EKS-GAG-00238

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00238

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TKL/STKR	387.8	3.1E-116	196	494	299

Status

Unreviewed

Ensembl Protein

ENSGALP00000013771

UniProt Accession

O42124;

Protein Name

Protein Synonyms/Alias

BMP type II receptor; Type II bone morphogenetic protein receptor;

Gene Name

BRK-3

Gene Synonyms/Alias

BRK-3; BMPR2;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000008459	ENSGALP00000013771	ENSGALT00000013786
ENSGALG00000008459	ENSGALP00000038285	ENSGALT00000039075
ENSGALG00000008459	ENSGALP00000038286	ENSGALT00000039076

Organism

Gallus gallus

Functional Description

Protein Length

1031

Protein Sequence
(FASTA)

MKSVTKNIFH SLSKAAQSEE RLCAFKDPYQ QDHGISESRI SQENGTILCM KGSTCYGLWE 60

KTREGDIHLV KQGCWSHIGD PQECHFEECI VTTTPSLIQN GTYRFCCCST DLCNVNFTEN 120

FPPPDPTDTT PYNSSHSFHR DETIVIVLAS VSVLAVLIAA LFFGYRMLAG DRKQGLHSMN 180

MMEAAASEPS LDLDNLKLLE LIGRGRYGAV YKGSLDERPV AVKVFSFANR QNFVNERNIY 240

RIPLMEHDNI ARFIVGDERF TADGRMEYLL VMEYYPNGSL CKYLSLHTSD WVSSCRLAHS 300

ITRGLAYLHT ELPRGDHYKP AISHRDLNSR NVLVKNDGTC VISDFGLSMK LTGNRLVRPG 360

EEDNAAISEV GTIRYMAPEV LEGAVNLRDC ESALKQVDMY ALGLIYWEIF MRCTDLFPGE 420

SVPEYQMAFQ TEVGNHPTFE DMQVLVSREK QRPKFPEAWK ENSLAVRSLK ETIEDCWDQD 480

AEARLTAQCA EERMAELMMI WERNKSVSPT VNPMSTAMQN ERNLSHHRRV SKIRPYPDYS 540

SSSYIEDSIH HTDSIVKNIS SEHSMSTTPL TSGEKNRNSI NYERQQAQAR IPSPETSVTS 600

LSTNTTTTNT TGLTPSTGMT TISEIPYSDE TNLHTTNVMQ PGGPTPVCLQ LTEEDLETNK 660

LDPKEVDKNL KESSDENLME HSLKQFSGPD PLSSTSSSLL YPLIKLAVEV TGQQDFTQAS 720

NGQACLIPDV PSAQVYPLPK QQNLPKRPTS LPLNTKNSTK EPRLKFGGKH KSNLKQVETG 780

VAKMNTINAA EPHVVTVTMN GVAGRTHSIN SHAGTTQYAN GAVPSGQTAS SVAQRAQEML 840

QNQFSGEDSR LNINSSPDEH EPLLRREQQV GHDEGVLDRL VDRRERQLDN GRTNVNNNNS 900

NPCPVQDTAT LSIQNVARNP GQTQTRRAQR PNSLDLSATN SLDSSSMQLG DSSQDGKSGS 960

GEKIKKRVKT PYSLKRWRPS TWVISTEPLH CEVNNNGGDR AVHSKSSTAV YLAEGGTATT 1020

MVSKDAGVNC L 1031

Nucleotide Sequence
(FASTA)

