EKS-GAG-00189

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00189

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	384.9	2.1E-115	69	363	295

Status

Unreviewed

Ensembl Protein

ENSGALP00000012448

UniProt Accession

Q5ZIF0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K1

Gene Synonyms/Alias

MAP2K1; RCJMB04_27f19;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000007687	ENSGALP00000012448	ENSGALT00000012462

Organism

Gallus gallus

Functional Description

Protein Length

395

Protein Sequence
(FASTA)

MPKKKPGPIQ LNPAPDGSAV NGTSSAETNL EALQKKLEEL ELDEQQRKRL EAFLTQKQKV 60

GELKDDDFEK ISELGAGNGG VVFKVSHKPS GLIMARKLIH LEIKPAIRNQ IIRELQVLHE 120

CNSPYIVGFY GAFYSDGEIS ICMEHMDGGS LDQVLKKAGR IPEQILGKVS IAVIKGLTYL 180

REKHKIMHRD VKPSNILVNS RGEIKLCDFG VSGQLIDSMA NSFVGTRSYM SPERLQGTHY 240

SVQSDIWSMG LSLVEMAIGR YPIPPPDSKE LELMFGCPVE GDSPVTETSP RQRTPGRPMS 300

SYGPDSRPPM AIFELLDYIV NEPPPKLPNG VFGSEFQDFV NKCLIKNPAE RADLKQLMIH 360

AFIKRSEAEE VDFAGWLCST IGLNQPSTPT HAAGV 395

Nucleotide Sequence
(FASTA)

ATGCCCAAGA AGAAGCCAGG GCCGATCCAG CTCAACCCCG CTCCGGATGG CTCCGCCGTC 60

AACGGGACCA GCTCTGCCGA GACAAACTTG GAAGCGCTTC AGAAGAAGCT GGAAGAGCTA 120

GAGCTGGATG AACAGCAAAG GAAGCGCCTT GAAGCTTTCC TTACCCAGAA ACAAAAAGTT 180

GGGGAGCTGA AGGATGATGA CTTCGAGAAG ATCAGTGAGC TGGGAGCAGG GAATGGTGGG 240

GTGGTGTTCA AAGTATCTCA CAAGCCTTCT GGCCTCATCA TGGCAAGAAA GTTGATTCAT 300

CTAGAAATCA AGCCAGCTAT TCGAAACCAG ATCATCCGTG AGCTGCAGGT TCTACATGAG 360

TGCAATTCAC CATACATAGT GGGCTTTTAT GGAGCTTTTT ACAGCGATGG GGAAATCAGC 420

ATTTGCATGG AACACATGGA TGGTGGCTCA TTGGATCAAG TGCTGAAAAA GGCTGGAAGA 480

ATTCCAGAGC AGATACTGGG CAAAGTCAGC ATTGCAGTAA TAAAAGGACT CACATATCTG 540

AGAGAAAAGC ATAAAATAAT GCACAGAGAT GTTAAACCAT CTAACATCTT GGTAAACTCT 600

AGAGGTGAGA TCAAGCTTTG TGATTTTGGT GTCAGTGGAC AACTGATAGA TTCTATGGCA 660

AACTCATTTG TTGGCACGCG CTCCTACATG TCTCCGGAAA GACTGCAGGG AACTCATTAT 720

TCAGTGCAGT CAGATATATG GAGTATGGGG CTGTCTCTGG TAGAAATGGC CATCGGCAGA 780

TACCCAATTC CTCCTCCTGA CTCTAAGGAG CTCGAGTTGA TGTTTGGCTG CCCGGTAGAG 840

GGAGATTCTC CAGTCACAGA GACCTCACCC AGGCAAAGAA CACCTGGTCG ACCAATGAGC 900

TCCTATGGAC CAGACAGCAG ACCCCCAATG GCAATCTTTG AACTTCTGGA TTACATCGTC 960

AATGAGCCAC CTCCAAAACT GCCCAATGGT GTCTTTGGTT CTGAATTTCA AGATTTTGTT 1020

AACAAATGTT TAATTAAAAA TCCTGCTGAG AGAGCTGATT TGAAGCAGCT GATGATTCAC 1080

GCTTTCATTA AGAGATCTGA AGCAGAGGAG GTGGATTTTG CAGGATGGCT TTGCTCAACC 1140

ATAGGCCTTA ACCAACCGAG TACACCCACG CATGCTGCTG GAGTCTGA 1188

Domain Profile

S: 2     ekleelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyiv  61

         ek++elGaGnggvV kv+hk+sg i+a+K i+leik+++++qi+rel+vl+++ nspyiv

Q: 69    EKISELGAGNGGVVFKVSHKPSGLIMARKLIHLEIKPAIRNQIIRELQVLHEC-NSPYIV  127

         799**************************************************.******

S: 62    kfyGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkek  121

         +fyGaf+s+g++sicme+mdg+sld+vlkk    ++ripe++lgk+++av+k+l+yl+ek

Q: 128   GFYGAFYSDGEISICMEHMDGGSLDQVLKK----AGRIPEQILGKVSIAVIKGLTYLREK  183

         *****************************9....8*************************

S: 122   lkiiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsv  181

         +ki+HRDvKPsNiLvns+Ge+KlCDFGvsgql+ds+A+s+vGt+sYm+PEr++g ++Ysv

Q: 184   HKIMHRDVKPSNILVNSRGEIKLCDFGVSGQLIDSMANSFVGTRSYMSPERLQG-THYSV  242

         ******************************************************.*****

S: 182   ksdvWslGltlvelatgrypyeklke..................................  207

         +sd+Ws+Gl+lve+a+gryp++++++

Q: 243   QSDIWSMGLSLVEMAIGRYPIPPPDSkelelmfgcpvegdspvtetsprqrtpgrpmssy  302

         ************************999*********************************

S: 208   .........ilellkaivneeppklpeeefseefqefvskClkkdekeRpklkellkhaf  258

                  i+ell++ivne+ppklp+  f +efq+fv+kCl+k+++eR++lk+l+ haf

Q: 303   gpdsrppmaIFELLDYIVNEPPPKLPNGVFGSEFQDFVNKCLIKNPAERADLKQLMIHAF  362

         ***********************************************************9

S: 259   i  259

Q: 363   I  363

Domain Sequence
(FASTA)

EKISELGAGN GGVVFKVSHK PSGLIMARKL IHLEIKPAIR NQIIRELQVL HECNSPYIVG 60

FYGAFYSDGE ISICMEHMDG GSLDQVLKKA GRIPEQILGK VSIAVIKGLT YLREKHKIMH 120

RDVKPSNILV NSRGEIKLCD FGVSGQLIDS MANSFVGTRS YMSPERLQGT HYSVQSDIWS 180

MGLSLVEMAI GRYPIPPPDS KELELMFGCP VEGDSPVTET SPRQRTPGRP MSSYGPDSRP 240

PMAIFELLDY IVNEPPPKLP NGVFGSEFQD FVNKCLIKNP AERADLKQLM IHAFI 295

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tupaia belangeri"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004708	; F:MAP kinase kinase activity
GO:0004674	; F:protein serine/threonine kinase activity
GO:0004728	; F:receptor signaling protein tyrosine phosphatase activity
GO:0007050	; P:cell cycle arrest
GO:0048870	; P:cell motility
GO:0090398	; P:cellular senescence
GO:0008285	; P:negative regulation of cell proliferation
GO:0045597	; P:positive regulation of cell differentiation

KEGG

gga:415549

;

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013