EKS-GAG-00338
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00338
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Axl514.46.4E-155504769266
StatusUnreviewed
Ensembl ProteinENSGALP00000014051
UniProt AccessionF1NLR2;
Protein Name
Protein Synonyms/Alias Tyrosine-protein kinase receptor TYRO3;
Gene NameTYRO3
Gene Synonyms/Alias TYRO3;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000008631ENSGALP00000014051ENSGALT00000014067
ENSGALG00000008631ENSGALP00000032003ENSGALT00000032640
OrganismGallus gallus
Functional Description
Protein Length872
Protein Sequence
(FASTA)
MELKRSMALL RLLLLGLWAA ARDGVVAAGM KFTGSPIKLK VSQGQPVKLN CSLEGMEDPE 60
MLWIKDGAVV QSVDQVYIPV DEDHWIGFLS LKSVERTDSG KYWCQVENGG KKEESQQVWL 120
IVEGVPYFTV EPEDVSVSPN APFHMACAAV GPPEPVTIVW WMGDSRVGLP DISPSILNVS 180
GINQSTVFSC EAHNVKGLSS SRTATVQIKA MPLPPLNVTV SQVTSSNASV VWVPGFDGRA 240
PLHSCTLQVA ESPDGQEVST EVAPVPPFAY GVQGLKHSTN YSVRVQCSNE MGSSPFTERV 300
YFQTLELAPS STPQNIHVIQ RDPGLVLEWE GVAPDVLKEN VLGYRLEWIQ DNVTQGEMIV 360
QDTKANLTTW NPLKDLIIRV CVLNSAGCGP WSDLFLLEAQ EVMGGQRQPP YGTSWVPVAL 420
GILTALVTAV ALALILLRKR RKETRFGHAF GSVVGRGDPA VHFRAARSFN REGPELIEAT 480
LESVGISDEL KTKLKDVLIQ EQQFTLGRML GKGEFGSVRE ALLKLDDGSF QKVAVKMLKA 540
DIFTSTDIEE FLREAACMKE FDHPHVTKLI GVSLRSRPKG RLPIPMVILP FMKHGDLHAF 600
LLMSRIGENP FNLPVQTLLK FMIDIASGME YLSSKNFIHR DLAARNCMLD ENMNVSVADF 660
GLSKKIYSGD YYRQGCASKL PVKWLALESL ADNLYTTHSD VWAFGVTMWE IVTRGQTPYA 720
GIENAEIYNY LISGNRLKQP PECLEDVYDL MCRCWHPEPK LRPSFGVLRS QLEMIRGRMS 780
TLSLSQDPLY VNIGKDKESS VSDPAVHTSF GNTDGDETIA GAAAAAITSD YRYIMSPLCL 840
GDDVEGERHP EGQEGENKSL LYELETEGEK SC 872
Nucleotide Sequence
(FASTA)
ATGGAGCTGA AGCGGAGCAT GGCTCTGCTG CGGCTCCTCT TGCTGGGACT GTGGGCTGCG 60
GCGCGGGACG GCGTCGTGGC GGCAGGTATG AAGTTTACAG GATCTCCAAT CAAATTAAAG 120
GTGTCCCAGG GTCAACCCGT CAAACTAAAT TGCAGCCTGG AGGGAATGGA AGATCCCGAG 180
ATGTTGTGGA TCAAGGACGG AGCAGTGGTG CAAAGCGTAG ACCAGGTGTA CATTCCAGTA 240
GATGAAGATC ACTGGATCGG CTTCCTCAGC CTGAAATCCG TCGAGAGGAC AGATTCTGGG 300
AAGTACTGGT GCCAGGTTGA GAACGGGGGG AAGAAGGAAG AATCACAGCA AGTGTGGCTC 360
ATAGTGGAAG GTGTGCCCTA CTTTACTGTG GAACCTGAGG ATGTGTCCGT GTCCCCTAAT 420
GCCCCATTTC ATATGGCCTG TGCTGCTGTT GGTCCCCCTG AACCAGTGAC AATTGTCTGG 480
TGGATGGGAG ACTCTAGAGT GGGGCTTCCA GACATCTCCC CCTCCATCCT AAACGTGTCA 540
GGTATTAATC AAAGCACAGT GTTCTCCTGC GAAGCTCACA ACGTAAAGGG ATTGTCTTCA 600
TCTCGGACAG CCACTGTTCA GATTAAAGCC ATGCCTCTGC CACCCCTCAA CGTGACGGTG 660
AGCCAGGTCA CCAGCAGCAA TGCCAGTGTG GTCTGGGTGC CGGGGTTTGA TGGCCGTGCT 720
CCCCTCCATT CTTGCACTCT TCAGGTTGCT GAGTCCCCAG ATGGCCAGGA GGTCTCCACC 780
GAAGTCGCCC CAGTGCCTCC CTTTGCCTAT GGCGTGCAGG GCCTGAAGCA CTCCACCAAC 840
TACAGTGTTC GTGTGCAGTG CAGCAATGAG ATGGGCAGCT CCCCTTTCAC AGAGAGAGTT 900
TACTTCCAGA CACTGGAGCT TGCTCCAAGC AGCACCCCAC AAAATATCCA TGTGATCCAA 960
