EKS-GAG-00371

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00371

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
AGC/DMPK	495.8	3.2E-149	18	284	267

Status

Unreviewed

Ensembl Protein

ENSGALP00000038574

UniProt Accession

E1BWT5;

Protein Name

Protein Synonyms/Alias

Gene Name

CDC42BPA

Gene Synonyms/Alias

CDC42BPA;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009158	ENSGALP00000038574	ENSGALT00000039364
ENSGALG00000009158	ENSGALP00000014905	ENSGALT00000014921

Organism

Gallus gallus

Functional Description

Protein Length

1660

Protein Sequence
(FASTA)

AKPFTSKVKQ MRLHKEDFEI LKVIGRGAFG EVAVVKLKNA DKVFAMKILN KWEMLKRAET 60

ACFREERDVL VNGDNQWITT LHYAFQDENY LYLVMDYYVG GDLLTLLSKF EDRLPEDMAR 120

FYLAEMVIAI DSVHQLHYVH RDIKPDNILM DMNGHIRLAD FGSCLKLMED GTVQSSVAVG 180

TPDYISPEIL QAMEDGKGKY GPECDWWSLG VCMYEMLYGE TPFYAESLVE TYGKIMNHKE 240

RFQFPAQVTD VSESAKDLIR RLICSREHRL GQNGIEDFKN HPFFAGIDWD NIRNCDAPYI 300

PEVSSPTDTS NFDVDDDCLK NSETMPPPSH TAFSGHHLPF VGFTYTSSCV LSDRSCLRLT 360

AGPPSMDLDA NIQRTLEDSL ATEAYERRIR RLEQEKLELS RKLQESTQTV QALQYSTVDG 420

PIAASKDLEI KSLKEEIEKL KKQVTDSGHL EQQLEEASTA RRELDDASRQ IKAFEKQVRT 480

LKQEREDLNK ELAESSDRLK SQAKELKDAH SQRKLAMQEF SEMNERLTDL HSQKQKLARQ 540

LRDKEEEMEV VMQKVESLRQ ELRRTERLKK ELEVQAEAAA AEASKDRKLR ERSEQYSKQL 600

ESEVEGLKQK QIGRSPGVSS IEHQQEITKL KADLEKKSVF YEEELSKREI MHANEIKSLK 660

KELRDAESQQ LALKKEIMIL KDKLEKTRRE NQSEREEFET EFKQKYEREK ILLTEENKKL 720

SNELDKLTTM FERLSMNNRQ LEEEMRDLAD KKESVAHWEA QITEIIQWVS DEKDARGYLQ 780

ALASKMTEEL EALRNSSLGA RATDMPWKMR RFAKLDMSAR LELQSALDAE IRAKQAIQDE 840

LNKVKASCIS TECKLQESEK KNLELLTDIE RLKKETEELR SEKGVKHQDS QNSFLAFLNA 900

PTSALDQFEV TDHPPRSIHT PTMRTAYIGS GLSAPKPKAH QFVVKSFNTP TKCNQCTSLM 960

VGLIRQGCTC EEVCGFSCHV TCADKAPAVC PIPPEQTKGP LGIDPQKGIG TAYEGHVRVP 1020

KPAGVKKGWQ RALAVICDFK LFLYDIAEGK ASQPSVVVSQ VIDMRDEEFS VSSVLASDVI 1080

HANRKDIPCI FRVTASQLSA TSNKCSILIL TDGENEKSKW VGVLNELHRI LKKNKLKDRS 1140

VYVPKEAYDS TLPLIKTTQS AAIIDHERIA LGNEEGLFVV HVTKDEIIRV GDNKKVHQIE 1200

LIPSEQLIAV ISGRNRHVRL FPMTALDGRE TEFYKLAETK GCQSIVSGHV RHGALTCLCV 1260

AMKRQVLCYE LNQSKTRHKK IKEIQVQGNV QWMSVFSERL CVGYQSGFLK HPLHGEGSPY 1320

SLLHPDDHTL SFISQQPTDA ICAVEISNKE YLLCFSSVGV YVDCQGRRSR QQELMWPATP 1380

SSCCYNAPYL SVYSENAIDI FDVNSMEWIQ TIPLKKVRPL NTEGSLNLLG LETVRLIYFK 1440

NKMAEGDELV VPETSDNSRK QMVRNINNKR RYSFRVPEEE RMQQRREMLR DPEMRNKLIS 1500

NPTNFNHIAH MGPGDGIQIL KDLPMNLRPQ ESRTVFSGSV SIPSITKSRT EPGRSMSASS 1560

GLAARSSAQN GSALRREFSG GSYGAKRQPM ASPSDGSLSS GGLDQGSDAP TRDYEREDSD 1620

SPRHSTASNS SNLSSPPSPV SPHKTKSLSL ESSDHVSWDS 1660

Nucleotide Sequence
(FASTA)

