EKS-GAG-00254
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00254
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk517.95.8E-1567351004270
StatusUnreviewed
Ensembl ProteinENSGALP00000014021
UniProt AccessionF1NLU3;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameLTK
Gene Synonyms/Alias
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000008615ENSGALP00000014021ENSGALT00000014037
OrganismGallus gallus
Functional Description
Protein Length1205
Protein Sequence
(FASTA)
WNSMMAQIGR IERPFKITLL YSNCGAQEAG LLAVGSLQLR NCFHDKENPD LSIYNKGSSF 60
PCLHGGCVSH LQICEFISDC PTKEVEGMRC DSLPEGSHCS FEKGSCGWTL NETAASPWSI 120
KGFNDMIHSG HFLYLRADSN HTNGMAKAFS TSLPASIATE DYQIQFSVHV FGSYNGTISF 180
SVREERNGVP VTLPMWERAG SWSDHWFLIT LPMPVLQNRF QLQLLATWGW NSQADIAIDN 240
ITFGMDCFAD DTARHFILIN PCPKITKSIF ITVPETGKPP WDNTGSQIEV AKPRYRWFST 300
CGASGPHGPT QAQCDNAYRG SNVSVIVEKE GRLRGVQVWR VPATNRYRIS AYGAAGGKGA 360
KNHNERSHGV FISATFQLEK DELLYILVGQ QGEDACPGAN PQTQKICLGE SSVIEEDYKK 420
KKDLKDWAGG GGGGGGATYV FRQKDGIFEP LLIAAGGGGK AYLKAQDNSL DDVPLEQFEN 480
STAVPGVSGR TGAAGGGGGW QDVTLLPQAG KSLLEGGEGG QACHQALAKL QWATSGGFGG 540
GGGACTSGGG GGGYRGGHAS KNDDITAGGQ YGISFVNPIG EIFLHPLAAV ENDGEVEVQI 600
YLNCSHCHSD NCKRDPDTNL PVCQCEMGAV LANDNVTCTV PQGHVPEGHL PLPLLLAVVA 660
VIVMLGMILT GGSLSIIYHL KKQQLEGARA RLQSPEYKLS KIRTSAIMTD YNPNYCFAGK 720
AATLSELKEI PRKNISLLRA LGHGAFGEVY EGTVVGIAGD PSPLQVAIKT LPEVCSEQDE 780
MDFLMEALII SKFNHQNIVQ CIGVSLQTLP RFILLELMAG GDMKSFLRQN RPRVNQPSVL 840
TMQDLLNIAR DIACGCKYLE ENHFIHRDIA ARNCLLTCTG AGRIAKIGDF GMARDIYRAS 900
YYRKGGRAML PVKWMPPEAF LEGIFTSKTD TWSFGVLLWE IFSLGYMPYP CKTNQEVLEF 960
VTSGGRMDPP KNCPGPVYRI MTQCWQHSPE YRPNFSTILE RIKYCTQDPD VINTQLPMEC 1020
SPTPEDEGNT VVRPSVPSGI VPLLVSPSLT PQMTPKSLDT HCTGHKLVQC PQELLVENLS 1080
NRTARGPSLP CLSDFNSASW IQNSNQKLEF SNPPTHRLKN KTKNLWNPTY GSWVLENSCH 1140
LSPISKLKVT PEREDSGFDG NCSSSPSSRA SPASPSRNNC PHLDIGGIEL VKLQNFPCGN 1200
VNYAY 1205
Nucleotide Sequence
(FASTA)
TGGAACTCCA TGATGGCTCA GATTGGCCGA ATAGAAAGAC CTTTTAAAAT CACCTTGCTG 60
TATTCGAACT GTGGCGCTCA AGAGGCTGGA CTGCTGGCAG TGGGCTCCTT GCAGCTCAGA 120
AACTGCTTCC ATGATAAAGA AAACCCAGAT CTTTCTATAT ATAACAAAGG CTCTTCCTTC 180
