EKS-GAG-00054

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00054

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
CMGC/CDK	371.3	3.1E-111	120	404	285

Status

Unreviewed

Ensembl Protein

ENSGALP00000014734

UniProt Accession

E1BS76;

Protein Name

Protein Synonyms/Alias

Gene Name

CDK14

Gene Synonyms/Alias

CDK14;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009062	ENSGALP00000014734	ENSGALT00000014750

Organism

Gallus gallus

Functional Description

Protein Length

454

Protein Sequence
(FASTA)

MKKLRRTLSE SFSRIALKKE DSSFDEICVT KMSTRNCQGM DSVIKPLDTI PEDKKVRVQR 60

TQSSFDPFEK PTNQVKRVHS ENNACINFKT SSAGKESPKV RRHSSPSSPT SPKFGKADSY 120

EKLEKLGEGS YATVYKGKSK VNGKLVALKV IRLQEEEGTP FTAIREASLL KGLKHANIVL 180

LHDIIHTKET LTLVFEYVHT DLCQYMDKHP GGLHPENVKL FLFQLLRGLS YIHQRYILHR 240

DLKPQNLLIS DTGELKLADF GLARAKSVPS HTYSNEVVTL WYRPPDVLLG STEYSTCLDM 300

WGVGCIFVEM IQGVAAFPGM KDIQDQLERI FLVLGTPNED TWPGVHSLPH FKPERFTQYS 360

PKNLRQAWNK LSYVNHAEDL ASKLLQCFPK NRLSAQAALS HEYFSDLPPR LWELTDMSSI 420

FTVPNVRLQA ETGESMRVFG KNNSYGKGVS NSKH 454

Nucleotide Sequence
(FASTA)

