EKS-GAG-00253
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00253
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
TK/Alk530.67.7E-160435704270
StatusUnreviewed
Ensembl ProteinENSGALP00000014687
UniProt AccessionF1NHS5;
Protein NameTyrosine-protein kinase receptor
Protein Synonyms/Alias
Gene NameALK
Gene Synonyms/Alias ALK;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000009034ENSGALP00000014687ENSGALT00000014703
ENSGALG00000009034ENSGALP00000014686ENSGALT00000014702
OrganismGallus gallus
Functional Description
Protein Length941
Protein Sequence
(FASTA)
HWLFTTCGAS GAYGPTQSQC NDAYRNSNLS VIVGAEGILQ GIQIWRVPAT NTYSISGYGA 60
AGGKGGKNTM VRSHGVSVLG IFDLQKDDTL YILVGQQGED ACPSTNDVIQ KVCIGENNVI 120
EEEIRVNRSV NEWAGGGGGG GGATYIFKME NGEPVPLIIA AGGGGRAYRA KTDTFHPERL 180
ENDSSVPGLN GNSGAAGGGG GWNDNTSFLW SGKSLLEGAT GGRSCPQAMK KWGWETRGGF 240
GGGGGGCSSG GGGGGYIGGN AAEDNDPEMD GEDGVSFINP IGTLYTPALK VTEGHGEVDI 300
RLHLNCSHCE MDECRVDLET QKVICFCEPG TDLAEDGVSC IVAAEPTVHL PLSLVLSVVT 360
SALVAALILA FSGIMIVYRR KHQELQAMQM ELQSPEYKLS KLRTSTIMTD YNPNYCFAGK 420
TTSISDLKEV PRKNISLIRG LGHGAFGEVY EGQVAGIPSD PTPLQVAVKT LPEVCSEQDE 480
LDFLMEALII SKFNHQNIVR CIGVSLQALP RFILLELMAG GDLKSFLRET RPRPNQLSSL 540
SMLDLLHVAH DIACGCQYLE ENHFIHRDIA ARNCLLTCRG PGRVAKIGDF GMARDIYRAS 600
YYRKGGCAML PVKWMPPEAF MEGIFTSKTD TWSFGVLLWE IFSLGYMPYP SKSNQEVLEF 660
VTNGGRMDPP KNCPGPVYRI MTQCWQHQPE DRPNFAIILE RIEYCTQDPD VINTALPVEY 720
GPSIEEEEKV AIRPEDPEGI PPLLVSSHQD KKDDKQTLPS PPPLPSAITA GKALGKAGSL 780
ELSVPGKVQA ASGGGHINMA YAQSNPPSEL HKSRGSRNKP TNLWNPTYGS WFAEKQASKN 840
KPLLEKEMPE RENLGHEGNC TVGPNIVTGR LPGSSLLLEP SSLTASVKEV PLFRLRHFPC 900
GNVNYGYQQQ GLPLEASTPP CATSYEDPAL RNKNHISQQG P 941
Nucleotide Sequence
(FASTA)
CACTGGCTGT TCACAACATG TGGTGCTAGC GGAGCCTATG GCCCCACACA GAGCCAATGC 60
AATGATGCCT ACAGGAACTC CAACCTCAGT GTGATCGTTG GAGCTGAGGG GATTCTCCAA 120
GGTATTCAAA TCTGGAGAGT ACCAGCAACC AACACGTACA GCATCTCAGG TTATGGAGCT 180
GCTGGTGGGA AAGGAGGGAA GAACACCATG GTGAGATCCC ACGGCGTGTC TGTACTGGGC 240
ATTTTTGACC TCCAGAAGGA TGATACGTTA TATATCTTGG TGGGACAGCA AGGAGAAGAT 300
GCTTGCCCTA GTACTAATGA CGTTATACAG AAAGTCTGCA TTGGAGAGAA CAACGTGATT 360
GAAGAGGAGA TACGTGTGAA CAGAAGTGTC AATGAATGGG CAGGAGGAGG TGGAGGCGGG 420
GGAGGTGCAA CTTATATATT TAAGATGGAG AATGGAGAAC CGGTCCCCCT GATAATTGCA 480
GCAGGAGGTG GTGGCAGGGC CTACAGGGCC AAAACAGACA CATTTCATCC AGAAAGGCTG 540
GAGAATGATT CCTCTGTTCC AGGGCTGAAT GGAAATTCAG GAGCTGCAGG TGGTGGAGGT 600
GGCTGGAATG ATAACACTTC CTTCCTGTGG TCAGGAAAAT CCTTGCTGGA AGGTGCTACT 660
GGAGGAAGAT CCTGCCCCCA GGCCATGAAG AAGTGGGGGT GGGAGACAAG AGGGGGTTTC 720
GGAGGGGGTG GAGGGGGGTG CTCCTCAGGT GGAGGAGGCG GAGGATATAT AGGTGGCAAT 780
GCTGCAGAGG ACAATGACCC TGAGATGGAT GGGGAGGATG GTGTGTCCTT TATTAATCCG 840
ATTGGTACTT TATACACTCC AGCACTTAAA GTGACAGAGG GGCACGGAGA GGTGGATATT 900
