EKS-GAG-00155

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00155

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/PKA	483.0	2.0E-145	91	345	255

Status

Unreviewed

Ensembl Protein

ENSGALP00000014351

UniProt Accession

E1BRS0;

Protein Name

Protein Synonyms/Alias

Gene Name

PRKACB

Gene Synonyms/Alias

PRKACB;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000008841	ENSGALP00000014351	ENSGALT00000014367

Organism

Gallus gallus

Functional Description

Protein Length

398

Protein Sequence
(FASTA)

MAAQKEVPCA QCTGTATALQ RLEGFANRLF HRHSKGGAHD LRVPLENESH HVSELAVLWD 60

KSMKEFLAKA KEDFLRKWES PPQNTAGLDD FERQKTLGTG SFGRVMMVKH KATEQYYAMK 120

ILDKQKVVKL KQIEHTLNEK RILQAVNFPF LVKLEYSFKD NSNLYMVMEY VPGGEMFSHL 180

RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL IYRDLKPENL LIDQQGYIQV TDFGFAKRVK 240

GRTWTLCGTP EYLAPEIILS KGYNKAVDWW ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS 300

GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG NLKNGVNDIK NHKWFATTDW IAIYQRKVEA 360

PFIPKCRGPG DTSNFDDYEE EDIRASLTEK CAKEFADF 398

Nucleotide Sequence
(FASTA)

ATGGCGGCTC AGAAGGAGGT ACCTTGTGCC CAGTGCACGG GGACAGCCAC CGCGCTGCAG 60

AGACTGGAAG GTTTCGCTAA TCGCCTTTTC CATAGGCATT CAAAGGGCGG TGCGCATGAC 120

CTGAGAGTGC CTCTGGAAAA TGAGAGCCAT CACGTCTCTG AACTTGCTGT CCTATGGGAC 180

AAATCAATGA AAGAGTTCCT AGCCAAAGCC AAAGAAGACT TTTTAAGAAA ATGGGAAAGC 240

CCACCTCAGA ATACTGCTGG CCTAGATGAT TTTGAGAGGC AAAAAACTCT TGGAACAGGA 300

TCATTCGGAA GAGTTATGAT GGTGAAGCAT AAAGCCACAG AACAGTATTA TGCCATGAAG 360

ATACTGGACA AACAAAAGGT TGTCAAACTG AAGCAGATAG AACACACACT GAATGAAAAG 420

AGAATATTAC AAGCAGTGAA CTTTCCTTTC CTTGTAAAAC TGGAGTATTC TTTTAAGGAC 480

AATTCTAATT TATACATGGT AATGGAGTAT GTTCCTGGTG GTGAAATGTT CTCACATCTA 540

AGAAGAATTG GAAGGTTCAG TGAACCACAT GCACGGTTTT ATGCAGCTCA GATAGTGCTA 600

ACATTTGAGT ACCTCCATTC ATTAGACCTC ATCTACAGAG ATCTAAAGCC TGAAAATCTT 660

TTAATTGATC AGCAAGGATA CATCCAGGTC ACGGACTTTG GCTTTGCAAA AAGAGTAAAA 720

GGAAGAACTT GGACGTTATG TGGGACTCCA GAATACCTGG CACCTGAAAT AATTCTCAGC 780

AAGGGTTACA ACAAGGCAGT GGATTGGTGG GCATTAGGAG TGTTAATCTA CGAAATGGCA 840

GCTGGATATC CCCCATTCTT TGCAGATCAA CCCATTCAAA TTTATGAGAA GATTGTGTCT 900

GGCAAGGTAA GGTTCCCATC ACACTTCAGT TCAGACCTAA AGGATCTTCT AAGAAATTTA 960

CTCCAGGTAG ATTTGACCAA ACGATATGGA AATCTCAAGA ATGGTGTAAA TGACATAAAA 1020

AACCACAAGT GGTTTGCAAC TACAGATTGG ATTGCCATTT ATCAGAGAAA GGTAGAAGCT 1080

CCATTCATAC CAAAGTGCAG AGGCCCTGGA GATACCAGCA ACTTTGATGA CTATGAAGAA 1140

GAAGATATTC GTGCGTCTCT AACAGAAAAA TGTGCAAAAG AATTTGCTGA TTTTTAG 1197

Domain Profile

S: 1     ferlktlGtGsfGrvelvrekeskkyyalkvlskekvvklkqvehvknekrvlkavefpf  60

         fer+ktlGtGsfGrv++v++k++++yya+k+l+k+kvvklkq+eh+ nekr+l+av+fpf

Q: 91    FERQKTLGTGSFGRVMMVKHKATEQYYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPF  150

         7899********************************************************

S: 61    lvkllasfkdesnlylvleyveGGelfsylrkvrrfsekaarfyaaeivlaleylhsldl  120

         lvkl++sfkd+snly+v+eyv+GGe+fs+lr+++rfse++arfyaa+ivl++eylhsldl

Q: 151   LVKLEYSFKDNSNLYMVMEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDL  210

         ************************************************************

S: 121   iyrdlkpenllldkeGyikvtdfGfakkvkdrtwtlcGtpeylapeiiqskgynkavdww  180

         iyrdlkpenll+d++Gyi+vtdfGfak+vk+rtwtlcGtpeylapeii skgynkavdww

Q: 211   IYRDLKPENLLIDQQGYIQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWW  270

         ************************************************************

S: 181   alGvliyellaGyppffddqpikiyekivsgklkfpsklssdlkdllkkllqvdltkrlg  240

         alGvliye++aGyppff+dqpi+iyekivsgk++fps++ssdlkdll++llqvdltkr+g

Q: 271   ALGVLIYEMAAGYPPFFADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRYG  330

         ************************************************************

S: 241   nlkngvedikehkwf  255

         nlkngv+dik+hkwf

Q: 331   NLKNGVNDIKNHKWF  345

         **************9

Domain Sequence
(FASTA)

FERQKTLGTG SFGRVMMVKH KATEQYYAMK ILDKQKVVKL KQIEHTLNEK RILQAVNFPF 60

LVKLEYSFKD NSNLYMVMEY VPGGEMFSHL RRIGRFSEPH ARFYAAQIVL TFEYLHSLDL 120

IYRDLKPENL LIDQQGYIQV TDFGFAKRVK GRTWTLCGTP EYLAPEIILS KGYNKAVDWW 180

ALGVLIYEMA AGYPPFFADQ PIQIYEKIVS GKVRFPSHFS SDLKDLLRNL LQVDLTKRYG 240

NLKNGVNDIK NHKWF 255

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gadus morhua"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Macropus eugenii"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>Saccharomyces cerevisiae"; ?>Schizosaccharomyces pombe"; ?>

Gene Ontology

GO:0005813	; C:centrosome
GO:0005524	; F:ATP binding
GO:0004691	; F:cAMP-dependent protein kinase activity
GO:0000287	; F:magnesium ion binding

KEGG

gga:424542

;

InterPros

IPR000961	; AGC-kinase_C.
IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013