EKS-GAG-00272

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00272

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
STE/STE20	329.2	2.0E-98	444	691	248

Status

Unreviewed

Ensembl Protein

ENSGALP00000014534

UniProt Accession

E1BWY7;

Protein Name

Protein Synonyms/Alias

Gene Name

PAK7

Gene Synonyms/Alias

PAK7;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000008947	ENSGALP00000014534	ENSGALT00000014550
ENSGALG00000008947	ENSGALP00000014532	ENSGALT00000014548

Organism

Gallus gallus

Functional Description

Protein Length

709

Protein Sequence
(FASTA)

MFGKKKKRLE ISGPSNFEHR VHTGFDHREQ KFTGLPQQWH SLLADTANRP KPMVDPSCIT 60

PIQLAPMKTI VRGNKPRKDT SINGLLEEFD NISVTRSNSL RKESPPAHHQ GNANHVPRHQ 120

EENGYITYSQ YSSESDTTTD YVMDKYRDKT LYGEELDRYY KGGYAAKQNG HMMKVTSRDI 180

YYSEMTPLKS DLSRFLPDYH AQVEAKPKPL EYGGLKLEYQ RIPSGSSLDY RDPFPYARLE 240

YSDGDWGHSP AKDDYDKRPK SSYVDPASPQ PTMRQRSRSG SGLQEPAMPY GASAFKAHQQ 300

GHSYSSYTYP RLSETAAGIS KVDYDRAQLV VSPPLSGSDT YPRGPVKLPQ SQSKVSYSSS 360

SYQYPLVYHK ASHYHQPSLQ PSSPYISTAS YPSSPSITSS AYPPPSWGSS SDQQPSRVSH 420

EQFRAALQLV VSPGDPREYL DSFIKIGEGS TGVVCIATEK HTGKQVAVKK MDLRKQQRRE 480

LLFNEVVIMR DYHHENVVDM YNSYLVSDEL WVVMEFLEGG ALTDIVTHTR MNEEQIATVC 540

LSVLRALSYL HNQGVIHRDI KSDSILLTSD GRIKLSDFGF CAQVSKEVPR RKSLVGTPYW 600

MAPEVISRMP YGTEVDIWSL GIMVIEMIDG EPPYFNEPPL QAMRRIRDNL PPRVKDMHKV 660

SSVLRGFLDL MLVREPSQRA TAQELLRHPF LKLAGAPSCI VPLMRQHRH 709

Nucleotide Sequence
(FASTA)

