EKS-GAG-00172
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00172
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/MAST308.16.0E-9230296267
StatusReviewed
Ensembl ProteinENSGALP00000012119
UniProt AccessionE1C2I2;
Protein NameSerine/threonine-protein kinase greatwall
Protein Synonyms/Alias GW; GWL; Microtubule-associated serine/threonine-protein kinase-like; MAST-L;
Gene NameMASTL
Gene Synonyms/Alias MASTL; GW, GWL;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000007507ENSGALP00000012119ENSGALT00000012133
OrganismGallus gallus
Functional DescriptionSerine/threonine kinase that plays a key role in M phaseby acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited (By similarity).
Protein Length881
Protein Sequence
(FASTA)
MSTVEPLSDE GVAAGPRRIE VPRPPSIEEF TIVKPISRGA FGKVYLGRKA GRLYAVKVMK 60
KADMINKNMV HQVQAERDAL ALSKSPFIVH LYYSLQSANN VYLVMEYLIG GDVKSLLHIY 120
GYFDEEMAVK YISEAALALD YLHRHGIIHR DLKPDNMLIS NQGHIKLTDF GLSRVTLNRE 180
INMIDILTTP SMAKPKHDYS RTPGQLLSLI SSLGFYTPVG MKMPINPNSG GASDSLHEVI 240
SPLSMIEKEN TPLSTKLFKT GLDTSPLTPV MPVRSLTPAL LQSRERFGAS TASSQSCMYL 300
SSMESECCSS PRLEKDVKQT EDEMCSTGTS NSRPPLPSSR EVLNSKDPKV LKKELESAIS 360
PISSNDCGSR QKLGTERSEI TDTPVTTLDT KGIVRKCLSE NKIWEEKLVA RREMTNEMLE 420
TASSQQSPLF LKDPVQPVKE EEIFEKPGVK RSFELVDTSP CQELNYVKKT NAEYKRGCWI 480
SELSASKSTG LTTEIQSLML SGEICESKEI MRCIDRQQTE KPLVPTVAKN LLCDLDADHE 540
KDKEYMNSSL LCADDEKPLG ALSADSDLSF PETSVSESHL EKQLVDLDKG VKDLSFEEPK 600
AEDLLTMSPN CQEASRNGVE ADVVQNCTML CCEQDNHQKH TEETDTISSP SEKMTETVHL 660
FRKNNVVFRS YNSPINVSNV SDPCSMASLD IMDLSPACSG SYPTAITPLQ KTPRQGDAGT 720
PYRTPKSVRR GAAPVEGERI LGTPDYLAPE LLLTKPHGSA VDWWALGVCL FEFLTGIPPF 780
NDETPAQVFQ NILKRDIPWP EGEEKLSDNA QNAIDILLTF DSTKRAGLKE LKHHPLFHGV 840
DWDNLQNQPM PFIPQPDDET DTSYFEARNN AQHLTVSGFS L 881
Nucleotide Sequence
(FASTA)
ATGAGCACGG TAGAGCCGCT GTCGGATGAG GGCGTTGCTG CCGGCCCGAG GCGCATCGAG 60
GTTCCCCGGC CGCCCTCCAT CGAGGAGTTC ACCATCGTGA AGCCTATCAG CCGCGGCGCC 120
TTCGGGAAGG TGTACCTGGG CCGCAAGGCG GGCCGGCTGT ACGCCGTGAA GGTTATGAAG 180
AAAGCAGACA TGATCAATAA GAACATGGTT CACCAGGTCC AGGCAGAGAG GGATGCGTTG 240
GCTCTCAGCA AAAGTCCTTT TATTGTACAC TTATACTACT CGCTCCAGTC AGCCAATAAT 300
GTCTATTTGG TGATGGAGTA CCTTATTGGT GGTGATGTCA AATCTCTTCT CCATATTTAT 360
GGATATTTTG ATGAAGAAAT GGCTGTCAAG TATATTTCTG AGGCAGCACT GGCTCTTGAC 420
TATCTTCACA GACATGGGAT AATCCACAGG GATCTGAAGC CAGACAATAT GCTCATTTCC 480
AATCAGGGCC ACATAAAGCT GACAGATTTT GGGCTTTCCA GAGTTACTCT GAACAGAGAG 540
ATAAACATGA TAGATATCCT TACTACACCA TCAATGGCAA AGCCAAAACA TGACTACTCA 600
CGTACTCCAG GACAACTGTT GTCTCTTATC AGCTCTCTGG GTTTTTATAC TCCTGTTGGA 660
ATGAAAATGC CAATCAATCC CAATTCAGGT GGAGCATCTG ACAGTCTGCA TGAAGTGATT 720
TCACCCTTAT CTATGATCGA AAAGGAAAAC ACTCCTCTTT CAACTAAATT ATTCAAAACA 780
GGTCTGGATA CTTCTCCGTT AACTCCTGTT ATGCCAGTGA GAAGTTTGAC TCCTGCTCTG 840