CCCTGCCTTC ACGGAGGCTG TGTTAGCCAC TTACAAATCT GTGAATTCAT CAGTGATTGC 240
CCTACCAAAG AAGTGGAAGG AATGAGATGT GATAGTCTCC CAGAGGGTTC ACATTGCTCT 300
TTTGAAAAGG GTTCGTGCGG CTGGACACTG AATGAGACTG CAGCATCTCC TTGGTCTATC 360
AAGGGTTTTA ATGACATGAT TCACAGTGGA CACTTTCTCT ATCTGCGAGC AGATAGCAAT 420
CACACAAATG GTATGGCCAA GGCTTTCAGT ACAAGCTTGC CAGCTAGTAT TGCCACTGAA 480
GATTACCAGA TCCAATTCTC AGTGCATGTT TTTGGCAGCT ACAATGGTAC CATCTCCTTC 540
TCTGTCAGGG AAGAGAGAAA TGGAGTTCCA GTTACCTTGC CAATGTGGGA AAGAGCAGGA 600
AGCTGGAGTG ACCATTGGTT TCTCATCACT TTACCAATGC CAGTGCTTCA GAACAGGTTT 660
CAACTGCAAC TTCTGGCAAC CTGGGGCTGG AATTCCCAAG CTGACATCGC TATTGACAAT 720
ATTACGTTTG GAATGGATTG CTTTGCTGAT GATACTGCAA GGCACTTTAT TCTGATTAAT 780
CCCTGCCCCA AAATTACTAA ATCCATCTTC ATTACAGTCC CAGAAACAGG TAAGCCTCCA 840
TGGGATAACA CAGGATCACA GATAGAGGTA GCTAAGCCAA GATACAGGTG GTTCTCAACA 900
TGTGGTGCCA GTGGTCCACA CGGGCCAACT CAAGCTCAGT GTGACAACGC CTACAGGGGC 960
AGCAATGTGT CGGTGATTGT AGAGAAGGAG GGCAGGCTCC GAGGAGTGCA AGTCTGGAGA 1020
GTGCCAGCTA CAAACCGGTA CAGAATTTCT GCCTATGGAG CAGCTGGAGG GAAGGGAGCC 1080
AAAAACCACA ATGAGAGGTC CCACGGGGTC TTCATCTCGG CCACCTTCCA GCTGGAGAAA 1140
GATGAGCTGC TGTACATCTT AGTGGGGCAG CAGGGGGAGG ATGCCTGCCC TGGGGCCAAT 1200
CCTCAGACCC AGAAGATCTG CTTAGGGGAG TCATCTGTCA TTGAAGAAGA TTACAAAAAA 1260
AAAAAGGACC TGAAGGACTG GGCTGGAGGA GGTGGGGGTG GAGGAGGAGC AACCTACGTC 1320
TTTAGACAGA AGGATGGGAT TTTCGAACCT TTGCTCATCG CAGCAGGAGG AGGAGGAAAA 1380
GCCTATCTGA AGGCTCAGGA CAACTCCCTG GATGACGTAC CTCTGGAGCA ATTTGAGAAC 1440
AGCACTGCAG TACCGGGAGT CAGTGGAAGA ACTGGGGCAG CAGGTGGAGG TGGTGGCTGG 1500
CAAGATGTGA CTCTGCTTCC TCAAGCTGGG AAATCCCTCT TGGAAGGTGG AGAAGGGGGT 1560
CAAGCTTGTC ACCAAGCATT AGCCAAGCTC CAGTGGGCTA CCTCTGGTGG TTTTGGTGGT 1620
GGAGGAGGAG CTTGTACTTC TGGTGGAGGA GGTGGAGGTT ACAGAGGGGG GCATGCCTCT 1680
AAAAATGATG ATATCACAGC TGGTGGGCAG TATGGCATCT CGTTTGTGAA TCCCATTGGA 1740
GAGATCTTCT TGCATCCCCT TGCAGCCGTG GAGAATGATG GTGAGGTGGA GGTTCAGATC 1800
TATCTTAACT GTAGCCACTG CCACTCAGAC AACTGTAAGA GAGACCCTGA CACCAACCTG 1860
CCAGTCTGCC AATGTGAGAT GGGGGCTGTG CTAGCCAATG ACAATGTCAC CTGCACTGTT 1920
CCACAGGGTC ATGTCCCAGA GGGACATCTG CCTCTCCCAC TCCTCCTAGC TGTGGTGGCT 1980
