATTC TTTTTATGTG 1260
CTTGATAACC ACAATCTGCA GCAACTGTGG GACTGGAACC ATCATAACTT GACGATCAAG 1320
GAGGGGAAAA TGTACTTTGC ATTTAATCCT AAACTGTGTG TTTCTGAGAT CTACCGTATG 1380
GAGGAAGTTT CAGGAACAAA AGGGCGACAG AGCAAAGGAG ATATAAATCC AAGGAACAAT 1440
GGGGAGAGAG CCTCTTGTGA AAGCCACATT CTGCGTTTTG TTTCCAACAC AACACTGAAG 1500
AATCGGATTA AACTGACGTG GGAGCGGTAT CGCCCTCCAG ATTACAGAGA TCTCATTAGC 1560
TTCACTGTTT ACTACAAAGA AGCGCCGTTC AAAAATGTGA CAGAGTATGA TGGACAAGAT 1620
GCGTGCGGCT CCAATAGCTG GAATATGGTT GATGTTGACT TGCCACCAAA CAAGGAGAAT 1680
GACCCTGGAA TCTTACTGCA GGGATTGAAA CCTTGGACTC AGTATGCCAT TTATGTCAAG 1740
GCTGTTACCC TCACAATGAT GGAGAACCAT CACATTCATG GAGCAAAAAG TGAAATTGTG 1800
TATATACGAA CCAATGCTGC AGTACCATCC ATTCCCTTAG ATGTTATTTC AGCATCCAAC 1860
TCCTCTTCCC AATTGATTGT GAAATGGAAT CCTCCCTCTC TTCCCAATGG CAACCTCTCA 1920
TACTATATTG TACGATGGCA GCAGCAACCT CAGGACAGTT ACCTTTACAG ACACAATTAC 1980
TGCTCCAAAG ATAAAGTCCC AATTCGAAGA TATGCTGATG GTACCATTGA TACAGAAGAA 2040
GCTACTGAAC CCACCAAGCC AGAGGGCTGT GGGGGAGAAA AAGGACCTTG TTGTGCTTGT 2100
CCCAAGACAG AGGCAGAAAA ACAAGCTGAG AAGGAGGAAG CGGAGTACCG GAAAGTCTTT 2160
GAGAACTTCC TTCACAACTC CATCTTTGTC CCCAGACCTG ATCGGAAGCG GAGGGATGTG 2220
TTCCGAATTG CAAATGCCAC TTTGGCCACT CGAAACAGGA ACATAACTGG GGCAGATCAC 2280
TTCACCAATG CTTCTGACGC AGAGGAGAGT GAGGTGGAAT ACCCGTTCTT TGAGACCAAA 2340
GTGGATGGCA AGGAGAGAAC TGTGATCTCC CATCTCCAGC CTTTTACTCT TTACCGCATT 2400
GATATTCACA GCTGCAACCA TGAAGCTGAC ACGCTTGGTT GCAGCGCTTC CAACTTTGTC 2460
TTTGCAAGAA CCATGCCTTC AGAGGGAGCA GATAACATTC CAGGAACAGT AGCATGGGAA 2520
GCAAAAGAAG AAAATACTGT CTACCTGAAG TGGTTAGAGC CTACAAATCC AAATGGGCTG 2580
ATACTGATGT ATGAAATCAA GTATGGGCAG CATGGGGAGG AGAAACGAGA ATGTGTTTCG 2640
AGACAGGAGT ACAAGAAGCT TGGAGGGGCA AAGCTGACAC ATCTGAACCC CGGAAACTAT 2700
TCTGCTAGAG TTCAGGCCAC GTCATTGGCT GGAAATGGAT CTTGGACTGA GCCAGTCTCT 2760
TTCTATGTAC AACCCAAATC AGCAAACTAT GACAACTTCC TCCATTTGAT AATTGTGCTC 2820
CCCATTGCTT TCCTGCTCAT CATTGGGGGT TTGCTGATAA TGCTGTATGT CTTTAACAAG 2880
AAGAGGAACA GTGACAGACT GGGCAATGGA GTACTTTATG CATCTGTGAA CCCTGAGTAC 2940
TTCAGTGCTT CGGATGTGTA CGTTCCAGAC GAATGGGAGG TGCCCCGCGA GAAGATCACC 3000
ATGTGCCGTG AGCTTGGGCA GGGCTCTTTT GGGATGGTCT ATGAGGGAAT AGCCAAGGGA 3060
GTGGTGAAGG ATGAGCCGGA GACCCGGGTG GCCATCAAAA CAGTCAATGA GTCTGCAAGC 3120
ATGCGTGAGA GGATAGAGTT CTTAAATGAG GCCTCGGTGA TGAAGGAGTT CAATTGTCAC 3180
CACGTGGTTC GCCTGCTAGG TGTTGTTTCT CAGGGCCAGC CTACCCTAGT TATCATGGAG 3240