ATGAAGTCAG TGACAAAAAA TATTTTTCAT TCTTTGTCTA AAGCTGCACA GAGTGAGGAG 60

CGGCTGTGTG CATTTAAGGA CCCGTATCAG CAGGACCACG GAATCAGCGA GAGCCGAATC 120

TCCCAAGAGA ATGGCACCAT TTTGTGCATG AAAGGTAGTA CCTGCTATGG ACTTTGGGAA 180

AAAACACGAG AAGGAGACAT ACATCTCGTA AAACAAGGAT GCTGGTCTCA TATAGGAGAC 240

CCACAGGAGT GTCACTTCGA GGAGTGTATA GTTACAACCA CCCCTTCCTT GATTCAGAAT 300

GGAACATATC GGTTCTGCTG TTGTAGCACT GACTTATGTA ATGTCAACTT CACTGAAAAC 360

TTCCCACCTC CTGACCCAAC CGATACGACG CCTTACAATT CTTCTCATTC TTTTCATCGG 420

GATGAGACGA TAGTCATTGT CCTTGCATCT GTGTCTGTAC TAGCTGTCTT GATTGCTGCT 480

CTGTTCTTTG GATACAGAAT GCTTGCAGGA GACCGTAAAC AAGGATTGCA CAGTATGAAC 540

ATGATGGAGG CAGCAGCATC AGAGCCCTCA TTGGATCTGG ACAATCTTAA GTTACTGGAG 600

TTGATTGGCC GGGGTCGATA CGGAGCAGTG TACAAAGGCT CCCTAGATGA ACGCCCCGTT 660

GCTGTGAAAG TATTTTCTTT TGCTAATCGT CAAAACTTTG TCAATGAGAG GAATATTTAC 720

AGGATTCCAC TGATGGAACA TGACAACATT GCCCGCTTCA TTGTGGGAGA CGAGAGATTC 780

ACTGCAGATG GGCGTATGGA ATATTTATTG GTGATGGAAT ATTATCCCAA TGGTTCACTG 840

TGCAAATATC TGAGTCTCCA CACAAGTGAC TGGGTGAGCT CTTGCCGGCT GGCACATTCT 900

ATAACCAGGG GCTTGGCGTA CCTGCACACA GAGCTACCTC GAGGAGACCA TTACAAACCT 960

GCAATATCCC ATCGTGACTT GAACAGCCGC AATGTACTGG TAAAGAATGA TGGAACATGT 1020

GTAATTAGCG ATTTTGGGCT CTCCATGAAG TTAACTGGAA ACAGACTGGT GCGCCCAGGT 1080

GAGGAAGACA ATGCAGCCAT TAGCGAGGTC GGTACAATCC GCTATATGGC CCCAGAAGTG 1140

CTTGAAGGAG CAGTGAACTT AAGGGACTGT GAATCTGCTT TGAAACAAGT AGATATGTAT 1200

GCACTAGGCC TCATCTACTG GGAGATATTT ATGCGATGTA CAGACCTCTT CCCAGGGGAA 1260

TCTGTGCCAG AGTACCAGAT GGCTTTCCAG ACAGAAGTCG GAAACCATCC CACTTTTGAA 1320

GATATGCAAG TCTTGGTGTC CAGGGAAAAA CAAAGACCAA AATTCCCAGA AGCATGGAAA 1380

GAGAACAGCT TGGCTGTGAG ATCACTTAAA GAAACAATCG AAGACTGCTG GGATCAAGAT 1440

GCTGAAGCTC GATTAACTGC CCAATGTGCT GAGGAGAGAA TGGCAGAACT CATGATGATT 1500

TGGGAGAGAA ATAAATCAGT TAGTCCAACA GTCAATCCAA TGTCAACTGC CATGCAGAAT 1560

GAGCGGAACT TGTCACATCA TAGACGAGTG TCAAAAATAA GGCCGTATCC AGATTATTCT 1620

TCTTCTTCCT ACATTGAAGA TTCAATCCAC CACACTGACA GCATAGTGAA GAACATTTCG 1680

TCTGAACATT CGATGTCCAC TACGCCGCTG ACTTCAGGGG AAAAGAATAG AAACTCCATT 1740

AACTATGAGC GGCAACAAGC ACAAGCTCGC ATCCCTAGTC CTGAGACAAG TGTCACCAGT 1800

TTGTCCACCA ATACTACTAC CACCAATACA ACTGGCCTCA CTCCTAGCAC TGGCATGACC 1860

ACCATATCTG AAATACCTTA TTCAGATGAA ACAAACTTAC ATACTACAAA TGTCATGCAG 1920

CCAGGTGGGC CCACGCCAGT TTGTCTGCAG CTAACAGAGG AGGATTTAGA GACAAATAAA 1980

