EKS-GAG-00244

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00244

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
Other/BUB	347.7	3.9E-104	787	1053	267

Status

Unreviewed

Ensembl Protein

ENSGALP00000013385

UniProt Accession

F1NDM5;

Protein Name

Protein Synonyms/Alias

Gene Name

BUB1

Gene Synonyms/Alias

BUB1;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000008233	ENSGALP00000013385	ENSGALT00000013400

Organism

Gallus gallus

Functional Description

Protein Length

1086

Protein Sequence
(FASTA)

MDVEKIARSY EAQIQNYQGS DPLEPWDRYV QWVEGSLPPQ EKQKRLPRLL EQLVKAFVTD 60

KKYHQDGRFV NCCIKLAEFI NPPCVYFDYL CGQGIGTNTS AFYIAWAQQL VKEGLVQCAV 120

SVVQKGLRNQ AQPQENLQQL YCWLQNYDPW NPSLQGAATV KPLQTSNAEN QMAPHTGVTV 180

PDDLAYMCRN QGLDSAGTQS CSSDGRQQVT CVTYISKSGV LPTSLSSAVE CKQVAMYDKN 240

LLICEGSELS FEELRANRYF KKYVRFKKQK EQEEEEKEFV RKKEAAVLEL QALQQKLEQL 300

TQLTKSLEET RLEPASTTSV VPNKTEVHPH VALSAALQQN WMAPCQSSGL VPDQPQSSTL 360

LSKSLTLESA KPAGHWTTSA SLMKTPYKKD AITTQQELRE VQNGLLHPPF NNVSAQEQAQ 420

PDSAVQWSTR KEHSKKTSSI GLTTCTDVEV SRAGNASFAS GNASQATPNT SLGGAMQATP 480

FKVQPSPTVH TKEALGFLMD VFQTPVFPEL SPLEESEEQF EAFFCKSELD GTLKANVVAP 540

VVPMFSIFED EEEKENNGIP PPKSKTEEPR TIGERPLTDC IEEETRTPEF LQDDCIVWNA 600

SCTNKTLASC PNNTRDFTEA ARLVSTPFNY LSVRSRQALE DKASKNDLQQ MDWEFSEELH 660

KKAKTKKLSP ALKHIAEQGE CQGNAITTAA SHKLHEQITT SRAEYSSSVG VDKTSHEKLS 720

GTQQDSRTAR AGGASVLVEN PWDKELICKF LSELPKPLST YANYFEWKSV LPPIQARAEL 780

HLGSLSVCVD SLVGEGAFAQ VYQASVLNAS DPRSNQKVIF KVQKPANPWE FYIATQLVER 840

LDPSIHHLYI HLYSAHFFQN GSILIGELYN YGTLLNAINI YKKLPEKVMP QAFVIYFAVK 900

ILHMVEELHS CKIIHGDIKP DNFMLGEFLD NDTCDIDDLS HGLTLIDLGQ SIDMKLFPEG 960

TAFTAKCETS GFQCIEMLTQ KPWNYQTDYF GIAATVYCML FGTYMQVKNE SGVWKPEGSF 1020

RRLVNAELWK EFFDIMLNIP SCHSLPSLTA LRNRLKDLFC KSYAKEIKLL RRRLVVLLIE 1080

HKRSRK 1086

Nucleotide Sequence
(FASTA)