GCCAAACCAT TTACATCTAA AGTGAAACAG ATGCGACTAC ATAAAGAAGA TTTTGAAATC 60

CTGAAGGTGA TTGGTCGGGG AGCTTTTGGT GAGGTTGCAG TAGTAAAACT GAAGAATGCA 120

GATAAGGTTT TTGCCATGAA GATACTTAAT AAGTGGGAGA TGCTGAAGAG AGCTGAAACA 180

GCATGTTTTC GAGAAGAGAG AGATGTGTTA GTGAATGGAG ATAACCAGTG GATCACAACA 240

TTACATTACG CGTTCCAGGA TGAAAACTAT TTATACCTGG TTATGGATTA TTACGTTGGA 300

GGAGACCTAC TGACGTTGCT TAGCAAGTTT GAGGACAGAT TACCTGAAGA TATGGCTCGA 360

TTTTATTTGG CTGAAATGGT GATAGCCATC GATTCTGTGC ATCAGTTGCA TTATGTCCAC 420

AGGGATATTA AACCAGACAA CATCTTGATG GATATGAATG GCCATATTCG ATTAGCAGAT 480

TTTGGTTCTT GTCTGAAACT GATGGAAGAT GGAACGGTTC AATCTTCAGT AGCTGTTGGG 540

ACGCCAGACT ACATCTCTCC AGAAATTTTG CAGGCCATGG AAGATGGAAA AGGGAAGTAT 600

GGGCCTGAGT GTGACTGGTG GTCCCTAGGC GTTTGCATGT ATGAAATGCT TTATGGAGAA 660

ACACCCTTTT ATGCTGAGTC CTTGGTGGAG ACCTATGGGA AAATAATGAA CCACAAAGAG 720

AGGTTCCAGT TTCCTGCTCA AGTGACGGAT GTCTCTGAAA GTGCAAAGGA CCTCATCCGA 780

AGGCTAATTT GTAGCAGAGA GCATCGGCTT GGACAGAATG GGATAGAAGA CTTTAAGAAC 840

CATCCATTTT TTGCTGGGAT TGACTGGGAC AACATTAGAA ACTGTGATGC ACCTTACATT 900

CCAGAAGTCA GCAGCCCCAC TGATACATCA AACTTCGATG TGGATGATGA TTGCTTAAAA 960

AATTCTGAGA CGATGCCTCC ACCATCACAC ACTGCGTTTT CTGGTCATCA TTTACCATTT 1020

GTAGGTTTCA CATATACAAG TAGCTGTGTG CTTTCAGACC GCAGCTGTCT AAGACTGACA 1080

GCTGGACCAC CCTCCATGGA TCTTGATGCC AACATTCAAA GAACTTTGGA GGACAGTTTA 1140

GCAACAGAAG CTTATGAGAG GAGAATAAGA CGTCTAGAGC AGGAAAAGCT TGAACTTAGT 1200

AGAAAACTGC AAGAGTCCAC TCAGACAGTC CAGGCTCTTC AGTATTCAAC AGTGGATGGC 1260

CCAATTGCAG CAAGCAAAGA TTTAGAAATT AAAAGCTTAA AAGAAGAAAT TGAAAAGTTG 1320

AAGAAACAGG TAACAGATTC TGGACATCTA GAACAGCAAC TTGAAGAGGC CAGCACTGCA 1380

AGGCGGGAGT TGGACGATGC TTCCAGACAA ATAAAGGCTT TTGAGAAACA GGTTAGAACA 1440

CTGAAGCAAG AGAGGGAAGA TCTTAATAAG GAACTGGCAG AGTCTAGTGA CAGATTAAAA 1500

TCTCAAGCCA AAGAGCTGAA AGATGCACAC AGCCAGCGGA AATTGGCAAT GCAGGAGTTC 1560

TCAGAGATGA ACGAGCGGCT GACAGACTTG CACTCTCAAA AACAAAAGCT TGCCCGCCAG 1620

CTCCGAGATA AGGAAGAAGA AATGGAAGTG GTGATGCAAA AAGTAGAAAG TTTAAGGCAA 1680

GAGTTACGCA GAACAGAGAG ACTTAAAAAA GAACTGGAAG TCCAAGCTGA AGCTGCGGCT 1740

GCTGAGGCAT CCAAAGACAG GAAATTGCGA GAGCGGAGTG AGCAGTACTC TAAGCAGCTG 1800

GAAAGTGAAG TAGAGGGGCT AAAGCAAAAA CAGATTGGTC GCTCACCTGG GGTAAGCAGT 1860

ATAGAACACC AGCAAGAGAT CACTAAATTA AAGGCAGACC TGGAAAAGAA AAGTGTTTTC 1920

TATGAAGAGG AACTATCTAA ACGTGAAATA ATGCATGCTA ATGAAATAAA AAGTCTGAAG 1980

