EKS-GAG-00205

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00205

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CAMK/CAMKL	334.8	3.1E-100	1	226	226

Status

Unreviewed

Ensembl Protein

ENSGALP00000011556

UniProt Accession

F1N8N8;

Protein Name

Protein Synonyms/Alias

Gene Name

SIK3

Gene Synonyms/Alias

SIK3;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000007144	ENSGALP00000011556	ENSGALT00000011570

Organism

Gallus gallus

Functional Description

Protein Length

1284

Protein Sequence
(FASTA)

VAIKIIDKTQ LDDENLKKIF REVQIMKMLC HPHIIRLYQV METERMIYLV TEYASGGEIF 60

DHLVAHGRMA EKEARRKFKQ IVAAVNFCHC RNIVHRDLKA ENLLLDANLN IKIADFGFSN 120

IFTPGQLLKT WCGSPPYAAP ELFEGKEYDG PKVDIWSLGV VLYVLVCGAL PFDGSTLQNL 180

RARVLSGKFR IPFFMSTECE HLIRHMLVLD PSKRLSMDQI CKHKWMKLGE ADAEFDRLIA 240

ECQHLKTERQ MEPLNEDVLL AMAEMGLDKE RTIQSLRADA YDHYSAIYSL LCDRLKRHKN 300

LRIAPSPSIP RTVTFPTSAN IQQTEQAGNT MNINVPQVQL INPENQIVET DGTMNLDSDE 360

GEEPSPEALV RYLSMRRHTV GVADPRTEVM EDLQKLLPGF PRVTPQAPFL QVTPNVNFMH 420

NVLPRQNLQP TGQLEYKEQS LLQPPTLQLL NGMGPLGRRA SDGGANIQLH AQQLLKRPRG 480

PSPLVTMTPA VPAVTPVDEE SSDGEPDQEA VQRYLANRSK RHTLAMTNPT AEIPPDLQRQ 540

LGQQSFRPRA WAPHLVPDQH RSIYKDSNTL HLPTERFSPV RRFSDGAASI QAFKAHLEKM 600

GNNSSIKQLQ QECEQLQKMY GGHMDERTLE KTQQQHMLYQ QEQHHQILHQ QIQDCIRPPQ 660

PSPPLQAQCE NQPALLTHQL QRLRIQPSSP PPNHPNNHLF RQPNSSPPPV SSSVLQPHGA 720

ASQSQFQGMP SHNTIFPQSG NCSPPPTMGL TCLALQQQSQ AQQVTIQVQE PGDMVSNNLL 780

QGASVAGQGM SSHTRGMSIS PSANQIQMQH RANLMASLTY GHRQLSKQLS ADSAESHSLN 840

VYRNPPANYD QVHLHPHLFP EQPRVSPSNY SPSGGVGFPP AQQALKVPQL DQYPNFPQNA 900

HQQQQHYTAS ALQQALLSPT PPDYSRHQQV PHILQGLLSP RHSLTGHTDM RLPQAEFAQL 960

IKRRQQQQQQ QQQQQEFQEL FRHMSQGDAG NMGTSMGQSL SERQSLSLPY QSADTYHPQN 1020

SPQHLLKIRA QECIQQVPAS VPPHGYVHQP ALFHSESMEE DCACEGARDS FPDSKNSNTL 1080

TKGCHETPLL VNAGGHGDPE SLLGTANHVQ ELGTHQYRHQ PAAGFSRNKV PSRESVVGNC 1140

MDRSSPGQAM QVPDHNGLGY PARPASSEHP RPRTLQRHHT IQNSDDAYVQ LDNLPGMSLM 1200

AGKALSSARM SDAVLSQSSL MASQQLRDRE SDECGESLEG QEHPNLGDGN QHLNTSCYPS 1260

TCITDVLLSY KHPEVPFGME QAGV 1284

Nucleotide Sequence
(FASTA)