CTTCAGTCAA GAGAAAGGTT TGGTGCCTCC ACTGCCAGTA GTCAGTCTTG CATGTATTTG 900
TCCAGTATGG AATCAGAATG CTGCAGCAGC CCCAGGTTGG AGAAAGATGT GAAGCAAACT 960
GAAGATGAGA TGTGTTCTAC GGGCACGAGT AACAGCAGAC CACCTCTCCC TTCTAGTAGA 1020
GAAGTACTAA ATAGCAAAGA TCCTAAAGTT CTTAAAAAAG AACTAGAATC TGCTATTTCT 1080
CCCATCAGTA GCAATGATTG TGGTAGCAGG CAGAAGCTGG GAACCGAACG TTCGGAAATA 1140
ACAGACACTC CAGTGACTAC GTTGGACACG AAAGGAATAG TAAGAAAGTG CCTCTCAGAA 1200
AACAAGATCT GGGAAGAAAA ACTCGTTGCA CGTAGAGAGA TGACCAATGA AATGTTAGAA 1260
ACTGCCAGTT CCCAACAGTC ACCTTTGTTC CTGAAAGATC CTGTCCAACC AGTCAAAGAA 1320
GAAGAAATTT TTGAGAAGCC GGGTGTAAAA AGAAGCTTTG AATTAGTCGA TACGAGTCCT 1380
TGTCAGGAAC TGAACTACGT TAAAAAAACA AATGCAGAAT ATAAACGTGG CTGTTGGATC 1440
TCAGAACTTT CAGCAAGCAA AAGTACGGGT TTGACAACTG AAATTCAATC CTTAATGCTC 1500
AGTGGTGAGA TCTGCGAAAG CAAAGAAATT ATGAGATGTA TTGATAGGCA ACAAACAGAG 1560
AAACCACTTG TTCCAACTGT AGCCAAAAAT CTTTTGTGTG ATCTGGATGC AGACCATGAA 1620
AAGGATAAAG AGTATATGAA CTCAAGTCTT TTGTGTGCTG ATGATGAAAA ACCTTTAGGA 1680
GCCCTGAGTG CAGATTCTGA CCTTTCGTTT CCTGAAACGT CTGTTTCCGA AAGCCATTTA 1740
GAAAAGCAGC TCGTAGATTT GGATAAAGGT GTTAAAGACC TCTCCTTTGA GGAACCTAAA 1800
GCAGAAGACT TGCTAACAAT GTCACCCAAC TGCCAAGAAG CTTCACGAAA TGGAGTGGAG 1860
GCGGATGTTG TTCAGAACTG CACGATGTTA TGTTGTGAGC AGGATAATCA CCAAAAACAC 1920
ACTGAAGAAA CTGACACCAT ATCGTCTCCT TCTGAAAAGA TGACGGAAAC AGTCCATCTC 1980
TTCAGAAAAA ATAATGTTGT TTTTCGAAGT TATAATAGTC CAATTAATGT ATCTAATGTG 2040
TCGGATCCAT GTAGCATGGC TTCTTTAGAC ATAATGGATC TTTCACCTGC TTGTAGTGGC 2100
TCTTACCCAA CAGCTATTAC TCCATTACAG AAAACACCTC GTCAGGGGGA TGCAGGCACA 2160
CCGTACAGGA CCCCAAAGAG TGTAAGAAGA GGAGCTGCCC CAGTGGAAGG TGAACGCATC 2220
CTGGGGACCC CAGACTATTT GGCACCTGAG CTGCTTTTGA CTAAGCCTCA TGGTTCTGCT 2280
GTAGACTGGT GGGCTCTCGG AGTTTGCCTG TTTGAGTTTC TAACTGGGAT TCCACCTTTT 2340
AATGATGAAA CACCAGCACA AGTCTTCCAG AATATTTTGA AAAGAGATAT TCCCTGGCCG 2400
GAGGGTGAAG AAAAGCTGTC TGACAATGCC CAAAATGCAA TAGATATTCT TCTAACCTTT 2460
GACAGTACTA AGAGAGCTGG ACTGAAGGAA CTGAAGCATC ACCCCCTCTT TCATGGAGTA 2520
GACTGGGATA ATCTACAGAA TCAGCCTATG CCTTTCATAC CACAGCCGGA TGATGAGACT 2580
GATACCTCTT ACTTTGAAGC TAGGAATAAC GCGCAGCACC TGACTGTGTC TGGATTTAGC 2640
CTATAG 2646
Domain Profile
S: 1     feiiklisrGayGavylvrhketrkrfavkkikkqdlilknqvqqvfaerdilalaenpf  60
         f+i+k+isrGa+G+vyl  ++++++++avk++kk+d+i+kn+v+qv+aerd+lal+++pf
Q: 30    FTIVKPISRGAFGKVYL--GRKAGRLYAVKVMKKADMINKNMVHQVQAERDALALSKSPF  87
         89***************..9****************************************
S: 61    vvslyysletrrnlylvmeyveGGdvksllkniGaldvemarlyiaevvlaleylhryGi  120
         +v+lyysl++++n+ylvmey++GGdvksll+++G++d+ema++yi+e +lal+ylhr+Gi
Q: 88    IVHLYYSLQSANNVYLVMEYLIGGDVKSLLHIYGYFDEEMAVKYISEAALALDYLHRHGI  147
         ************************************************************