AGGGATCCTG GTTTGGTTTT GGAATGGGAA GGCGTGGCTC CAGACGTGCT GAAAGAAAAT 1020
GTCCTGGGAT ACAGGCTGGA GTGGATTCAG GATAATGTGA CTCAGGGGGA GATGATCGTA 1080
CAGGATACAA AAGCAAATCT CACAACGTGG AACCCTCTCA AAGACCTAAT CATCAGGGTG 1140
TGTGTGCTGA ACTCGGCTGG GTGCGGACCA TGGAGTGACC TCTTCCTGCT GGAAGCCCAG 1200
GAGGTCATGG GTGGTCAGAG ACAGCCTCCT TATGGGACGT CCTGGGTTCC TGTGGCATTG 1260
GGCATTCTCA CAGCTCTGGT CACAGCTGTT GCCTTGGCTC TTATTCTCCT TCGAAAAAGA 1320
AGAAAGGAAA CTCGATTTGG CCATGCCTTT GGTAGTGTGG TTGGCAGAGG GGATCCAGCT 1380
GTCCATTTCA GAGCTGCCAG GTCTTTCAAC AGGGAGGGCC CAGAGCTCAT TGAAGCAACA 1440
TTGGAGAGTG TAGGGATCAG TGATGAGCTG AAGACAAAAC TGAAAGATGT CCTTATCCAG 1500
GAGCAGCAGT TCACCTTGGG ACGAATGTTA GGCAAAGGAG AGTTTGGGTC AGTTCGAGAG 1560
GCACTACTGA AGCTAGATGA TGGCTCTTTC CAGAAAGTGG CAGTTAAGAT GCTGAAAGCG 1620
GACATCTTCA CCTCCACTGA CATCGAGGAG TTCCTGCGGG AGGCTGCGTG TATGAAGGAG 1680
TTTGACCACC CACATGTCAC TAAGCTGATT GGAGTCAGTC TACGAAGCCG TCCCAAGGGC 1740
CGTCTCCCAA TTCCCATGGT GATCCTGCCC TTCATGAAGC ATGGAGACCT TCATGCTTTT 1800
CTGCTGATGT CAAGGATCGG GGAAAACCCT TTTAACTTGC CTGTTCAGAC ACTCCTCAAG 1860
TTCATGATTG ACATTGCCAG TGGGATGGAG TACTTGAGCT CAAAAAATTT CATACACAGA 1920
GACCTTGCAG CTCGGAACTG CATGCTGGAT GAGAACATGA ATGTGAGTGT TGCAGACTTC 1980
GGGCTTTCTA AGAAAATCTA CAGTGGAGAC TACTACCGTC AGGGCTGTGC CTCCAAGCTG 2040
CCAGTGAAGT GGCTTGCTCT GGAAAGCCTG GCAGATAATC TGTACACAAC ACACAGCGAT 2100
GTGTGGGCGT TTGGGGTGAC CATGTGGGAG ATTGTGACCC GAGGGCAAAC CCCTTATGCT 2160
GGCATTGAGA ATGCAGAAAT CTACAACTAC CTCATCAGTG GGAACAGGCT GAAGCAGCCA 2220
CCGGAGTGCC TGGAAGATGT CTACGATCTC ATGTGCAGAT GTTGGCATCC TGAGCCCAAG 2280
CTACGCCCAA GCTTTGGAGT GCTCCGGTCC CAGCTGGAAA TGATTCGGGG GAGGATGTCC 2340
ACACTCTCCT TAAGCCAAGA CCCTCTCTAT GTCAACATTG GGAAGGACAA AGAGTCATCT 2400
GTCAGTGACC CTGCCGTGCA CACCTCTTTT GGAAACACGG ACGGTGATGA GACCATTGCT 2460
GGGGCAGCAG CTGCTGCCAT CACGAGTGAC TATCGCTACA TCATGAGCCC CTTGTGCCTT 2520
GGAGATGATG TCGAGGGTGA AAGGCATCCA GAAGGGCAGG AAGGGGAGAA CAAAAGCCTT 2580
CTGTATGAGC TGGAGACAGA AGGAGAGAAA AGTTGTTAG 2619
Domain Profile
S: 1     lvlgkvlgegefgsvmegqlkqedgsilkvavktlkldiiarseieeflseaacmkefdh  60
         ++lg++lg+gefgsv+e+ lk +dgs++kvavk+lk+di+++++ieefl+eaacmkefdh
Q: 504   FTLGRMLGKGEFGSVREALLKLDDGSFQKVAVKMLKADIFTSTDIEEFLREAACMKEFDH  563
         68**********************************************************
S: 61    pnvirlvgvslessekgrlpkpvvilpfmkygdlhafllysrlgenpvylplqtlvkfmv  120
         p+v +l+gvsl+s+ kgrlp+p+vilpfmk+gdlhafll+sr+genp++lp+qtl+kfm+
Q: 564   PHVTKLIGVSLRSRPKGRLPIPMVILPFMKHGDLHAFLLMSRIGENPFNLPVQTLLKFMI  623
         ************************************************************
S: 121   diasgmeylssrnfihrdlaarncmlaedmtvcvadfglskkiysgdyyrqgriaklpvk  180
         diasgmeylss+nfihrdlaarncml+e+m v vadfglskkiysgdyyrqg+++klpvk