CTGATGACAC GTGGGGACCT CAAAAGTTAC CTGAGATCAT TGAGGCCAGA CACAGAGAGT 3300
AATCCTGGCC AAGCACCTCC AACTCTGAAG AAGATGATTC AAATGGCAGG AGAGATTGCT 3360
GATGGGATGG CATACCTCAA CGCCAACAAA TTTGTTCACA GAGATCTTGC TGCGAGGAAC 3420
TGCATGGTGG CAGAAGATTT CACGGTGAAA ATCGGAGATT TTGGCATGAC AAGAGATATC 3480
TACGAGACAG ATTATTACCG GAAAGGAGGG AAAGGTTTGC TGCCCGTCCG CTGGATGTCC 3540
CCGGAATCAC TGAAGGATGG AGTCTTCACA ACACACTCCG ATGTCTGGTC TTTTGGTGTT 3600
GTACTTTGGG AGATCGCAAC ATTAGCGGAG CAGCCGTACC AAGGCATGAC CAATGAGCAA 3660
GTGCTCCGCT TTGTGATGGA AGGAGGTCTG CTGGAAAAAC CAGACAATTG CCCTGATATG 3720
CTGTTTGAAC TGATGCGCAT GTGCTGGCAG TACAACCCGA AGATGAGGCC GTCCTTCCTG 3780
GAAATCATCA GCAGCATTAA GGACGAGCTG GATCCGGCGT TCAAAGAGGT CTCCTTCTTC 3840
TACAGCGAAG AGAACAAGCC TCCGGACACA GAGGAGCTTG ACCTGGAGAC TGAGAACATG 3900
GAGAGCATTC CTTTAGATCC CTCCTCTACC CTCCAACCCA CTGACAAGCA CTCAGGACAC 3960
AAAGCCGAGA ACGGCCCGGG CGTGGTGGTC CTTCGGGCCA GCTTCGAGGA GAGACAGCCG 4020
TACGCACACA TGAACGGGGG ACGCAAGAAC GAGAGGGCCT TACCGCTGCC CCAGTCTTCG 4080
GCCTGCTGA 4089
Domain Profile
S: 1     ivllrelGqGsfGmvyeGvakdvvkgeeetrvaiktvneaassrerieflkeasvmkefk  60
         i++ relGqGsfGmvyeG+ak+vvk+e etrvaiktvne+as+reriefl+easvmkef+
Q: 999   ITMCRELGQGSFGMVYEGIAKGVVKDEPETRVAIKTVNESASMRERIEFLNEASVMKEFN  1058
         799*********************************************************
S: 61    thhvvrllGvvskgqpalvvmelmkkGdlksylrslrpeeeneaalappaldkliqmaae  120
         +hhvvrllGvvs+gqp+lv+melm++Gdlksylrslrp++e +++ app+l+k+iqma+e
Q: 1059  CHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPDTESNPGQAPPTLKKMIQMAGE  1118
         ************************************************************
S: 121   iadGmayleakkfvhrdlaarncmvaedltvkiGdfGmtrdiyetdyyrkggkgllpvrw  180
         iadGmayl+a+kfvhrdlaarncmvaed+tvkiGdfGmtrdiyetdyyrkggkgllpvrw
Q: 1119  IADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYETDYYRKGGKGLLPVRW  1178
         ************************************************************
S: 181   mspeslkdGvftsksdvwsfGvvlweivtlaeqpyqGlsneqvlkfvldggvlekpencp  240
         mspeslkdGvft++sdvwsfGvvlwei+tlaeqpyqG++neqvl+fv++gg+lekp+ncp
Q: 1179  MSPESLKDGVFTTHSDVWSFGVVLWEIATLAEQPYQGMTNEQVLRFVMEGGLLEKPDNCP  1238
         ************************************************************
S: 241   elltelmrlcwqynpklrpsfleivell  268
         ++l+elmr+cwqynpk+rpsflei++++
Q: 1239  DMLFELMRMCWQYNPKMRPSFLEIISSI  1266
         *************************976
