EKS-GAG-00103

Eukaryotic Protein Kinase & Protein Phosphatase Database

Tag

Content

EKPD ID

EKS-GAG-00103

Classification

Group/Family	Score	E-Value	Start	End	Domain Length
TK/Met	476.6	2.1E-143	1079	1339	261

Status

Unreviewed

Ensembl Protein

ENSGALP00000015284

UniProt Accession

F1P040;

Protein Name

Protein Synonyms/Alias

Gene Name

MET

Gene Synonyms/Alias

MET;

Ensembl Information

Ensembl Gene ID	Ensembl Protein ID	Ensembl Transcript ID
ENSGALG00000009390	ENSGALP00000038148	ENSGALT00000038938
ENSGALG00000009390	ENSGALP00000015284	ENSGALT00000015300

Organism

Gallus gallus

Functional Description

Protein Length

1382

Protein Sequence
(FASTA)

MKPVTAYPSG IILFLFALLQ RSHGQCKEAA KKSEMNLNVK YDLPNFITET PIQNVVLYKH 60

HVYIGAVNKI YVLNETLQNI SVYKTGPILE SPGCAPCEDC KDKANLSNSV WKDNVNMALL 120

LETYYDDQLI SCGSVSGGVC HRHIIPPDNP ADIESEVHCM YSPQVDGEAD NCPDCVVSTL 180

GTKVLVTEKD RFVNFFVGNT VTSAFQPPHV LHSISVRRLK ETQDGFEFLT DQSYIDILPQ 240

FRDSYPIKYV HAFEHDHFVY FLTVQRESLD SQTFHTRIIR FCTLDSEMHS YMEMPLECIF 300

TEKRRKRSIR KEVFNILQAA YVSKPGAALA HEMGLGLNDD ILYGVFAQSK PDSSEPTNRS 360

AVCAVSVRTI NEFFNKIVDK QNMKCLQHFY GKDSKYCLNR AFSRNASYCR AQDDEYRLEV 420

TTPLQRVDLF MGQFNNILLT SISVFTKGNL TIANLGTSEG RFMQIVVSRS EPTAPHVSFQ 480

LDSHAVSPQV VVEQSAAADG YTLVVTGKKI TKVPLNGPGC HHFQSCSQCL LAPAFMRCGW 540

CGQQCLRAPE CNGGTWTQET CLPRVYEILP SSAPLEGGTK LTLCGWDFGF SKNNRFELRN 600

TVVHIGGQIC ALEAKSSNKN KLECTAPAAK NASFNISSSV SVGHGKTLFN TFSYVNPIIT 660

SISPTYGPKS GGTLLTIAGK YLNSGKSRRI FVGEKPCSLK STSESSVECY TPAQRIPQEY 720

RVRVGIDGAI RDAKGYFTYR EDPVVLKIHP AKSFLSGGST ITAQGINLNS VCFPRMVITV 780

PKLGMNFSVA CSHRSSSEII CCTTPSLKAF NLQPPFVTKV FFIFDGVSSL YFDFDYVNNP 840

VFKHFEKPVL ISRSNPNVLE IKGNHIDSEA VKGEVLKVGN KSCENLLLQS ETILCTVPSD 900

LLKSNSELNI EWKQEVLSTV IGKVLIRQDQ NFTGLIAGVV STSVLIFIFL VFFLWRRKKK 960

QIKDLGSDLV RYDGRVHTPH LDRLVSARSV SPTTEMVSSE SVDYRSTFLE DQFPSMSQNG 1020

SCRPAQYPHS DLSPILSSGD SDLASPLLQT NVHIDISALN PDLVKEVQHV VIGADSLMVH 1080

FSEVIGRGHF GCVYHGTLLD NDGRKIHCAV KSLNRITDLE EVAQFLKEGI IMKDFTHPNV 1140

LSLLGICLPN EGSPLVVLPY MKHGDLRNFI RNETHNPTVK DLIGFGLQVA KGMKYLASKK 1200

FVHRDLAARN CMLDEKFTVK VADFGLARDV YDKEYYSVHN KTGAKLPVKW MALESLQTQK 1260

FTTKSDVWSF GVLLWELMTR GAPPYPDVNS FDITVYLLQG RRLLQPEYCP DPLYEVMLKC 1320

WHPKPEMRPA FSELVSKIST IFSTFIGEHY VHVNATYVNV KCVAPYPSLL SSQDNTDMDV 1380

DT 1382

Nucleotide Sequence
(FASTA)

