EKS-GAG-00192

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00192

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE7	334.7	4.4E-100	162	412	251

Status

Unreviewed

Ensembl Protein

ENSGALP00000012866

UniProt Accession

F1NUM0;

Protein Name

Protein Synonyms/Alias

Gene Name

MAP2K5

Gene Synonyms/Alias

MAP2K5;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000007930	ENSGALP00000012868	ENSGALT00000012883
ENSGALG00000007930	ENSGALP00000012841	ENSGALT00000012856
ENSGALG00000007930	ENSGALP00000012866	ENSGALT00000012881

Organism

Gallus gallus

Functional Description

Protein Length

441

Protein Sequence
(FASTA)

SRAMESHQVL VIRIKIPDGG AVDWTVHSAP QLLFRDVLDV IGQVLPDATT TAFEYEDEDG 60

DRITVRSDEE MKAMLSYYYS TVMEQQVNGQ LIEPLQIYPR ACKPPGKRNI HGLKVNTRAG 120

SANNSSSAVS DSLASNSLKK SSAELKKILA NGQMNEQDIR YRDILGHGNG GTVYKAYHVP 180

SGKILAVKVI PLDITLELQK QIMSELEILY KCDSSYIIGF YGAFFVENRI SLCTEFMDGG 240

SLDVYRKIPE HVLGRIAVAV VKGLTYLWSL KILHRDVKPS NMLVNTRGQV KLCDFGVSTQ 300

LVNSIAKTYV GTNAYMAPER ISGEQYGIHS DVWSLGISFM ELALGRFPYP QIQKNQGSLM 360

PLQLLQCIVD EESPVLPAGE FSEPFVHFIT QCMRKQPKER PAPEDLMGHP FIVQYNDGHA 420

EVVSMWVCRT LEERRSAQGA P 441

Nucleotide Sequence
(FASTA)