ATGGATGTGG AGAAGATCGC GCGAAGTTAC GAGGCGCAGA TCCAAAACTA CCAAGGGAGC 60

GACCCGCTGG AGCCATGGGA CAGGTACGTG CAGTGGGTAG AGGGCTCTCT CCCGCCGCAG 120

GAAAAACAGA AGCGCCTGCC GCGTCTCCTG GAGCAGCTTG TGAAGGCGTT CGTGACCGAC 180

AAGAAATATC ACCAGGATGG CAGATTTGTT AACTGCTGCA TTAAGCTGGC AGAGTTCATC 240

AACCCTCCTT GCGTGTATTT TGACTACCTG TGCGGTCAGG GAATTGGTAC AAATACCTCT 300

GCCTTCTATA TTGCTTGGGC TCAGCAGCTT GTAAAAGAGG GCCTTGTGCA GTGTGCAGTA 360

TCTGTTGTTC AAAAAGGACT TCGCAACCAG GCACAACCAC AAGAGAACCT GCAACAGCTG 420

TATTGCTGGC TGCAGAATTA TGATCCTTGG AATCCTTCTC TGCAAGGTGC TGCTACTGTA 480

AAACCACTTC AAACTTCAAA TGCTGAAAAT CAAATGGCTC CTCACACAGG TGTTACAGTT 540

CCTGATGATC TGGCATACAT GTGCAGAAAT CAGGGTCTTG ATTCTGCTGG TACTCAGTCC 600

TGCTCTTCTG ATGGAAGACA ACAAGTAACA TGTGTTACAT ACATCTCTAA ATCTGGAGTT 660

CTTCCTACAT CATTGTCTTC TGCTGTGGAA TGCAAACAGG TTGCAATGTA TGATAAAAAT 720

CTTCTCATTT GTGAAGGCTC TGAACTTTCA TTTGAGGAGC TGAGAGCCAA CCGATACTTC 780

AAGAAATACG TGCGCTTCAA GAAACAAAAA GAACAGGAAG AGGAAGAGAA GGAGTTTGTA 840

AGGAAAAAGG AGGCAGCTGT CCTCGAACTG CAAGCCCTGC AGCAGAAGCT GGAACAGCTC 900

ACTCAGCTCA CCAAAAGCTT GGAGGAAACT AGGCTGGAAC CTGCATCTAC AACATCCGTT 960

GTGCCAAATA AGACAGAGGT GCATCCCCAT GTGGCACTCA GTGCAGCTCT GCAGCAGAAC 1020

TGGATGGCAC CTTGCCAAAG CTCAGGTCTG GTACCAGACC AGCCTCAGTC AAGTACTTTG 1080

TTATCAAAAT CTCTTACACT GGAGTCAGCA AAACCAGCTG GCCACTGGAC GACATCAGCC 1140

TCCCTGATGA AAACACCATA CAAGAAGGAT GCAATCACAA CTCAACAGGA GCTTAGAGAA 1200

GTCCAGAATG GATTGCTACA CCCTCCATTC AACAATGTTT CAGCTCAGGA ACAGGCACAA 1260

CCTGACTCAG CTGTTCAGTG GAGTACCAGA AAAGAGCACT CTAAAAAGAC ATCATCCATT 1320

GGACTAACTA CGTGCACAGA TGTGGAAGTA TCTAGAGCTG GAAATGCTTC CTTTGCTTCT 1380

GGAAATGCTT CTCAGGCTAC ACCAAACACC TCACTGGGAG GAGCAATGCA GGCAACACCA 1440

TTCAAAGTGC AACCTTCACC AACAGTTCAT ACAAAAGAAG CATTGGGATT TCTAATGGAT 1500

GTATTTCAAA CACCTGTCTT CCCTGAATTA TCTCCTCTTG AAGAAAGCGA GGAGCAATTT 1560

GAAGCCTTTT TCTGCAAAAG TGAGCTTGAT GGAACCTTGA AAGCAAATGT CGTCGCCCCC 1620

GTTGTACCCA TGTTTTCTAT CTTTGAAGAT GAAGAGGAAA AAGAGAACAA TGGGATTCCA 1680

CCACCAAAAA GCAAGACAGA AGAGCCCAGA ACTATTGGAG AGCGTCCCTT GACTGACTGC 1740

ATAGAAGAAG AGACAAGGAC ACCAGAGTTC TTGCAGGATG ATTGTATAGT GTGGAATGCA 1800

TCATGTACTA ATAAAACGTT AGCTTCCTGT CCAAACAACA CAAGAGACTT TACAGAAGCT 1860

GCCCGGCTTG TATCAACACC GTTTAATTAC CTGTCAGTGC GTTCACGGCA AGCTTTGGAG 1920

GACAAAGCTT CCAAGAATGA CTTGCAGCAA ATGGATTGGG AATTTTCTGA AGAACTGCAC 1980

AAGAAGGCAA AAACTAAGAA GCTAAGCCCT GCTCTTAAAC ACATTGCAGA ACAAGGAGAG 2040

TGTCAAGGAA ATGCCATCAC TACAGCTGCT TCTCACAAAT TACATGAGCA GATTACCACT 2100

AGTAGAGCTG AATATTCTTC ATCTGTTGGG GTGGACAAGA CTTCTCATGA AAAACTCTCT 2160

GGAACTCAGC AGGACAGCAG AACAGCCAGG GCTGGTGGAG CTTCAGTCCT TGTTGAGAAC 2220

CCTTGGGATA AGGAATTGAT TTGCAAATTC TTATCAGAGC TCCCTAAGCC ACTCAGTACC 2280

TATGCCAACT ACTTTGAATG GAAATCTGTT CTTCCACCTA TCCAAGCGAG GGCTGAACTC 2340

CATCTTGGTT CCCTCTCAGT CTGTGTGGAC AGCTTGGTTG GAGAAGGAGC TTTTGCTCAA 2400

GTCTACCAGG CTTCTGTTCT GAACGCGAGT GACCCTAGAA GCAATCAGAA AGTAATATTC 2460

AAGGTCCAGA AACCTGCCAA TCCTTGGGAA TTCTACATAG CAACTCAACT GGTAGAAAGA 2520

CTCGATCCAA GTATACACCA TCTTTATATC CACCTTTATT CTGCTCATTT CTTTCAAAAT 2580

GGAAGTATTT TGATTGGTGA GCTCTATAAC TATGGAACTT TGCTGAATGC CATAAACATT 2640