ATGAAGCCTG TTACTGCCTA TCCTTCTGGG ATTATCCTAT TCCTGTTTGC GTTGCTGCAA 60

AGAAGTCATG GACAATGCAA AGAGGCAGCT AAAAAATCAG AGATGAACTT GAATGTAAAA 120

TATGATCTTC CTAACTTCAT CACAGAGACG CCAATTCAGA ATGTAGTTTT ATACAAGCAT 180

CATGTTTATA TTGGAGCAGT CAACAAGATT TATGTACTAA ACGAGACTCT CCAAAACATT 240

TCTGTCTACA AGACTGGGCC AATTTTGGAG AGTCCTGGCT GCGCACCATG TGAAGACTGC 300

AAAGATAAAG CTAATCTGTC TAACAGCGTA TGGAAGGATA ATGTCAACAT GGCACTGCTC 360

TTAGAAACCT ATTACGATGA TCAGCTCATC AGCTGTGGTA GTGTGTCTGG AGGTGTCTGT 420

CACCGTCACA TCATTCCCCC TGACAACCCT GCTGACATAG AAAGCGAGGT GCACTGCATG 480

TATTCACCGC AGGTAGACGG AGAGGCAGAT AATTGTCCTG ACTGTGTTGT AAGCACTTTA 540

GGAACCAAAG TTCTGGTGAC TGAAAAGGAC AGGTTTGTCA ACTTCTTTGT TGGAAACACC 600

GTGACATCTG CATTTCAACC TCCCCATGTA CTGCATTCAA TATCAGTTAG AAGGTTGAAA 660

GAGACACAGG ATGGGTTTGA ATTTCTTACA GATCAGTCTT ATATAGATAT CCTCCCTCAG 720

TTCCGCGACT CGTATCCCAT TAAGTATGTC CATGCCTTTG AGCATGACCA CTTTGTCTAT 780

TTTTTGACTG TCCAGAGAGA ATCTCTTGAC TCCCAAACTT TTCACACTAG AATTATTCGC 840

TTCTGCACTT TAGATTCAGA GATGCATTCT TACATGGAAA TGCCTCTTGA GTGTATTTTT 900

ACTGAAAAGC GGAGGAAGAG GTCCATTAGA AAGGAGGTAT TCAACATTTT GCAAGCTGCA 960

TATGTAAGCA AACCCGGTGC AGCCCTAGCC CATGAAATGG GCCTTGGATT GAATGATGAT 1020

ATTCTCTATG GCGTTTTTGC ACAAAGCAAA CCAGATTCCT CAGAACCAAC AAACAGATCT 1080

GCTGTCTGCG CAGTCTCCGT GCGAACAATC AATGAGTTCT TCAACAAGAT TGTTGACAAG 1140

CAGAACATGA AATGTCTTCA GCACTTTTAT GGGAAAGATA GCAAATACTG CTTGAACAGG 1200

GCTTTTTCAA GAAATGCTTC ATACTGCAGA GCACAAGATG ATGAATACCG CTTAGAAGTT 1260

ACGACTCCCT TGCAGAGGGT TGACTTGTTC ATGGGCCAGT TCAACAACAT CCTGTTAACT 1320

TCGATATCTG TCTTCACCAA AGGGAACCTT ACCATTGCCA ACCTGGGAAC TTCAGAGGGC 1380

CGCTTCATGC AGATAGTGGT TTCCCGCTCC GAGCCCACAG CTCCACACGT CAGCTTTCAG 1440

CTGGACTCCC ACGCCGTCTC TCCCCAGGTT GTTGTCGAGC AGTCGGCAGC AGCAGATGGC 1500

TATACTCTGG TAGTGACTGG AAAAAAGATA ACCAAGGTGC CGCTGAACGG GCCGGGCTGC 1560

CACCACTTCC AGTCCTGCAG CCAGTGCCTG CTGGCACCTG CCTTCATGCG CTGCGGCTGG 1620

TGTGGCCAGC AGTGCCTGAG GGCTCCCGAG TGCAACGGAG GGACCTGGAC CCAGGAGACC 1680

TGCTTGCCGA GAGTTTATGA GATTCTCCCA AGCAGCGCTC CTTTAGAAGG CGGGACAAAA 1740

CTGACACTGT GCGGATGGGA CTTCGGGTTC AGCAAAAATA ACAGATTTGA ATTAAGAAAT 1800

ACAGTAGTCC ATATCGGAGG ACAAATCTGT GCTCTGGAAG CAAAATCTAG CAACAAAAAC 1860

AAGCTGGAAT GCACAGCTCC TGCTGCAAAA AATGCTAGTT TTAATATATC CAGTAGTGTT 1920