CTGGATCCAA AAGAAGTAGA TAAGAATCTG AAAGAAAGTT CTGATGAGAA TCTGATGGAA 2040

CATTCGCTCA AGCAGTTTAG TGGACCAGAT CCACTCAGCA GCACTAGTTC CAGCTTGCTT 2100

TATCCGTTGA TAAAACTTGC AGTAGAGGTG ACAGGACAAC AGGATTTCAC ACAAGCTAGT 2160

AACGGTCAAG CATGTTTGAT TCCAGATGTC CCATCTGCTC AGGTCTATCC TTTACCCAAG 2220

CAACAGAACC TTCCGAAGAG GCCTACTAGC CTTCCTCTAA ACACCAAAAA TTCAACGAAG 2280

GAGCCACGGT TAAAATTTGG TGGCAAGCAC AAATCAAACT TGAAGCAAGT TGAAACAGGT 2340

GTTGCCAAGA TGAACACTAT CAATGCTGCA GAACCTCATG TGGTGACCGT TACCATGAAT 2400

GGAGTGGCTG GTAGAACCCA CAGCATAAAC TCTCATGCTG GCACAACCCA GTATGCCAAT 2460

GGGGCAGTGC CGTCTGGTCA GACAGCCAGT TCAGTAGCAC AGAGGGCCCA GGAAATGCTT 2520

CAGAACCAGT TCAGTGGAGA GGATAGTCGA CTGAATATTA ATTCAAGCCC TGATGAGCAT 2580

GAACCATTGT TGAGGCGGGA GCAGCAGGTT GGCCATGATG AAGGTGTTCT GGACCGCCTA 2640

GTAGACAGGA GAGAGCGACA ACTTGATAAT GGCCGAACAA ATGTTAATAA CAATAACAGT 2700

AATCCGTGTC CAGTGCAAGA CACAGCTACA CTCAGTATCC AGAATGTAGC CAGAAATCCT 2760

GGGCAGACTC AGACTAGAAG AGCACAGAGG CCTAATTCGC TGGATCTATC CGCCACAAAT 2820

AGTTTGGATA GCAGTAGTAT GCAGTTAGGT GACTCCTCAC AGGACGGCAA ATCGGGCTCA 2880

GGAGAGAAGA TCAAGAAACG TGTGAAAACT CCTTACTCAC TGAAGCGATG GCGTCCTTCG 2940

ACATGGGTCA TCTCCACTGA GCCGCTGCAC TGCGAGGTCA ACAATAACGG CGGTGACCGG 3000

GCAGTGCACT CCAAATCCAG CACTGCTGTT TACCTTGCAG AAGGAGGCAC TGCCACCACA 3060

ATGGTATCTA AGGACGCAGG AGTGAACTGC CTGTGA 3096

Domain Profile

S: 1     lklleligkGrygeVwkaklrgeevAvKifstedeaswkrEkeiyqtvllrhenilqfia  60

         lkllelig+Gryg+V+k++l+++ vAvK+fs ++++++++E++iy+ +l++h+ni +fi+

Q: 196   LKLLELIGRGRYGAVYKGSLDERPVAVKVFSFANRQNFVNERNIYRIPLMEHDNIARFIV  255

         6899********************************************************

S: 61    adk.keedsltelllvteyhekgsLsdyLkretldveellrlalslasGlahLHeeivgt  119

          d+  ++d ++e+llv+ey+++gsL++yL+ +t+d+ +++rla+s+++Gla+LH+e++

Q: 256   GDErFTADGRMEYLLVMEYYPNGSLCKYLSLHTSDWVSSCRLAHSITRGLAYLHTELPRG  315

         **98999*************************************************9766

S: 120   kgkkKpaiaHRDlkskNilvkkdltcciaDlGLalkleeekee....ldlaansqvGtkR  175

          +++Kpai+HRDl+s+N+lvk+d+tc+i+D+GL++kl+ ++ +    +d+aa+s+vGt R

Q: 316   -DHYKPAISHRDLNSRNVLVKNDGTCVISDFGLSMKLTGNRLVrpgeEDNAAISEVGTIR  374

         .46**********************************9999877787999**********

S: 176   YmaPEvleealnlkdfe.afkraDvYslgLvlWEvasRcee..vdeeveeyklpfeevvg  232

         YmaPEvle+a+nl+d+e a+k++D+Y+lgL++WE+++Rc++  ++e+v+ey+++f+++vg