AAGGAACTAC GGGATGCAGA GAGCCAGCAG CTTGCACTTA AGAAGGAGAT CATGATTTTG 2040

AAAGACAAGT TAGAGAAAAC CAGAAGAGAA AACCAAAGTG AAAGAGAGGA ATTTGAAACA 2100

GAGTTCAAAC AGAAGTATGA ACGGGAAAAG ATTCTGCTAA CAGAGGAAAA CAAGAAACTT 2160

TCAAATGAAC TTGATAAGCT CACCACCATG TTTGAGAGGC TGAGTATGAA TAACCGGCAG 2220

CTGGAAGAAG AAATGAGAGA CCTAGCTGAT AAAAAGGAAT CTGTAGCCCA CTGGGAGGCC 2280

CAAATTACCG AGATCATCCA ATGGGTAAGT GATGAAAAAG ATGCTCGAGG TTATCTTCAA 2340

GCCTTGGCTT CTAAAATGAC AGAAGAACTA GAGGCCCTGA GGAATTCCAG CTTGGGTGCA 2400

AGAGCTACAG ACATGCCCTG GAAGATGCGC CGTTTTGCAA AGCTAGATAT GTCCGCAAGG 2460

TTGGAACTAC AGTCAGCTCT TGATGCTGAA ATCAGAGCCA AACAGGCTAT TCAAGATGAG 2520

TTGAATAAAG TCAAAGCTTC CTGTATCTCT ACAGAGTGTA AATTGCAAGA ATCAGAGAAG 2580

AAGAATTTGG AACTGTTGAC AGATATTGAA AGGCTGAAGA AGGAGACAGA AGAACTTAGA 2640

TCAGAAAAGG GTGTAAAGCA CCAAGACTCA CAGAATTCTT TCTTGGCATT TTTGAATGCG 2700

CCTACCTCTG CTCTGGATCA ATTTGAAGTT ACGGATCATC CTCCTCGATC AATTCACACA 2760

CCAACCATGC GGACTGCGTA TATTGGATCG GGACTCTCTG CACCAAAGCC TAAAGCCCAT 2820

CAGTTTGTAG TGAAATCATT TAATACCCCA ACAAAATGCA ATCAATGCAC ATCTCTAATG 2880

GTTGGTTTAA TAAGACAGGG CTGCACTTGT GAAGAAGTGT GTGGATTCTC CTGCCACGTG 2940

ACCTGTGCAG ACAAGGCCCC CGCAGTATGT CCAATCCCTC CTGAACAGAC TAAGGGCCCT 3000

TTGGGAATAG ATCCTCAGAA AGGTATAGGA ACAGCTTACG AAGGACATGT CCGAGTACCA 3060

AAACCAGCTG GTGTAAAGAA AGGTTGGCAG AGAGCACTGG CGGTAATCTG TGATTTTAAA 3120

CTCTTCCTGT ATGATATAGC AGAAGGAAAA GCATCGCAGC CAAGTGTGGT AGTGAGTCAG 3180

GTCATAGACA TGAGGGATGA AGAATTCTCA GTGAGTTCTG TCTTGGCTTC GGATGTCATC 3240

CATGCAAATC GAAAAGATAT CCCCTGTATC TTTAGAGTCA CAGCTTCCCA ACTCTCTGCA 3300

ACCAGTAATA AGTGTTCAAT CCTGATTCTA ACAGACGGTG AGAATGAAAA AAGCAAGTGG 3360

GTAGGAGTGC TGAATGAATT GCATAGGATC TTGAAGAAAA ACAAACTCAA AGACCGCTCA 3420

GTCTATGTTC CCAAAGAAGC TTATGACAGC ACCTTACCCC TCATCAAAAC AACGCAGTCA 3480

GCAGCAATCA TAGATCATGA AAGAATAGCA CTGGGGAATG AAGAAGGGTT ATTTGTTGTG 3540

CATGTCACCA AAGATGAGAT AATCCGTGTT GGTGATAATA AGAAGGTTCA TCAGATTGAG 3600

CTTATCCCAA GCGAACAGCT CATTGCAGTA ATCTCAGGAC GAAACCGTCA CGTGCGACTT 3660

TTCCCTATGA CAGCCCTGGA TGGAAGGGAG ACTGAGTTTT ATAAGTTGGC AGAAACAAAA 3720

GGCTGCCAGT CGATAGTTTC TGGACACGTG CGCCATGGAG CCCTTACATG CCTTTGTGTA 3780

GCTATGAAAA GGCAAGTCCT CTGTTATGAA CTAAATCAGA GTAAGACACG TCACAAAAAG 3840

ATCAAGGAGA TCCAAGTCCA GGGGAACGTC CAGTGGATGT CGGTCTTCAG TGAGCGTCTT 3900