AGGCTGCACC TTAACTGCAG TCACTGTGAG ATGGACGAGT GCCGTGTTGA TCTTGAGACT 960
CAAAAAGTCA TTTGCTTTTG TGAGCCAGGC ACAGACTTGG CTGAGGATGG TGTGTCTTGC 1020
ATAGTTGCAG CTGAGCCAAC GGTCCATCTC CCTCTCTCCT TGGTTTTGTC AGTAGTAACT 1080
TCAGCATTGG TTGCTGCCTT AATTTTGGCT TTTTCAGGAA TCATGATAGT GTATCGTCGG 1140
AAGCACCAGG AGCTACAAGC CATGCAGATG GAGTTACAGA GCCCAGAATA CAAGCTAAGC 1200
AAGCTGCGTA CCTCCACTAT TATGACAGAC TACAATCCCA ACTACTGCTT TGCAGGAAAG 1260
ACTACATCCA TTAGTGACCT CAAAGAGGTG CCTCGCAAAA ACATCTCCCT CATCCGGGGT 1320
TTGGGCCACG GAGCCTTTGG TGAGGTATAT GAAGGTCAGG TGGCAGGGAT CCCCAGCGAC 1380
CCCACTCCCT TGCAGGTGGC TGTGAAAACA TTGCCTGAAG TGTGTTCAGA GCAAGATGAG 1440
CTGGACTTCC TCATGGAAGC TCTCATTATT AGCAAGTTCA ATCACCAGAA TATTGTGCGT 1500
TGTATCGGAG TGAGCTTGCA GGCGCTGCCC CGTTTCATCT TGTTAGAGCT CATGGCTGGA 1560
GGTGACCTCA AATCGTTCCT GAGGGAGACG CGGCCCAGAC CGAATCAGCT TTCCTCCCTC 1620
TCCATGCTGG ACTTGCTCCA CGTGGCTCAT GACATTGCTT GTGGGTGTCA GTACCTGGAG 1680
GAGAACCACT TCATTCACAG GGATATTGCT GCTAGGAACT GCCTCCTTAC CTGTCGAGGG 1740
CCTGGAAGAG TGGCTAAAAT TGGAGACTTT GGCATGGCCC GGGATATATA CAGAGCCAGC 1800
TACTATCGGA AGGGAGGGTG TGCGATGCTG CCTGTCAAAT GGATGCCTCC CGAGGCTTTC 1860
ATGGAAGGGA TATTTACATC AAAAACAGAC ACATGGTCCT TTGGCGTATT GCTGTGGGAG 1920
ATATTCTCAT TGGGATACAT GCCTTATCCT AGCAAAAGTA ACCAGGAGGT TCTGGAGTTT 1980
GTAACCAATG GAGGAAGGAT GGATCCACCT AAAAACTGCC CAGGCCCTGT ATACCGCATT 2040
ATGACCCAGT GCTGGCAGCA CCAGCCGGAA GACAGGCCAA ACTTTGCCAT AATCCTGGAG 2100
AGGATCGAGT ACTGCACTCA GGACCCAGAT GTCATCAACA CTGCTTTGCC AGTAGAATAT 2160
GGCCCGTCGA TTGAAGAGGA AGAGAAGGTA GCAATACGCC CAGAAGATCC AGAAGGAATT 2220
CCTCCTCTCT TGGTTTCCTC GCACCAAGAC AAAAAGGATG ACAAGCAAAC CCTGCCATCT 2280
CCACCACCCC TGCCATCAGC CATCACTGCA GGAAAAGCTC TAGGGAAAGC AGGATCCTTG 2340
GAGCTGTCAG TCCCTGGGAA GGTGCAGGCA GCCTCAGGTG GGGGACATAT CAACATGGCT 2400
TATGCCCAGT CCAATCCCCC TTCTGAGCTG CACAAAAGCA GGGGCTCCAG GAACAAGCCT 2460
ACCAACCTCT GGAATCCAAC GTATGGTTCC TGGTTTGCCG AGAAGCAAGC CAGCAAAAAC 2520
AAACCTCTGC TGGAGAAAGA AATGCCTGAG AGGGAGAACT TGGGACACGA AGGAAACTGT 2580
ACTGTGGGGC CCAATATAGT GACTGGCAGG CTACCAGGCT CCTCCCTGCT ATTAGAGCCA 2640
TCTTCCCTAA CAGCAAGCGT TAAAGAAGTG CCTCTCTTTA GGCTCCGTCA CTTCCCCTGT 2700
GGGAATGTCA ACTATGGATA CCAACAGCAG GGCTTGCCTT TGGAAGCCTC CACGCCACCT 2760
TGTGCTACCA GTTACGAGGA CCCCGCCCTT AGAAACAAGA ACCACATATC CCAGCAGGGG 2820
CCC 2823
Domain Profile
S: 1     ielvralGkGafGevyeglvsglpgdasklavavktlpesaseqdeldflkealiiskfn  60
         i l+r+lG+GafGevyeg+v+g+p+d+++l+vavktlpe++seqdeldfl+ealiiskfn
Q: 435   ISLIRGLGHGAFGEVYEGQVAGIPSDPTPLQVAVKTLPEVCSEQDELDFLMEALIISKFN  494
         679*********************************************************
S: 61    henivrliGvsleklprlillellaGGdlksflresrpkpeqlsslamkdllkvaldvak  120
         h+nivr+iGvsl++lpr+illel+aGGdlksflre+rp+p+qlssl+m dll+va+d+a+
Q: 495   HQNIVRCIGVSLQALPRFILLELMAGGDLKSFLRETRPRPNQLSSLSMLDLLHVAHDIAC  554