S: 121   vhrdlkPdnllitseGhikltdfGlskvglmslttnlyegyidkdarefldkqvcgtPey  180
         +hrdlkPdn+li+++GhikltdfGls+v+l+          +++++ ++l     +tP++
Q: 148   IHRDLKPDNMLISNQGHIKLTDFGLSRVTLN----------REINMIDIL-----TTPSM  192
         *******************************..........9*****999.....*****
S: 181   iaPevilrqgygkpvdwwalgiilyeflvgivpffgdtpeelfaqvlsdeivwP....ek  236
         ++P    +++y++++++++++i++++f++++  +    p++  a+   +e++ P    ek
Q: 193   AKP----KHDYSRTPGQLLSLISSLGFYTPVGMKMPINPNSGGASDSLHEVISPlsmiEK  248
         ***....**********************9998877777655554444555555554455
S: 237   de.alssealelisellesnP..............rerlgtgsaaevkq  270
         ++ +ls+++ ++   +    P              rer+g+ s+a++++
Q: 249   ENtPLSTKLFKTGLDTSPLTPvmpvrsltpallqsRERFGA-STASSQS  296
         54478877776665555555588888888888888888888.4444444
Domain Sequence
(FASTA)
FTIVKPISRG AFGKVYLGRK AGRLYAVKVM KKADMINKNM VHQVQAERDA LALSKSPFIV 60
HLYYSLQSAN NVYLVMEYLI GGDVKSLLHI YGYFDEEMAV KYISEAALAL DYLHRHGIIH 120
RDLKPDNMLI SNQGHIKLTD FGLSRVTLNR EINMIDILTT PSMAKPKHDY SRTPGQLLSL 180
ISSLGFYTPV GMKMPINPNS GGASDSLHEV ISPLSMIEKE NTPLSTKLFK TGLDTSPLTP 240
VMPVRSLTPA LLQSRERFGA STASSQS 267
KeywordATP-binding; Cell cycle; Cell division; Complete proteome; Cytoplasm; Cytoskeleton; Kinase; Mitosis; Nucleotide-binding; Nucleus; Phosphoprotein; Reference proteome; Serine/threonine-protein kinase; Transferase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>
EKS-AIM-00191
EKS-ANC-00196
EKS-BOT-00202
EKS-CAJ-00208
EKS-CAF-00211
EKS-CAP-00226
EKS-CII-00126
EKS-CIS-00237
EKS-DAR-00511
EKS-DRM-00105
EKS-EQC-00196
EKS-FEC-00192
EKS-GAA-00250
EKS-GOG-00198
EKS-HOS-00208
EKS-ICT-00193
EKS-LAC-00213
EKS-LOA-00199
EKS-MAM-00204
EKS-MEG-00158
EKS-MOD-00199
EKS-MUM-00208
EKS-MUP-00207
EKS-MYL-00208
EKS-NOL-00191
EKS-ORN-00264
EKS-ORA-00181
EKS-ORC-00186
EKS-ORL-00242
EKS-OTG-00211
EKS-PAT-00195
EKS-PES-00182
EKS-PEM-00107
EKS-POA-00196
EKS-PRC-00077
EKS-PTV-00177
EKS-RAN-00200
EKS-SAH-00196
EKS-SOA-00059
EKS-SUS-00178
EKS-TAG-00227
EKS-TAR-00264
EKS-TEN-00260
EKS-XET-00228
EKS-XIM-00257
EKS-SAC-00058
EKS-SCP-00071
Gene Ontology
GO:0005813; C:centrosome
GO:0032154; C:cleavage furrow
GO:0005634; C:nucleus
GO:0005524; F:ATP binding
GO:0051721; F:protein phosphatase 2A binding
GO:0004674; F:protein serine/threonine kinase activity
GO:0051301; P:cell division
GO:0000086; P:G2/M transition of mitotic cell cycle
GO:0007067; P:mitosis
GO:0034048; P:negative regulation of protein phosphatase type 2A activity
GO:0051726; P:regulation of cell cycle
GO:0006974; P:response to DNA damage stimulus
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00069; Pkinase; 2.
SMARTs
SM00133; S_TK_X; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; FALSE_NEG.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
Prints
Created Date20-Feb-2013