TCTGTTGGAC ATGGAAAAAC ATTATTCAAT ACATTTTCAT ATGTGAATCC TATAATAACA 1980

AGTATCTCCC CCACCTACGG CCCCAAATCT GGAGGAACAT TGCTAACAAT AGCTGGCAAA 2040

TACCTAAACA GTGGAAAATC CAGAAGGATT TTTGTTGGTG AGAAACCATG CAGCTTGAAA 2100

AGCACATCGG AAAGCAGTGT GGAGTGCTAC ACTCCAGCAC AACGAATCCC CCAGGAATAC 2160

CGCGTGAGGG TGGGAATTGA CGGAGCCATC AGAGATGCAA AAGGTTATTT CACCTACAGA 2220

GAAGACCCCG TTGTTTTAAA AATTCATCCG GCCAAATCTT TTCTTAGTGG TGGAAGTACA 2280

ATTACAGCTC AGGGAATCAA CCTGAACTCA GTGTGCTTCC CTCGGATGGT GATTACTGTA 2340

CCTAAACTGG GAATGAACTT CTCCGTGGCG TGTAGCCACC GTTCTAGCTC AGAGATAATC 2400

TGCTGTACAA CTCCTTCCCT GAAAGCCTTC AATCTTCAAC CACCCTTTGT AACCAAAGTA 2460

TTCTTCATTT TTGATGGTGT CAGCTCCTTG TACTTTGATT TTGATTATGT AAATAATCCC 2520

GTATTTAAAC ATTTTGAAAA GCCAGTGCTC ATCTCAAGGA GCAACCCAAA CGTTCTGGAA 2580

ATTAAGGGAA ATCATATTGA TTCAGAAGCT GTTAAAGGAG AGGTGCTAAA AGTTGGAAAT 2640

AAAAGCTGTG AAAACCTCCT CTTGCAGTCA GAAACAATTC TGTGCACAGT TCCCAGTGAT 2700

CTCCTGAAAT CCAACAGTGA GCTAAATATA GAGTGGAAGC AAGAAGTTTT GTCAACAGTT 2760

ATTGGGAAAG TGCTGATCCG GCAAGATCAG AATTTCACAG GACTGATTGC TGGAGTTGTT 2820

TCAACATCTG TTTTAATTTT TATCTTTTTG GTATTTTTTC TCTGGAGAAG GAAGAAGAAG 2880

CAGATTAAAG ATCTGGGAAG TGACCTGGTG CGCTATGATG GCAGAGTGCA CACTCCTCAC 2940

CTGGACAGGC TGGTGAGTGC AAGGAGTGTC AGTCCAACAA CGGAAATGGT CTCCAGTGAA 3000

TCTGTAGATT ACAGGTCAAC ATTCCTAGAA GATCAGTTCC CAAGCATGTC TCAGAATGGA 3060

TCGTGCAGAC CTGCCCAATA TCCTCACTCT GACCTCTCCC CAATTCTGTC CAGTGGGGAC 3120

TCAGATTTAG CCAGTCCTCT TCTTCAAACT AACGTCCACA TCGATATCAG TGCCTTAAAT 3180

CCTGACCTGG TCAAAGAAGT CCAGCACGTT GTTATTGGTG CTGATAGCCT GATGGTACAT 3240

TTCAGCGAAG TAATAGGAAG AGGACATTTT GGGTGTGTGT ACCATGGAAC ACTGCTGGAT 3300

AATGATGGCA GGAAAATTCA CTGTGCTGTG AAGTCACTGA ATAGAATTAC AGACCTGGAA 3360

GAAGTGGCTC AGTTTCTGAA AGAAGGAATA ATCATGAAAG ATTTCACTCA TCCCAATGTT 3420

CTGTCGCTAC TGGGAATCTG TTTACCCAAC GAAGGATCCC CCTTAGTGGT CCTTCCGTAC 3480

ATGAAACATG GAGACCTTCG AAACTTCATT AGGAATGAGA CTCACAATCC AACAGTTAAA 3540

GATTTAATTG GATTTGGTCT TCAGGTTGCA AAAGGGATGA AATACCTTGC AAGCAAAAAG 3600

TTTGTCCACA GAGACTTGGC AGCAAGAAAC TGTATGTTGG ATGAAAAATT CACTGTCAAG 3660

GTGGCTGATT TTGGTCTTGC TAGAGATGTC TATGATAAAG AGTACTACAG TGTGCACAAT 3720

AAAACAGGAG CTAAGCTGCC AGTGAAATGG ATGGCTTTAG AAAGTTTACA AACTCAGAAG 3780

TTCACGACAA AGTCAGATGT GTGGTCCTTC GGTGTGCTTT TATGGGAACT TATGACAAGA 3840

