EKS-GAG-00148
Eukaryotic Protein Kinase & Protein Phosphatase Database
TagContent
EKPD IDEKS-GAG-00148
Classification
Group/FamilyScoreE-ValueStartEndDomain Length
AGC/PKC442.75.1E-133122390269
StatusUnreviewed
Ensembl ProteinENSGALP00000015235
UniProt AccessionE1BWA3;
Protein Name
Protein Synonyms/Alias
Gene NamePRKCI
Gene Synonyms/Alias PRKCI;
Ensembl Information
Ensembl Gene IDEnsembl Protein IDEnsembl Transcript ID
ENSGALG00000009364ENSGALP00000015235ENSGALT00000015251
ENSGALG00000009364ENSGALP00000038526ENSGALT00000039316
OrganismGallus gallus
Functional Description
Protein Length464
Protein Sequence
(FASTA)
MCFPVYQNGL ACLAQEKIRA HCAICSDRIW GLGRQGYKCI NCKLLVHKKC HKLVNTECGR 60
HTLQPEPIMP MDPSSVHPDN VESVIPYNPS SHESLDHVGE EKEAMGIRES GKASSSLGLQ 120
DFDLLRVIGR GSYAKVLLVR LKKTERIYAM KVVKKELVND DEDIDWVQTE KHVFEQASNH 180
PFLVGLHSCF QTESRLFFVI EYVNGGDLMF HMQRQRKLPE EHARFYSAEI SLALNYLHER 240
GIIYRDLKLD NVLLDSEGHI KLTDYGMCKE GLRPGDTTST FCGTPNYIAP EILRGEDYGF 300
SVDWWALGVL MFEMMAGRSP FDIVGSSDNP DQNTEDYLFQ VILEKQIRIP RSLSVKAAGV 360
LKSFLNKDPK ERLGCHPQTG FADIQGHPFF RNVDWDLMEQ KQVVPPFKPN ISGEFGLDNF 420
DSQFTNEPVQ LTPDDDDIVK KIDQSEFEGF EYINPLLMSA EECV 464
Nucleotide Sequence
(FASTA)
ATGTGTTTCC CTGTGTACCA GAACGGCCTG GCATGCCTTG CCCAGGAGAA GATACGAGCT 60
CACTGTGCCA TCTGCAGTGA CCGAATATGG GGCCTGGGTC GCCAGGGATA CAAATGCATC 120
AATTGCAAAC TCCTTGTTCA CAAGAAGTGT CACAAACTGG TCAATACTGA ATGTGGTCGT 180
CATACACTAC AACCAGAACC AATAATGCCT ATGGACCCAT CATCAGTGCA TCCAGATAAC 240
GTAGAATCAG TGATTCCATA TAATCCATCA AGTCATGAGA GCTTAGACCA TGTTGGTGAA 300
GAAAAGGAGG CAATGGGCAT AAGAGAAAGC GGCAAAGCTT CTTCCAGTCT GGGTCTTCAG 360
GATTTTGATT TGCTCCGAGT TATAGGAAGA GGCAGTTATG CTAAAGTACT GCTTGTTCGA 420
TTGAAGAAAA CAGAACGCAT TTATGCAATG AAGGTGGTGA AGAAAGAACT CGTCAATGAT 480
GATGAGGATA TTGATTGGGT TCAGACAGAG AAACATGTCT TTGAACAGGC TTCAAATCAT 540
CCTTTCCTTG TTGGACTGCA CTCTTGCTTC CAGACAGAAA GCAGGTTATT CTTTGTTATA 600
GAGTATGTAA ATGGAGGAGA TCTGATGTTT CACATGCAGA GACAGAGAAA ACTGCCAGAA 660
GAGCATGCCA GATTTTATTC TGCTGAAATC AGCCTTGCAT TGAATTATTT ACATGAACGA 720
GGAATAATCT ACAGAGATTT AAAACTAGAT AATGTGCTAC TAGATTCTGA AGGACATATT 780
AAACTCACAG ATTATGGCAT GTGCAAGGAA GGGCTGAGGC CTGGTGATAC AACAAGCACG 840
TTCTGTGGAA CTCCAAACTA TATTGCTCCT GAAATTCTTC GAGGAGAAGA TTATGGCTTC 900
AGTGTAGACT GGTGGGCACT TGGTGTACTT ATGTTTGAAA TGATGGCAGG CAGGTCACCA 960
TTTGATATAG TCGGAAGTTC TGACAATCCT GATCAGAACA CAGAAGACTA TCTTTTTCAA 1020
GTAATTTTGG AAAAGCAGAT CCGGATTCCC CGATCCCTTT CTGTTAAAGC AGCAGGTGTT 1080
CTAAAGAGTT TCCTTAATAA GGATCCAAAG GAGCGGTTAG GCTGCCACCC CCAGACAGGA 1140
TTTGCAGATA TCCAGGGACA TCCATTTTTT CGCAATGTTG ATTGGGATCT GATGGAGCAA 1200
AAGCAAGTGG TGCCTCCATT CAAACCAAAT ATATCTGGAG AATTTGGTCT GGATAACTTT 1260
GATTCCCAGT TCACCAATGA ACCTGTGCAG CTCACTCCAG ATGATGACGA TATTGTGAAG 1320
AAGATTGACC AGTCTGAATT TGAAGGCTTT GAATACATAA ATCCTCTTTT GATGTCAGCT 1380
GAGGAATGCG TCTGA 1395
Domain Profile
S: 1     fellkvlGkGsfgkvllaelkktdelyaikvlkkdvvlqdddveltlvekrvlalaskkp  60
         f+ll+v+G+Gs++kvll++lkkt+++ya+kv+kk++v++d+d++++++ek+v+++as++p
Q: 122   FDLLRVIGRGSYAKVLLVRLKKTERIYAMKVVKKELVNDDEDIDWVQTEKHVFEQASNHP  181
         89**********************************************************
S: 61    flvqlfscfqtedrlffvleyvnGGdlmfhiqkarklkeerarfyaaeiilalkflhekg  120
         flv l+scfqte+rlffv+eyvnGGdlmfh+q++rkl+ee+arfy+aei+lal++lhe+g