TCCCGCGCCA TGGAGAGCCA CCAGGTGCTG GTGATCCGCA TCAAGATCCC CGACGGCGGG 60

GCCGTGGACT GGACCGTGCA CTCGGCGCCC CAGCTGCTCT TCAGGGACGT GCTGGATGTC 120

ATCGGTCAAG TTCTGCCAGA TGCAACGACA ACAGCGTTTG AGTATGAAGA TGAGGACGGT 180

GATCGGATTA CTGTCAGAAG TGATGAAGAA ATGAAGGCCA TGCTGTCCTA TTATTACTCC 240

ACTGTAATGG AACAGCAAGT AAATGGACAG TTAATAGAGC CTCTCCAGAT ATATCCAAGA 300

GCCTGCAAGC CTCCTGGGAA ACGGAACATA CATGGCCTGA AGGTAAATAC GCGAGCAGGG 360

TCTGCTAATA ATAGCAGTTC CGCAGTCTCG GATTCCCTTG CAAGCAATAG CTTAAAGAAG 420

TCTTCTGCAG AGCTGAAGAA GATACTTGCT AATGGCCAGA TGAATGAACA AGACATACGG 480

TATCGAGACA TCCTCGGTCA TGGCAATGGA GGCACGGTCT ACAAGGCGTA CCACGTCCCT 540

AGTGGGAAAA TCCTGGCAGT AAAGGTCATA CCCTTGGATA TAACGCTGGA GCTCCAGAAA 600

CAGATCATGT CAGAGTTGGA GATTCTCTAT AAGTGCGACT CGTCATATAT CATAGGATTT 660

TATGGTGCTT TTTTTGTAGA AAACAGAATT TCTTTGTGTA CAGAGTTCAT GGATGGGGGT 720

TCTTTGGATG TTTATAGAAA AATTCCAGAG CACGTACTGG GAAGAATAGC AGTAGCTGTC 780

GTGAAAGGCC TTACGTATTT ATGGAGTCTG AAGATTTTGC ACAGAGACGT GAAGCCGTCC 840

AACATGCTGG TGAACACGCG AGGGCAGGTG AAGCTGTGTG ACTTCGGGGT GAGCACCCAG 900

CTGGTGAATT CTATAGCCAA GACGTATGTC GGAACAAATG CTTACATGGC GCCGGAACGG 960

ATTTCGGGAG AGCAATACGG GATTCATTCG GACGTTTGGA GTTTAGGGAT TTCCTTCATG 1020

GAGCTTGCTC TTGGGAGGTT TCCATATCCT CAGATTCAGA AAAACCAGGG ATCTTTAATG 1080

CCTCTCCAGT TATTGCAGTG CATTGTTGAT GAGGAGTCGC CCGTCCTTCC AGCCGGGGAG 1140

TTCTCGGAGC CATTTGTACA CTTCATCACT CAATGCATGA GAAAGCAACC AAAGGAAAGA 1200

CCAGCACCTG AAGATTTAAT GGGCCACCCC TTCATCGTGC AGTACAACGA CGGCCATGCA 1260

GAGGTGGTGT CCATGTGGGT GTGCAGGACG TTGGAGGAGC GGCGCTCAGC CCAGGGCGCA 1320

CCGTGA 1326

Domain Profile

S: 4     leelGaGnggvVekvlhkksgkilavKtirleikkeeqkqilrelevlkkssnspyivkf  63

          + lG+Gngg+V+k+ h +sgkilavK i l+i+ e qkqi++ele+l k+ +s+yi++f

Q: 162   RDILGHGNGGTVYKAYHVPSGKILAVKVIPLDITLELQKQIMSELEILYKC-DSSYIIGF  220

         5689***********************************************.********

S: 64    yGafvsegdvsicmelmdgtsldkvlkkvlekkkripekvlgkiavavvkaleylkeklk  123

         yGaf+ e+++s+c+e+mdg+sld v++k       ipe+vlg+iavavvk+l+yl+ +lk

Q: 221   YGAFFVENRISLCTEFMDGGSLD-VYRK-------IPEHVLGRIAVAVVKGLTYLW-SLK  271

         ***********************.6876.......9********************.78*

S: 124   iiHRDvKPsNiLvnskGevKlCDFGvsgqlvdsiAksavGtksYmaPEriegkkkYsvks  183

         i+HRDvKPsN+Lvn++G+vKlCDFGvs+qlv+siAk++vGt++YmaPEri+g ++Y ++s

Q: 272   ILHRDVKPSNMLVNTRGQVKLCDFGVSTQLVNSIAKTYVGTNAYMAPERISG-EQYGIHS  330

         ****************************************************.*******

S: 184   dvWslGltlvelatgrypyeklke......ilellkaivneeppklpeeefseefqefvs  237

         dvWslG++++ela gr+py++ ++      +l+ll++iv+ee+p+lp+ efse f++f++

Q: 331   DVWSLGISFMELALGRFPYPQIQKnqgslmPLQLLQCIVDEESPVLPAGEFSEPFVHFIT  390

         **********************9999**********************************

S: 238   kClkkdekeRpklkellkhafi  259

         +C++k++keRp  ++l+ h+fi

Q: 391   QCMRKQPKERPAPEDLMGHPFI  412

         *********************7

Domain Sequence
(FASTA)

RDILGHGNGG TVYKAYHVPS GKILAVKVIP LDITLELQKQ IMSELEILYK CDSSYIIGFY 60

GAFFVENRIS LCTEFMDGGS LDVYRKIPEH VLGRIAVAVV KGLTYLWSLK ILHRDVKPSN 120

MLVNTRGQVK LCDFGVSTQL VNSIAKTYVG TNAYMAPERI SGEQYGIHSD VWSLGISFME 180

LALGRFPYPQ IQKNQGSLMP LQLLQCIVDE ESPVLPAGEF SEPFVHFITQ CMRKQPKERP 240

APEDLMGHPF I 251

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005819	; C:spindle
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0000165	; P:MAPK cascade

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000270	; OPR_PB1.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00564	; PB1; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00666	; PB1; 1.
SM00220	; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013