GTAATTGTGA TGCTCGGAAT GATCCTCACT GGTGGCAGCC TATCTATCAT TTATCACCTT 2040
AAGAAGCAGC AACTGGAAGG AGCCAGAGCA CGACTGCAGA GCCCGGAATA TAAACTGAGT 2100
AAAATCCGCA CATCAGCCAT CATGACAGAT TACAACCCCA ACTACTGCTT TGCTGGGAAG 2160
GCCGCCACTC TGAGTGAGCT GAAGGAGATC CCACGGAAGA ACATCTCTCT GCTTCGGGCA 2220
CTAGGACATG GTGCGTTTGG TGAGGTTTAT GAAGGAACAG TGGTAGGCAT CGCAGGGGAT 2280
CCCAGTCCTC TCCAAGTGGC TATTAAGACA CTGCCAGAAG TCTGCTCCGA GCAAGATGAG 2340
ATGGATTTCC TGATGGAAGC ACTGATTATC AGTAAGTTCA ATCATCAGAA TATTGTGCAG 2400
TGCATTGGTG TTAGCCTGCA GACGCTGCCT CGCTTCATTC TTCTTGAGCT CATGGCTGGA 2460
GGAGATATGA AGAGTTTTCT TCGTCAGAAT CGACCCAGAG TGAATCAGCC ATCCGTGCTA 2520
ACGATGCAGG ACCTGCTGAA CATAGCTAGA GATATCGCCT GTGGCTGTAA ATATCTGGAA 2580
GAGAATCATT TCATACACAG AGATATAGCT GCAAGGAATT GCCTTTTGAC CTGCACTGGG 2640
GCAGGTCGAA TAGCCAAAAT CGGTGACTTC GGGATGGCCA GAGATATCTA CAGAGCAAGT 2700
TACTATCGCA AGGGAGGAAG AGCCATGCTT CCTGTCAAGT GGATGCCACC AGAAGCTTTT 2760
CTAGAAGGCA TTTTTACCTC CAAAACTGAC ACCTGGTCCT TTGGTGTCCT TCTCTGGGAG 2820
ATTTTCTCTC TAGGCTACAT GCCATATCCC TGCAAAACTA ATCAGGAAGT GCTGGAATTT 2880
GTCACCAGTG GAGGAAGAAT GGACCCGCCA AAGAACTGTC CAGGGCCTGT GTACCGCATC 2940
ATGACGCAGT GCTGGCAGCA CAGCCCAGAA TACCGGCCAA ACTTCTCTAC CATCCTGGAA 3000
AGAATTAAGT ACTGCACACA GGACCCTGAT GTGATCAACA CACAGCTGCC CATGGAGTGT 3060
AGCCCAACAC CAGAGGATGA AGGGAACACA GTTGTGCGCC CAAGTGTTCC CAGTGGGATA 3120
GTGCCCCTGT TGGTGAGCCC TTCTCTTACA CCTCAGATGA CACCAAAAAG CCTGGATACC 3180
CACTGTACTG GGCACAAACT CGTACAATGT CCACAAGAGC TACTGGTGGA GAACCTCAGC 3240
AACCGGACTG CTCGAGGGCC CAGCCTGCCA TGCCTCAGTG ATTTCAACAG TGCGTCCTGG 3300
ATCCAGAATT CAAACCAGAA GTTAGAATTC AGCAATCCAC CAACCCACAG ACTGAAGAAC 3360
AAAACTAAAA ACCTTTGGAA TCCAACCTAT GGATCATGGG TGCTAGAGAA CAGCTGTCAC 3420
TTAAGCCCCA TCTCCAAACT GAAAGTAACT CCAGAGCGAG AAGATTCAGG CTTTGATGGA 3480
AATTGCAGTT CTTCTCCTAG TTCTCGGGCA TCTCCAGCAT CTCCAAGTCG AAACAACTGT 3540
CCTCACTTAG ATATTGGTGG GATCGAACTG GTGAAACTCC AGAATTTCCC CTGTGGGAAT 3600
GTAAATTATG CATAT 3615
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i l+ralG+GafGevyeg v g+ gd+s+l+va+ktlpe++seqde+dfl+ealiiskfn
Q: 735   ISLLRALGHGAFGEVYEGTVVGIAGDPSPLQVAIKTLPEVCSEQDEMDFLMEALIISKFN  794