TACAAAAAGC TTCCTGAAAA GGTGATGCCT CAAGCATTTG TAATCTATTT TGCTGTGAAA 2700

ATTCTTCATA TGGTAGAAGA GCTCCATAGC TGCAAAATCA TTCATGGTGA CATTAAACCC 2760

GATAATTTCA TGCTTGGAGA ATTTCTGGAC AATGATACAT GTGACATAGA TGATCTCTCA 2820

CATGGCCTGA CGCTCATTGA TTTGGGACAG AGTATAGATA TGAAACTCTT TCCTGAAGGA 2880

ACTGCATTTA CTGCAAAGTG TGAAACATCT GGGTTCCAGT GTATTGAAAT GCTGACCCAG 2940

AAACCATGGA ACTACCAGAC AGACTACTTT GGCATTGCAG CAACTGTCTA CTGCATGCTG 3000

TTTGGTACTT ACATGCAAGT GAAGAATGAA AGTGGTGTCT GGAAGCCTGA AGGATCTTTC 3060

AGAAGGCTTG TCAATGCTGA ACTGTGGAAA GAGTTCTTTG ACATCATGCT AAACATACCA 3120

AGTTGCCATA GCCTGCCTTC TTTAACCGCT TTGCGCAACA GACTGAAGGA CTTATTTTGC 3180

AAGTCGTATG CAAAGGAAAT AAAGCTCCTT AGGAGAAGAC TTGTTGTGTT GCTCATAGAG 3240

CACAAACGGT CACGAAAATA G 3261

Domain Profile

S: 1     leiekeigeGayakvykaeh....dsksgelvalKvekpansWefYIclqlkeRlkeeel  56

         ++++ ++geGa+a+vy+a      d +s+++v+ Kv+kpan+WefYI +ql eRl  +++

Q: 787   VCVDSLVGEGAFAQVYQASVlnasDPRSNQKVIFKVQKPANPWEFYIATQLVERLD-PSI  845

         5899**************999888899****************************9.78*

S: 57    lksiieissallfqdasllvleyasygtlldlinkvkevtnkvmdeelvvllivqllkiv  116

         ++ +i+++sa+ fq++s+l+ e+++ygtll++in +k+  +kvm+++ v++++v++l++v

Q: 846   HHLYIHLYSAHFFQNGSILIGELYNYGTLLNAINIYKKLPEKVMPQAFVIYFAVKILHMV  905

         ************************************************************

S: 117   eklHeveIiHgDlkPdnfllgnrimdkad.kdkeekglkliDfgrsiDmkllpdgtkfkg  175

         e+lH+++IiHgD+kPdnf+lg+ +++ ++  d+ ++gl liD+g+siDmkl+p+gt+f++

Q: 906   EELHSCKIIHGDIKPDNFMLGEFLDNDTCdIDDLSHGLTLIDLGQSIDMKLFPEGTAFTA  965

         ********************98887665548999**************************

S: 176   kaktdafeciemlagkswsYqvDlfglaavihvllfgkyleviqeggswklkqkikrllk  235

         k++t++f+cieml+ k+w+Yq+D+fg+aa+++++lfg+y++v++e+g wk++ +++rl++

Q: 966   KCETSGFQCIEMLTQKPWNYQTDYFGIAATVYCMLFGTYMQVKNESGVWKPEGSFRRLVN  1025

         ************************************************************

S: 236   kelwekiferlLNisdastlpsleelve  263

          elw+++f+ +LNi+++++lpsl  l++

Q: 1026  AELWKEFFDIMLNIPSCHSLPSLTALRN  1053

         *************************994

Domain Sequence
(FASTA)

VCVDSLVGEG AFAQVYQASV LNASDPRSNQ KVIFKVQKPA NPWEFYIATQ LVERLDPSIH 60

HLYIHLYSAH FFQNGSILIG ELYNYGTLLN AINIYKKLPE KVMPQAFVIY FAVKILHMVE 120

ELHSCKIIHG DIKPDNFMLG EFLDNDTCDI DDLSHGLTLI DLGQSIDMKL FPEGTAFTAK 180

CETSGFQCIE MLTQKPWNYQ TDYFGIAATV YCMLFGTYMQ VKNESGVWKP EGSFRRLVNA 240

ELWKEFFDIM LNIPSCHSLP SLTALRN 267

Keyword

Complete proteome; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0000777	; C:condensed chromosome kinetochore
GO:0000780	; C:condensed nuclear chromosome, centromeric region
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0007063	; P:regulation of sister chromatid cohesion
GO:0071173	; P:spindle assembly checkpoint

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR013212	; Mad3_BUB1_I.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR008271	; Ser/Thr_kinase_AS.
IPR015661	; Ser/Thr_kinase_Bub1.

Pfam

PF08311	; Mad3_BUB1_I; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00777

; Mad3_BUB1_I; 1.

Prosites

PS51489	; BUB1_N; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013