GTTGCTATAA AGATAATTGA TAAGACACAG CTGGATGACG AGAATCTGAA GAAGATATTT 60

AGAGAAGTTC AGATTATGAA GATGCTCTGC CATCCACATA TCATCAGGTT ATATCAGGTT 120

ATGGAGACAG AGAGGATGAT TTATCTAGTG ACAGAGTATG CTAGCGGAGG GGAAATATTT 180

GATCACTTGG TGGCCCACGG GCGCATGGCG GAGAAGGAAG CTCGGAGAAA GTTCAAGCAA 240

ATCGTGGCTG CTGTCAACTT CTGTCACTGC CGTAACATAG TTCACAGAGA TCTCAAAGCA 300

GAAAATCTTC TTCTGGATGC TAACCTTAAC ATCAAAATAG CAGACTTTGG GTTCAGTAAC 360

ATCTTCACAC CTGGCCAGCT GCTAAAAACG TGGTGTGGGA GTCCTCCCTA CGCTGCCCCG 420

GAGCTCTTTG AGGGGAAGGA ATACGATGGG CCCAAGGTTG ACATTTGGAG TCTTGGCGTG 480

GTGCTGTATG TGCTGGTCTG TGGTGCTCTG CCCTTCGATG GGAGCACACT GCAGAATCTG 540

CGTGCCAGGG TGCTCAGCGG GAAGTTTCGC ATTCCATTCT TCATGTCCAC AGAATGTGAA 600

CATCTGATCC GCCACATGCT GGTCTTGGAC CCAAGTAAGC GGCTCTCTAT GGACCAGATC 660

TGCAAACACA AGTGGATGAA GCTTGGGGAA GCTGATGCAG AGTTTGATAG GCTGATAGCA 720

GAGTGTCAGC ACCTGAAGAC AGAGAGGCAG ATGGAGCCAT TGAACGAGGA TGTGTTGTTA 780

GCTATGGCAG AAATGGGGCT GGACAAGGAA CGCACAATTC AGTCATTAAG AGCTGATGCT 840

TATGATCACT ACAGTGCAAT CTACAGCTTG CTCTGTGACC GTCTGAAGCG ACACAAGAAT 900

CTGCGCATTG CCCCATCTCC AAGTATACCA CGGACAGTGA CCTTCCCCAC CTCTGCTAAC 960

ATCCAGCAGA CAGAACAGGC AGGCAATACC ATGAACATCA ATGTGCCACA AGTCCAGCTC 1020

ATCAACCCTG AAAACCAAAT TGTGGAGACT GATGGAACAA TGAACCTGGA CAGCGATGAA 1080

GGGGAAGAAC CATCACCTGA AGCTCTGGTC CGTTACCTCT CTATGAGAAG GCACACGGTC 1140

GGAGTAGCTG ACCCACGGAC GGAGGTCATG GAAGATCTGC AGAAGCTCCT GCCTGGCTTC 1200

CCTCGTGTCA CTCCTCAGGC TCCATTCCTG CAGGTGACCC CAAATGTGAA CTTCATGCAC 1260

AATGTGCTGC CTAGGCAGAA CCTGCAGCCC ACGGGTCAGC TGGAATACAA GGAGCAGTCC 1320

CTGCTGCAGC CCCCCACTCT GCAGCTGTTG AATGGCATGG GCCCTCTGGG GCGGAGAGCA 1380

TCCGACGGTG GAGCTAACAT CCAGTTACAT GCACAGCAAC TGCTGAAACG TCCTCGAGGT 1440

CCATCTCCAC TCGTCACTAT GACTCCAGCC GTCCCAGCTG TCACTCCCGT GGACGAGGAG 1500

AGCTCTGATG GGGAGCCAGA TCAGGAAGCT GTGCAGAGAT ACTTGGCAAA TAGGTCAAAA 1560

AGGCACACTC TGGCAATGAC CAACCCTACA GCTGAAATCC CTCCAGACTT GCAGAGGCAG 1620

CTAGGACAGC AGTCCTTCCG ACCCCGGGCT TGGGCTCCAC ACCTGGTACC CGATCAGCAC 1680

CGTTCTATTT ACAAGGACTC CAATACTCTG CACCTCCCCA CCGAACGCTT CTCCCCGGTT 1740