         6799********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+niv++iGvsl++lpr+illel+aGGd+ksflr++rp+ +q+s l+m+dll++a+d+a+
Q: 795   HQNIVQCIGVSLQTLPRFILLELMAGGDMKSFLRQNRPRVNQPSVLTMQDLLNIARDIAC  854
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gckyleen+fihrdiaarn+ll+++G++r+aki+dfGmardiyra+yyrkggra+lpvkw
Q: 855   GCKYLEENHFIHRDIAARNCLLTCTGAGRIAKIGDFGMARDIYRASYYRKGGRAMLPVKW  914
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeafleGiftsktd+wsfGvllwe+fslG++pyp k+nqevle+v++Ggr+d+pk++p
Q: 915   MPPEAFLEGIFTSKTDTWSFGVLLWEIFSLGYMPYPCKTNQEVLEFVTSGGRMDPPKNCP  974
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h+pe rp+f +iler+++
Q: 975   GPVYRIMTQCWQHSPEYRPNFSTILERIKY  1004
         ***************************986
Domain Sequence
(FASTA)
ISLLRALGHG AFGEVYEGTV VGIAGDPSPL QVAIKTLPEV CSEQDEMDFL MEALIISKFN 60
HQNIVQCIGV SLQTLPRFIL LELMAGGDMK SFLRQNRPRV NQPSVLTMQD LLNIARDIAC 120
GCKYLEENHF IHRDIAARNC LLTCTGAGRI AKIGDFGMAR DIYRASYYRK GGRAMLPVKW 180
MPPEAFLEGI FTSKTDTWSF GVLLWEIFSL GYMPYPCKTN QEVLEFVTSG GRMDPPKNCP 240
GPVYRIMTQC WQHSPEYRPN FSTILERIKY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Caenorhabditis elegans"; ?>Danio rerio"; ?>Gasterosteus aculeatus"; ?>Latimeria chalumnae"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Oreochromis niloticus"; ?>Oryzias latipes"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pteropus vampyrus"; ?>Sarcophilus harrisii"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-ANC-00293
EKS-CAE-00256
EKS-DAR-00653
EKS-GAA-00375
EKS-LAC-00314
EKS-MAE-00034
EKS-MEG-00249
EKS-ORN-00393
EKS-ORL-00363
EKS-PAT-00291
EKS-PES-00269
EKS-PEM-00167
EKS-PTV-00067
EKS-SAH-00288
EKS-TAG-00317
EKS-TAR-00396
EKS-XET-00374
EKS-XIM-00391
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0006915; P:apoptotic process
GO:0008283; P:cell proliferation
GO:0071300; P:cellular response to retinoic acid
GO:0048666; P:neuron development
GO:0014065; P:phosphatidylinositol 3-kinase cascade
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR002172; LDrepeatLR_classA_rpt.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS50060; MAM_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013