Domain Sequence
(FASTA)
ITMCRELGQG SFGMVYEGIA KGVVKDEPET RVAIKTVNES ASMRERIEFL NEASVMKEFN 60
CHHVVRLLGV VSQGQPTLVI MELMTRGDLK SYLRSLRPDT ESNPGQAPPT LKKMIQMAGE 120
IADGMAYLNA NKFVHRDLAA RNCMVAEDFT VKIGDFGMTR DIYETDYYRK GGKGLLPVRW 180
MSPESLKDGV FTTHSDVWSF GVVLWEIATL AEQPYQGMTN EQVLRFVMEG GLLEKPDNCP 240
DMLFELMRMC WQYNPKMRPS FLEIISSI 268
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00013
EKS-BOT-00014
EKS-CAE-00002
EKS-CAJ-00017
EKS-CAF-00016
EKS-CAP-00015
EKS-CII-00007
EKS-DAR-00020
EKS-DRM-00003
EKS-EQC-00017
EKS-FEC-00015
EKS-GAA-00024
EKS-GOG-00020
EKS-HOS-00017
EKS-LOA-00014
EKS-MAM-00016
EKS-MEG-00016
EKS-MOD-00014
EKS-MUM-00014
EKS-MUP-00017
EKS-MYL-00017
EKS-NOL-00017
EKS-ORN-00025
EKS-ORA-00015
EKS-ORC-00015
EKS-ORL-00022
EKS-OTG-00015
EKS-PAT-00016
EKS-PES-00016
EKS-PEM-00008
EKS-POA-00015
EKS-RAN-00016
EKS-SAH-00013
EKS-SUS-00013
EKS-TAG-00014
EKS-TAR-00025
EKS-TEN-00027
EKS-TUT-00007
EKS-XET-00015
EKS-XIM-00025
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005886; C:plasma membrane
GO:0005524; F:ATP binding
GO:0043559; F:insulin binding
GO:0005010; F:insulin-like growth factor-activated receptor activity
GO:0006955; P:immune response
GO:0051389; P:inactivation of MAPKK activity
GO:0048009; P:insulin-like growth factor receptor signaling pathway
GO:0043066; P:negative regulation of apoptotic process
GO:0051898; P:negative regulation of protein kinase B signaling cascade
GO:0048015; P:phosphatidylinositol-mediated signaling
GO:0030335; P:positive regulation of cell migration
GO:0045740; P:positive regulation of DNA replication
GO:0043410; P:positive regulation of MAPK cascade
GO:0051897; P:positive regulation of protein kinase B signaling cascade
GO:0046777; P:protein autophosphorylation
GO:0051262; P:protein tetramerization
GO:0046328; P:regulation of JNK cascade
KEGG
InterPros
IPR000494; EGF_rcpt_L.
IPR003961; Fibronectin_type3.
IPR006211; Furin-like_Cys-rich_dom.
IPR006212; Furin_repeat.
IPR009030; Growth_fac_rcpt.
IPR013783; Ig-like_fold.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR016246; Tyr_kinase_insulin-like_rcpt.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00041; fn3; 1.
PF00757; Furin-like; 1.
PF07714; Pkinase_Tyr; 1.
PF01030; Recep_L_domain; 2.
SMARTs
SM00060; FN3; 3.
SM00261; FU; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 3.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013