ATGTTCGGAA AGAAAAAGAA AAGGCTTGAA ATTTCTGGGC CCTCTAACTT CGAACATCGT 60

GTCCATACTG GCTTTGACCA CCGGGAGCAG AAGTTCACAG GACTACCTCA GCAGTGGCAC 120

AGCCTGCTGG CGGACACGGC CAACAGGCCA AAGCCTATGG TGGACCCATC ATGCATCACT 180

CCCATTCAGC TCGCGCCTAT GAAGACTATT GTCAGAGGAA ATAAGCCTCG GAAGGATACT 240

TCAATCAATG GCCTGCTCGA AGAGTTTGAC AATATCTCTG TGACTCGATC CAATTCCCTG 300

CGGAAGGAAA GTCCTCCTGC ACACCACCAA GGCAATGCAA ACCATGTGCC AAGGCACCAG 360

GAGGAAAATG GTTACATCAC GTATTCGCAG TACTCCAGTG AGTCAGACAC AACAACAGAC 420

TATGTCATGG ACAAGTATAG AGACAAGACT CTCTATGGGG AAGAGCTAGA CAGGTACTAC 480

AAAGGGGGCT ACGCTGCCAA GCAGAACGGG CACATGATGA AAGTCACTTC CAGAGACATC 540

TATTATTCAG AAATGACACC CCTGAAATCA GACCTCTCCA GGTTTCTCCC AGATTACCAT 600

GCACAAGTGG AAGCGAAGCC CAAACCGCTC GAATATGGAG GTCTAAAGCT GGAGTACCAG 660

AGGATTCCCA GTGGATCCTC ACTGGACTAC AGAGACCCCT TCCCTTACGC CAGGCTGGAG 720

TACAGCGACG GCGACTGGGG GCACAGCCCA GCCAAGGATG ACTATGACAA GAGGCCCAAG 780

TCATCCTACG TGGACCCGGC AAGCCCTCAG CCAACCATGA GGCAGAGATC CAGGTCGGGC 840

TCTGGTCTGC AGGAGCCAGC CATGCCCTAT GGAGCAAGTG CATTTAAAGC ACACCAGCAA 900

GGACACTCCT ACAGCTCCTA CACCTACCCT CGCTTGTCTG AAACTGCAGC AGGCATCTCC 960

AAGGTGGATT ACGACCGAGC ACAGCTGGTA GTTAGCCCAC CACTCTCTGG ATCGGACACC 1020

TACCCAAGGG GCCCAGTAAA GCTACCTCAA AGTCAAAGCA AAGTCAGCTA TTCCAGCAGC 1080

AGCTACCAGT ACCCTCTGGT CTACCACAAA GCATCCCACT ACCACCAGCC ATCCCTCCAG 1140

CCAAGCTCTC CCTATATTTC CACCGCCTCC TACCCCAGCT CCCCAAGTAT CACATCAAGT 1200

GCTTATCCCC CTCCCAGCTG GGGCTCCTCC TCAGACCAGC AGCCCTCCCG GGTGTCCCAC 1260

GAACAGTTCA GAGCTGCCCT GCAGCTGGTC GTCAGTCCCG GGGATCCCCG GGAGTACTTG 1320

GACAGCTTCA TCAAGATCGG GGAGGGCTCC ACGGGGGTAG TCTGCATTGC CACTGAGAAG 1380

CACACGGGAA AGCAAGTCGC TGTGAAGAAA ATGGATCTCA GGAAACAGCA GAGGAGGGAG 1440

CTGCTGTTCA ATGAGGTTGT AATCATGAGA GATTACCATC ACGAAAACGT GGTTGACATG 1500

TACAACAGTT ACCTTGTCAG CGATGAGCTG TGGGTGGTGA TGGAGTTCCT GGAGGGCGGT 1560

GCTCTGACAG ACATCGTGAC TCACACCAGG ATGAACGAGG AGCAGATAGC GACCGTCTGC 1620

CTGTCTGTCC TGAGAGCTCT GTCCTACCTG CACAACCAGG GTGTCATCCA CCGCGACATC 1680

AAAAGTGACT CCATCCTCCT CACAAGCGAT GGGCGGATCA AATTGTCCGA CTTCGGGTTC 1740

TGTGCCCAGG TGTCCAAGGA GGTGCCAAGG AGGAAGTCGC TGGTTGGGAC GCCATACTGG 1800

ATGGCACCAG AGGTGATATC ACGCATGCCC TATGGCACCG AGGTGGACAT CTGGTCGCTG 1860

GGCATCATGG TGATAGAAAT GATCGACGGC GAACCTCCCT ACTTCAATGA GCCACCGCTG 1920

CAGGCCATGC GTCGGATCCG GGATAACTTA CCGCCCCGCG TGAAGGACAT GCACAAGGTC 1980

TCCTCTGTCC TCCGGGGCTT CTTGGACTTG ATGCTGGTGC GGGAACCCTC GCAGAGAGCC 2040

ACGGCACAGG AACTGTTGAG ACACCCATTC CTTAAGCTGG CCGGGGCCCC TTCCTGCATC 2100

GTGCCCCTCA TGAGGCAGCA CCGGCAC 2127

Domain Profile

S: 5     eeigkGalgkvylarekktgelvaikkinlekqekleelqkeisvlkklkhpniveyles  64

          +ig+G++g v++a+ek+tg++va+kk++l+kq++ e+l++e+ ++++++h+n+v++++s

Q: 444   IKIGEGSTGVVCIATEKHTGKQVAVKKMDLRKQQRRELLFNEVVIMRDYHHENVVDMYNS  503

         68**********************************************************

S: 65    flkeeelwlvmeylagGslsdlvkeelkselkEeqiayilrevlkaLeylHskkviHrdi  124

         +l+++elw+vme+l+gG+l+d+v+   +++++Eeqia+++ +vl+aL+ylH+++viHrdi

Q: 504   YLVSDELWVVMEFLEGGALTDIVT---HTRMNEEQIATVCLSVLRALSYLHNQGVIHRDI  560

         ************************...9********************************

S: 125   kakniLlteegeVkLsdfgvaaqlektrkkrktvvgtpywmAPEviaqeekgYdekaDiw  184

         k+++iLlt++g++kLsdfg++aq++k++ +rk++vgtpywmAPEvi+  +  Y +++Diw

Q: 561   KSDSILLTSDGRIKLSDFGFCAQVSKEVPRRKSLVGTPYWMAPEVIS--RMPYGTEVDIW  618

         ***********************************************..9**********

S: 185   slGItaielaegepPfkdleplkallkilkneppklkskkkfskefkefvekclqknpek  244

         slGI++ie+++gepP+++++pl+a+ +i +n pp++k+ +k+s+ ++ f++ +l ++p++

Q: 619   SLGIMVIEMIDGEPPYFNEPPLQAMRRIRDNLPPRVKDMHKVSSVLRGFLDLMLVREPSQ  678

         ************************************************************

S: 245   RpsasellkhkFl  257

         R++a+ell+h+Fl

Q: 679   RATAQELLRHPFL  691

         ************7

Domain Sequence
(FASTA)

IKIGEGSTGV VCIATEKHTG KQVAVKKMDL RKQQRRELLF NEVVIMRDYH HENVVDMYNS 60

YLVSDELWVV MEFLEGGALT DIVTHTRMNE EQIATVCLSV LRALSYLHNQ GVIHRDIKSD 120

SILLTSDGRI KLSDFGFCAQ VSKEVPRRKS LVGTPYWMAP EVISRMPYGT EVDIWSLGIM 180

VIEMIDGEPP YFNEPPLQAM RRIRDNLPPR VKDMHKVSSV LRGFLDLMLV REPSQRATAQ 240

ELLRHPFL 248

Keyword

ATP-binding; Complete proteome; Kinase; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Dipodomys ordii"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Erinaceus europaeus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Procavia capensis"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Tursiops truncatus"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0005739	; C:mitochondrion
GO:0005524	; F:ATP binding
GO:0004674	; F:protein serine/threonine kinase activity

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000095	; PAK_box_Rho-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.

Pfam

PF00786	; PBD; 1.
PF00069	; Pkinase; 1.

SMARTs

SM00285	; PBD; 1.
SM00220	; S_TKc; 1.

Prosites

PS50108	; CRIB; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.

Prints

Created Date

20-Feb-2013