ATGAAAAAGT TGCGGAGAAC TTTGTCGGAG AGCTTCAGCC GAATAGCCTT GAAGAAAGAA 60

GACAGCAGCT TTGATGAGAT ATGTGTCACA AAGATGTCTA CACGGAACTG CCAGGGAATG 120

GATTCAGTGA TCAAACCTCT GGATACAATT CCTGAGGATA AGAAAGTCAG GGTCCAGAGG 180

ACGCAGAGTA GCTTCGATCC CTTTGAGAAA CCAACTAATC AAGTGAAGAG GGTTCATTCT 240

GAGAACAACG CTTGCATTAA CTTCAAAACT TCATCTGCAG GGAAAGAATC ACCCAAAGTC 300

CGACGGCATT CCAGCCCTAG CTCTCCTACA AGTCCCAAGT TTGGAAAAGC AGACTCATAT 360

GAAAAACTGG AAAAACTAGG GGAAGGGTCC TATGCTACAG TATACAAAGG GAAAAGCAAG 420

GTTAATGGAA AGCTGGTGGC ACTGAAGGTG ATAAGATTAC AAGAAGAGGA AGGAACTCCA 480

TTTACAGCTA TCAGGGAAGC TTCTCTTCTG AAAGGACTGA AACATGCAAA CATTGTGCTG 540

CTTCATGACA TCATTCACAC CAAGGAGACT TTAACACTCG TTTTTGAATA TGTGCACACT 600

GATTTATGTC AGTACATGGA CAAACACCCT GGAGGGCTTC ATCCAGAAAA TGTGAAGTTA 660

TTTTTATTTC AGTTGCTGCG AGGACTGTCT TACATCCACC AGCGTTACAT TTTGCACAGG 720

GACCTGAAAC CACAGAATCT TCTGATCAGT GACACGGGGG AGTTAAAGCT GGCAGACTTT 780

GGTCTTGCAA GAGCTAAATC AGTTCCCAGC CATACGTATT CTAATGAAGT GGTAACCCTA 840

TGGTACAGAC CTCCAGATGT CCTTTTGGGA TCAACAGAAT ATTCTACCTG CCTTGATATG 900

TGGGGAGTGG GATGTATCTT TGTAGAAATG ATTCAAGGGG TCGCAGCTTT TCCAGGAATG 960

AAAGACATTC AAGATCAACT TGAAAGGATA TTTCTGGTAC TTGGAACACC AAATGAAGAT 1020

ACGTGGCCTG GAGTCCACTC ATTACCCCAT TTCAAACCAG AACGGTTTAC ACAGTACAGC 1080

CCTAAAAACC TTAGACAAGC ATGGAATAAG CTGAGCTATG TGAATCATGC GGAAGATCTA 1140

GCCTCCAAAC TACTCCAGTG TTTCCCAAAG AACAGATTGT CAGCACAGGC AGCCCTGAGC 1200

CATGAGTATT TCAGTGATCT GCCCCCTCGG CTATGGGAGC TAACCGATAT GTCTTCTATT 1260

TTTACTGTAC CGAATGTAAG ATTACAAGCA GAGACCGGAG AAAGCATGAG AGTCTTTGGG 1320

AAAAACAATA GTTATGGCAA AGGTGTATCA AACAGCAAAC ATTGA 1365

Domain Profile

S: 1     yeklekigeGtygkvykakdketgevvAlKkirlekekegvpitalrEisllkelkhkni  60

         yeklek+geG+y++vyk+k+k +g++vAlK irl++e eg p+ta+rE sllk lkh+ni

Q: 120   YEKLEKLGEGSYATVYKGKSKVNGKLVALKVIRLQEE-EGTPFTAIREASLLKGLKHANI  178

         99********************************998.9*********************

S: 61    vkLlevvakdkkklyLvfefleqdLkkllkkkkkkklsleevkslllqlleglaylHsnk  120

         v L+++++ +k++l+Lvfe++++dL ++++k++  +l++e+vk +l+qll+gl+y+H++

Q: 179   VLLHDIIH-TKETLTLVFEYVHTDLCQYMDKHPG-GLHPENVKLFLFQLLRGLSYIHQRY  236

         ********.99***********************.*************************

S: 121   ilHRDlKpqNlLiskegklklaDfGlarafssplktytkevvTlwYraPelLlgakeYst  180

         ilHRDlKpqNlLis++g+lklaDfGlara s+p++ty++evvTlwYr+P++Llg++eYst

Q: 237   ILHRDLKPQNLLISDTGELKLADFGLARAKSVPSHTYSNEVVTLWYRPPDVLLGSTEYST  296

         ************************************************************

S: 181   avDiWsvgcilaelltrkplfqgkse.idqlerifkllgtpsekvwpevsklpeyk.ksf  238

          +D+W+vgci++e+++  + f+g ++ +dqlerif +lgtp+e++wp+v++lp++k ++f

Q: 297   CLDMWGVGCIFVEMIQGVAAFPGMKDiQDQLERIFLVLGTPNEDTWPGVHSLPHFKpERF  356

         ************************99679***************************99**

S: 239   pkkkkkklkekvkklk..ekaldllekllaldpkkRisakealqhkyf  284

         +++++k+l++ ++kl+  ++a dl +kll++ pk+R+sa++al+h+yf

Q: 357   TQYSPKNLRQAWNKLSyvNHAEDLASKLLQCFPKNRLSAQAALSHEYF  404

         ************99997678***************************9

Domain Sequence
(FASTA)

YEKLEKLGEG SYATVYKGKS KVNGKLVALK VIRLQEEEGT PFTAIREASL LKGLKHANIV 60

LLHDIIHTKE TLTLVFEYVH TDLCQYMDKH PGGLHPENVK LFLFQLLRGL SYIHQRYILH 120

RDLKPQNLLI SDTGELKLAD FGLARAKSVP SHTYSNEVVT LWYRPPDVLL GSTEYSTCLD 180

MWGVGCIFVE MIQGVAAFPG MKDIQDQLER IFLVLGTPNE DTWPGVHSLP HFKPERFTQY 240

SPKNLRQAWN KLSYVNHAED LASKLLQCFP KNRLSAQAAL SHEYF 285

Keyword

ATP-binding; Complete proteome; Nucleotide-binding; Reference proteome.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Drosophila melanogaster"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tarsius syrichta"; ?>Tetraodon nigroviridis"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0000308	; C:cytoplasmic cyclin-dependent protein kinase holoenzyme complex
GO:0005829	; C:cytosol
GO:0005634	; C:nucleus
GO:0005886	; C:plasma membrane
GO:0005524	; F:ATP binding
GO:0004693	; F:cyclin-dependent protein kinase activity
GO:0000086	; P:G2/M transition of mitotic cell cycle
GO:0060828	; P:regulation of canonical Wnt receptor signaling pathway

KEGG

InterPros

IPR011009	; Kinase-like_dom.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.

Pfam

PF00069

; Pkinase; 1.

SMARTs

SM00220

; S_TKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.

Prints

Created Date

20-Feb-2013