EKS-GAG-00337

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00337

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Axl	521.5	4.4E-157	578	841	264

Status

Unreviewed

Ensembl Protein

ENSGALP00000013423

UniProt Accession

F1P3V0;

Protein Name

Protein Synonyms/Alias

Gene Name

MERTK

Gene Synonyms/Alias

MERTK;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000008257	ENSGALP00000039287	ENSGALT00000040079
ENSGALG00000008257	ENSGALP00000013423	ENSGALT00000013438

Organism

Gallus gallus

Functional Description

Protein Length

974

Protein Sequence
(FASTA)

MGGGRCALLC ALLCALPLPR CGAAEFGDAG GHGGLRSLSA GAPLARPLWA KHHRPKRGLT 60

SGRWPPQGAK PSATSVGQLK FNPTVGHVVI NELKDVTFNC SIKVPQLLVR PDSPGISLWK 120

DGRELHTLDR IATSHFEILD EEEVAMTSTF SIRAAQRSDN GSYVCKLNIS GIEIASDPIL 180

VQLEGLPHFI QQPEKLNVTR NSPFNLTCQA VGPPEPVEIY WFRNNVQLNM KPYISPSVLT 240

VPGLNETALF SCEAHNSKGL TASNPGQVNV KGIPSAPKAV HVLKRMAHSI VISWVPGFDA 300

FSALNSCSVQ VKEAVPQSNV SLLLFNTSVP PHVYRIQQLW PMADYNISVS CKNEVGWSAF 360

SPWITASTTE GAPTTQPLNV TVSLNESSSF LEIRWVKPPL ERTHGELQGY HIWHTWQDSK 420

GLQNISLEAQ PNATVAILPV VATNATCSVR VAAVTKGGVG PFSSPVEVFV PASGLITSSP 480

SSTPASGNTD SFIVALGFVC GTVAVGLILC LSVVIQKRCM ETKYGNAFSR NDSELVVNYT 540

AKKSYCRRAV ELTLGSLGVS SELQQKLQDV VIDRNALSLG KVLGEGEFGS VMEGRLSQPE 600

GTPQKVAVKT MKLDNFSHRE IEEFLSEAAC MKDFDHPNVI KLLGVCIELS SQQIPKPMVV 660

LPFMKYGDLH SFLLRSRLEM APQFVPLQML LKFMVDIALG MEYLSSRQFL HRDLAARNCM 720

LRDDMTVCVA DFGLSKKIYS GDYYRQGRIA KMPVKWIAIE SLADRVYTTK SDVWAFGVTM 780

WEIATRGMTP YPGVQNHEIY EYLFHGQRLK KPENCLDELY DIMSSCWRAE PADRPTFSQL 840

KVHLEKLLES LPAPRGSKDV IYVNTSLPEE SPDSTQDLGL DSVIPQADSD LDPGDIAEPC 900

CSHTKAALVA VDIHDGGSRY VLESEGSPTE DAYVPLLPHE GSAWTEASTL PVGSSLAAQL 960

PCADGCLEDS EALL 974

Nucleotide Sequence
(FASTA)