GGGGCACCAC CTTATCCTGA TGTAAATTCT TTTGATATAA CTGTTTACTT ATTACAAGGA 3900

AGAAGGCTGC TACAACCTGA ATACTGCCCT GACCCACTGT ATGAAGTCAT GCTGAAATGT 3960

TGGCATCCGA AACCTGAGAT GCGTCCAGCA TTTTCTGAAC TTGTTTCAAA AATATCAACA 4020

ATCTTCTCCA CTTTCATTGG GGAACACTAC GTTCATGTCA ATGCTACTTA TGTCAACGTG 4080

AAGTGTGTTG CTCCCTATCC TTCTCTTCTA TCATCACAAG ACAATACAGA CATGGATGTA 4140

GACACATGA 4149

Domain Profile

S: 1     vdkeeviGkGhfGvvykgelsdsaskkikvavksleritdiekveeflreglvmkeldhp  60

         v+++eviG+GhfG+vy+g+l+d++++ki++avksl+ritd+e+v +fl+eg++mk++ hp

Q: 1079  VHFSEVIGRGHFGCVYHGTLLDNDGRKIHCAVKSLNRITDLEEVAQFLKEGIIMKDFTHP  1138

         7999********************************************************

S: 61    nvlsllGialddeglplvvlpymkkGdlksfirneernltvkdllefalqvakgmeylas  120

         nvlsllGi+l++eg+plvvlpymk+Gdl++firne++n+tvkdl++f+lqvakgm+ylas

Q: 1139  NVLSLLGICLPNEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLAS  1198

         ************************************************************

S: 121   kkfvhrdlaarnclldekltvkvadfGlardvldkelyvveeerdarlpvkwlaleslqt  180

         kkfvhrdlaarnc+ldek+tvkvadfGlardv+dke+y+v+++++a+lpvkw+aleslqt

Q: 1199  KKFVHRDLAARNCMLDEKFTVKVADFGLARDVYDKEYYSVHNKTGAKLPVKWMALESLQT  1258

         ************************************************************

S: 181   fkqfttksdvwsfGvllwelltrgatpysevasfdltlylkegrrlrkpeycpdklydvm  240

         +k fttksdvwsfGvllwel+trga+py++v+sfd+t+yl +grrl +peycpd ly+vm

Q: 1259  QK-FTTKSDVWSFGVLLWELMTRGAPPYPDVNSFDITVYLLQGRRLLQPEYCPDPLYEVM  1317

         **.*********************************************************

S: 241   lkcwkakpaerpqfsdlvsiis  262

         lkcw++kp++rp fs+lvs+is

Q: 1318  LKCWHPKPEMRPAFSELVSKIS  1339

         *******************997

Domain Sequence
(FASTA)

VHFSEVIGRG HFGCVYHGTL LDNDGRKIHC AVKSLNRITD LEEVAQFLKE GIIMKDFTHP 60

NVLSLLGICL PNEGSPLVVL PYMKHGDLRN FIRNETHNPT VKDLIGFGLQ VAKGMKYLAS 120

KKFVHRDLAA RNCMLDEKFT VKVADFGLAR DVYDKEYYSV HNKTGAKLPV KWMALESLQT 180

QKFTTKSDVW SFGVLLWELM TRGAPPYPDV NSFDITVYLL QGRRLLQPEY CPDPLYEVML 240

KCWHPKPEMR PAFSELVSKI S 261

Keyword

ATP-binding; Complete proteome; Disulfide bond; Kinase; Membrane; Nucleotide-binding; Phosphoprotein; Receptor; Reference proteome; Transferase; Transmembrane; Transmembrane helix; Tyrosine-protein kinase.