CGGCGTTTCT CTGATGGTGC TGCCAGCATC CAGGCTTTCA AAGCCCACCT GGAGAAGATG 1800

GGCAATAACA GTAGCATCAA ACAGCTTCAG CAGGAATGTG AACAGCTTCA GAAGATGTAT 1860

GGTGGGCACA TGGATGAGAG GACACTGGAG AAGACACAGC AGCAGCACAT GCTGTACCAG 1920

CAAGAGCAGC ACCATCAGAT TCTTCATCAG CAGATCCAGG ACTGTATCCG GCCACCTCAG 1980

CCATCTCCAC CCTTGCAAGC TCAATGTGAA AACCAACCAG CTCTGCTCAC TCACCAGCTT 2040

CAGAGGTTAC GGATTCAGCC ATCCAGCCCA CCCCCAAACC ACCCTAATAA CCACCTCTTC 2100

AGGCAACCAA ACAGCAGCCC ACCTCCTGTG AGCAGCAGCG TGCTGCAGCC CCACGGTGCA 2160

GCCTCCCAGT CCCAGTTCCA AGGGATGCCA TCCCACAACA CAATCTTCCC GCAGTCTGGT 2220

AACTGTTCCC CTCCCCCAAC CATGGGGCTG ACGTGCCTGG CCCTGCAGCA GCAGTCCCAG 2280

GCCCAGCAGG TCACCATCCA AGTGCAGGAA CCCGGCGACA TGGTCAGCAA CAACCTCCTG 2340

CAAGGGGCCT CGGTGGCCGG GCAGGGCATG TCCTCCCACA CGCGGGGTAT GTCCATCAGC 2400

CCCAGTGCCA ACCAGATCCA GATGCAGCAC CGCGCCAACC TGATGGCCTC CCTCACCTAT 2460

GGCCACAGGC AGCTGTCCAA GCAGCTCAGC GCCGACAGCG CCGAGTCGCA CAGTCTGAAC 2520

GTGTACAGGA ATCCCCCCGC CAACTACGAC CAGGTGCACT TACACCCCCA CCTGTTCCCA 2580

GAGCAGCCTC GTGTTTCCCC CAGTAACTAC AGCCCATCAG GAGGAGTTGG ATTTCCTCCA 2640

GCTCAGCAAG CTCTCAAAGT CCCACAGCTT GACCAGTATC CCAATTTCCC TCAAAATGCA 2700

CATCAGCAAC AACAGCACTA CACCGCATCG GCACTACAGC AAGCACTGTT GTCCCCAACA 2760

CCTCCTGACT ACAGCCGACA CCAGCAGGTA CCGCACATCC TCCAGGGACT TCTTTCTCCC 2820

CGTCACTCTC TCACGGGGCA CACGGACATG CGGCTGCCCC AGGCAGAATT TGCACAGCTC 2880

ATCAAACGAC GGCAGCAGCA GCAACAGCAG CAGCAGCAGC AGCAAGAGTT TCAAGAATTG 2940

TTCAGGCACA TGAGTCAAGG GGATGCTGGG AACATGGGCA CCAGCATGGG ACAGAGCCTG 3000

TCGGAGCGTC AGTCGTTGTC TTTGCCTTAT CAGAGTGCTG ACACCTATCA TCCACAGAAC 3060

AGCCCCCAGC ATCTCTTAAA AATCAGGGCT CAAGAATGTA TCCAGCAGGT ACCTGCATCA 3120

GTGCCACCAC ACGGATACGT ACACCAGCCA GCTCTGTTCC ACTCGGAGAG CATGGAGGAG 3180

GACTGTGCGT GCGAGGGCGC CAGGGACAGC TTTCCAGACA GTAAGAATTC AAATACATTG 3240

ACCAAAGGTT GCCACGAGAC CCCTCTGCTT GTAAATGCAG GAGGGCATGG GGACCCAGAA 3300

TCTTTGCTAG GAACTGCTAA TCACGTTCAG GAGCTGGGGA CGCATCAATA CAGACATCAG 3360

CCCGCTGCTG GATTCAGTAG GAATAAGGTG CCCAGCAGAG AGTCCGTCGT AGGGAACTGT 3420

ATGGACAGGA GCTCCCCCGG CCAAGCGATG CAGGTGCCTG ACCACAACGG GCTGGGCTAC 3480