ATGGGCGGCG GGCGCTGCGC GCTGCTCTGC GCGCTGCTCT GCGCTCTGCC CCTCCCGCGC 60

TGCGGGGCCG CTGAGTTTGG TGATGCTGGT GGACATGGAG GCCTGAGGTC CCTATCTGCA 120

GGAGCCCCGC TGGCAAGGCC CCTGTGGGCA AAGCACCACC GCCCCAAACG AGGCCTCACC 180

AGTGGCCGCT GGCCTCCCCA GGGCGCAAAG CCTTCTGCCA CCTCCGTGGG ACAGCTGAAA 240

TTTAACCCCA CAGTGGGACA CGTTGTGATA AATGAGCTCA AAGATGTCAC ATTTAACTGC 300

TCCATCAAAG TACCTCAGCT GCTAGTCCGG CCAGACTCCC CTGGCATTTC CCTGTGGAAG 360

GATGGCAGGG AGCTGCACAC GCTGGACCGC ATCGCCACCA GCCACTTTGA GATCCTTGAT 420

GAGGAGGAGG TAGCCATGAC CTCTACATTC AGCATCCGTG CTGCTCAGCG CTCGGATAAC 480

GGCTCCTACG TCTGCAAACT CAACATCTCT GGCATTGAGA TTGCATCTGA TCCCATCTTG 540

GTACAGCTGG AAGGGCTCCC ACACTTCATT CAACAGCCTG AGAAGCTGAA TGTCACCAGG 600

AACAGCCCCT TCAACCTCAC GTGCCAAGCT GTGGGCCCAC CAGAGCCTGT GGAAATCTAC 660

TGGTTTCGTA ACAATGTCCA ACTCAACATG AAGCCCTACA TCTCCCCATC AGTTCTGACT 720

GTCCCAGGTC TCAATGAAAC AGCACTGTTC AGTTGTGAGG CTCACAACAG CAAAGGGCTG 780

ACTGCTTCCA ACCCCGGGCA GGTCAACGTG AAAGGAATAC CATCTGCACC AAAAGCTGTG 840

CATGTCCTGA AGAGAATGGC CCACAGCATT GTGATCTCCT GGGTGCCAGG CTTCGATGCG 900

TTCTCTGCCT TGAACAGCTG CAGTGTGCAG GTCAAGGAAG CCGTTCCACA AAGCAATGTC 960

TCACTTCTGC TCTTTAACAC GTCGGTGCCT CCCCACGTGT ATCGCATCCA GCAGCTGTGG 1020

CCCATGGCAG ACTATAACAT CAGTGTTTCC TGCAAGAATG AAGTCGGTTG GTCGGCATTT 1080

AGCCCCTGGA TAACAGCCAG TACCACGGAA GGAGCTCCAA CTACCCAGCC ACTGAATGTC 1140

ACAGTGTCAC TCAACGAATC CAGCTCCTTC CTGGAAATCC GATGGGTGAA GCCACCCCTT 1200

GAGAGGACAC ACGGGGAGCT GCAGGGATAT CATATCTGGC ACACGTGGCA GGACTCCAAG 1260

GGGCTGCAGA ACATCTCCTT GGAAGCCCAG CCTAATGCCA CAGTGGCCAT CCTGCCTGTG 1320

GTGGCCACCA ATGCCACGTG CTCAGTGCGT GTGGCTGCTG TCACCAAGGG AGGCGTGGGG 1380

CCCTTCAGCA GCCCAGTGGA GGTCTTTGTT CCTGCCAGTG GGCTAATAAC CTCATCTCCC 1440

TCTTCGACAC CAGCATCTGG GAACACAGAC TCCTTTATAG TAGCACTGGG CTTCGTCTGT 1500

GGTACGGTTG CTGTTGGGCT GATCCTCTGC TTGTCTGTGG TCATCCAGAA AAGATGCATG 1560

GAAACAAAGT ATGGGAATGC CTTCAGCAGA AATGATTCAG AGCTGGTGGT AAACTACACA 1620

GCCAAGAAGT CCTACTGCCG GAGAGCCGTC GAACTGACAT TGGGTAGCCT GGGAGTCAGC 1680

AGCGAGCTCC AGCAGAAGCT GCAGGACGTT GTCATTGACA GAAATGCCCT CAGCCTGGGG 1740

AAGGTCCTGG GAGAGGGGGA GTTCGGGTCA GTGATGGAGG GACGTCTCAG CCAGCCAGAA 1800

GGCACCCCAC AGAAGGTGGC TGTCAAGACC ATGAAGTTGG ATAACTTTTC CCATAGAGAG 1860

ATAGAAGAAT TCCTCAGTGA AGCAGCATGC ATGAAGGACT TTGACCACCC CAATGTCATC 1920

AAGCTCCTAG GTGTGTGCAT CGAGCTGAGC TCTCAGCAGA TCCCCAAGCC CATGGTGGTT 1980

CTCCCATTCA TGAAATATGG TGACCTGCAC AGCTTCCTGC TTCGCTCCCG GCTGGAGATG 2040

GCCCCCCAGT TCGTGCCCCT GCAGATGCTG CTGAAGTTCA TGGTGGATAT TGCCCTGGGA 2100

ATGGAGTACC TGAGCAGTCG GCAGTTTCTT CACAGGGATT TGGCGGCTCG GAACTGCATG 2160

TTACGGGATG ACATGACGGT GTGTGTGGCA GACTTTGGGC TGTCCAAGAA GATCTACAGC 2220

GGCGATTACT ACCGTCAGGG CCGAATAGCA AAAATGCCAG TGAAGTGGAT TGCGATAGAG 2280

TCCCTGGCTG ACCGTGTCTA CACCACCAAG AGTGATGTGT GGGCATTTGG CGTTACCATG 2340

TGGGAGATAG CGACCAGAGG GATGACTCCG TACCCAGGGG TGCAGAACCA CGAGATTTAT 2400

GAGTATCTAT TCCACGGGCA GCGGCTCAAA AAGCCTGAGA ACTGCTTAGA TGAACTGTAC 2460

GATATCATGT CCTCCTGCTG GAGGGCTGAA CCTGCTGACC GACCGACGTT CTCACAGCTG 2520