Sequence Source

Ensembl

Orthology

Ortholog group

Ailuropoda melanoleuca"; ?>Anolis carolinensis"; ?>Bos taurus"; ?>Caenorhabditis elegans"; ?>Callithrix jacchus"; ?>Canis familiaris"; ?>Cavia porcellus"; ?>Ciona intestinalis"; ?>Ciona savignyi"; ?>Danio rerio"; ?>Echinops telfairi"; ?>Equus caballus"; ?>Felis catus"; ?>Gasterosteus aculeatus"; ?>Gorilla gorilla"; ?>Homo sapiens"; ?>Ictidomys tridecemlineatus"; ?>Latimeria chalumnae"; ?>Loxodonta africana"; ?>Macaca mulatta"; ?>Meleagris gallopavo"; ?>Monodelphis domestica"; ?>Mus musculus"; ?>Mustela putorius furo"; ?>Myotis lucifugus"; ?>Nomascus leucogenys"; ?>Ochotona princeps"; ?>Oreochromis niloticus"; ?>Ornithorhynchus anatinus"; ?>Oryctolagus cuniculus"; ?>Oryzias latipes"; ?>Otolemur garnettii"; ?>Pan troglodytes"; ?>Pelodiscus sinensis"; ?>Petromyzon marinus"; ?>Pongo abelii"; ?>Pteropus vampyrus"; ?>Rattus norvegicus"; ?>Sarcophilus harrisii"; ?>Sorex araneus"; ?>Sus scrofa"; ?>Taeniopygia guttata"; ?>Takifugu rubripes"; ?>Tetraodon nigroviridis"; ?>Vicugna pacos"; ?>Xenopus tropicalis"; ?>Xiphophorus maculatus"; ?>

Gene Ontology

GO:0009925	; C:basal plasma membrane
GO:0016021	; C:integral to membrane
GO:0005524	; F:ATP binding
GO:0005008	; F:hepatocyte growth factor-activated receptor activity
GO:0000187	; P:activation of MAPK activity
GO:0042593	; P:glucose homeostasis
GO:0007275	; P:multicellular organismal development
GO:0014812	; P:muscle cell migration
GO:0051450	; P:myoblast proliferation
GO:0010828	; P:positive regulation of glucose transport
GO:0046777	; P:protein autophosphorylation
GO:0060665	; P:regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling

KEGG

InterPros

IPR013783	; Ig-like_fold.
IPR014756	; Ig_E-set.
IPR002909	; IPT_TIG_rcpt.
IPR011009	; Kinase-like_dom.
IPR003659	; Plexin-like.
IPR016201	; Plexin-like_fold.
IPR002165	; Plexin_repeat.
IPR000719	; Prot_kinase_cat_dom.
IPR017441	; Protein_kinase_ATP_BS.
IPR001627	; Semaphorin/CD100_Ag.
IPR001245	; Ser-Thr/Tyr_kinase_cat_dom.
IPR008266	; Tyr_kinase_AS.
IPR020635	; Tyr_kinase_cat_dom.
IPR016244	; Tyr_kinase_HGF/MSP_rcpt.
IPR015943	; WD40/YVTN_repeat-like_dom.

Pfam

PF07714	; Pkinase_Tyr; 1.
PF01437	; PSI; 1.
PF01403	; Sema; 1.
PF01833	; TIG; 2.

SMARTs

SM00429	; IPT; 4.
SM00423	; PSI; 1.
SM00630	; Sema; 1.
SM00219	; TyrKc; 1.

Prosites

PS00107	; PROTEIN_KINASE_ATP; 1.
PS50011	; PROTEIN_KINASE_DOM; 1.
PS00109	; PROTEIN_KINASE_TYR; 1.
PS51004	; SEMA; 1.

Prints

PR00109

; TYRKINASE.

Created Date

20-Feb-2013