Q: 375   YMAPEVLEGAVNLRDCEsALKQVDMYALGLIYWEIFMRCTDlfPGESVPEYQMAFQTEVG  434

         *****************99*****************************************

S: 233   sdPsleemkevvvekklrPkipeawkkke.alkelsklleecWdadpeaRltalrvkkrl  291

         ++P++e+m+ +v ++k+rPk+peawk+++ a+++l++++e+cWd+d+eaRlta++ ++r+

Q: 435   NHPTFEDMQVLVSREKQRPKFPEAWKENSlAVRSLKETIEDCWDQDAEARLTAQCAEERM  494

         ***************************9999*************************9987

Domain Sequence
(FASTA)

LKLLELIGRG RYGAVYKGSL DERPVAVKVF SFANRQNFVN ERNIYRIPLM EHDNIARFIV 60

GDERFTADGR MEYLLVMEYY PNGSLCKYLS LHTSDWVSSC RLAHSITRGL AYLHTELPRG 120

DHYKPAISHR DLNSRNVLVK NDGTCVISDF GLSMKLTGNR LVRPGEEDNA AISEVGTIRY 180

MAPEVLEGAV NLRDCESALK QVDMYALGLI YWEIFMRCTD LFPGESVPEY QMAFQTEVGN 240

HPTFEDMQVL VSREKQRPKF PEAWKENSLA VRSLKETIED CWDQDAEARL TAQCAEERM 299

Keyword

ATP-binding; Complete proteome; Membrane; Nucleotide-binding; Receptor; Reference proteome; Transmembrane.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Microcebus murinus"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005901	; C:caveola
GO:0009986	; C:cell surface
GO:0005887	; C:integral to plasma membrane
GO:0005524	; F:ATP binding
GO:0005024	; F:transforming growth factor beta-activated receptor activity
GO:0030509	; P:BMP signaling pathway
GO:0009267	; P:cellular response to starvation
GO:0030308	; P:negative regulation of cell growth
GO:2000279	; P:negative regulation of DNA biosynthetic process
GO:0045906	; P:negative regulation of vasoconstriction
GO:0030513	; P:positive regulation of BMP signaling pathway
GO:0030501	; P:positive regulation of bone mineralization
GO:0010595	; P:positive regulation of endothelial cell migration
GO:0001938	; P:positive regulation of endothelial cell proliferation
GO:0010634	; P:positive regulation of epithelial cell migration
GO:0045669	; P:positive regulation of osteoblast differentiation
GO:0010862	; P:positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0006366	; P:transcription from RNA polymerase II promoter
GO:0048010	; P:vascular endothelial growth factor receptor signaling pathway

KEGG

gga:374147

;

InterPros

IPR000472	; Activin_rcpt.
IPR015770	; BMPRII.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.

Pfam

PF01064	; Activin_recp; 1.
PF00069	; Pkinase; 1.

SMARTs

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013