TGTGTGGGCT ACCAGTCAGG TTTCTTAAAG CATCCCCTTC ATGGAGAAGG CAGCCCATAC 3960

AGTCTGCTCC ATCCAGATGA CCACACGCTA TCGTTTATCT CACAGCAGCC AACTGATGCC 4020

ATCTGTGCAG TCGAAATCTC AAATAAAGAA TACCTGCTGT GTTTTAGCAG CGTAGGGGTT 4080

TACGTTGACT GCCAGGGCCG GAGATCAAGA CAACAAGAAT TGATGTGGCC TGCAACTCCA 4140

TCATCTTGCT GTTACAATGC ACCATACCTC TCTGTGTATA GCGAAAATGC AATTGATATC 4200

TTTGACGTGA ACTCCATGGA GTGGATTCAG ACTATTCCTC TCAAAAAGGT ACGACCCTTG 4260

AATACAGAAG GATCACTCAA CCTTTTAGGT TTGGAGACAG TTAGATTAAT ATATTTCAAA 4320

AACAAAATGG CAGAGGGTGA TGAACTGGTG GTTCCTGAAA CATCAGATAA CAGCCGGAAG 4380

CAAATGGTTC GAAACATCAA CAACAAGCGC CGCTATTCAT TCAGAGTACC AGAAGAGGAG 4440

AGGATGCAGC AGAGGAGGGA GATGCTACGC GATCCAGAAA TGAGAAATAA ATTAATTTCT 4500

AACCCAACTA ATTTTAACCA CATAGCACAT ATGGGTCCTG GAGATGGTAT ACAGATTCTC 4560

AAAGACCTTC CAATGAATCT TCGGCCTCAG GAAAGTCGGA CCGTATTCAG TGGCTCTGTC 4620

AGTATCCCAT CGATCACGAA ATCCCGCACA GAACCAGGAC GATCGATGAG CGCAAGCAGT 4680

GGGTTAGCAG CAAGATCATC TGCACAAAAT GGCAGTGCAT TGCGGAGGGA ATTCTCAGGA 4740

GGTAGCTATG GAGCAAAGCG TCAGCCTATG GCATCGCCCT CAGATGGTTC GTTATCCTCT 4800

GGTGGCCTGG ACCAAGGCAG TGATGCACCA ACAAGGGACT ATGAGCGAGA GGACTCCGAC 4860

TCACCGAGAC ACTCCACTGC ATCGAACAGC TCCAACCTCA GCAGCCCTCC CAGCCCTGTT 4920

TCTCCTCACA AGACCAAGAG CCTCTCGCTG GAGAGCTCTG ACCACGTGAG TTGGGACTCA 4980

TGA 4983

Domain Profile

S: 1     feilkviGrGafgevavvrekatekvyamkilkklellkraesaffreerdvlvkadsew  60

         feilkviGrGafgevavv+ k+++kv+amkil+k+e+lkrae+a+freerdvlv++d++w

Q: 18    FEILKVIGRGAFGEVAVVKLKNADKVFAMKILNKWEMLKRAETACFREERDVLVNGDNQW  77

         89**********************************************************

S: 61    ivqlqyafqdekylylvmeylvGGdlltllskyedklpeelarfylaelvlaldsvhelg  120

         i++l+yafqde+ylylvm+y+vGGdlltllsk+ed+lpe++arfylae+v+a+dsvh+l+

Q: 78    ITTLHYAFQDENYLYLVMDYYVGGDLLTLLSKFEDRLPEDMARFYLAEMVIAIDSVHQLH  137

         ************************************************************

S: 121   yvhrdikpdnilldksGhikladfGsclklnedgtvkssvavGtpdyispevlkaleegk  180

         yvhrdikpdnil+d++Ghi+ladfGsclkl+edgtv+ssvavGtpdyispe+l+a+e+gk

Q: 138   YVHRDIKPDNILMDMNGHIRLADFGSCLKLMEDGTVQSSVAVGTPDYISPEILQAMEDGK  197

         ************************************************************

S: 181   geygkecdwwslGvilyellvgetpfyaeslvetyskilnhkeslkfpede.kvseeakd  239