         ************************************************************
S: 121   GckyleenkfihrdiaarnillsskGpsrvakiadfGmardiyraeyyrkggrallpvkw  180
         Gc+yleen+fihrdiaarn+ll+++Gp+rvaki+dfGmardiyra+yyrkgg+a+lpvkw
Q: 555   GCQYLEENHFIHRDIAARNCLLTCRGPGRVAKIGDFGMARDIYRASYYRKGGCAMLPVKW  614
         ************************************************************
S: 181   mppeafleGiftsktdvwsfGvllwevfslGvvpypgksnqevlelvveGgrldspkeip  240
         mppeaf+eGiftsktd+wsfGvllwe+fslG++pyp+ksnqevle+v++Ggr+d+pk++p
Q: 615   MPPEAFMEGIFTSKTDTWSFGVLLWEIFSLGYMPYPSKSNQEVLEFVTNGGRMDPPKNCP  674
         ************************************************************
S: 241   gsvyrimtdcwkhepedrpkfvsilerlqa  270
         g+vyrimt+cw+h+pedrp+f++iler+++
Q: 675   GPVYRIMTQCWQHQPEDRPNFAIILERIEY  704
         ***************************986
Domain Sequence
(FASTA)
ISLIRGLGHG AFGEVYEGQV AGIPSDPTPL QVAVKTLPEV CSEQDELDFL MEALIISKFN 60
HQNIVRCIGV SLQALPRFIL LELMAGGDLK SFLRETRPRP NQLSSLSMLD LLHVAHDIAC 120
GCQYLEENHF IHRDIAARNC LLTCRGPGRV AKIGDFGMAR DIYRASYYRK GGCAMLPVKW 180
MPPEAFMEGI FTSKTDTWSF GVLLWEIFSL GYMPYPSKSN QEVLEFVTNG GRMDPPKNCP 240
GPVYRIMTQC WQHQPEDRPN FAIILERIEY 270
KeywordATP-binding; Complete proteome; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Tyrosine-protein kinase.
Sequence SourceEnsembl
Orthology
Ortholog group
Anolis carolinensis"; ?>Bos taurus"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Pongo abelii"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>
EKS-ANC-00292
EKS-BOT-00308
EKS-CAJ-00312
EKS-CAF-00313
EKS-CAP-00341
EKS-DRM-00153
EKS-EQC-00292
EKS-FEC-00287
EKS-GAA-00374
EKS-GOG-00304
EKS-HOS-00307
EKS-ICT-00290
EKS-LAC-00315
EKS-LOA-00317
EKS-MAM-00304
EKS-MEG-00248
EKS-MOD-00295
EKS-MUM-00338
EKS-MUP-00298
EKS-MYL-00306
EKS-NOL-00278
EKS-ORA-00265
EKS-ORC-00284
EKS-OTG-00308
EKS-PES-00268
EKS-POA-00292
EKS-RAN-00317
EKS-SAH-00287
EKS-SUS-00272
EKS-TAG-00316
EKS-TEN-00398
EKS-XET-00375
Gene Ontology
GO:0016021; C:integral to membrane
GO:0005524; F:ATP binding
GO:0004714; F:transmembrane receptor protein tyrosine kinase activity
GO:0000187; P:activation of MAPK activity
GO:0048666; P:neuron development
GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway
KEGG
InterPros
IPR026830; ALK.
IPR008985; ConA-like_lec_gl_sf.
IPR011009; Kinase-like_dom.
IPR002172; LDrepeatLR_classA_rpt.
IPR000998; MAM_dom.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266; Tyr_kinase_AS.
IPR020635; Tyr_kinase_cat_dom.
IPR002011; Tyr_kinase_rcpt_2_CS.
Pfam
PF00629; MAM; 1.
PF07714; Pkinase_Tyr; 1.
SMARTs
SM00192; LDLa; 1.
SM00219; TyrKc; 1.
Prosites
PS50060; MAM_2; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00109; PROTEIN_KINASE_TYR; 1.
PS00239; RECEPTOR_TYR_KIN_II; 1.
Prints
PR00109; TYRKINASE.
Created Date20-Feb-2013