Q: 182   FLVGLHSCFQTESRLFFVIEYVNGGDLMFHMQRQRKLPEEHARFYSAEISLALNYLHERG  241
         ************************************************************
S: 121   iiyrdlkldnvlldaeGhikladfGlckeeilegkttstfcGtPdyiaPeilkeeeygks  180
         iiyrdlkldnvlld+eGhikl+d+G+cke++  g+ttstfcGtP+yiaPeil++e+yg+s
Q: 242   IIYRDLKLDNVLLDSEGHIKLTDYGMCKEGLRPGDTTSTFCGTPNYIAPEILRGEDYGFS  301
         ************************************************************
S: 181   vdwwalGvllyemlagqsPfe.........gededelfesilekevlyPkslskeaveil  231
         vdwwalGvl++em+ag+sPf+         +++ed+lf++ilek++++P+sls++a+ +l
Q: 302   VDWWALGVLMFEMMAGRSPFDivgssdnpdQNTEDYLFQVILEKQIRIPRSLSVKAAGVL  361
         *****************************99*****************************
S: 232   kglltkdpekrlGvk.eegeedikehaff  259
         k++l+kdp++rlG++ ++g +di+ h+ff
Q: 362   KSFLNKDPKERLGCHpQTGFADIQGHPFF  390
         **************989***********9
Domain Sequence
(FASTA)
FDLLRVIGRG SYAKVLLVRL KKTERIYAMK VVKKELVNDD EDIDWVQTEK HVFEQASNHP 60
FLVGLHSCFQ TESRLFFVIE YVNGGDLMFH MQRQRKLPEE HARFYSAEIS LALNYLHERG 120
IIYRDLKLDN VLLDSEGHIK LTDYGMCKEG LRPGDTTSTF CGTPNYIAPE ILRGEDYGFS 180
VDWWALGVLM FEMMAGRSPF DIVGSSDNPD QNTEDYLFQV ILEKQIRIPR SLSVKAAGVL 240
KSFLNKDPKE RLGCHPQTGF ADIQGHPFF 269
KeywordATP-binding; Complete proteome; Kinase; Metal-binding; Nucleotide-binding; Reference proteome; Serine/threonine-protein kinase; Transferase; Zinc; Zinc-finger.
Sequence SourceEnsembl
Orthology
Ortholog group
Ailuropoda melanoleuca"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Ornithorhynchus anatinus"; ?>Sus scrofa"; ?>Takifugu rubripes"; ?>
EKS-AIM-00167
EKS-MAM-00173
EKS-MEG-00137
EKS-MOD-00170
EKS-ORA-00151
EKS-SUS-00149
EKS-TAR-00224
Gene Ontology
GO:0016324; C:apical plasma membrane
GO:0005829; C:cytosol
GO:0005634; C:nucleus
GO:0043220; C:Schmidt-Lanterman incisure
GO:0005524; F:ATP binding
GO:0005543; F:phospholipid binding
GO:0004697; F:protein kinase C activity
GO:0008270; F:zinc ion binding
GO:0007015; P:actin filament organization
GO:0045216; P:cell-cell junction organization
GO:0035089; P:establishment of apical/basal cell polarity
GO:0035556; P:intracellular signal transduction
GO:0034351; P:negative regulation of glial cell apoptotic process
GO:0043524; P:negative regulation of neuron apoptotic process
GO:2000353; P:positive regulation of endothelial cell apoptotic process
GO:0090004; P:positive regulation of establishment of protein localization to plasma membrane
GO:0046326; P:positive regulation of glucose import
GO:0051092; P:positive regulation of NF-kappaB transcription factor activity
KEGG
InterPros
IPR000961; AGC-kinase_C.
IPR020454; DAG/PE-bd.
IPR011009; Kinase-like_dom.
IPR000270; OPR_PB1.
IPR012233; PKC_zeta.
IPR017892; Pkinase_C.
IPR002219; Prot_Kinase_C-like_PE/DAG-bd.
IPR000719; Prot_kinase_cat_dom.
IPR017441; Protein_kinase_ATP_BS.
IPR002290; Ser/Thr_dual-sp_kinase_dom.
IPR008271; Ser/Thr_kinase_AS.
Pfam
PF00130; C1_1; 1.
PF00564; PB1; 1.
PF00069; Pkinase; 1.
PF00433; Pkinase_C; 1.
SMARTs
SM00109; C1; 1.
SM00666; PB1; 1.
SM00133; S_TK_X; 1.
SM00220; S_TKc; 1.
Prosites
PS51285; AGC_KINASE_CTER; 1.
PS00107; PROTEIN_KINASE_ATP; 1.
PS50011; PROTEIN_KINASE_DOM; 1.
PS00108; PROTEIN_KINASE_ST; 1.
PS00479; ZF_DAG_PE_1; 1.
PS50081; ZF_DAG_PE_2; 1.
Prints
PR00008; DAGPEDOMAIN.
Created Date20-Feb-2013