         g+yg+ecdwwslGv++ye+l+getpfyaeslvety+ki+nhke+++fp+++ +vse+akd

Q: 198   GKYGPECDWWSLGVCMYEMLYGETPFYAESLVETYGKIMNHKERFQFPAQVtDVSESAKD  257

         **************************************************99********

S: 240   likklltsreerlgregiedlkkhpff  266

         li++l++sre+rlg++gied+k+hpff

Q: 258   LIRRLICSREHRLGQNGIEDFKNHPFF  284

         **************************9

Domain Sequence
(FASTA)

FEILKVIGRG AFGEVAVVKL KNADKVFAMK ILNKWEMLKR AETACFREER DVLVNGDNQW 60

ITTLHYAFQD ENYLYLVMDY YVGGDLLTLL SKFEDRLPED MARFYLAEMV IAIDSVHQLH 120

YVHRDIKPDN ILMDMNGHIR LADFGSCLKL MEDGTVQSSV AVGTPDYISP EILQAMEDGK 180

GKYGPECDWW SLGVCMYEML YGETPFYAES LVETYGKIMN HKERFQFPAQ VTDVSESAKD 240

LIRRLICSRE HRLGQNGIED FKNHPFF 267

Keyword

ATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Equus caballus"; ?>Gadus morhua"; ?>Gorilla gorilla"; ?>Ictidomys tridecemlineatus"; ?>Loxodonta africana"; ?>Monodelphis domestica"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0042641	; C:actomyosin
GO:0005524	; F:ATP binding
GO:0000287	; F:magnesium ion binding
GO:0005543	; F:phospholipid binding
GO:0004674	; F:protein serine/threonine kinase activity
GO:0005083	; F:small GTPase regulator activity
GO:0031532	; P:actin cytoskeleton reorganization
GO:0031032	; P:actomyosin structure organization
GO:0016477	; P:cell migration
GO:0035556	; P:intracellular signal transduction
GO:0000226	; P:microtubule cytoskeleton organization
GO:0007097	; P:nuclear migration

KEGG

InterPros

IPR000961	; AGC-kinase_C.
IPR001180	; Citron.
IPR011009	; Kinase-like_dom.
IPR014930	; Myotonic_dystrophy_kinase_coil.
IPR000095	; PAK_box_Rho-bd.
IPR011993	; PH_like_dom.
IPR017892	; Pkinase_C.
IPR001849	; Pleckstrin_homology.
IPR002219	; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR002290	; Ser/Thr_dual-sp_kinase_dom.
IPR008271	; Ser/Thr_kinase_AS.
IPR026611	; Ser/Thr_kinase_MRCK.

Pfam

PF00130	; C1_1; 1.
PF00780	; CNH; 1.
PF08826	; DMPK_coil; 1.
PF00069	; Pkinase; 1.
PF00433	; Pkinase_C; 1.

SMARTs

SM00109	; C1; 1.
SM00036	; CNH; 1.
SM00285	; PBD; 1.
SM00233	; PH; 1.
SM00133	; S_TK_X; 1.
SM00220	; S_TKc; 1.

Prosites

PS51285	; AGC_KINASE_CTER; 1.
PS50219	; CNH; 1.
PS50108	; CRIB; 1.
PS50003	; PH_DOMAIN; 1.
PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00108	; PROTEIN_KINASE_ST; 1.
PS50081	; ZF_DAG_PE_2; 1.

Prints

Created Date

20-Feb-2013