AAAGTTCATC TGGAGAAGCT TTTGGAAAGC CTTCCTGCCC CGAGGGGGTC CAAGGACGTC 2580

ATCTACGTCA ACACCAGCCT GCCAGAGGAG AGCCCCGACT CCACCCAGGA TTTGGGCTTG 2640

GATTCGGTCA TCCCCCAAGC GGACTCTGAC TTGGACCCCG GGGACATTGC TGAGCCCTGC 2700

TGCTCCCACA CGAAGGCAGC GCTGGTGGCA GTGGATATCC ACGATGGGGG CTCGAGGTAC 2760

GTCCTTGAAA GTGAGGGCAG CCCCACAGAG GATGCTTACG TCCCACTGCT GCCCCACGAG 2820

GGCTCGGCGT GGACCGAGGC CAGCACCTTG CCTGTTGGCA GCTCGCTTGC AGCTCAGCTG 2880

CCATGTGCTG ATGGCTGCCT GGAGGACTCC GAAGCGCTGC TGTGA 2925

Domain Profile

S: 2     vlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdhp  61

          lgkvlgegefgsvmeg+l q +g+ +kvavkt+kld+++++eieeflseaacmk+fdhp

Q: 578   SLGKVLGEGEFGSVMEGRLSQPEGTPQKVAVKTMKLDNFSHREIEEFLSEAACMKDFDHP  637

         79**********************************************************

S: 62    nvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmvd  121

         nvi+l+gv++e s+++ +pkp+v+lpfmkygdlh+fll srl+  p+++plq+l+kfmvd

Q: 638   NVIKLLGVCIELSSQQ-IPKPMVVLPFMKYGDLHSFLLRSRLEMAPQFVPLQMLLKFMVD  696

         **************99.*******************************************

S: 122   iasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvkw  181

         ia gmeylssr+f+hrdlaarncml++dmtvcvadfglskkiysgdyyrqgriak+pvkw

Q: 697   IALGMEYLSSRQFLHRDLAARNCMLRDDMTVCVADFGLSKKIYSGDYYRQGRIAKMPVKW  756

         ************************************************************

S: 182   iaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedcl  241

         iaiesladrvyt+ksdvwafgvtmweiatrg+tpy+gv+n+eiy+yl +g+rlk+pe+cl

Q: 757   IAIESLADRVYTTKSDVWAFGVTMWEIATRGMTPYPGVQNHEIYEYLFHGQRLKKPENCL  816

         ************************************************************

S: 242   delydlmyrcweadpkdrpsfsvlr  266

         delyd+m++cw+a+p drp+fs+l+

Q: 817   DELYDIMSSCWRAEPADRPTFSQLK  841

         **********************997

Domain Sequence
(FASTA)

SLGKVLGEGE FGSVMEGRLS QPEGTPQKVA VKTMKLDNFS HREIEEFLSE AACMKDFDHP 60

NVIKLLGVCI ELSSQQIPKP MVVLPFMKYG DLHSFLLRSR LEMAPQFVPL QMLLKFMVDI 120

ALGMEYLSSR QFLHRDLAAR NCMLRDDMTV CVADFGLSKK IYSGDYYRQG RIAKMPVKWI 180

AIESLADRVY TTKSDVWAFG VTMWEIATRG MTPYPGVQNH EIYEYLFHGQ RLKKPENCLD 240

ELYDIMSSCW RAEPADRPTF SQLK 264

Keyword

ATP-binding; Complete proteome; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005737	; C:cytoplasm
GO:0005615	; C:extracellular space
GO:0016021	; C:integral to membrane
GO:0016028	; C:rhabdomere
GO:0005524	; F:ATP binding
GO:0004713	; F:protein tyrosine kinase activity
GO:0043277	; P:apoptotic cell clearance
GO:0051250	; P:negative regulation of lymphocyte activation
GO:0050766	; P:positive regulation of phagocytosis
GO:0043491	; P:protein kinase B signaling cascade
GO:0032940	; P:secretion by cell

KEGG

InterPros

IPR003961	; Fibronectin_type3.
IPR007110	; Ig-like.
IPR013783	; Ig-like_fold.
IPR003599	; Ig_sub.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.

Pfam

PF00041	; fn3; 2.
PF07714	; Pkinase_Tyr; 1.

SMARTs

SM00060	; FN3; 2.
SM00409	; IG; 2.
SM00219	; TyrKc; 1.

Prosites

PS50853	; FN3; 2.
PS50835	; IG_LIKE; 2.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013