CCAGCACGGC CGGCGTCCAG CGAGCACCCG CGGCCCCGCA CCCTGCAGAG ACATCACACC 3540

ATCCAGAACA GTGATGATGC CTACGTGCAG TTAGATAACC TGCCTGGGAT GAGTTTAATG 3600

GCAGGAAAAG CACTCAGCTC TGCTCGGATG TCTGATGCCG TCCTCAGCCA GTCGTCGCTC 3660

ATGGCCAGCC AGCAGCTGCG TGACAGGGAG AGCGACGAAT GCGGGGAAAG TTTGGAAGGT 3720

CAAGAGCATC CCAACCTAGG TGATGGCAAC CAGCATCTAA ACACCTCTTG TTACCCATCG 3780

ACATGTATCA CAGATGTCCT ACTGAGCTAC AAGCACCCAG AGGTGCCCTT TGGGATGGAG 3840

CAGGCAGGGG TGTAA 3855

Domain Profile

S: 27    vavKiikkkklseeslekikrEieilkklkhpniikllevietkkklylvleyasggeLf  86

         va+Kii+k++l++e+l+ki+rE++i+k+l hp+ii+l++v+et++++ylv+eyasgge+f

Q: 1     VAIKIIDKTQLDDENLKKIFREVQIMKMLCHPHIIRLYQVMETERMIYLVTEYASGGEIF  60

         8***********************************************************

S: 87    dyieekgrlkekearklfkqlvsavkYlhskgivHrDlKpeNllldkkenikiaDFGlan  146

         d+++++gr+ ekear+ fkq+v+av+++h ++ivHrDlK+eNllld++ nikiaDFG++n

Q: 61    DHLVAHGRMAEKEARRKFKQIVAAVNFCHCRNIVHRDLKAENLLLDANLNIKIADFGFSN  120

         ************************************************************

S: 147   lfkegklletfcGsppYaaPellkgkkYegpkvDvWslGvvLyalvtgklPfdeenlkel  206

         +f++g+ll+t+cGsppYaaPel++gk+Y+gpkvD+WslGvvLy+lv+g+lPfd+++l++l

Q: 121   IFTPGQLLKTWCGSPPYAAPELFEGKEYDGPKVDIWSLGVVLYVLVCGALPFDGSTLQNL  180

         ************************************************************

S: 207   lekilkgkleipkklskelesLlrklLvvdpekRatieeilkhewl  252

         ++++l+gk++ip+ +s+e+e+L+r++Lv dp+kR+++++i kh+w+

Q: 181   RARVLSGKFRIPFFMSTECEHLIRHMLVLDPSKRLSMDQICKHKWM  226

         *********************************************8

Domain Sequence
(FASTA)

VAIKIIDKTQ LDDENLKKIF REVQIMKMLC HPHIIRLYQV METERMIYLV TEYASGGEIF 60

DHLVAHGRMA EKEARRKFKQ IVAAVNFCHC RNIVHRDLKA ENLLLDANLN IKIADFGFSN 120

IFTPGQLLKT WCGSPPYAAP ELFEGKEYDG PKVDIWSLGV VLYVLVCGAL PFDGSTLQNL 180

RARVLSGKFR IPFFMSTECE HLIRHMLVLD PSKRLSMDQI CKHKWM 226

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR015940	; UBA/transl_elong_EF1B_N_euk.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50030	; UBA; 1.

Prints

Created Date

20-Feb-2013