Q: 624   DIASGMEYLSSKNFIHRDLAARNCMLDENMNVSVADFGLSKKIYSGDYYRQGCASKLPVK  683
         ************************************************************
S: 181   wiaiesladrvytsksdvwafgvtmweiatrgqtpyagvenaeiydyllqgnrlkqpedc  240
         w+a+eslad++yt++sdvwafgvtmwei+trgqtpyag+enaeiy+yl+ gnrlkqp++c
Q: 684   WLALESLADNLYTTHSDVWAFGVTMWEIVTRGQTPYAGIENAEIYNYLISGNRLKQPPEC  743
         ************************************************************
S: 241   ldelydlmyrcweadpkdrpsfsvlr  266
         l+++ydlm rcw+ +pk rpsf vlr
Q: 744   LEDVYDLMCRCWHPEPKLRPSFGVLR  769
         ***********************998
Domain Sequence
(FASTA)
FTLGRMLGKG EFGSVREALL KLDDGSFQKV AVKMLKADIF TSTDIEEFLR EAACMKEFDH 60
PHVTKLIGVS LRSRPKGRLP IPMVILPFMK HGDLHAFLLM SRIGENPFNL PVQTLLKFMI 120
DIASGMEYLS SKNFIHRDLA ARNCMLDENM NVSVADFGLS KKIYSGDYYR QGCASKLPVK 180
WLALESLADN LYTTHSDVWA FGVTMWEIVT RGQTPYAGIE NAEIYNYLIS GNRLKQPPEC 240
LEDVYDLMCR CWHPEPKLRP SFGVLR 266
KeywordATP-binding; Complete proteome; Disulfide bond; Immunoglobulin domain; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Repeat; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>
EKS-AIM-00372
EKS-ANC-00384
EKS-BOT-00399
EKS-CAJ-00404
EKS-CAF-00400
EKS-CAP-00424
EKS-CIS-00152
EKS-DAR-00777
EKS-EQC-00387
EKS-FEC-00382
EKS-GAA-00488
EKS-GOG-00387
EKS-HOS-00403
EKS-ICT-00375
EKS-LAC-00416
EKS-LOA-00403
EKS-MAM-00399
EKS-MEG-00329
EKS-MOD-00385
EKS-MUM-00432
EKS-MUP-00390
EKS-MYL-00393
EKS-NOL-00364
EKS-ORN-00511
EKS-ORA-00344
EKS-ORC-00374
EKS-ORL-00465
EKS-OTG-00402
EKS-PAT-00375
EKS-PES-00355
EKS-POA-00391
EKS-PTV-00110
EKS-RAN-00411
EKS-SAH-00365
EKS-SUS-00346
EKS-TAG-00471
EKS-TAR-00502
EKS-TAS-00046
EKS-XET-00511
EKS-XIM-00503
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004713; F:protein tyrosine kinase activity
GO:0043277; P:apoptotic cell clearance
GO:0050728; P:negative regulation of inflammatory response
GO:0045824; P:negative regulation of innate immune response
GO:0051250; P:negative regulation of lymphocyte activation
GO:0043524; P:negative regulation of neuron apoptotic process
GO:0034122; P:negative regulation of toll-like receptor signaling pathway
GO:0070050; P:neuron homeostasis
GO:0046777; P:protein autophosphorylation
GO:0043491; P:protein kinase B signaling cascade
GO:0032940; P:secretion by cell
KEGG
InterPros
IPR003961; Fibronectin_type3.
IPR007110; Ig-like.
IPR013783; Ig-like_fold.
IPR013098; Ig_I-set.
IPR003599; Ig_sub.
IPR003598; Ig_sub2.
IPR011009; Kinase-like_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
Pfam
PF00041; fn3; 1.
PF07679; I-set; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00060; FN3; 2.
SM00409; IG; 1.
SM00408; IGc2; 1.
SM00219; TyrKc; 1.
Prosites
PS50853; FN3; 2.
PS50835; IG_LIKE; 2.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013